{"id":"https://openalex.org/W2103666099","doi":"https://doi.org/10.2174/156720211798120972","title":"Nrf2 and NF-\u03baB Modulation by Sulforaphane Counteracts Multiple Manifestations of Diabetic Neuropathy in Rats and High Glucose-Induced Changes","display_name":"Nrf2 and NF-\u03baB Modulation by Sulforaphane Counteracts Multiple Manifestations of Diabetic Neuropathy in Rats and High Glucose-Induced Changes","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2103666099","doi":"https://doi.org/10.2174/156720211798120972","mag":"2103666099","pmid":"https://pubmed.ncbi.nlm.nih.gov/22023613"},"language":"en","primary_location":{"id":"doi:10.2174/156720211798120972","doi":"https://doi.org/10.2174/156720211798120972","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156720211798120972","pdf_url":null,"source":{"id":"https://openalex.org/S6525137","display_name":"Current Neurovascular Research","issn_l":"1567-2026","issn":["1567-2026","1875-5739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Neurovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028449855","display_name":"Geeta Negi","orcid":"https://orcid.org/0009-0008-3724-7572","observed_orcids":["https://orcid.org/0009-0008-3724-7572"]},"institutions":[{"id":"https://openalex.org/I4210146715","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/040dgqr26","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210146715"]},{"id":"https://openalex.org/I4210152674","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/0418yqg16","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210152674"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Geeta Negi","raw_affiliation_strings":["Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sec-67, S.A.S.Nagar, Mohali, Punjab-160062, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sec-67, S.A.S.Nagar, Mohali, Punjab-160062, India","institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ashutosh Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashutosh Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039538410","display_name":"Shyam Sunder Sharma","orcid":"https://orcid.org/0000-0002-4221-4870","observed_orcids":["https://orcid.org/0000-0002-4221-4870"]},"institutions":[{"id":"https://openalex.org/I4210146715","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/040dgqr26","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210146715"]},{"id":"https://openalex.org/I4210152674","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/0418yqg16","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210152674"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Shyam S. Sharma","raw_affiliation_strings":["Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Sec-67, S.A.S.Nagar, Mohali, Punjab-160062, India.,India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Sec-67, S.A.S.Nagar, Mohali, Punjab-160062, India.,India","institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039538410"],"corresponding_institution_ids":["https://openalex.org/I4210146715","https://openalex.org/I4210152674"],"apc_list":null,"apc_paid":null,"fwci":2.4609,"has_fulltext":false,"cited_by_count":186,"citation_normalized_percentile":{"value":0.90257525,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"8","issue":"4","first_page":"294","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.4018999934196472,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulforaphane","display_name":"sulforaphane","score":0.9620000123977661},{"id":"https://openalex.org/keywords/diabetic-neuropathy","display_name":"diabetic neuropathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9769999980926514},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.7590000033378601},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8149999976158142},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9909999966621399},{"id":"https://openalex.org/keywords/motor-nerve-conduction-velocity","display_name":"motor nerve conduction velocity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/nerve-blood-flow","display_name":"nerve blood flow","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pain-behavior","display_name":"pain behavior","score":0.7059999704360962},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9010000228881836},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/neuro-2a-cells","display_name":"N2a cells","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C2780841255","wikidata":"https://www.wikidata.org/wiki/Q424489","display_name":"Sulforaphane","level":2,"score":0.9430724382400513},{"id":"https://openalex.org/C2779178840","wikidata":"https://www.wikidata.org/wiki/Q2046550","display_name":"Diabetic neuropathy","level":3,"score":0.7407637238502502},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5778634548187256},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5109080672264099},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5074071288108826},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5070428848266602},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4910428524017334},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.49066030979156494},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.4743046760559082},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.45647627115249634},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.44631797075271606},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4298897683620453},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.41583192348480225},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40350809693336487},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3739436864852905},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.34004417061805725},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3148840069770813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25221025943756104},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.24167495965957642}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D013454","descriptor_name":"Sulfoxides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013861","descriptor_name":"Thiocyanates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017879","descriptor_name":"Isothiocyanates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/156720211798120972","doi":"https://doi.org/10.2174/156720211798120972","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156720211798120972","pdf_url":null,"source":{"id":"https://openalex.org/S6525137","display_name":"Current Neurovascular Research","issn_l":"1567-2026","issn":["1567-2026","1875-5739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Neurovascular Research","raw_type":"journal-article"},{"id":"pmid:22023613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22023613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current neurovascular research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1516709032","https://openalex.org/W1761055895","https://openalex.org/W1761076309","https://openalex.org/W1971214222","https://openalex.org/W1972532680","https://openalex.org/W1974494901","https://openalex.org/W1981034583","https://openalex.org/W1982776595","https://openalex.org/W1983310681","https://openalex.org/W1983464571","https://openalex.org/W1987857240","https://openalex.org/W1991201692","https://openalex.org/W1991491499","https://openalex.org/W1991631628","https://openalex.org/W1996521867","https://openalex.org/W2009309902","https://openalex.org/W2021869209","https://openalex.org/W2022582116","https://openalex.org/W2040114786","https://openalex.org/W2058244337","https://openalex.org/W2059378857","https://openalex.org/W2059944694","https://openalex.org/W2061793908","https://openalex.org/W2063274987","https://openalex.org/W2070045152","https://openalex.org/W2077473701","https://openalex.org/W2083387782","https://openalex.org/W2087798692","https://openalex.org/W2088888375","https://openalex.org/W2096000363","https://openalex.org/W2106877484","https://openalex.org/W2109855059","https://openalex.org/W2137836635","https://openalex.org/W2137847782","https://openalex.org/W2140708403","https://openalex.org/W2153059926","https://openalex.org/W2155723421","https://openalex.org/W2160271650","https://openalex.org/W2166888255","https://openalex.org/W2171480976","https://openalex.org/W2316580498","https://openalex.org/W4234012592"],"related_works":["https://openalex.org/W3173780015","https://openalex.org/W2801864485","https://openalex.org/W2603565334","https://openalex.org/W2148472261","https://openalex.org/W2005273684","https://openalex.org/W2768334846","https://openalex.org/W2107907169","https://openalex.org/W2907393697","https://openalex.org/W1761076309","https://openalex.org/W2085262548"],"abstract_inverted_index":{"High":[0],"glucose":[1,76],"driven":[2],"reactive":[3],"oxygen":[4],"intermediates":[5],"production":[6],"and":[7,16,38,74,85,107,112,141,146,154,181,195,199,204,244],"inflammatory":[8,256],"damage":[9,18,257],"are":[10],"recognized":[11],"contributors":[12],"of":[13,34,47,70,122,139,157,172,189,235,241,255],"nerve":[14,99,103,156],"dysfunction":[15],"subsequent":[17],"in":[19,49,55,58,67,80,151,178,209,220,225,237,258],"diabetic":[20,31,53,158,227,259],"neuropathy.":[21,228,260],"Sulforaphane,":[22],"a":[23,28],"known":[24],"chemotherapeutic":[25],"agent":[26],"holds":[27],"promise":[29],"for":[30,95,169],"neuropathy":[32,54],"because":[33],"its":[35],"dual":[36],"antioxidant":[37],"anti-inflammatory":[39],"activities.":[40],"The":[41],"present":[42],"study":[43,211,230],"investigated":[44],"the":[45,68,222,232,248],"effect":[46,121],"sulforaphane":[48,66,83,123,173,217],"streptozotocin":[50],"(STZ)":[51],"induced":[52],"rats.":[56],"For":[57,79],"vitro":[59],"experiments":[60],"neuro2a":[61,152],"cells":[62,153],"were":[63,110],"incubated":[64],"with":[65,187],"presence":[69],"normal":[71],"(5.5":[72],"mM)":[73],"high":[75],"(30":[77],"mM).":[78],"vivo":[81],"studies,":[82],"(0.5":[84],"1":[86,149],"mg/kg)":[87],"was":[88,116,176],"administered":[89],"six":[90],"weeks":[91],"post":[92],"diabetes":[93],"induction":[94],"two":[96],"weeks.":[97],"Motor":[98],"conduction":[100],"velocity":[101],"(MNCV),":[102],"blood":[104],"flow":[105],"(NBF)":[106],"pain":[108],"behavior":[109],"improved":[111],"malondialdehyde":[113],"(MDA)":[114],"level":[115],"reduced":[117],"by":[118,136],"sulforaphane.":[119],"Antioxidant":[120],"is":[124,218,251],"derived":[125],"from":[126],"nuclear":[127],"erythroid":[128],"2-related":[129],"factor":[130],"2":[131],"(Nrf2)":[132],"activation":[133],"as":[134,174],"demonstrated":[135],"increased":[137],"expression":[138,180,198],"Nrf2":[140,236],"downstream":[142],"targets":[143],"hemeoxygenase-1":[144],"(HO-1)":[145],"NAD(P)H:quinone":[147],"oxidoreductase":[148],"(NQO-1)":[150],"sciatic":[155],"animals.":[159],"Nuclear":[160],"factor-kappa":[161],"B":[162],"(NF-\u03baB)":[163],"inhibition":[164],"seemed":[165],"to":[166],"be":[167],"responsible":[168],"antiinflammatory":[170],"activity":[171],"there":[175],"reduction":[177],"NF-\u03baB":[179,249],"I\u03baB":[182],"kinase":[183],"(IKK)":[184],"phosphorylation":[185],"along":[186],"abrogation":[188],"inducible":[190],"nitric":[191],"oxide":[192],"synthase":[193],"(iNOS)":[194],"cyclooxygenase-2":[196],"(COX-2)":[197],"tumor":[200],"necrosis":[201],"factor-\u03b1":[202],"(TNF-\u03b1)":[203],"interleukine-6":[205],"(IL-6)":[206],"levels.":[207],"Here":[208],"this":[210],"we":[212],"provide":[213],"an":[214,252],"evidence":[215],"that":[216,247],"effective":[219],"reversing":[221],"various":[223],"deficits":[224],"experimental":[226],"This":[229],"supports":[231],"defensive":[233],"role":[234],"neurons":[238],"under":[239],"conditions":[240],"oxidative":[242],"stress":[243],"also":[245],"suggests":[246],"pathway":[250],"important":[253],"modulator":[254]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}