{"id":"https://openalex.org/W2103775006","doi":"https://doi.org/10.1039/c4sc02078b","title":"Delivery of mirror image polypeptides into cells","display_name":"Delivery of mirror image polypeptides into cells","publication_year":2014,"publication_date":"2014-09-25","ids":{"openalex":"https://openalex.org/W2103775006","doi":"https://doi.org/10.1039/c4sc02078b","mag":"2103775006","pmid":"https://pubmed.ncbi.nlm.nih.gov/28706631","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5492103"},"language":"en","primary_location":{"id":"doi:10.1039/c4sc02078b","doi":"https://doi.org/10.1039/c4sc02078b","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c4sc02078b","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2015/sc/c4sc02078b","source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2015/sc/c4sc02078b","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056470805","display_name":"Amy E. Rabideau","orcid":"https://orcid.org/0000-0002-3433-6050","observed_orcids":["https://orcid.org/0000-0002-3433-6050"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy E. Rabideau","raw_affiliation_strings":["Cambridge","Department of Chemistry","Massachusetts Institute of Technology","USA","Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave. 18-596,Cambridge,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave. 18-596,Cambridge,USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041247421","display_name":"Xiaoli Liao","orcid":"https://orcid.org/0000-0002-9692-9855","observed_orcids":["https://orcid.org/0000-0002-9692-9855"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoli Liao","raw_affiliation_strings":["Cambridge","Department of Chemistry","Massachusetts Institute of Technology","USA","Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave. 18-596,Cambridge,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave. 18-596,Cambridge,USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021760386","display_name":"Bradley L. Pentelute","orcid":"https://orcid.org/0000-0002-7242-801X","observed_orcids":["https://orcid.org/0000-0002-7242-801X"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bradley L. Pentelute","raw_affiliation_strings":["Cambridge","Department of Chemistry","Massachusetts Institute of Technology","USA","Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave. 18-596,Cambridge,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave. 18-596,Cambridge,USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021760386"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":1.5044,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.81797112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"648","last_page":"653"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.4318999946117401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.6150000095367432},{"id":"https://openalex.org/keywords/peptide-stability","display_name":"peptide stability","score":0.9340000152587891},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.7766125202178955},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6757041811943054},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6175745725631714},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5587817430496216},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5247678756713867},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5185863971710205},{"id":"https://openalex.org/C2776929087","wikidata":"https://www.wikidata.org/wiki/Q189096","display_name":"Cell-penetrating peptide","level":3,"score":0.5175211429595947},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4457992911338806},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4181622266769409},{"id":"https://openalex.org/C41810244","wikidata":"https://www.wikidata.org/wiki/Q1935986","display_name":"Anthrax toxin","level":5,"score":0.4158731698989868},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31879469752311707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3182258605957031},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.225821852684021},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11745530366897583},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.07531538605690002},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1039/c4sc02078b","doi":"https://doi.org/10.1039/c4sc02078b","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c4sc02078b","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2015/sc/c4sc02078b","source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5492103","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5492103","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chem Sci","raw_type":"Text"},{"id":"pmid:28706631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28706631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical science","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/95627","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/95627","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Royal Society of Chemistry","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1039/c4sc02078b","doi":"https://doi.org/10.1039/c4sc02078b","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c4sc02078b","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2015/sc/c4sc02078b","source":{"id":"https://openalex.org/S184645833","display_name":"Chemical Science","issn_l":"2041-6520","issn":["2041-6520","2041-6539"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-3","ki-jl-2","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Science","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.46000000834465027,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2640378852","display_name":null,"funder_award_id":"1351807","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G5986892838","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G6209706364","display_name":"New England Regional Center of Excellence in Biodefense and Emerging Infectious D","funder_award_id":"U54AI057159","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6259695105","display_name":"CAREER: Using chemistry to probe anthrax toxin protein translocation","funder_award_id":"1351807","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6939764598","display_name":null,"funder_award_id":"CHE-1351807","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306271","display_name":"Damon Runyon Cancer Research Foundation","ror":"https://ror.org/01gd7b947"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103775006.pdf","grobid_xml":"https://content.openalex.org/works/W2103775006.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W111956875","https://openalex.org/W1485332704","https://openalex.org/W1515068677","https://openalex.org/W1557777477","https://openalex.org/W1576709265","https://openalex.org/W1610696702","https://openalex.org/W1974917488","https://openalex.org/W2000206128","https://openalex.org/W2004693684","https://openalex.org/W2007783940","https://openalex.org/W2010897967","https://openalex.org/W2012150510","https://openalex.org/W2015519364","https://openalex.org/W2019144805","https://openalex.org/W2022996046","https://openalex.org/W2024084467","https://openalex.org/W2025976409","https://openalex.org/W2027168767","https://openalex.org/W2043398190","https://openalex.org/W2070202134","https://openalex.org/W2075601360","https://openalex.org/W2077787026","https://openalex.org/W2090696823","https://openalex.org/W2108649505","https://openalex.org/W2116179149","https://openalex.org/W2120620959","https://openalex.org/W2135198179","https://openalex.org/W2143566830","https://openalex.org/W2146837416","https://openalex.org/W2148405034","https://openalex.org/W2153013945","https://openalex.org/W2167125107","https://openalex.org/W4213262935"],"related_works":["https://openalex.org/W7160557842","https://openalex.org/W4400356840","https://openalex.org/W7208138280","https://openalex.org/W2371399643","https://openalex.org/W4405720282","https://openalex.org/W414133032","https://openalex.org/W7167442412","https://openalex.org/W4392239286","https://openalex.org/W7165045029","https://openalex.org/W4319082388"],"abstract_inverted_index":{"Mirror":[0],"image":[1],"peptides":[2],"have":[3],"unique":[4],"stability":[5],"and":[6],"immunogenic":[7],"properties":[8],"in":[9],"mammals,":[10],"making":[11],"them":[12],"attractive":[13],"agents":[14],"to":[15],"investigate.":[16]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}