{"id":"https://openalex.org/W2103746754","doi":"https://doi.org/10.1016/s0014-2999(97)01255-7","title":"Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain","display_name":"Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W2103746754","doi":"https://doi.org/10.1016/s0014-2999(97)01255-7","mag":"2103746754","pmid":"https://pubmed.ncbi.nlm.nih.gov/9384246"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-2999(97)01255-7","doi":"https://doi.org/10.1016/s0014-2999(97)01255-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(97)01255-7","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069268756","display_name":"Thomas H. Burkey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas H Burkey","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, University of Arizona Health Sciences Center, Tucson 85724, USA","Departments of Pharmacology, Pharmacology and Toxicology, Biochemistry, Psychiatry and the Program in Neuroscience, College of Medicine, University of Arizona Health Sciences Center, 1501 N. Compbell Ave., Tucson, AZ 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, University of Arizona Health Sciences Center, Tucson 85724, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Departments of Pharmacology, Pharmacology and Toxicology, Biochemistry, Psychiatry and the Program in Neuroscience, College of Medicine, University of Arizona Health Sciences Center, 1501 N. Compbell Ave., Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015469925","display_name":"Raymond Mark Quock","orcid":"https://orcid.org/0000-0001-6616-4778","observed_orcids":["https://orcid.org/0000-0001-6616-4778"]},"institutions":[{"id":"https://openalex.org/I4210110323","display_name":"University of Illinois Chicago, Rockford campus","ror":"https://ror.org/02437s643","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238","https://openalex.org/I4210110323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond M Quock","raw_affiliation_strings":["Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, USA","institution_ids":["https://openalex.org/I4210110323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015816460","display_name":"Paul F. Consroe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Consroe","raw_affiliation_strings":["Departments of Pharmacology, Pharmacology and Toxicology, Biochemistry, Psychiatry and the Program in Neuroscience, College of Medicine, University of Arizona Health Sciences Center, 1501 N. Compbell Ave., Tucson, AZ 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Pharmacology and Toxicology, Biochemistry, Psychiatry and the Program in Neuroscience, College of Medicine, University of Arizona Health Sciences Center, 1501 N. Compbell Ave., Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024466186","display_name":"Frederick J. Ehlert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick J Ehlert","raw_affiliation_strings":["Department of Pharmacology, University of California at Irvine, College of Medicine, Irvine, CA 92717, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California at Irvine, College of Medicine, Irvine, CA 92717, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018398249","display_name":"Yoshiaki Hosohata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshiaki Hosohata","raw_affiliation_strings":["Departments of Pharmacology, Pharmacology and Toxicology, Biochemistry, Psychiatry and the Program in Neuroscience, College of Medicine, University of Arizona Health Sciences Center, 1501 N. Compbell Ave., Tucson, AZ 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Pharmacology and Toxicology, Biochemistry, Psychiatry and the Program in Neuroscience, College of Medicine, University of Arizona Health Sciences Center, 1501 N. Compbell Ave., Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026754955","display_name":"William R. Roeske","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R Roeske","raw_affiliation_strings":["Departments of Pharmacology, Pharmacology and Toxicology, Biochemistry, Psychiatry and the Program in Neuroscience, College of Medicine, University of Arizona Health Sciences Center, 1501 N. Compbell Ave., Tucson, AZ 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Pharmacology and Toxicology, Biochemistry, Psychiatry and the Program in Neuroscience, College of Medicine, University of Arizona Health Sciences Center, 1501 N. Compbell Ave., Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112699372","display_name":"Henry I. Yamamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Henry I Yamamura","raw_affiliation_strings":["Departments of Pharmacology, Pharmacology and Toxicology, Biochemistry, Psychiatry and the Program in Neuroscience, College of Medicine, University of Arizona Health Sciences Center, 1501 N. Compbell Ave., Tucson, AZ 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Pharmacology and Toxicology, Biochemistry, Psychiatry and the Program in Neuroscience, College of Medicine, University of Arizona Health Sciences Center, 1501 N. Compbell Ave., Tucson, AZ 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112699372"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":6.1679,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.96496509,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"336","issue":"2-3","first_page":"295","last_page":"298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.9729999899864197},{"id":"https://openalex.org/keywords/agonist-efficacy","display_name":"agonist efficacy","score":0.800000011920929},{"id":"https://openalex.org/keywords/cp-55-940","display_name":"CP55,940","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hu-210","display_name":"HU-210","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anandamide","display_name":"anandamide","score":0.9919999837875366},{"id":"https://openalex.org/keywords/delta9-tetrahydrocannabinol","display_name":"delta-9-tetrahydrocannabinol","score":0.9879999756813049},{"id":"https://openalex.org/keywords/g-protein-activation","display_name":"G protein activation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/partial-agonists","display_name":"partial agonists","score":0.8190000057220459},{"id":"https://openalex.org/keywords/receptor-occupancy","display_name":"receptor occupancy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/drug-potency","display_name":"drug potency","score":0.6859999895095825},{"id":"https://openalex.org/keywords/mouse-brain","display_name":"mouse brain","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.8164102435112},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.7595816850662231},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.6853548288345337},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6731234788894653},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6560146808624268},{"id":"https://openalex.org/C2779783865","wikidata":"https://www.wikidata.org/wiki/Q410228","display_name":"Anandamide","level":5,"score":0.6381103992462158},{"id":"https://openalex.org/C2776433454","wikidata":"https://www.wikidata.org/wiki/Q412529","display_name":"Rimonabant","level":5,"score":0.6332142353057861},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6033210158348083},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5818948745727539},{"id":"https://openalex.org/C2778563155","wikidata":"https://www.wikidata.org/wiki/Q190067","display_name":"Tetrahydrocannabinol","level":4,"score":0.5325654149055481},{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.4923924207687378},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4524863064289093},{"id":"https://openalex.org/C38533456","wikidata":"https://www.wikidata.org/wiki/Q1671589","display_name":"Intrinsic activity","level":4,"score":0.45007210969924927},{"id":"https://openalex.org/C2910065304","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid Receptor Agonists","level":5,"score":0.44657203555107117},{"id":"https://openalex.org/C2909767651","wikidata":"https://www.wikidata.org/wiki/Q190067","display_name":"Delta-9-tetrahydrocannabinol","level":4,"score":0.4347640872001648},{"id":"https://openalex.org/C2778684643","wikidata":"https://www.wikidata.org/wiki/Q5514740","display_name":"GTPgammaS","level":4,"score":0.41490209102630615},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22038143873214722},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21569320559501648},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11516395211219788}],"mesh":[{"descriptor_ui":"D000077285","descriptor_name":"Rimonabant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002186","descriptor_name":"Cannabinoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002186","descriptor_name":"Cannabinoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016244","descriptor_name":"Guanosine 5'-O-(3-Thiotriphosphate)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043882","descriptor_name":"Receptors, Cannabinoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053284","descriptor_name":"Polyunsaturated Alkamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-2999(97)01255-7","doi":"https://doi.org/10.1016/s0014-2999(97)01255-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(97)01255-7","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:9384246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9384246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W300694608","https://openalex.org/W1899328101","https://openalex.org/W1982062268","https://openalex.org/W1992114028","https://openalex.org/W2014664792","https://openalex.org/W2018953051","https://openalex.org/W2026687408","https://openalex.org/W2038140464","https://openalex.org/W2058003793","https://openalex.org/W2059977407","https://openalex.org/W2074631079","https://openalex.org/W2075894678","https://openalex.org/W2145087250","https://openalex.org/W2308715768","https://openalex.org/W4243627722","https://openalex.org/W6697890857"],"related_works":["https://openalex.org/W1922004193","https://openalex.org/W2134089663","https://openalex.org/W2170857974","https://openalex.org/W7096600147","https://openalex.org/W1936589897","https://openalex.org/W7215885988","https://openalex.org/W2076811819","https://openalex.org/W1982062268","https://openalex.org/W2156052800","https://openalex.org/W2301600795"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
