{"id":"https://openalex.org/W2103663236","doi":"https://doi.org/10.1016/j.mrfmmm.2006.08.011","title":"Deficiency of cell cycle checkpoints and DNA repair system predispose individuals to esophageal cancer","display_name":"Deficiency of cell cycle checkpoints and DNA repair system predispose individuals to esophageal cancer","publication_year":2006,"publication_date":"2006-10-03","ids":{"openalex":"https://openalex.org/W2103663236","doi":"https://doi.org/10.1016/j.mrfmmm.2006.08.011","mag":"2103663236","pmid":"https://pubmed.ncbi.nlm.nih.gov/17011594"},"language":"en","primary_location":{"id":"doi:10.1016/j.mrfmmm.2006.08.011","doi":"https://doi.org/10.1016/j.mrfmmm.2006.08.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mrfmmm.2006.08.011","pdf_url":null,"source":{"id":"https://openalex.org/S4394735698","display_name":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","issn_l":"0027-5107","issn":["0027-5107","1386-1964","1873-135X","1879-2871"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071790804","display_name":"Lina Shao","orcid":"https://orcid.org/0000-0002-6650-1698","observed_orcids":["https://orcid.org/0000-0002-6650-1698"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lina Shao","raw_affiliation_strings":["Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073876235","display_name":"Walter N. Hittelman","orcid":"https://orcid.org/0000-0002-0048-6640","observed_orcids":["https://orcid.org/0000-0002-0048-6640"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter N. Hittelman","raw_affiliation_strings":["Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, United States","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX, United States","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100684204","display_name":"Jie Ming Lin","orcid":"https://orcid.org/0000-0002-0150-0264","observed_orcids":["https://orcid.org/0000-0002-0150-0264"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Lin","raw_affiliation_strings":["Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, United States","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, United States","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088600970","display_name":"Hushan Yang","orcid":"https://orcid.org/0000-0001-9920-1731","observed_orcids":["https://orcid.org/0000-0001-9920-1731"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hushan Yang","raw_affiliation_strings":["Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, United States","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, United States","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044064524","display_name":"Jaffer A. Ajani","orcid":"https://orcid.org/0000-0001-9946-0629","observed_orcids":["https://orcid.org/0000-0001-9946-0629"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaffer A. Ajani","raw_affiliation_strings":["Department of GI Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States","GI Medical Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of GI Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"GI Medical Oncology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066957198","display_name":"Xifeng Wu","orcid":"https://orcid.org/0000-0001-5174-3769","observed_orcids":["https://orcid.org/0000-0001-5174-3769"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xifeng Wu","raw_affiliation_strings":["Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, United States","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066957198"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":3380,"currency":"USD","value_usd":3380},"apc_paid":null,"fwci":2.034,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.86959085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"602","issue":"1-2","first_page":"143","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.5253999829292297,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.5253999829292297,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.3917999863624573,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.05770000070333481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-cycle-checkpoints","display_name":"cell cycle checkpoints","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dna-repair-capacity","display_name":"DNA repair capacity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/s-phase-accumulation","display_name":"S phase accumulation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/benzo-a-pyrene-diol-epoxide","display_name":"benzo[a]pyrene diol epoxide","score":0.875},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.5659999847412109},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.7119426131248474},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6266988515853882},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5576632022857666},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5190837383270264},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.49021369218826294},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.48564115166664124},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4832816421985626},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4384348392486572},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43398311734199524},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4195308983325958},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3831655979156494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36809688806533813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3538798689842224},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3501570522785187},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3366253077983856},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.26996833086013794},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21502381563186646}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004852","descriptor_name":"Epoxy Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.mrfmmm.2006.08.011","doi":"https://doi.org/10.1016/j.mrfmmm.2006.08.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mrfmmm.2006.08.011","pdf_url":null,"source":{"id":"https://openalex.org/S4394735698","display_name":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","issn_l":"0027-5107","issn":["0027-5107","1386-1964","1873-135X","1879-2871"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","raw_type":"journal-article"},{"id":"pmid:17011594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17011594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2083640551","display_name":"Genetic Instability & Risk for Esophageal Carcinoma","funder_award_id":"R01CA111922","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3073125414","display_name":null,"funder_award_id":"CA 74880","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3785994788","display_name":"Molecular pathways linking obesity and RCC tumorigenesis (PQ1)","funder_award_id":"R01CA170298","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4693112801","display_name":null,"funder_award_id":"CA 91846","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5380964245","display_name":"SPORE in Genitourinary Cancer","funder_award_id":"P50CA091846","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7432495902","display_name":"Markers of Genetic Susceptibility to Bladder Cancer","funder_award_id":"R01CA074880","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W72623049","https://openalex.org/W1481863965","https://openalex.org/W1482506238","https://openalex.org/W1486933127","https://openalex.org/W1515564094","https://openalex.org/W1555498177","https://openalex.org/W1965239527","https://openalex.org/W1974838229","https://openalex.org/W1986384076","https://openalex.org/W2000565392","https://openalex.org/W2004008931","https://openalex.org/W2040143851","https://openalex.org/W2041444090","https://openalex.org/W2050631951","https://openalex.org/W2059971436","https://openalex.org/W2064458964","https://openalex.org/W2065022250","https://openalex.org/W2069358051","https://openalex.org/W2093021189","https://openalex.org/W2093400437","https://openalex.org/W2096136751","https://openalex.org/W2105369456","https://openalex.org/W2110905028","https://openalex.org/W2129695021","https://openalex.org/W2137948519","https://openalex.org/W2161886708","https://openalex.org/W2164096643","https://openalex.org/W2169664220","https://openalex.org/W2169830490","https://openalex.org/W2170010518","https://openalex.org/W2414626044","https://openalex.org/W4252560545","https://openalex.org/W4255683556","https://openalex.org/W6628873300","https://openalex.org/W6633180785"],"related_works":["https://openalex.org/W2162125799","https://openalex.org/W2314706796","https://openalex.org/W3185647201","https://openalex.org/W7208006446","https://openalex.org/W1986384076","https://openalex.org/W2162669570","https://openalex.org/W2051774501","https://openalex.org/W1621490299","https://openalex.org/W2296036711","https://openalex.org/W2086106389"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}