{"id":"https://openalex.org/W2103969450","doi":"https://doi.org/10.1081/ncn-120026873","title":"Synthesis and Antiviral Activity of 2-Substituted Analogs of Triciribine","display_name":"Synthesis and Antiviral Activity of 2-Substituted Analogs of Triciribine","publication_year":2003,"publication_date":"2003-11-26","ids":{"openalex":"https://openalex.org/W2103969450","doi":"https://doi.org/10.1081/ncn-120026873","mag":"2103969450","pmid":"https://pubmed.ncbi.nlm.nih.gov/14714765"},"language":"en","primary_location":{"id":"doi:10.1081/ncn-120026873","doi":"https://doi.org/10.1081/ncn-120026873","is_oa":false,"landing_page_url":"https://doi.org/10.1081/ncn-120026873","pdf_url":null,"source":{"id":"https://openalex.org/S111464279","display_name":"Nucleosides Nucleotides & Nucleic Acids","issn_l":"1525-7770","issn":["1525-7770","1532-2335"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides, Nucleotides and Nucleic Acids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112274519","display_name":"Anthony R. Porcari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anthony R. Porcari","raw_affiliation_strings":["Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA. Anthony.Porcari@pfizer.com","Department of Medicinal Chemistry , College of Pharmacy , Ann Arbor, Michigan, USA","Pfizer Global Research & Development , Ann Arbor Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan, 48105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA. Anthony.Porcari@pfizer.com","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Medicinal Chemistry , College of Pharmacy , Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Pfizer Global Research & Development , Ann Arbor Laboratories , 2800 Plymouth Road, Ann Arbor, Michigan, 48105","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004932382","display_name":"Roger G. Ptak","orcid":"https://orcid.org/0000-0002-8492-3085","observed_orcids":["https://orcid.org/0000-0002-8492-3085"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger G. Ptak\u2021","raw_affiliation_strings":["Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058536742","display_name":"Katherine Z. Borysko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Z. Borysko","raw_affiliation_strings":["Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076281231","display_name":"Julie M. Breitenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie M. Breitenbach","raw_affiliation_strings":["Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110073621","display_name":"John C. Drach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Drach","raw_affiliation_strings":["Department of Medicinal Chemistry, College of Pharmacy, Ann Arbor, Michigan, USA ; Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA","Department of Biologic and Materials Sciences , School of Dentistry, University of Michigan , Ann Arbor, Michigan, USA","Department of Medicinal Chemistry , College of Pharmacy , Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, Ann Arbor, Michigan, USA ; Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Biologic and Materials Sciences , School of Dentistry, University of Michigan , Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Medicinal Chemistry , College of Pharmacy , Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103853042","display_name":"Leroy B. Townsend","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leroy B. Townsend","raw_affiliation_strings":["Department of Medicinal Chemistry, College of Pharmacy, Ann Arbor, Michigan, USA ; Department of Chemistry, College of Literature, Sciences and Arts, Ann Arbor, Michigan, USA","Department of Chemistry , College of Literature, Sciences and Arts , Ann Arbor, Michigan, USA","Department of Medicinal Chemistry , College of Pharmacy , Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, Ann Arbor, Michigan, USA ; Department of Chemistry, College of Literature, Sciences and Arts, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Chemistry , College of Literature, Sciences and Arts , Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Medicinal Chemistry , College of Pharmacy , Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112274519"],"corresponding_institution_ids":["https://openalex.org/I180857899","https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":0.3873,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.66984885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"22","issue":"12","first_page":"2171","last_page":"2193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.30640000104904175,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.30640000104904175,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.30399999022483826,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.17790000140666962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triciribine","display_name":"triciribine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9259999990463257},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.9739999771118164},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.7400000095367432},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/steric-and-electronic-effects","display_name":"steric and electronic effects","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41952764987945557},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40068066120147705},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.34952473640441895},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32761597633361816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2927429974079132}],"mesh":[{"descriptor_ui":"D000073","descriptor_name":"Acenaphthenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007624","descriptor_name":"KB Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011684","descriptor_name":"Purine Nucleosides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011684","descriptor_name":"Purine Nucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011684","descriptor_name":"Purine Nucleosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012263","descriptor_name":"Ribonucleosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012265","descriptor_name":"Ribonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012265","descriptor_name":"Ribonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1081/ncn-120026873","doi":"https://doi.org/10.1081/ncn-120026873","is_oa":false,"landing_page_url":"https://doi.org/10.1081/ncn-120026873","pdf_url":null,"source":{"id":"https://openalex.org/S111464279","display_name":"Nucleosides Nucleotides & Nucleic Acids","issn_l":"1525-7770","issn":["1525-7770","1532-2335"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides, Nucleotides and Nucleic Acids","raw_type":"journal-article"},{"id":"pmid:14714765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14714765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleosides, nucleotides & nucleic acids","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4079792059","display_name":"Interdepartmental Training in Pharmacological Sciences","funder_award_id":"T32GM007767","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6872681075","display_name":"TRICIRIBINE AND NOVEL ANALOGS AS INHIBITORS OF HIV","funder_award_id":"R01AI033332","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8699594558","display_name":"TRICIRIBINE AND NOVEL ANALOGS AS INHIBITORS OF HIV","funder_award_id":"R01AI036872","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W154735814","https://openalex.org/W182429875","https://openalex.org/W1481862475","https://openalex.org/W1559827406","https://openalex.org/W1561013854","https://openalex.org/W1562372296","https://openalex.org/W1570389292","https://openalex.org/W1578779033","https://openalex.org/W1880887567","https://openalex.org/W1984934292","https://openalex.org/W1997385024","https://openalex.org/W1998521798","https://openalex.org/W1998567171","https://openalex.org/W1998577337","https://openalex.org/W2009563684","https://openalex.org/W2017421369","https://openalex.org/W2017739738","https://openalex.org/W2029142296","https://openalex.org/W2033245611","https://openalex.org/W2034003389","https://openalex.org/W2040047403","https://openalex.org/W2041896692","https://openalex.org/W2045155331","https://openalex.org/W2045340750","https://openalex.org/W2047820452","https://openalex.org/W2052298398","https://openalex.org/W2061113464","https://openalex.org/W2062750943","https://openalex.org/W2075395967","https://openalex.org/W2082775643","https://openalex.org/W2083134590","https://openalex.org/W2084259261","https://openalex.org/W2086260941","https://openalex.org/W2088281838","https://openalex.org/W2096451853","https://openalex.org/W2109896320","https://openalex.org/W2150097767","https://openalex.org/W2165260654","https://openalex.org/W2174141956","https://openalex.org/W2267026508","https://openalex.org/W2318253236","https://openalex.org/W2395196589","https://openalex.org/W2405214244","https://openalex.org/W2409670818","https://openalex.org/W2461826946","https://openalex.org/W2949088282"],"related_works":["https://openalex.org/W2951636829","https://openalex.org/W2017421369","https://openalex.org/W2610635568","https://openalex.org/W2092244248","https://openalex.org/W1998567171","https://openalex.org/W2062750943","https://openalex.org/W2044294631","https://openalex.org/W2949532041","https://openalex.org/W2107795674","https://openalex.org/W2953053701"],"abstract_inverted_index":{"Triciribine":[0],"(TCN)":[1],"and":[2,8,21,52,57,73,104,108,118],"triciribine":[3,137],"monophosphate":[4],"(TCN-P)":[5],"have":[6,27],"antiviral":[7,141],"antineoplastic":[9],"activity":[10,92,142],"at":[11,39,65,122,133],"low":[12],"or":[13,120],"submicromolar":[14],"concentrations.":[15],"In":[16],"an":[17],"effort":[18],"to":[19,33,59,111,151],"improve":[20],"better":[22],"understand":[23],"this":[24],"activity,":[25],"we":[26],"conducted":[28],"a":[29],"structure-activity":[30],"relationship":[31],"study":[32],"explore":[34],"the":[35,40,61,66,70,80,83,123,134,140],"effect":[36],"of":[37,42,63,76,82,136],"substitutions":[38,64,132],"2-position":[41,67,135],"triciribine.":[43],"2-Methyl-":[44],"(2-Me-TCN),":[45],"2-ethyl-":[46],"(2-Et-TCN),":[47],"2-phenyl-":[48],"(2-Ph-TCN),":[49],"2-chloro-":[50],"(2-Cl-TCN),":[51],"2-aminotriciribine":[53],"(2-NH2-TCN)":[54],"were":[55,89,109],"designed":[56],"synthesized":[58],"determine":[60],"effects":[62],"which":[68],"change":[69],"steric,":[71],"electronic,":[72],"hydrophobic":[74],"properties":[75],"TCN,":[77],"while":[78],"maintaining":[79],"integrity":[81],"tricyclic":[84],"ring":[85],"system.":[86],"These":[87],"compounds":[88],"evaluated":[90],"for":[91],"against":[93],"human":[94,105],"immunodeficiency":[95],"virus":[96,100],"(HIV-1),":[97],"herpes":[98],"simplex":[99],"type":[101],"1":[102],"(HSV-1),":[103],"cytomegalovirus":[106],"(HCMV)":[107],"found":[110],"be":[112],"either":[113],"less":[114],"active":[115,152],"than":[116],"TCN":[117],"TCN-P":[119],"inactive":[121],"highest":[124],"concentrations":[125],"tested,":[126],"100":[127],"microM.":[128],"We":[129],"conclude":[130],"that":[131],"adversely":[138],"affect":[139],"most":[143],"likely":[144],"because":[145],"these":[146],"analogs":[147],"are":[148],"not":[149],"phosphorylated":[150],"metabolites.":[153]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}