{"id":"https://openalex.org/W2103764596","doi":"https://doi.org/10.1046/j.1365-313x.2003.01923.x","title":"Spermine signalling in tobacco: activation of mitogen\u2010activated protein kinases by spermine is mediated through mitochondrial dysfunction","display_name":"Spermine signalling in tobacco: activation of mitogen\u2010activated protein kinases by spermine is mediated through mitochondrial dysfunction","publication_year":2003,"publication_date":"2003-11-06","ids":{"openalex":"https://openalex.org/W2103764596","doi":"https://doi.org/10.1046/j.1365-313x.2003.01923.x","mag":"2103764596","pmid":"https://pubmed.ncbi.nlm.nih.gov/14675447"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-313x.2003.01923.x","doi":"https://doi.org/10.1046/j.1365-313x.2003.01923.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-313x.2003.01923.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-313X.2003.01923.x","source":{"id":"https://openalex.org/S67862205","display_name":"The Plant Journal","issn_l":"0960-7412","issn":["0960-7412","1365-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-313X.2003.01923.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103425996","display_name":"Yoshihiro Takahashi","orcid":"https://orcid.org/0000-0002-4841-9914","observed_orcids":["https://orcid.org/0000-0002-4841-9914","https://orcid.org/0009-0000-8827-4601"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Takahashi","raw_affiliation_strings":["Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, Miyagi 980-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, Miyagi 980-8577, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019060194","display_name":"Thomas Berberich","orcid":"https://orcid.org/0000-0001-9442-4450","observed_orcids":["https://orcid.org/0000-0001-9442-4450"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["DE","JP"],"is_corresponding":false,"raw_author_name":"Thomas Berberich","raw_affiliation_strings":["Botanisches Institut, Goethe-Universita\u0308t, Postfach 11 19 32, D-60054, Frankfurt am Main, Germany, and","Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, Miyagi 980-8577, Japan,","Botanisches Institut, Goethe\u2010Universit\u00e4t, Postfach 11 19 32, D\u201060054, Frankfurt am Main, Germany, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Botanisches Institut, Goethe-Universita\u0308t, Postfach 11 19 32, D-60054, Frankfurt am Main, Germany, and","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, Miyagi 980-8577, Japan,","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Botanisches Institut, Goethe\u2010Universit\u00e4t, Postfach 11 19 32, D\u201060054, Frankfurt am Main, Germany, and","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Atsushi Miyazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Miyazaki","raw_affiliation_strings":["Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, Miyagi, 980-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, Miyagi, 980-8577, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014236841","display_name":"Shigemi Seo","orcid":"https://orcid.org/0000-0003-4940-288X","observed_orcids":["https://orcid.org/0000-0003-4940-288X"]},"institutions":[{"id":"https://openalex.org/I3018761593","display_name":"Institute of Agrobiological Sciences","ror":"https://ror.org/01786mp71","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1323638106","https://openalex.org/I3018761593"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigemi Seo","raw_affiliation_strings":["Plant Physiology Department, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba, Ibaraki 305-8602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Physiology Department, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba, Ibaraki 305-8602, Japan","institution_ids":["https://openalex.org/I3018761593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111897783","display_name":"Yuko Ohashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018761593","display_name":"Institute of Agrobiological Sciences","ror":"https://ror.org/01786mp71","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1323638106","https://openalex.org/I3018761593"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Ohashi","raw_affiliation_strings":["Plant Physiology Department, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba, Ibaraki 305-8602, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Physiology Department, National Institute of Agrobiological Sciences, Kannondai 2-1-2, Tsukuba, Ibaraki 305-8602, Japan","institution_ids":["https://openalex.org/I3018761593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109970563","display_name":"Tomonobu Kusano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomonobu Kusano","raw_affiliation_strings":["Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, Miyagi, 980-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, Miyagi, 980-8577, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":2.1685,"has_fulltext":true,"cited_by_count":139,"citation_normalized_percentile":{"value":0.87803687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"36","issue":"6","first_page":"820","last_page":"829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.057500001043081284,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spermine","display_name":"spermine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/polyamines","display_name":"polyamines","score":0.8360000252723694},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8349999785423279},{"id":"https://openalex.org/keywords/alternative-oxidase","display_name":"alternative oxidase","score":0.8379999995231628},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9369999766349792},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition","display_name":"mitochondrial permeability transition","score":0.7670000195503235},{"id":"https://openalex.org/keywords/bongkrekic-acid","display_name":"bongkrekic acid","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tobacco-leaf","display_name":"tobacco leaves","score":0.6800000071525574},{"id":"https://openalex.org/keywords/plant-signaling","display_name":"plant signaling","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6966387033462524},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.6692084074020386},{"id":"https://openalex.org/C2776109719","wikidata":"https://www.wikidata.org/wiki/Q424597","display_name":"Spermine","level":3,"score":0.6343849301338196},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.6282269954681396},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.576229453086853},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5488638281822205},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.49298855662345886},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4638981819152832},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4259992837905884},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39509180188179016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39069855213165283},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10846951603889465},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05439057946205139}],"mesh":[{"descriptor_ui":"D000099188","descriptor_name":"Alternative Oxidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002258","descriptor_name":"Carbonyl Cyanide m-Chlorophenyl Hydrazone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004121","descriptor_name":"Dimethyl Sulfoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013096","descriptor_name":"Spermine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013096","descriptor_name":"Spermine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-313x.2003.01923.x","doi":"https://doi.org/10.1046/j.1365-313x.2003.01923.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-313x.2003.01923.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-313X.2003.01923.x","source":{"id":"https://openalex.org/S67862205","display_name":"The Plant Journal","issn_l":"0960-7412","issn":["0960-7412","1365-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Journal","raw_type":"journal-article"},{"id":"pmid:14675447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14675447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant journal : for cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1046/j.1365-313x.2003.01923.x","doi":"https://doi.org/10.1046/j.1365-313x.2003.01923.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-313x.2003.01923.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-313X.2003.01923.x","source":{"id":"https://openalex.org/S67862205","display_name":"The Plant Journal","issn_l":"0960-7412","issn":["0960-7412","1365-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103764596.pdf","grobid_xml":"https://content.openalex.org/works/W2103764596.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1524838307","https://openalex.org/W1968606500","https://openalex.org/W1969828950","https://openalex.org/W1974980101","https://openalex.org/W1975890951","https://openalex.org/W1980436826","https://openalex.org/W1982687089","https://openalex.org/W1988122727","https://openalex.org/W1990213589","https://openalex.org/W1999013424","https://openalex.org/W1999032956","https://openalex.org/W1999182367","https://openalex.org/W2002109416","https://openalex.org/W2003748109","https://openalex.org/W2008709229","https://openalex.org/W2012751277","https://openalex.org/W2017878550","https://openalex.org/W2024653949","https://openalex.org/W2037852171","https://openalex.org/W2042689385","https://openalex.org/W2043161126","https://openalex.org/W2046955179","https://openalex.org/W2047070871","https://openalex.org/W2047915557","https://openalex.org/W2051312328","https://openalex.org/W2052989175","https://openalex.org/W2056832537","https://openalex.org/W2063912164","https://openalex.org/W2067761408","https://openalex.org/W2070038134","https://openalex.org/W2072655997","https://openalex.org/W2074649846","https://openalex.org/W2075229517","https://openalex.org/W2076485183","https://openalex.org/W2079542357","https://openalex.org/W2080786215","https://openalex.org/W2086800357","https://openalex.org/W2090677935","https://openalex.org/W2095480373","https://openalex.org/W2098719212","https://openalex.org/W2099992656","https://openalex.org/W2102731642","https://openalex.org/W2112945685","https://openalex.org/W2113340095","https://openalex.org/W2117525235","https://openalex.org/W2118357509","https://openalex.org/W2119003709","https://openalex.org/W2127974864","https://openalex.org/W2132733081","https://openalex.org/W2143204694","https://openalex.org/W2143264825","https://openalex.org/W2146044044","https://openalex.org/W2151061861","https://openalex.org/W2151476068","https://openalex.org/W2152921032","https://openalex.org/W2154606961","https://openalex.org/W2157640014","https://openalex.org/W2162512498","https://openalex.org/W2164671653","https://openalex.org/W2165205273","https://openalex.org/W2171719258","https://openalex.org/W2413934543","https://openalex.org/W4235658571","https://openalex.org/W4241048323"],"related_works":["https://openalex.org/W2137469046","https://openalex.org/W7095643940","https://openalex.org/W2137151536","https://openalex.org/W1970166144","https://openalex.org/W2106339963","https://openalex.org/W2098837577","https://openalex.org/W2112874016","https://openalex.org/W2109737985","https://openalex.org/W2888192178","https://openalex.org/W2945311118"],"abstract_inverted_index":{"Polyamines":[0],"(PAs)":[1],"play":[2],"important":[3],"roles":[4],"in":[5,144],"cell":[6],"proliferation,":[7],"growth":[8],"and":[9,48,73,82,103,124,128,149,166],"environmental":[10],"stress":[11],"responses":[12],"of":[13,35,60,91,112,115,126,160],"all":[14],"living":[15],"organisms.":[16],"In":[17],"this":[18],"study,":[19],"we":[20],"examine":[21],"whether":[22],"these":[23,101],"compounds":[24],"act":[25],"as":[26,41],"signal":[27],"mediators.":[28],"Spermine":[29],"(Spm)":[30],"specifically":[31,88],"activated":[32],"protein":[33,45,50,69],"kinases":[34,70],"tobacco":[36],"leaves,":[37],"which":[38,97,145],"were":[39,76],"identified":[40],"salicylic":[42],"acid":[43,108],"(SA)-induced":[44],"kinase":[46,51],"(SIPK)":[47],"wound-induced":[49],"(WIPK),":[52],"using":[53],"specific":[54],"antibodies.":[55],"Upon":[56],"Spm":[57,87,136],"treatment,":[58],"upregulation":[59,75],"WIPK,":[61],"but":[62],"not":[63],"SIPK,":[64],"was":[65,98],"observed.":[66],"Spm-induced":[67],"mitogen-activated":[68],"(MAPKs)":[71],"activation":[72,123],"WIPK":[74,127,167],"prevented":[77],"upon":[78],"pre-treatment":[79],"with":[80],"antioxidants":[81,102],"Ca2+":[83,104,150],"channel":[84,105],"blockers.":[85,106],"Additionally,":[86],"stimulated":[89],"expression":[90],"the":[92,113,157,161],"alternative":[93],"oxidase":[94],"(AOX)":[95],"gene,":[96],"disrupted":[99],"by":[100],"Bongkrekic":[107],"(BK),":[109],"an":[110],"inhibitor":[111],"opening":[114],"mitochondrial":[116,138],"permeability":[117],"transition":[118],"(PT)":[119],"pores,":[120],"suppressed":[121],"MAPKs":[122],"accumulation":[125],"AOX":[129],"mRNA.":[130],"Our":[131],"data":[132],"collectively":[133],"suggest":[134],"that":[135],"causes":[137],"dysfunction":[139],"via":[140],"a":[141,155],"signalling":[142],"pathway":[143],"reactive":[146],"oxygen":[147],"species":[148],"influx":[151],"are":[152,168],"involved.":[153],"As":[154],"result,":[156],"phosphorylation":[158],"activities":[159],"two":[162],"MAPK":[163],"enzymes":[164],"SIPK":[165],"stimulated.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}