{"id":"https://openalex.org/W2103886595","doi":"https://doi.org/10.2174/1381612043383502","title":"Development and Clinical Application of Peptide-Based Radiopharmaceuticals","display_name":"Development and Clinical Application of Peptide-Based Radiopharmaceuticals","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W2103886595","doi":"https://doi.org/10.2174/1381612043383502","mag":"2103886595","pmid":"https://pubmed.ncbi.nlm.nih.gov/15379661"},"language":"en","primary_location":{"id":"doi:10.2174/1381612043383502","doi":"https://doi.org/10.2174/1381612043383502","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612043383502","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042300545","display_name":"Martin Gotthardt","orcid":"https://orcid.org/0000-0002-6537-7744","observed_orcids":["https://orcid.org/0000-0002-6537-7744"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Gotthardt","raw_affiliation_strings":["Department of Nuclear Medicine, Philipps-University of Marburg, Baldingerstrasse 35043, Germany. gotthard@mailer.uni-marburg.de","Department of Nuclear Medicine, Philipps-University of Marburg, Baldingerstrasse 35043, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Philipps-University of Marburg, Baldingerstrasse 35043, Germany. gotthard@mailer.uni-marburg.de","institution_ids":["https://openalex.org/I161103922"]},{"raw_affiliation_string":"Department of Nuclear Medicine, Philipps-University of Marburg, Baldingerstrasse 35043, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012764804","display_name":"Otto C. Boerman","orcid":"https://orcid.org/0000-0001-6832-101X","observed_orcids":["https://orcid.org/0000-0001-6832-101X"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"O. Boermann","raw_affiliation_strings":["Department of Nuclear Medicine Philipps-University of Marburg Baldingerstrasse 35043 MarburgGermany,Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine Philipps-University of Marburg Baldingerstrasse 35043 MarburgGermany,Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110265404","display_name":"Thomas M. Behr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Behr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066158692","display_name":"Martin P Be\u0301he\u0301","orcid":"https://orcid.org/0000-0002-1110-2665","observed_orcids":["https://orcid.org/0000-0002-1110-2665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Behe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000396669","display_name":"Wim J.G. Oyen","orcid":"https://orcid.org/0000-0001-8235-7078","observed_orcids":["https://orcid.org/0000-0001-8235-7078"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"W. Oyen","raw_affiliation_strings":["Department of Nuclear Medicine Philipps-University of Marburg Baldingerstrasse 35043 MarburgGermany,Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine Philipps-University of Marburg Baldingerstrasse 35043 MarburgGermany,Germany","institution_ids":["https://openalex.org/I161103922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000396669","https://openalex.org/A5012764804"],"corresponding_institution_ids":["https://openalex.org/I161103922"],"apc_list":null,"apc_paid":null,"fwci":5.0088,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.95092001,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"24","first_page":"2951","last_page":"2963"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.059300001710653305,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatostatin-analogs","display_name":"somatostatin analogues","score":0.8679999709129333},{"id":"https://openalex.org/keywords/octreotide","display_name":"octreotide","score":0.996999979019165},{"id":"https://openalex.org/keywords/somatostatin-receptor-scintigraphy","display_name":"somatostatin receptor scintigraphy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/peptide-receptor-radionuclide-therapy","display_name":"peptide receptor radionuclide therapy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/neuroendocrine-tumors","display_name":"neuroendocrine tumors","score":0.9900000095367432},{"id":"https://openalex.org/keywords/peptide-modification","display_name":"peptide modification","score":0.6610000133514404},{"id":"https://openalex.org/keywords/gastrin","display_name":"gastrin","score":0.5770000219345093},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/vip","display_name":"VIP","score":0.7269999980926514},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.9810000061988831},{"id":"https://openalex.org/keywords/neurotensin","display_name":"neurotensin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.7166297435760498},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.71380615234375},{"id":"https://openalex.org/C2778976297","wikidata":"https://www.wikidata.org/wiki/Q419576","display_name":"Neurotensin","level":4,"score":0.6414324045181274},{"id":"https://openalex.org/C80115893","wikidata":"https://www.wikidata.org/wiki/Q2067077","display_name":"Somatostatin receptor","level":3,"score":0.5938756465911865},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5610671043395996},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.5477901101112366},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49431920051574707},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4807600677013397},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.45158419013023376},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43205028772354126},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.3243267238140106},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30686914920806885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29649388790130615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2708183526992798},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25328609347343445},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23251140117645264},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.12837234139442444},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.2174/1381612043383502","doi":"https://doi.org/10.2174/1381612043383502","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612043383502","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:15379661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15379661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/58192","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/58192","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/58192","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/58192","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Pharmaceutical Design, 10, 2951 - 63","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6200000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2002627846","https://openalex.org/W1968575643","https://openalex.org/W2413370117","https://openalex.org/W2264948392","https://openalex.org/W1583942119","https://openalex.org/W2384403857","https://openalex.org/W2140448717","https://openalex.org/W2419836907","https://openalex.org/W2158388939","https://openalex.org/W2100962748"],"abstract_inverted_index":{"Peptide-based":[0],"radiopharmaceuticals":[1],"have":[2],"been":[3],"introduced":[4],"into":[5,86],"clinical":[6,171,218],"work":[7],"more":[8],"than":[9,147,186],"a":[10,65,72,78,91,110,128],"decade":[11],"ago.":[12],"The":[13,94,116],"first":[14],"and":[15,34,59,208,224,236],"most":[16],"successful":[17,117],"imaging":[18],"agent":[19],"to":[20,54,60,77,109,113],"date":[21],"is":[22,28,50,84,122,179],"the":[23,47,56,87,101,106,134,138,142,187,206,214,228],"somatostatin":[24,31,148],"analog":[25],"octreotide.":[26],"It":[27],"used":[29],"for":[30,137,152,175,190,222],"receptor":[32],"scintigraphy":[33],"also":[35],"receptor-mediated":[36],"peptide-radiotherapy":[37],"of":[38,119,127,205,211,217,220,226,231,233],"neuroendocrine":[39],"tumors.":[40,197],"For":[41],"in":[42,52,82,170,182],"vivo":[43],"use":[44,153,219],"as":[45,154,157],"radiopharmaceutical,":[46],"natural":[48,130],"peptide":[49,80,95,131],"modified":[51,79],"order":[53],"enhance":[55],"metabolic":[57],"stability":[58],"allow":[61],"stable":[62,81],"labeling":[63],"with":[64],"so-called":[66],"residualizing":[67],"label.":[68],"This":[69],"means,":[70],"that":[71],"radiometal":[73],"chelator":[74],"complex":[75,103],"bound":[76],"serum":[83],"internalized":[85],"target":[88,112,139],"cells":[89],"via":[90],"specific":[92],"receptor.":[93],"then":[96],"undergoes":[97],"lysosomal":[98],"degradation":[99],"leaving":[100],"radiometal-chelator":[102],"trapped":[104],"inside":[105],"cell,":[107],"leading":[108],"high":[111],"background":[114],"ratio.":[115],"development":[118,151,232],"new":[120,234],"radiopeptides":[121,155,221],"thus":[123],"dependent":[124],"on":[125],"modifications":[126],"given":[129],"while":[132],"preserving":[133],"binding":[135],"affinity":[136],"receptor(s)":[140],"at":[141],"same":[143],"time.":[144],"Other":[145],"peptides":[146,192],"are":[149],"under":[150],"such":[156],"Minigastrin,":[158],"GLP-1,":[159],"VIP,":[160],"Substance":[161],"P,":[162],"or":[163],"Neurotensin.":[164],"Some":[165],"show":[166],"very":[167],"favorable":[168],"results":[169],"trials,":[172],"like":[173],"Minigastrin":[174],"example.":[176],"Furthermore,":[177],"there":[178],"increasing":[180],"interest":[181],"peptide-binding":[183],"sites":[184],"other":[185],"\"classical\"":[188],"receptors":[189],"regulatory":[191],"specifically":[193],"over-expressed":[194],"by":[195],"(neuroendocrine)":[196],"In":[198],"this":[199],"paper,":[200],"we":[201],"provide":[202],"an":[203],"overview":[204],"biochemical":[207],"radiochemical":[209],"aspects":[210],"radiopeptide":[212],"development,":[213],"current":[215,229],"state":[216,230],"diagnosis":[223],"therapy":[225],"tumors,":[227],"compounds,":[235],"future":[237],"developments.":[238]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}