{"id":"https://openalex.org/W2103786171","doi":"https://doi.org/10.1152/ajpregu.00674.2010","title":"Local network regulation of orexin neurons in the lateral hypothalamus","display_name":"Local network regulation of orexin neurons in the lateral hypothalamus","publication_year":2011,"publication_date":"2011-06-23","ids":{"openalex":"https://openalex.org/W2103786171","doi":"https://doi.org/10.1152/ajpregu.00674.2010","mag":"2103786171","pmid":"https://pubmed.ncbi.nlm.nih.gov/21697524"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.00674.2010","doi":"https://doi.org/10.1152/ajpregu.00674.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00674.2010","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061523754","display_name":"Julia Burt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130438778","display_name":"Memorial University of Newfoundland","ror":"https://ror.org/04haebc03","country_code":"CA","type":"education","lineage":["https://openalex.org/I130438778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Julia Burt","raw_affiliation_strings":["Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, Newfoundland, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, Newfoundland, Canada","institution_ids":["https://openalex.org/I130438778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052126366","display_name":"Christian O. Alberto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130438778","display_name":"Memorial University of Newfoundland","ror":"https://ror.org/04haebc03","country_code":"CA","type":"education","lineage":["https://openalex.org/I130438778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christian O. Alberto","raw_affiliation_strings":["Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, Newfoundland, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, Newfoundland, Canada","institution_ids":["https://openalex.org/I130438778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101640327","display_name":"Matthew P. Parsons","orcid":"https://orcid.org/0000-0001-9772-1549","observed_orcids":["https://orcid.org/0000-0001-9772-1549"]},"institutions":[{"id":"https://openalex.org/I130438778","display_name":"Memorial University of Newfoundland","ror":"https://ror.org/04haebc03","country_code":"CA","type":"education","lineage":["https://openalex.org/I130438778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Matthew P. Parsons","raw_affiliation_strings":["Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, Newfoundland, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, Newfoundland, Canada","institution_ids":["https://openalex.org/I130438778"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014015821","display_name":"Michiru Hirasawa","orcid":"https://orcid.org/0000-0002-2491-8102","observed_orcids":["https://orcid.org/0000-0002-2491-8102"]},"institutions":[{"id":"https://openalex.org/I130438778","display_name":"Memorial University of Newfoundland","ror":"https://ror.org/04haebc03","country_code":"CA","type":"education","lineage":["https://openalex.org/I130438778"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Michiru Hirasawa","raw_affiliation_strings":["Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, Newfoundland, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, Faculty of Medicine, Memorial University, St. John's, Newfoundland, Canada","institution_ids":["https://openalex.org/I130438778"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014015821"],"corresponding_institution_ids":["https://openalex.org/I130438778"],"apc_list":null,"apc_paid":null,"fwci":0.6304,"has_fulltext":false,"cited_by_count":107,"citation_normalized_percentile":{"value":0.49136069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"301","issue":"3","first_page":"R572","last_page":"R580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orexin-neurons","display_name":"orexin neurons","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lateral-hypothalamus","display_name":"lateral hypothalamus","score":0.8360000252723694},{"id":"https://openalex.org/keywords/perifornical-area","display_name":"perifornical area","score":0.9959999918937683},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9350000023841858},{"id":"https://openalex.org/keywords/glutamatergic-input","display_name":"glutamatergic input","score":0.7580000162124634},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.699999988079071},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.8399999737739563},{"id":"https://openalex.org/keywords/neurotransmitter-co-release","display_name":"neurotransmitter co-release","score":0.6510000228881836},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.8849999904632568},{"id":"https://openalex.org/keywords/melanin-concentrating-hormone","display_name":"melanin-concentrating hormone","score":0.9409999847412109},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone","display_name":"thyrotropin-releasing hormone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neurotensin","display_name":"neurotensin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.8989999890327454},{"id":"https://openalex.org/keywords/sleep-wake-regulation","display_name":"sleep-wake regulation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.9919999837875366},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/wakefulness","display_name":"wakefulness","score":0.7670000195503235},{"id":"https://openalex.org/keywords/consummatory-behavior","display_name":"consummatory behavior","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.9268778562545776},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7456927299499512},{"id":"https://openalex.org/C2780714764","wikidata":"https://www.wikidata.org/wiki/Q17125841","display_name":"Lateral hypothalamus","level":3,"score":0.6909292340278625},{"id":"https://openalex.org/C2779320081","wikidata":"https://www.wikidata.org/wiki/Q246710","display_name":"Wakefulness","level":3,"score":0.5793294906616211},{"id":"https://openalex.org/C2776119998","wikidata":"https://www.wikidata.org/wiki/Q1070023","display_name":"Orexin-A","level":5,"score":0.5095446705818176},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4936255216598511},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.4748830199241638},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.4466102123260498},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.4445452392101288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4425485134124756},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.4183439016342163},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.3752777576446533},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3465622663497925},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34463363885879517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32231763005256653},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.2555145025253296},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21465444564819336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16979444026947021},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.16080594062805176},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068797","descriptor_name":"Orexins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001069","descriptor_name":"Appetite Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajpregu.00674.2010","doi":"https://doi.org/10.1152/ajpregu.00674.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00674.2010","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:21697524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21697524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1007.8329","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1007.8329","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajpregu.physiology.org/content/ajpregu/301/3/R572.full.pdf","raw_type":"text"},{"id":"mag:2345256895","doi":null,"is_oa":false,"landing_page_url":"https://www.angeredsnarsjukhus.se/upload/Angereds%20n%E4rsjukhus/BUV/Barnlakarkurs/Am%20J%20Physiol%20Regul%20Integr%20Comp%20Physiol-2011-Burt-R572-80.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W1481893565","https://openalex.org/W1627229807","https://openalex.org/W1646110612","https://openalex.org/W1793127045","https://openalex.org/W1900806505","https://openalex.org/W1947202934","https://openalex.org/W1966198821","https://openalex.org/W1966436493","https://openalex.org/W1967578358","https://openalex.org/W1969056832","https://openalex.org/W1970530799","https://openalex.org/W1977039131","https://openalex.org/W1977858533","https://openalex.org/W1978082185","https://openalex.org/W1980603718","https://openalex.org/W1980656761","https://openalex.org/W1986738450","https://openalex.org/W1988005306","https://openalex.org/W1988390116","https://openalex.org/W1988546336","https://openalex.org/W1989388706","https://openalex.org/W1989396560","https://openalex.org/W1989965906","https://openalex.org/W1992304947","https://openalex.org/W1992895646","https://openalex.org/W1993137505","https://openalex.org/W1994915333","https://openalex.org/W1998976350","https://openalex.org/W1999433238","https://openalex.org/W2000544916","https://openalex.org/W2001932594","https://openalex.org/W2001980298","https://openalex.org/W2002293846","https://openalex.org/W2002437895","https://openalex.org/W2003317794","https://openalex.org/W2005109180","https://openalex.org/W2006547733","https://openalex.org/W2007790823","https://openalex.org/W2008099612","https://openalex.org/W2009189044","https://openalex.org/W2009392202","https://openalex.org/W2011056838","https://openalex.org/W2011580879","https://openalex.org/W2012847023","https://openalex.org/W2016787168","https://openalex.org/W2024183517","https://openalex.org/W2024422611","https://openalex.org/W2024609999","https://openalex.org/W2026133902","https://openalex.org/W2027171495","https://openalex.org/W2027180375","https://openalex.org/W2027740042","https://openalex.org/W2027884975","https://openalex.org/W2028381892","https://openalex.org/W2028959193","https://openalex.org/W2029551228","https://openalex.org/W2033166789","https://openalex.org/W2037923116","https://openalex.org/W2039199726","https://openalex.org/W2039390777","https://openalex.org/W2039870075","https://openalex.org/W2040700968","https://openalex.org/W2040773018","https://openalex.org/W2041677480","https://openalex.org/W2041731336","https://openalex.org/W2042433573","https://openalex.org/W2043864709","https://openalex.org/W2047362129","https://openalex.org/W2047685291","https://openalex.org/W2048743332","https://openalex.org/W2049424163","https://openalex.org/W2051778074","https://openalex.org/W2056060248","https://openalex.org/W2057101237","https://openalex.org/W2058489268","https://openalex.org/W2058586676","https://openalex.org/W2059126465","https://openalex.org/W2061994623","https://openalex.org/W2063619992","https://openalex.org/W2063635646","https://openalex.org/W2064416917","https://openalex.org/W2064442671","https://openalex.org/W2064453868","https://openalex.org/W2067102106","https://openalex.org/W2067136906","https://openalex.org/W2067584086","https://openalex.org/W2069497885","https://openalex.org/W2071407687","https://openalex.org/W2072154498","https://openalex.org/W2072338511","https://openalex.org/W2074010758","https://openalex.org/W2074082111","https://openalex.org/W2076231255","https://openalex.org/W2077425962","https://openalex.org/W2078178845","https://openalex.org/W2079636816","https://openalex.org/W2083671702","https://openalex.org/W2084556601","https://openalex.org/W2085070592","https://openalex.org/W2085712847","https://openalex.org/W2086671563","https://openalex.org/W2087582180","https://openalex.org/W2088397165","https://openalex.org/W2092297104","https://openalex.org/W2097222916","https://openalex.org/W2099485542","https://openalex.org/W2100730137","https://openalex.org/W2100743305","https://openalex.org/W2101251885","https://openalex.org/W2102915623","https://openalex.org/W2103409581","https://openalex.org/W2107605597","https://openalex.org/W2108775520","https://openalex.org/W2111547035","https://openalex.org/W2113373744","https://openalex.org/W2113440620","https://openalex.org/W2115861749","https://openalex.org/W2115902692","https://openalex.org/W2120144854","https://openalex.org/W2122301924","https://openalex.org/W2123400242","https://openalex.org/W2127282658","https://openalex.org/W2136226444","https://openalex.org/W2138262820","https://openalex.org/W2142867361","https://openalex.org/W2143609607","https://openalex.org/W2149809624","https://openalex.org/W2152211310","https://openalex.org/W2152807333","https://openalex.org/W2152921732","https://openalex.org/W2153883114","https://openalex.org/W2154839829","https://openalex.org/W2155490928","https://openalex.org/W2155918485","https://openalex.org/W2158972964","https://openalex.org/W2159953069","https://openalex.org/W2162014506","https://openalex.org/W2167591942","https://openalex.org/W2169650679","https://openalex.org/W2187221227","https://openalex.org/W2320863189","https://openalex.org/W2359251903","https://openalex.org/W4252265800"],"related_works":["https://openalex.org/W2345256895","https://openalex.org/W2480950082","https://openalex.org/W2139482507","https://openalex.org/W2144470561","https://openalex.org/W4401263918","https://openalex.org/W2292110179","https://openalex.org/W4362671332","https://openalex.org/W2039199726","https://openalex.org/W7098264340","https://openalex.org/W2783655353"],"abstract_inverted_index":{"Obesity":[0],"and":[1,32,53,59,73,115,120,138,172,199,219],"inadequate":[2],"sleep":[3],"are":[4],"among":[5],"the":[6,17,41,56,68,74,90,112,143,183,213],"most":[7],"common":[8],"causes":[9],"of":[10,44,51,70,124,132,145,151,186,193,216],"health":[11],"problems":[12],"in":[13,27,39],"modern":[14],"society.":[15],"Thus,":[16],"discovery":[18],"that":[19],"orexin":[20,64,71,146,161,187],"(hypocretin)":[21],"neurons":[22,52,65,72,77,153,188],"play":[23],"a":[24],"pivotal":[25],"role":[26],"sleep/wake":[28],"regulation,":[29],"energy":[30,217],"balance,":[31],"consummatory":[33,201],"behaviors":[34],"has":[35],"sparked":[36],"immense":[37],"interest":[38],"understanding":[40],"regulatory":[42],"mechanisms":[43,176,215],"these":[45,205],"neurons.":[46,147],"The":[47],"local":[48,91],"network":[49,92],"consisting":[50],"astrocytes":[54],"within":[55],"lateral":[57],"hypothalamus":[58],"perifornical":[60],"area":[61],"(LH/PFA),":[62],"where":[63,93],"reside,":[66],"shapes":[67],"output":[69,195],"LH/PFA.":[75],"Orexin":[76],"not":[78],"only":[79],"send":[80],"projections":[81],"to":[82,89,98,189,196],"remote":[83],"brain":[84],"areas":[85],"but":[86],"also":[87,141],"contribute":[88],"they":[94],"release":[95,131],"multiple":[96],"neurotransmitters":[97,103,155],"modulate":[99],"its":[100],"activity.":[101],"These":[102,174],"have":[104],"opposing":[105],"actions,":[106],"whose":[107],"balance":[108,218],"is":[109],"determined":[110],"by":[111],"amount":[113],"released":[114],"postsynaptic":[116],"receptor":[117],"desensitization.":[118],"Modulation":[119],"negative":[121],"feedback":[122],"regulation":[123],"excitatory":[125],"glutamatergic":[126],"inputs":[127],"as":[128,130,136,164],"well":[129],"astrocyte-derived":[133],"factors,":[134],"such":[135,163],"lactate":[137],"ATP,":[139],"can":[140],"affect":[142],"excitability":[144],"Furthermore,":[148],"distinct":[149],"populations":[150],"LH/PFA":[152],"express":[154],"with":[156],"known":[157],"electrophysiological":[158],"actions":[159],"on":[160,204],"neurons,":[162],"melanin-concentrating":[165],"hormone,":[166,170],"corticotropin-releasing":[167],"factor,":[168],"thyrotropin-releasing":[169],"neurotensin,":[171],"GABA.":[173],"LH/PFA-specific":[175],"may":[177],"be":[178],"important":[179],"for":[180],"fine":[181],"tuning":[182],"firing":[184],"activity":[185],"maintain":[190],"optimal":[191],"levels":[192],"prolonged":[194],"sustain":[197],"wakefulness":[198],"stimulate":[200],"behaviors.":[202],"Building":[203],"exciting":[206],"findings":[207],"should":[208],"shed":[209],"further":[210],"light":[211],"onto":[212],"cellular":[214],"sleep-wake":[220],"regulation.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
