{"id":"https://openalex.org/W2103873547","doi":"https://doi.org/10.3727/000000003108749017","title":"Overexpression of CYP2D6 Attenuates the Toxicity of MPP \u00depl in Actively Dividing and Differentiated PC12 Cells","display_name":"Overexpression of CYP2D6 Attenuates the Toxicity of MPP \u00depl in Actively Dividing and Differentiated PC12 Cells","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2103873547","doi":"https://doi.org/10.3727/000000003108749017","mag":"2103873547","pmid":"https://pubmed.ncbi.nlm.nih.gov/14686785","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5991163"},"language":"en","primary_location":{"id":"doi:10.3727/000000003108749017","doi":"https://doi.org/10.3727/000000003108749017","is_oa":true,"landing_page_url":"https://doi.org/10.3727/000000003108749017","pdf_url":null,"source":{"id":"https://openalex.org/S134577766","display_name":"Gene Expression","issn_l":"1052-2166","issn":["1052-2166","1555-3884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Expression","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3727/000000003108749017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085872433","display_name":"Naomi Matoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"NAOMI MATOH","raw_affiliation_strings":["*Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079206027","display_name":"Seigo Tanaka","orcid":"https://orcid.org/0000-0002-4304-202X","observed_orcids":["https://orcid.org/0000-0002-4304-202X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SEIGO TANAKA","raw_affiliation_strings":["*Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009286968","display_name":"Masanori Takehashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MASANORI TAKEHASHI","raw_affiliation_strings":["*Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111385682","display_name":"Marek Banasik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MAREK BANASIK","raw_affiliation_strings":["*Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024186876","display_name":"Todd J Stedeford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TODD STEDEFORD","raw_affiliation_strings":["*Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074775445","display_name":"Eliezer Masliah","orcid":"https://orcid.org/0000-0002-2117-5569","observed_orcids":["https://orcid.org/0000-0002-2117-5569"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ELIEZER MASLIAH","raw_affiliation_strings":["\u00a7Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0624"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0624","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100836408","display_name":"Shigehiko Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHIGEHIKO SUZUKI","raw_affiliation_strings":["\u2020Department of Plastic Surgery, School of Medicine, Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Department of Plastic Surgery, School of Medicine, Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110032426","display_name":"Yoshihiko Nishimura","orcid":"https://orcid.org/0009-0001-0613-6561","observed_orcids":["https://orcid.org/0009-0001-0613-6561"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YOSHIHIKO NISHIMURA","raw_affiliation_strings":["\u2020Department of Plastic Surgery, School of Medicine, Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Department of Plastic Surgery, School of Medicine, Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105989049","display_name":"Kunihiro Ueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KUNIHIRO UEDA","raw_affiliation_strings":["*Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.361,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.57075379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"11","issue":"3","first_page":"117","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mpp","display_name":"MPP+","score":0.9129999876022339},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.800000011920929},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.8450000286102295},{"id":"https://openalex.org/keywords/poor-metabolizers","display_name":"poor metabolizers","score":0.7110000252723694},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.699999988079071},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.5230000019073486},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.7557350397109985},{"id":"https://openalex.org/C2777600422","wikidata":"https://www.wikidata.org/wiki/Q3704421","display_name":"Debrisoquine","level":5,"score":0.730087161064148},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6712474822998047},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6129024028778076},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.6004505753517151},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5993930697441101},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.544792652130127},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5170165300369263},{"id":"https://openalex.org/C2776300020","wikidata":"https://www.wikidata.org/wiki/Q422423","display_name":"Bromide","level":2,"score":0.4911336600780487},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4724576771259308},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.46487903594970703},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.43388962745666504},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3610481321811676},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3577265739440918},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3141006827354431},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23339295387268066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1385795772075653},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006540","descriptor_name":"Herbicides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015632","descriptor_name":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015655","descriptor_name":"1-Methyl-4-phenylpyridinium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3727/000000003108749017","doi":"https://doi.org/10.3727/000000003108749017","is_oa":true,"landing_page_url":"https://doi.org/10.3727/000000003108749017","pdf_url":null,"source":{"id":"https://openalex.org/S134577766","display_name":"Gene Expression","issn_l":"1052-2166","issn":["1052-2166","1555-3884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Expression","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4953419","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5991163","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5991163","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5991163","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Expr","raw_type":"Text"},{"id":"pmid:14686785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14686785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene expression","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.3727/000000003108749017","doi":"https://doi.org/10.3727/000000003108749017","is_oa":true,"landing_page_url":"https://doi.org/10.3727/000000003108749017","pdf_url":null,"source":{"id":"https://openalex.org/S134577766","display_name":"Gene Expression","issn_l":"1052-2166","issn":["1052-2166","1555-3884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Expression","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3317175073","display_name":"UCSD Alzheimer's Disease Research Center P50","funder_award_id":"P50AG005131","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3457996028","display_name":null,"funder_award_id":"AG-5131","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1510659084","https://openalex.org/W1756143557","https://openalex.org/W1938076507","https://openalex.org/W1969800514","https://openalex.org/W1971567889","https://openalex.org/W1978406998","https://openalex.org/W1992352764","https://openalex.org/W2005102504","https://openalex.org/W2011777799","https://openalex.org/W2013407711","https://openalex.org/W2015749075","https://openalex.org/W2019411611","https://openalex.org/W2033236007","https://openalex.org/W2038762906","https://openalex.org/W2047493712","https://openalex.org/W2047817576","https://openalex.org/W2049875222","https://openalex.org/W2065737912","https://openalex.org/W2071965727","https://openalex.org/W2081384413","https://openalex.org/W2083829438","https://openalex.org/W2086518349","https://openalex.org/W2089277648","https://openalex.org/W2090641365","https://openalex.org/W2091618097","https://openalex.org/W2117340265","https://openalex.org/W2133800815","https://openalex.org/W2158439853","https://openalex.org/W2159728608","https://openalex.org/W2160131033","https://openalex.org/W2169838870","https://openalex.org/W2419230771"],"related_works":["https://openalex.org/W7051734195","https://openalex.org/W2061442264","https://openalex.org/W2100337542","https://openalex.org/W2007360321","https://openalex.org/W6964889136","https://openalex.org/W2090641365","https://openalex.org/W2946063483","https://openalex.org/W2592169580","https://openalex.org/W2071030401","https://openalex.org/W7033489109"],"abstract_inverted_index":{"Clonal":[0],"pheochromocytoma":[1],"cell":[2],"lines":[3],"overexpressing":[4,95],"cytochrome":[5],"P450":[6],"2D6":[7],"(CYP2D6)":[8],"were":[9],"established.":[10],"CYP2D6":[11,42,96,115],"was":[12,26,80,86],"localized":[13],"in":[14,22,77,88,116],"the":[15,23,51,58,67,78,110],"endoplasmic":[16],"reticulum,":[17],"and":[18,47,92],"its":[19],"enzymatic":[20],"activity":[21,113],"microsomal":[24],"fraction":[25],"confirmed":[27],"by":[28,66],"using":[29],"high":[30],"performance":[31],"liquid":[32],"chromatography":[33],"analysis":[34],"with":[35],"[guanidine-14C]debrisoquine":[36],"as":[37,64],"a":[38,123],"substrate.":[39],"Overexpression":[40],"of":[41,54,61,73,84,114],"protected":[43],"both":[44,89],"actively":[45,90],"dividing":[46,91],"differentiated":[48,93],"cells":[49,94],"against":[50],"toxic":[52],"effects":[53],"1-methyl-4-phenylpyridinium":[55],"ion":[56],"at":[57,100],"concentration":[59],"range":[60],"20-40":[62],"microM,":[63],"assessed":[65],"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium":[68],"bromide":[69],"assay.":[70],"The":[71,82],"production":[72],"reactive":[74],"oxygen":[75],"species":[76],"mitochondria":[79],"suppressed.":[81],"cytotoxicity":[83],"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine":[85],"unchanged":[87],"versus":[97],"mock-transfected":[98],"controls":[99],"concentrations":[101],"up":[102],"to":[103,128],"500":[104],"microM.":[105],"These":[106],"results":[107],"suggest":[108],"that":[109],"lowered":[111],"enzyme":[112],"individuals":[117],"termed":[118],"\"poor":[119],"metabolizers\"":[120],"may":[121],"represent":[122],"risk":[124],"factor":[125],"from":[126],"exposure":[127],"select":[129],"neurotoxicants.":[130]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
