{"id":"https://openalex.org/W2103611295","doi":null,"title":"Cetylated fatty acids improve knee function in patients with osteoarthritis.","display_name":"Cetylated fatty acids improve knee function in patients with osteoarthritis.","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W2103611295","mag":"2103611295","pmid":"https://pubmed.ncbi.nlm.nih.gov/12180734"},"language":"en","primary_location":{"id":"pmid:12180734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12180734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113482783","display_name":"Robert L. Hesslink","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Hesslink","raw_affiliation_strings":["Hesslink Ventures, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hesslink Ventures, San Diego, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079872798","display_name":"David W. Armstrong","orcid":"https://orcid.org/0000-0001-7939-8100","observed_orcids":["https://orcid.org/0000-0001-7939-8100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Armstrong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108093266","display_name":"M V Nagendran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M V Nagendran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065889932","display_name":"Srinand Sreevatsan","orcid":"https://orcid.org/0000-0002-5162-2403","observed_orcids":["https://orcid.org/0000-0002-5162-2403"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srinan Sreevatsan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029158444","display_name":"Raj R. Barathur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raj Barathur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3217,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.79317062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"8","first_page":"1708","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/knee-range-of-motion","display_name":"knee range of motion","score":0.984000027179718},{"id":"https://openalex.org/keywords/knee-flexion","display_name":"knee flexion","score":0.9679999947547913},{"id":"https://openalex.org/keywords/knee-function","display_name":"knee function","score":0.8059999942779541},{"id":"https://openalex.org/keywords/lequesne-algofunctional-index","display_name":"Lequesne algofunctional index","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9501739740371704},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8451192378997803},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8153589963912964},{"id":"https://openalex.org/C60465272","wikidata":"https://www.wikidata.org/wiki/Q494478","display_name":"Range of motion","level":2,"score":0.715830385684967},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.5945179462432861},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4895216226577759},{"id":"https://openalex.org/C2908736133","wikidata":"https://www.wikidata.org/wiki/Q37425","display_name":"Knee Joint","level":2,"score":0.46877235174179077},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.34678971767425537},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3394954204559326},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05473712086677551},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006304","descriptor_name":"Health Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014885","descriptor_name":"Waxes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016059","descriptor_name":"Range of Motion, Articular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016059","descriptor_name":"Range of Motion, Articular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12180734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12180734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Clinical Trial"},{"id":"mag:2103611295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12180734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W4583921","https://openalex.org/W35206376","https://openalex.org/W375164547","https://openalex.org/W1821469868","https://openalex.org/W1928883490","https://openalex.org/W1964874409","https://openalex.org/W1965034704","https://openalex.org/W1966730475","https://openalex.org/W1980828524","https://openalex.org/W1987657041","https://openalex.org/W1991114001","https://openalex.org/W2018599016","https://openalex.org/W2023265227","https://openalex.org/W2039277520","https://openalex.org/W2040833772","https://openalex.org/W2047655389","https://openalex.org/W2057156659","https://openalex.org/W2057574048","https://openalex.org/W2061288807","https://openalex.org/W2063856128","https://openalex.org/W2068864388","https://openalex.org/W2074458829","https://openalex.org/W2085182901","https://openalex.org/W2087304709","https://openalex.org/W2089695535","https://openalex.org/W2089965961","https://openalex.org/W2112066469","https://openalex.org/W2123670288","https://openalex.org/W2126449177","https://openalex.org/W2133949731","https://openalex.org/W2134977749","https://openalex.org/W2142328693","https://openalex.org/W2153862724","https://openalex.org/W2166202725","https://openalex.org/W2188846236","https://openalex.org/W2257293420","https://openalex.org/W2320758398","https://openalex.org/W2419269154","https://openalex.org/W2461273343","https://openalex.org/W2983297087","https://openalex.org/W4243199887"],"related_works":["https://openalex.org/W7095658192","https://openalex.org/W4412823196","https://openalex.org/W4413573820","https://openalex.org/W2165700041","https://openalex.org/W4391894236","https://openalex.org/W2024928866","https://openalex.org/W2904540302","https://openalex.org/W2068233382","https://openalex.org/W7157246734","https://openalex.org/W4250006272"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"the":[3,65,106,119,133,159,167,174],"benefit":[4],"of":[5,13,60,149,158,169,176],"cetylated":[6],"fatty":[7],"acids":[8],"(CFA)":[9],"on":[10],"knee":[11,27,58,85,101,147],"range":[12,59,148],"motion":[14,61,150],"and":[15,33,36,64,151],"function":[16,153],"in":[17,84,100,132,146,154],"patients":[18,24,74,91,155],"with":[19,25,62,76,156],"osteoarthritis":[20],"(OA).":[21],"METHODS:":[22],"Sixty-four":[23],"chronic":[26],"OA":[28,157],"were":[29],"evaluated":[30],"at":[31,34],"baseline":[32],"30":[35],"68":[37,72,125],"days":[38,126],"after":[39,124],"consuming":[40],"either":[41],"placebo":[42,93,134],"(vegetable":[43],"oil;":[44],"n":[45,51],"=":[46,52],"31)":[47],"or":[48],"CFA":[49,77,120,142,161],"(Celadrin;":[50],"33).":[53],"Evaluations":[54],"included":[55],"physician":[56],"assessment,":[57],"goniometry,":[63],"Lequesne":[66],"Algofunctional":[67],"Index":[68],"(LAI).":[69],"RESULTS:":[70],"After":[71],"days,":[73],"treated":[75],"exhibited":[78],"significant":[79,110],"(p":[80,111],"<":[81,112],"0.001)":[82,113],"increase":[83],"flexion":[86],"(10.1":[87],"degrees)":[88],"compared":[89,127],"to":[90,105,128,140,166],"given":[92],"(1.1":[94],"degrees).":[95],"Neither":[96],"group":[97,121,135],"reported":[98],"improvement":[99,117,131,145],"extension.":[102],"Patient":[103],"responses":[104],"LAI":[107],"indicated":[108],"a":[109,129],"shift":[114],"towards":[115],"functional":[116],"for":[118,173],"(-5.4":[122],"points)":[123],"modest":[130],"(-2.1":[136],"points).":[137],"CONCLUSION:":[138],"Compared":[139],"placebo,":[141],"provides":[143],"an":[144,164],"overall":[152],"knee.":[160],"may":[162],"be":[163],"alternative":[165],"use":[168],"nonsteroidal":[170],"antiinflammatory":[171],"drugs":[172],"treatment":[175],"OA.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}