{"id":"https://openalex.org/W2103974096","doi":"https://doi.org/10.1093/humrep/der373","title":"Non-invasive metabolomic profiling of Day 2 and 5 embryo culture medium: a prospective randomized trial","display_name":"Non-invasive metabolomic profiling of Day 2 and 5 embryo culture medium: a prospective randomized trial","publication_year":2011,"publication_date":"2011-11-07","ids":{"openalex":"https://openalex.org/W2103974096","doi":"https://doi.org/10.1093/humrep/der373","mag":"2103974096","pmid":"https://pubmed.ncbi.nlm.nih.gov/22068638"},"language":"en","primary_location":{"id":"doi:10.1093/humrep/der373","doi":"https://doi.org/10.1093/humrep/der373","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/der373","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016640596","display_name":"Thorir Hardarson","orcid":"https://orcid.org/0000-0002-3339-1744","observed_orcids":["https://orcid.org/0000-0002-3339-1744"]},"institutions":[{"id":"https://openalex.org/I4210161615","display_name":"Fertilitetscentrum","ror":"https://ror.org/059rgaq66","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210161615"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"T. Hardarson","raw_affiliation_strings":["Fertilitetscentrum, G\u00f6teborg, Sweden. thorir.hardarson@fcivf.com","Fertilitetscentrum, G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fertilitetscentrum, G\u00f6teborg, Sweden. thorir.hardarson@fcivf.com","institution_ids":["https://openalex.org/I4210161615"]},{"raw_affiliation_string":"Fertilitetscentrum, G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I4210161615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056758466","display_name":"Aisling Ahlstr\u00f6m","orcid":"https://orcid.org/0000-0002-5074-912X","observed_orcids":["https://orcid.org/0000-0002-5074-912X"]},"institutions":[{"id":"https://openalex.org/I4210161615","display_name":"Fertilitetscentrum","ror":"https://ror.org/059rgaq66","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210161615"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"A. Ahlstrom","raw_affiliation_strings":["Fertilitetscentrum, G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fertilitetscentrum, G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I4210161615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004708832","display_name":"Lena Rogberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161615","display_name":"Fertilitetscentrum","ror":"https://ror.org/059rgaq66","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210161615"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"L. Rogberg","raw_affiliation_strings":["Fertilitetscentrum, G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fertilitetscentrum, G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I4210161615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004421988","display_name":"Lucy L. Botros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267349","display_name":"Molecular Biometrics, Inc. (United States)","ror":"https://ror.org/02b4s9z68","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267349"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Botros","raw_affiliation_strings":["Molecular Biometrics Inc., Norwood, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biometrics Inc., Norwood, MA, USA","institution_ids":["https://openalex.org/I4405267349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029294298","display_name":"Torbj\u00f6rn Hillensj\u00f8","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161615","display_name":"Fertilitetscentrum","ror":"https://ror.org/059rgaq66","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210161615"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"T. Hillensjo","raw_affiliation_strings":["Fertilitetscentrum, G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fertilitetscentrum, G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I4210161615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111607853","display_name":"G\u00f6ran Westlander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161615","display_name":"Fertilitetscentrum","ror":"https://ror.org/059rgaq66","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210161615"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"G. Westlander","raw_affiliation_strings":["Fertilitetscentrum, G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fertilitetscentrum, G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I4210161615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081189347","display_name":"Denny Sakkas","orcid":"https://orcid.org/0000-0002-9509-6791","observed_orcids":["https://orcid.org/0000-0002-9509-6791","https://orcid.org/0000-0002-8729-4958"]},"institutions":[{"id":"https://openalex.org/I4405267349","display_name":"Molecular Biometrics, Inc. (United States)","ror":"https://ror.org/02b4s9z68","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267349"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Sakkas","raw_affiliation_strings":["Molecular Biometrics Inc., Norwood, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biometrics Inc., Norwood, MA, USA","institution_ids":["https://openalex.org/I4405267349"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019438291","display_name":"Matts Wikland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161615","display_name":"Fertilitetscentrum","ror":"https://ror.org/059rgaq66","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210161615"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"M. Wikland","raw_affiliation_strings":["Fertilitetscentrum, G\u00f6teborg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fertilitetscentrum, G\u00f6teborg, Sweden","institution_ids":["https://openalex.org/I4210161615"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016640596"],"corresponding_institution_ids":["https://openalex.org/I4210161615"],"apc_list":{"value":4097,"currency":"EUR","value_usd":4630},"apc_paid":null,"fwci":20.3725,"has_fulltext":false,"cited_by_count":157,"citation_normalized_percentile":{"value":0.99659776,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"27","issue":"1","first_page":"89","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.1168999969959259,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/near-infrared-spectroscopy","display_name":"near-infrared spectroscopy","score":0.984000027179718},{"id":"https://openalex.org/keywords/embryo-culture-medium","display_name":"embryo culture media","score":0.7799999713897705},{"id":"https://openalex.org/keywords/embryo-selection","display_name":"embryo selection","score":0.6919999718666077},{"id":"https://openalex.org/keywords/embryo-viability","display_name":"embryo viability","score":0.7549999952316284},{"id":"https://openalex.org/keywords/single-embryo-transfer","display_name":"single embryo transfer","score":0.8240000009536743},{"id":"https://openalex.org/keywords/clinical-pregnancy-rate","display_name":"clinical pregnancy rate","score":0.7889999747276306},{"id":"https://openalex.org/keywords/embryo-morphological-assessment","display_name":"embryo morphological assessment","score":0.6029999852180481},{"id":"https://openalex.org/keywords/noninvasive-screening","display_name":"non-invasive screening","score":0.609000027179718},{"id":"https://openalex.org/keywords/implantation-potential","display_name":"implantation potential","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.609703004360199},{"id":"https://openalex.org/C2779335785","wikidata":"https://www.wikidata.org/wiki/Q5370217","display_name":"Embryo culture","level":4,"score":0.5925911068916321},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49379763007164},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.46158933639526367},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.43618905544281006},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4008982181549072},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3889770209789276},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.3232002556324005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29774945974349976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2933730483055115},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2276119887828827},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.14903965592384338},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07812187075614929},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06965452432632446},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018873","descriptor_name":"Pregnancy Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020554","descriptor_name":"Sperm Injections, Intracytoplasmic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046149","descriptor_name":"Embryo Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/humrep/der373","doi":"https://doi.org/10.1093/humrep/der373","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/der373","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},{"id":"pmid:22068638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22068638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1967579958","https://openalex.org/W1970093123","https://openalex.org/W2045546001","https://openalex.org/W2055429354","https://openalex.org/W2075626712","https://openalex.org/W2084819239","https://openalex.org/W2086624692","https://openalex.org/W2096759308","https://openalex.org/W2106224719","https://openalex.org/W2111075937","https://openalex.org/W2112594871","https://openalex.org/W2116049890","https://openalex.org/W2123860397","https://openalex.org/W2133826923","https://openalex.org/W2147121501","https://openalex.org/W2147584128","https://openalex.org/W2150616034","https://openalex.org/W2153569531","https://openalex.org/W2154167618","https://openalex.org/W2160428364","https://openalex.org/W2268327008","https://openalex.org/W3102853388"],"related_works":["https://openalex.org/W2046694952","https://openalex.org/W2021839814","https://openalex.org/W1970845208","https://openalex.org/W2072091356","https://openalex.org/W2154167618","https://openalex.org/W1966126334","https://openalex.org/W1971822624","https://openalex.org/W2071382101","https://openalex.org/W2084819239","https://openalex.org/W2111711549"],"abstract_inverted_index":{"BACKGROUND:":[0],"Near":[1],"infrared":[2],"(NIR)":[3],"spectroscopy":[4,67,149],"is":[5],"a":[6,42,97,111,172,269],"technology":[7,277],"proposed":[8,25],"to":[9,40,47,63,152,188,246,260,279],"facilitate":[10],"non-invasive":[11],"screening":[12],"for":[13,19,179],"the":[14,27,51,80,105,118,131,145,153,163,166,180,184,192,201,211,221,224,236,266],"most":[15],"optimal":[16],"human":[17],"embryo":[18,70,83,134,261,293],"uterine":[20],"transfer.":[21],"It":[22],"has":[23],"been":[24],"that":[26,45,252],"NIR":[28,66,106,148,202,222,254,276],"spectral":[29],"profile":[30],"of":[31,54,125,165,177,268,292],"an":[32,74,289],"embryo's":[33],"spent":[34,69],"culture":[35,71],"medium":[36,72],"can":[37,285],"be":[38,189,286],"used":[39,287],"generate":[41],"viability":[43],"score":[44],"correlates":[46],"implantation":[48],"potential.":[49],"As":[50],"initial":[52],"proof":[53],"principle":[55],"studies":[56],"were":[57,198],"all":[58],"retrospective,":[59],"our":[60],"aim":[61],"was":[62,108,117,136,150,159,218,240],"investigate":[64],"whether":[65],"on":[68,139],"in":[73,103,144,191,210,256],"on-site,":[75],"prospective":[76],"setting":[77],"could":[78],"improve":[79,265],"ongoing":[81,212],"single":[82],"transfer":[84],"(SET)":[85],"pregnancy":[86,120,213,271],"rate":[87,121,214],"after":[88,122],"Day":[89],"2":[90],"and":[91,195,203,223],"5":[92],"transfers.":[93],"METHODS:":[94],"We":[95],"conducted":[96],"single-centre,":[98],"double-blinded,":[99],"randomized":[100,128,199,216],"controlled":[101],"trial":[102],"which":[104],"group":[107,133,147],"compared":[109],"with":[110],"control":[112,132,204,225],"group.":[113],"The":[114,157,232,275],"primary":[115,181],"outcome":[116],"clinical":[119],"6-7":[123],"weeks":[124],"gestation":[126],"per":[127,215],"patient.":[129],"In":[130],"selection":[135],"based":[137],"only":[138],"traditional":[140],"morphological":[141,154],"evaluation":[142],"while":[143],"treatment":[146],"added":[151],"evaluation.":[155],"RESULTS:":[156],"study":[158,237,250],"terminated":[160],"early":[161],"as":[162,288],"analysis":[164],"Data":[167],"Safety":[168],"Monitoring":[169],"Board":[170],"showed":[171],"very":[173],"low":[174],"conditional":[175],"power":[176],"superiority":[178],"outcome.":[182],"Of":[183],"752":[185],"patients":[186,197],"calculated":[187],"included":[190],"study,":[193],"164":[194],"163":[196],"into":[200],"groups,":[205],"respectively.":[206],"No":[207],"significant":[208],"difference":[209,234],"patient":[217],"found":[219],"between":[220,235],"group,":[226],"34.8":[227],"versus":[228],"35.6%,":[229],"(P=":[230],"0.97).":[231],"proportional":[233],"groups":[238],"mean":[239],"-0.8%":[241],"(95%":[242],"confidence":[243],"interval":[244],"-11.4":[245],"10.2).":[247],"CONCLUSIONS:":[248],"This":[249],"shows":[251],"adding":[253],"spectroscopy,":[255],"its":[257],"present":[258],"form,":[259],"morphology":[262],"does":[263],"not":[264],"chance":[267],"viable":[270],"when":[272],"performing":[273],"SET.":[274],"appears":[278],"need":[280],"further":[281],"development":[282],"before":[283],"it":[284],"objective":[290],"marker":[291],"viability.":[294],"CLINICAL":[295],"TRIALS":[296],"IDENTIFIER:":[297],"ISRCTN23817363.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}