{"id":"https://openalex.org/W2103971999","doi":"https://doi.org/10.1186/ar1830","title":"Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)\u03b3 agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1\u03b2-stimulated rat chondrocytes: evidence for PPAR\u03b3-independent inhibition by 15-deoxy-\u039412,14prostaglandin J2","display_name":"Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)\u03b3 agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1\u03b2-stimulated rat chondrocytes: evidence for PPAR\u03b3-independent inhibition by 15-deoxy-\u039412,14prostaglandin J2","publication_year":2005,"publication_date":"2005-09-22","ids":{"openalex":"https://openalex.org/W2103971999","doi":"https://doi.org/10.1186/ar1830","mag":"2103971999","pmid":"https://pubmed.ncbi.nlm.nih.gov/16277686","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1297580"},"language":"en","primary_location":{"id":"doi:10.1186/ar1830","doi":"https://doi.org/10.1186/ar1830","is_oa":true,"landing_page_url":"https://doi.org/10.1186/ar1830","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar1830","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar1830","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104909577","display_name":"Arnaud Bianchi","orcid":"https://orcid.org/0000-0003-4925-5269","observed_orcids":["https://orcid.org/0000-0003-4925-5269"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arnaud Bianchi","raw_affiliation_strings":["Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505 Vandoeuvre-l\u00e8s-Nancy, France. arnaud.bianchi@medecine.uhp-nancy.fr","Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505 Vandoeuvre-l\u00e8s-Nancy, France. arnaud.bianchi@medecine.uhp-nancy.fr","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039109659","display_name":"David Moulin","orcid":"https://orcid.org/0000-0001-6619-5769","observed_orcids":["https://orcid.org/0000-0001-6619-5769"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David Moulin","raw_affiliation_strings":["Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075976588","display_name":"Sylvie S\u00e9billaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvie Sebillaud","raw_affiliation_strings":["Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088868160","display_name":"Meriem Koufany","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Meriem Koufany","raw_affiliation_strings":["Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109945938","display_name":"M M Galteau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Madeleine Galteau","raw_affiliation_strings":["Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111654358","display_name":"Patrick Netter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick Netter","raw_affiliation_strings":["Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111589653","display_name":"Bernard L. Terlain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Terlain","raw_affiliation_strings":["Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027662912","display_name":"Jean\u2010Yves Jouzeau","orcid":"https://orcid.org/0000-0003-2429-945X","observed_orcids":["https://orcid.org/0000-0003-2429-945X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean-Yves Jouzeau","raw_affiliation_strings":["Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, UMR 7561 CNRS-UHP, 54505, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physiopathologie et Pharmacologie Articulaires, Vand\u0153uvre-l\u00e8s-Nancy, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027662912"],"corresponding_institution_ids":["https://openalex.org/I1294671590"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":3.2193,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.92288874,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"6","first_page":"R1325","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.04910000041127205,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mpges-1","display_name":"mPGES-1","score":0.847000002861023},{"id":"https://openalex.org/keywords/ppargamma-agonists","display_name":"PPAR\u03b3 agonists","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9200000166893005},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8379999995231628},{"id":"https://openalex.org/keywords/6-keto-pgf1alpha","display_name":"6-keto-PGF1 alpha","score":0.9049999713897705},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8080000281333923},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nf-kappab-transactivation","display_name":"NF-\u03baB transactivation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/ikappabalpha","display_name":"I\u03baB\u03b1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/ppargamma-independent-mechanism","display_name":"PPAR\u03b3-independent mechanism","score":0.7749999761581421},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.8085486888885498},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.5897039175033569},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.528403639793396},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4887549877166748},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4867575168609619},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45810484886169434},{"id":"https://openalex.org/C130241916","wikidata":"https://www.wikidata.org/wiki/Q20970208","display_name":"Peroxisome proliferator-activated receptor gamma","level":4,"score":0.41974180936813354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29994356632232666}],"mesh":[{"descriptor_ui":"D000071876","descriptor_name":"Prostaglandin-E Synthases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077154","descriptor_name":"Rosiglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015230","descriptor_name":"Prostaglandin D2","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015230","descriptor_name":"Prostaglandin D2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/ar1830","doi":"https://doi.org/10.1186/ar1830","is_oa":true,"landing_page_url":"https://doi.org/10.1186/ar1830","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar1830","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research & Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:97854","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1297580","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1297580","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1297580","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Res Ther","raw_type":"Text"},{"id":"pmid:16277686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16277686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-01715324v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-01715324","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arthritis Research and Therapy, 2005, 7 (6), pp.R1325-R1337. ⟨10.1186/ar1830⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/ar1830","doi":"https://doi.org/10.1186/ar1830","is_oa":true,"landing_page_url":"https://doi.org/10.1186/ar1830","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar1830","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103971999.pdf","grobid_xml":"https://content.openalex.org/works/W2103971999.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W40627026","https://openalex.org/W62702228","https://openalex.org/W1487971131","https://openalex.org/W1494611500","https://openalex.org/W1553744918","https://openalex.org/W1568585026","https://openalex.org/W1580962701","https://openalex.org/W1584270516","https://openalex.org/W1633340712","https://openalex.org/W1639924204","https://openalex.org/W1803320375","https://openalex.org/W1812573520","https://openalex.org/W1929902529","https://openalex.org/W1963764925","https://openalex.org/W1964073342","https://openalex.org/W1967714756","https://openalex.org/W1969724362","https://openalex.org/W1972505498","https://openalex.org/W1973135913","https://openalex.org/W1978506520","https://openalex.org/W1979466688","https://openalex.org/W1981501553","https://openalex.org/W1992036838","https://openalex.org/W1992724479","https://openalex.org/W1992733480","https://openalex.org/W1993243592","https://openalex.org/W1994659489","https://openalex.org/W1994928222","https://openalex.org/W1996267589","https://openalex.org/W2002519246","https://openalex.org/W2019802394","https://openalex.org/W2021835061","https://openalex.org/W2027107698","https://openalex.org/W2031069559","https://openalex.org/W2031685248","https://openalex.org/W2032607036","https://openalex.org/W2036123458","https://openalex.org/W2045725952","https://openalex.org/W2045989280","https://openalex.org/W2050906978","https://openalex.org/W2052893433","https://openalex.org/W2054526986","https://openalex.org/W2058097591","https://openalex.org/W2060021617","https://openalex.org/W2063971720","https://openalex.org/W2072696221","https://openalex.org/W2073656249","https://openalex.org/W2077641423","https://openalex.org/W2087259247","https://openalex.org/W2087908472","https://openalex.org/W2090510390","https://openalex.org/W2094334874","https://openalex.org/W2095290224","https://openalex.org/W2100677911","https://openalex.org/W2105367621","https://openalex.org/W2111199059","https://openalex.org/W2113683216","https://openalex.org/W2124371647","https://openalex.org/W2133633020","https://openalex.org/W2135047663","https://openalex.org/W2140014359","https://openalex.org/W2147330842","https://openalex.org/W2149233326","https://openalex.org/W2149275181","https://openalex.org/W2161908800","https://openalex.org/W2170831952","https://openalex.org/W2186067809","https://openalex.org/W2255670530","https://openalex.org/W2408180244","https://openalex.org/W2444613250","https://openalex.org/W4205493149","https://openalex.org/W4238600219"],"related_works":["https://openalex.org/W2060021617","https://openalex.org/W4404595762","https://openalex.org/W1566642695","https://openalex.org/W1967313588","https://openalex.org/W2052893433","https://openalex.org/W1568585026","https://openalex.org/W2091557699","https://openalex.org/W1973135913","https://openalex.org/W2140014359","https://openalex.org/W2036123458"],"abstract_inverted_index":{"Microsomal":[0],"prostaglandin":[1,21,111,241],"E":[2],"synthase":[3],"(mPGES)-1":[4],"is":[5,231,274],"a":[6,17,114,190],"newly":[7],"identified":[8],"inducible":[9,29],"enzyme":[10],"of":[11,28,40,84,97,140,172,207,239,252,264,268,278],"the":[12,26,38,95,154,204,223,240,250,269,275],"arachidonic":[13],"acid":[14],"cascade":[15,242],"with":[16,35,48,93,121,182,256],"key":[18],"function":[19],"in":[20,44,113,225,254],"(PG)E2":[22],"synthesis.":[23],"We":[24],"investigated":[25],"kinetics":[27],"cyclo-oxygenase":[30],"(COX)-2":[31],"and":[32,42,52,75,86,156,194,212],"mPGES-1":[33,76,148,210,230,273],"expression":[34,69,77,145,149,211],"respect":[36],"to":[37,118],"production":[39],"6-keto-PGF1alpha":[41,85,129],"PGE2":[43,87,98,125,213,235],"rat":[45,227],"chondrocytes":[46],"stimulated":[47],"10":[49,119,135,168,173],"ng/ml":[50],"IL-1beta,":[51],"compared":[53],"their":[54],"modulation":[55],"by":[56,179,186,260],"peroxisome-proliferator-activated":[57],"receptor":[58],"(PPAR)gamma":[59],"agonists.":[60],"Real-time":[61],"PCR":[62],"analysis":[63],"showed":[64],"that":[65,198],"IL-1beta":[66,208],"induced":[67],"COX-2":[68,144],"maximally":[70,78],"(37-fold)":[71],"at":[72,80,134,152,167],"12":[73],"hours":[74,90],"(68-fold)":[79],"24":[81,89],"hours.":[82],"Levels":[83],"peaked":[88],"after":[91],"stimulation":[92],"IL-1beta;":[94],"induction":[96],"was":[99,160],"greater":[100],"(11-fold":[101],"versus":[102,132],"70-fold,":[103],"respectively).":[104],"The":[105],"cyclopentenone":[106],"15-deoxy-Delta12,14prostaglandin":[107],"J2":[108],"(15d-PGJ2)":[109],"decreased":[110,143,147],"synthesis":[112,251],"dose-dependent":[115],"manner":[116],"(0.1":[117],"microM),":[120],"more":[122],"potency":[123],"on":[124,128,163,209],"level":[126,130],"than":[127],"(-90%":[131],"-66%":[133],"microM).":[136],"A":[137],"high":[138],"dose":[139],"15d-PGJ2":[141,175,216,247,261],"partly":[142],"but":[146],"almost":[150,201],"completely":[151,202],"both":[153],"mRNA":[155],"protein":[157],"levels.":[158],"Rosiglitazone":[159],"poorly":[161],"effective":[162],"these":[164],"parameters":[165],"even":[166],"microM.":[169],"Inhibitory":[170],"effects":[171],"microM":[174],"were":[176],"neither":[177],"reduced":[178],"PPARgamma":[180,187,265],"blockade":[181],"GW-9662":[183],"nor":[184],"enhanced":[185],"overexpression,":[188],"supporting":[189],"PPARgamma-independent":[191],"mechanism.":[192],"EMSA":[193],"TransAM":[195],"analyses":[196],"demonstrated":[197],"mutated":[199],"IkappaBalpha":[200],"suppressed":[203],"stimulating":[205],"effect":[206],"production,":[214],"whereas":[215],"inhibited":[217],"NF-kappaB":[218,244,270],"transactivation.":[219],"These":[220],"data":[221],"demonstrate":[222],"following":[224],"IL-1-stimulated":[226],"chondrocytes:":[228],"first,":[229],"rate":[232],"limiting":[233],"for":[234],"synthesis;":[236],"second,":[237],"activation":[238],"requires":[243],"activation;":[245],"third,":[246],"strongly":[248],"inhibits":[249],"prostaglandins,":[253],"contrast":[255],"rosiglitazone;":[257],"fourth,":[258],"inhibition":[259,267],"occurs":[262],"independently":[263],"through":[266],"pathway;":[271],"fifth,":[272],"main":[276],"target":[277],"15d-PGJ2.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}