{"id":"https://openalex.org/W2103848615","doi":"https://doi.org/10.1016/j.jaci.2014.12.1416","title":"Dissecting Molecular Mechanisms of Synergy Between IL-13 and IL-17A in Severe Asthma","display_name":"Dissecting Molecular Mechanisms of Synergy Between IL-13 and IL-17A in Severe Asthma","publication_year":2015,"publication_date":"2015-02-01","ids":{"openalex":"https://openalex.org/W2103848615","doi":"https://doi.org/10.1016/j.jaci.2014.12.1416","mag":"2103848615"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2014.12.1416","doi":"https://doi.org/10.1016/j.jaci.2014.12.1416","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2014.12.1416","pdf_url":"http://www.jacionline.org/article/S0091674914031972/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jacionline.org/article/S0091674914031972/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069729022","display_name":"Sara L. Stoffers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara L. Stoffers","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054563387","display_name":"St\u00e9phane Lajoie","orcid":"https://orcid.org/0000-0002-0514-1801","observed_orcids":["https://orcid.org/0000-0002-0514-1801"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephane Lajoie","raw_affiliation_strings":["Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020168230","display_name":"Adelaide G. van Lier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adelaide G. van Lier","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100445857","display_name":"Xue Zhang","orcid":"https://orcid.org/0000-0002-8179-138X","observed_orcids":["https://orcid.org/0000-0002-8179-138X","https://orcid.org/0009-0005-2970-5789"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Zhang","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Division of Human Genetics, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Division of Human Genetics, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021558797","display_name":"Umasundari Sivaprasad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Umasundari Sivaprasad","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Division of Asthma Research, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Division of Asthma Research, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018950903","display_name":"Melinda Butsch Kovacic","orcid":"https://orcid.org/0000-0001-6907-1446","observed_orcids":["https://orcid.org/0000-0001-6907-1446"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melinda Butsch Kovacic","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Division of Asthma Research, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Division of Asthma Research, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083291881","display_name":"Marsha A. Wills-Karp","orcid":"https://orcid.org/0000-0001-7929-1362","observed_orcids":["https://orcid.org/0000-0001-7929-1362"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marsha Wills-Karp","raw_affiliation_strings":["Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047392866","display_name":"Ian Paul Lewkowich","orcid":"https://orcid.org/0000-0001-8133-3568","observed_orcids":["https://orcid.org/0000-0001-8133-3568"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian P. Lewkowich","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Division of Immunobiology, Cincinnati, OH","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.08657344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"135","issue":"2","first_page":"AB146","last_page":"AB146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.9380000233650208},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":1.0},{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/traf6","display_name":"TRAF6","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.996999979019165},{"id":"https://openalex.org/keywords/c-ebpbeta","display_name":"C/EBP\u03b2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9919999837875366},{"id":"https://openalex.org/keywords/stat6-phosphorylation","display_name":"STAT6 phosphorylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytokine-synergy","display_name":"cytokine synergy","score":0.949999988079071},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6332857608795166},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.630684494972229},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5160755515098572},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.49244698882102966},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.45896458625793457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4557979702949524},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.454571008682251},{"id":"https://openalex.org/C32046619","wikidata":"https://www.wikidata.org/wiki/Q14878303","display_name":"Interleukin 13","level":4,"score":0.4523778557777405},{"id":"https://openalex.org/C47348012","wikidata":"https://www.wikidata.org/wiki/Q99486570","display_name":"Interleukin 17","level":3,"score":0.4413776397705078},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4259512424468994},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4127851128578186},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40877753496170044},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.39552628993988037},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.39339685440063477},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3829740285873413},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18272611498832703},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07632577419281006}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jaci.2014.12.1416","doi":"https://doi.org/10.1016/j.jaci.2014.12.1416","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2014.12.1416","pdf_url":"http://www.jacionline.org/article/S0091674914031972/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jaci.2014.12.1416","doi":"https://doi.org/10.1016/j.jaci.2014.12.1416","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2014.12.1416","pdf_url":"http://www.jacionline.org/article/S0091674914031972/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103848615.pdf","grobid_xml":"https://content.openalex.org/works/W2103848615.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2415646315","https://openalex.org/W2075472967","https://openalex.org/W2894894320","https://openalex.org/W2788597745","https://openalex.org/W2061808825","https://openalex.org/W3030535439","https://openalex.org/W2071916225","https://openalex.org/W2006389735","https://openalex.org/W2032507581","https://openalex.org/W2628117813"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}