{"id":"https://openalex.org/W2103680912","doi":"https://doi.org/10.1128/mbio.01169-14","title":"Relaxed Selection Drives a Noisy Noncoding Transcriptome in Members of the Mycobacterium tuberculosis Complex","display_name":"Relaxed Selection Drives a Noisy Noncoding Transcriptome in Members of the Mycobacterium tuberculosis Complex","publication_year":2014,"publication_date":"2014-08-06","ids":{"openalex":"https://openalex.org/W2103680912","doi":"https://doi.org/10.1128/mbio.01169-14","mag":"2103680912","pmid":"https://pubmed.ncbi.nlm.nih.gov/25096875","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4128351"},"language":"en","primary_location":{"id":"doi:10.1128/mbio.01169-14","doi":"https://doi.org/10.1128/mbio.01169-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01169-14","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/mbio.01169-14","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045560083","display_name":"Adam M. Dinan","orcid":"https://orcid.org/0000-0003-2812-1616","observed_orcids":["https://orcid.org/0000-0003-2812-1616"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Adam M. Dinan","raw_affiliation_strings":["School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland","UCD Conway Institute, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"UCD Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072150062","display_name":"Pin Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134627","display_name":"Wellcome Centre for Cell Biology","ror":"https://ror.org/03xbccz06","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210134627","https://openalex.org/I87048295","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pin Tong","raw_affiliation_strings":["Wellcome Trust Cell Biology Centre, The University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Cell Biology Centre, The University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210134627","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065328461","display_name":"Amanda J. Lohan","orcid":"https://orcid.org/0000-0002-3574-7572","observed_orcids":["https://orcid.org/0000-0002-3574-7572"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Amanda J. Lohan","raw_affiliation_strings":["UCD Conway Institute, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCD Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111922455","display_name":"Kevin M. Conlon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Kevin M. Conlon","raw_affiliation_strings":["UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084039745","display_name":"Aleksandra A. Miranda-CasoLuengo","orcid":"https://orcid.org/0000-0001-7794-7698","observed_orcids":["https://orcid.org/0000-0001-7794-7698"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Aleksandra A. Miranda-CasoLuengo","raw_affiliation_strings":["School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland","UCD Conway Institute, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"UCD Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050430126","display_name":"Kerri M. Malone","orcid":"https://orcid.org/0000-0002-3974-0810","observed_orcids":["https://orcid.org/0000-0002-3974-0810"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Kerri M. Malone","raw_affiliation_strings":["UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075853590","display_name":"Stephen Vincent Gordon","orcid":"https://orcid.org/0000-0002-4833-5542","observed_orcids":["https://orcid.org/0000-0002-4833-5542"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Stephen V. Gordon","raw_affiliation_strings":["School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland","UCD Conway Institute, University College Dublin, Dublin, Ireland","UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"UCD Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088084068","display_name":"Brendan Loftus","orcid":"https://orcid.org/0000-0001-8871-8356","observed_orcids":["https://orcid.org/0000-0001-8871-8356"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Brendan J. Loftus","raw_affiliation_strings":["School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088084068"],"corresponding_institution_ids":["https://openalex.org/I100930933"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.9177,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.75921632,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"4","first_page":"e01169","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.6333000063896179,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.6333000063896179,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.18529999256134033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.06030000001192093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis-complex","display_name":"Mycobacterium tuberculosis complex","score":0.9390000104904175},{"id":"https://openalex.org/keywords/mycobacterium-marinum","display_name":"Mycobacterium marinum","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mycobacterium-bovis","display_name":"Mycobacterium bovis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/transcription-start-site","display_name":"transcription start sites","score":0.8059999942779541},{"id":"https://openalex.org/keywords/promoter-conservation","display_name":"promoter conservation","score":0.4830000102519989},{"id":"https://openalex.org/keywords/transcriptional-attenuation","display_name":"transcriptional attenuation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/relaxed-selection","display_name":"relaxed selection","score":0.8659999966621399},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.8379999995231628},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7250000238418579},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8061273694038391},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.7111931443214417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6006631255149841},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5940923094749451},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.4920803904533386},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.45578354597091675},{"id":"https://openalex.org/C2778497218","wikidata":"https://www.wikidata.org/wiki/Q133447","display_name":"Mycobacterium bovis","level":4,"score":0.43026915192604065},{"id":"https://openalex.org/C2781119180","wikidata":"https://www.wikidata.org/wiki/Q508803","display_name":"Mycobacterium marinum","level":4,"score":0.42542222142219543},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.39759278297424316},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37890493869781494},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.3668903112411499},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36347874999046326},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.20005068182945251},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.17680326104164124},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1070595383644104},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/mbio.01169-14","doi":"https://doi.org/10.1128/mbio.01169-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01169-14","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4128351","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4128351","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Text"},{"id":"pmid:25096875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25096875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:977487ea3f484e57a869e66215280580","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/977487ea3f484e57a869e66215280580","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mBio, Vol 5, Iss 4 (2014)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:dfb4712138a24332a916eb22066a1dc4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dfb4712138a24332a916eb22066a1dc4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mBio, Vol 5, Iss 4 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/mbio.01169-14","doi":"https://doi.org/10.1128/mbio.01169-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01169-14","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6814738720","display_name":"The evolution of riboregulation in mycobacterial pathogens and its role in host-pathogen interactions","funder_award_id":"099817/Z/12/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W329997404","https://openalex.org/W1970558305","https://openalex.org/W1971628194","https://openalex.org/W1986286674","https://openalex.org/W1986882903","https://openalex.org/W1988714210","https://openalex.org/W1992492991","https://openalex.org/W1993548347","https://openalex.org/W2016324622","https://openalex.org/W2016517200","https://openalex.org/W2024817467","https://openalex.org/W2042617317","https://openalex.org/W2046374424","https://openalex.org/W2050610109","https://openalex.org/W2052791500","https://openalex.org/W2055861579","https://openalex.org/W2056067932","https://openalex.org/W2062896692","https://openalex.org/W2065739216","https://openalex.org/W2069221265","https://openalex.org/W2076651976","https://openalex.org/W2082788472","https://openalex.org/W2083710504","https://openalex.org/W2101010252","https://openalex.org/W2102075559","https://openalex.org/W2106350024","https://openalex.org/W2106813347","https://openalex.org/W2108775641","https://openalex.org/W2110443215","https://openalex.org/W2115622704","https://openalex.org/W2116373379","https://openalex.org/W2119872537","https://openalex.org/W2124985265","https://openalex.org/W2125119899","https://openalex.org/W2136085069","https://openalex.org/W2137015675","https://openalex.org/W2143950161","https://openalex.org/W2147571700","https://openalex.org/W2150390148","https://openalex.org/W2151636105","https://openalex.org/W2151722133","https://openalex.org/W2153426549","https://openalex.org/W2154431984","https://openalex.org/W2155347381","https://openalex.org/W2158804744","https://openalex.org/W2160368540","https://openalex.org/W2162922496","https://openalex.org/W2164217177","https://openalex.org/W2168095798","https://openalex.org/W2169217202","https://openalex.org/W2170089172","https://openalex.org/W2613703036"],"related_works":["https://openalex.org/W2492805588","https://openalex.org/W6888389964","https://openalex.org/W4313558188","https://openalex.org/W4225865855","https://openalex.org/W4394909225","https://openalex.org/W2042617317","https://openalex.org/W2972289605","https://openalex.org/W2136085069","https://openalex.org/W3007241099","https://openalex.org/W7101091195"],"abstract_inverted_index":{"Related":[0],"species":[1,67,262],"are":[2,44,105],"often":[3],"used":[4],"to":[5,22,39,107,136,249,290],"understand":[6],"the":[7,37,41,54,75,83,89,122,134,171,183,205,231,254,275,304,316,341],"molecular":[8],"underpinning":[9],"of":[10,14,18,26,50,57,77,80,88,92,97,121,130,170,174,179,182,204,211,220,235,278,281,306,322,340],"virulence":[11],"through":[12,86,168,253,320],"examination":[13],"a":[15,23,98,145,155,163,197,218,227,261],"shared":[16],"set":[17],"biological":[19],"features":[20],"attributable":[21],"core":[24],"genome":[25,194],"orthologous":[27],"genes.":[28],"An":[29],"important":[30],"but":[31,61,195],"insufficiently":[32],"studied":[33],"issue,":[34],"however,":[35],"is":[36,154,265,300],"extent":[38],"which":[40,189],"regulatory":[42],"architectures":[43],"similarly":[45],"conserved.":[46],"A":[47],"small":[48],"number":[49],"studies":[51],"have":[52,63,108],"compared":[53,64],"primary":[55,90,172],"transcriptomes":[56],"different":[58],"bacterial":[59],"species,":[60,114],"few":[62],"closely":[65,99],"related":[66,100],"with":[68,95,115,177],"clearly":[69],"divergent":[70],"evolutionary":[71,165],"histories.":[72],"We":[73,158,238,258],"addressed":[74],"impact":[76],"differing":[78],"modes":[79],"evolution":[81],"within":[82],"genus":[84],"Mycobacterium":[85],"comparison":[87,169,203,321],"transcriptome":[91,173,269,296],"M.":[93,102,116,123,139,175,184,212,215,287,291,323,326,345],"marinum":[94,213],"that":[96,178,260,295,310,330],"lineage,":[101],"bovis.":[103],"Both":[104],"thought":[106],"evolved":[109],"from":[110],"an":[111,150,191,279],"ancestral":[112],"generalist":[113],"bovis":[117,176,216,288,324],"and":[118,153,214,226,244,270,309,325],"other":[119],"members":[120],"tuberculosis":[124,185,346],"complex":[125,186,347],"having":[126],"subsequently":[127],"undergone":[128],"downsizing":[129],"their":[131,311],"genomes":[132],"during":[133],"transition":[135],"obligate":[137],"pathogenicity.":[138],"marinum,":[140],"in":[141,230,267,286,298],"contrast,":[142],"has":[143],"retained":[144],"large":[146],"genome,":[147],"appropriate":[148],"for":[149],"environmental":[151],"organism,":[152],"broad-host-range":[156],"pathogen.":[157],"also":[159],"examined":[160],"changes":[161],"over":[162],"shorter":[164],"time":[166],"period":[167],"another":[180],"member":[181],"(M.":[187],"tuberculosis)":[188],"possesses":[190],"almost":[192],"identical":[193],"maintains":[196],"distinct":[198],"host":[199],"preference.":[200],"Importance:":[201],"Our":[202],"transcriptional":[206,242,255,342],"start":[207],"site":[208],"(TSS)":[209],"maps":[210],"uncovers":[217],"pillar":[219],"conserved":[221,241],"promoters,":[222],"noncoding":[223],"RNA":[224],"(NCRNA),":[225],"genome-wide":[228],"signal":[229],"-35":[232],"promoter":[233,284,335],"regions":[234],"both":[236],"species.":[237],"identify":[239],"evolutionarily":[240],"attenuation":[243],"highlight":[245],"its":[246,268],"potential":[247],"contribution":[248],"multidrug":[250],"resistance":[251],"mediated":[252],"regulator":[256],"whiB7.":[257],"show":[259],"population":[263],"history":[264],"reflected":[266],"posit":[271],"relaxed":[272],"selection":[273],"as":[274],"main":[276],"driver":[277],"abundance":[280],"canonical":[282],"-10":[283],"sites":[285,308],"relative":[289],"marinum.":[292],"It":[293],"appears":[294],"composition":[297],"mycobacteria":[299],"driven":[301],"primarily":[302],"by":[303],"availability":[305],"such":[307],"frequencies":[312],"diverge":[313],"significantly":[314],"across":[315],"mycobacterial":[317],"clade.":[318],"Finally,":[319],"tuberculosis,":[327],"we":[328],"illustrate":[329],"single":[331],"nucleotide":[332],"polymorphism":[333],"(SNP)-driven":[334],"differences":[336,343],"likely":[337],"underpin":[338],"many":[339],"between":[344],"lineages.":[348]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
