{"id":"https://openalex.org/W2103597781","doi":"https://doi.org/10.1242/dev.120.6.1549","title":"Expression of a mouse Zfy-1/lacZ transgene in the somatic cells of the embryonic gonad and germ cells of the adult testis","display_name":"Expression of a mouse Zfy-1/lacZ transgene in the somatic cells of the embryonic gonad and germ cells of the adult testis","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W2103597781","doi":"https://doi.org/10.1242/dev.120.6.1549","mag":"2103597781","pmid":"https://pubmed.ncbi.nlm.nih.gov/8050362"},"language":"en","primary_location":{"id":"doi:10.1242/dev.120.6.1549","doi":"https://doi.org/10.1242/dev.120.6.1549","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.120.6.1549","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041036914","display_name":"Brian Zambrowicz","orcid":"https://orcid.org/0000-0001-8831-0406","observed_orcids":["https://orcid.org/0000-0001-8831-0406"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian P. Zambrowicz","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Biochemistry, University of Washington SL-15 1 , Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Biochemistry, University of Washington SL-15 1 , Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James W. Zimmermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James W. Zimmermann","raw_affiliation_strings":["School of Veterinary Medicine, University of Pennsylvania 2 Laboratory of Reproductive Physiology , , Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, University of Pennsylvania 2 Laboratory of Reproductive Physiology , , Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030051691","display_name":"Christopher J. Harendza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Harendza","raw_affiliation_strings":["School of Veterinary Medicine, University of Pennsylvania 2 Laboratory of Reproductive Physiology , , Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, University of Pennsylvania 2 Laboratory of Reproductive Physiology , , Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065488747","display_name":"Elizabeth M. Simpson","orcid":"https://orcid.org/0000-0002-0654-4303","observed_orcids":["https://orcid.org/0000-0002-0654-4303"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth M. Simpson","raw_affiliation_strings":["Howard Hughes Research Laboratories at Whitehead Institute 3 , and Department of Biology , , 9 Cambridge Center, Cambridge MA 02142, USA","Massachusetts Institute of Technology 3 , and Department of Biology , , 9 Cambridge Center, Cambridge MA 02142, USA","Jackson Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Research Laboratories at Whitehead Institute 3 , and Department of Biology , , 9 Cambridge Center, Cambridge MA 02142, USA","institution_ids":[]},{"raw_affiliation_string":"Massachusetts Institute of Technology 3 , and Department of Biology , , 9 Cambridge Center, Cambridge MA 02142, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069145017","display_name":"David C. Page","orcid":"https://orcid.org/0000-0001-9920-3411","observed_orcids":["https://orcid.org/0000-0001-9920-3411","https://orcid.org/0000-0001-5489-6453"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C. Page","raw_affiliation_strings":["Howard Hughes Research Laboratories at Whitehead Institute 3 , and Department of Biology , , 9 Cambridge Center, Cambridge MA 02142, USA","Massachusetts Institute of Technology 3 , and Department of Biology , , 9 Cambridge Center, Cambridge MA 02142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Research Laboratories at Whitehead Institute 3 , and Department of Biology , , 9 Cambridge Center, Cambridge MA 02142, USA","institution_ids":[]},{"raw_affiliation_string":"Massachusetts Institute of Technology 3 , and Department of Biology , , 9 Cambridge Center, Cambridge MA 02142, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089013559","display_name":"Ralph L. Brinster","orcid":"https://orcid.org/0000-0003-1408-7656","observed_orcids":["https://orcid.org/0000-0003-1408-7656"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph L. Brinster","raw_affiliation_strings":["School of Veterinary Medicine, University of Pennsylvania 2 Laboratory of Reproductive Physiology , , Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, University of Pennsylvania 2 Laboratory of Reproductive Physiology , , Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055765486","display_name":"Richard D. Palmiter","orcid":"https://orcid.org/0000-0001-6587-0582","observed_orcids":["https://orcid.org/0000-0001-6587-0582"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard D. Palmiter","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Biochemistry, University of Washington SL-15 1 , Seattle, WA 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Biochemistry, University of Washington SL-15 1 , Seattle, WA 98195, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5055765486"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":2.9484,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.91624097,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"120","issue":"6","first_page":"1549","last_page":"1559"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/y-chromosome","display_name":"Y chromosome","score":0.7889999747276306},{"id":"https://openalex.org/keywords/zinc-finger-proteins","display_name":"zinc finger proteins","score":0.8980000019073486},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.5040000081062317},{"id":"https://openalex.org/keywords/lacz-reporter","display_name":"lacZ reporter","score":0.8539999723434448},{"id":"https://openalex.org/keywords/embryonic-gonads","display_name":"embryonic gonads","score":0.800000011920929},{"id":"https://openalex.org/keywords/germ-cells","display_name":"germ cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/genital-ridge","display_name":"genital ridge","score":0.9290000200271606},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5059999823570251},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.5379999876022339},{"id":"https://openalex.org/keywords/promoter","display_name":"promoter","score":0.5799999833106995},{"id":"https://openalex.org/keywords/sex-determination","display_name":"sex determination","score":0.6129999756813049},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9198129177093506},{"id":"https://openalex.org/C148102462","wikidata":"https://www.wikidata.org/wiki/Q1257300","display_name":"Gonadal ridge","level":4,"score":0.6952635049819946},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6524170637130737},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.568640410900116},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5291246175765991},{"id":"https://openalex.org/C2781471917","wikidata":"https://www.wikidata.org/wiki/Q213456","display_name":"Gonad","level":2,"score":0.47969791293144226},{"id":"https://openalex.org/C2779122487","wikidata":"https://www.wikidata.org/wiki/Q281579","display_name":"Germ cell","level":3,"score":0.47693389654159546},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.46963903307914734},{"id":"https://openalex.org/C2780246931","wikidata":"https://www.wikidata.org/wiki/Q202771","display_name":"Y chromosome","level":3,"score":0.4638891816139221},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4002666771411896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3518717885017395},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09893161058425903}],"mesh":[{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007763","descriptor_name":"Lac Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014998","descriptor_name":"Y Chromosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016335","descriptor_name":"Zinc Fingers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/dev.120.6.1549","doi":"https://doi.org/10.1242/dev.120.6.1549","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.120.6.1549","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:8050362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8050362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1540295841","display_name":null,"funder_award_id":"HD-22532","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G1598826313","display_name":null,"funder_award_id":"HD-23657","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2760558347","display_name":null,"funder_award_id":"HD 09172","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5379528310","display_name":"MALE GERM CELL DEVELOPMENT IN TRANSGENIC MICE","funder_award_id":"5r37hd023657-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6148140828","display_name":"GENETIC STUDIES OF GONADAL SEX DETERMINATION IN MAMMALS","funder_award_id":"5r01hd022532-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1531234455","https://openalex.org/W1667112181","https://openalex.org/W1934915777","https://openalex.org/W1968458490","https://openalex.org/W1970650510","https://openalex.org/W1976398150","https://openalex.org/W2001607246","https://openalex.org/W2007969716","https://openalex.org/W2013246689","https://openalex.org/W2014908391","https://openalex.org/W2018697286","https://openalex.org/W2025196751","https://openalex.org/W2041424739","https://openalex.org/W2060389225","https://openalex.org/W2063808566","https://openalex.org/W2068285267","https://openalex.org/W2071709406","https://openalex.org/W2079935561","https://openalex.org/W2080891422","https://openalex.org/W2081087045","https://openalex.org/W2081330088","https://openalex.org/W2083110824","https://openalex.org/W2085512588","https://openalex.org/W2095317307","https://openalex.org/W2121165949","https://openalex.org/W2129067581","https://openalex.org/W2129411155","https://openalex.org/W2132291850","https://openalex.org/W2139315148","https://openalex.org/W2159345508","https://openalex.org/W2172068275","https://openalex.org/W2182720429","https://openalex.org/W2189202827","https://openalex.org/W2314225431","https://openalex.org/W6640545109","https://openalex.org/W6683392168"],"related_works":["https://openalex.org/W2139315148","https://openalex.org/W2060389225","https://openalex.org/W2081330088","https://openalex.org/W2219488575","https://openalex.org/W2136672186","https://openalex.org/W2159345508","https://openalex.org/W1987557061","https://openalex.org/W2129067581","https://openalex.org/W4417488048","https://openalex.org/W2121887576"],"abstract_inverted_index":{"The":[0,88],"Zfy-1":[1,22,54,67,126,160,238,267],"and":[2,16,29,32,44,101,108,114,269],"Zfy-2":[3],"genes,":[4],"which":[5,172],"arose":[6],"by":[7,81,120,130,145],"gene":[8],"duplication,":[9],"map":[10],"to":[11,117,140],"the":[12,26,50,59,95,149,165,184,190,203,205,223,262,266,276,280],"mouse":[13],"Y":[14],"chromosome":[15],"encode":[17],"nearly":[18],"identical":[19],"zinc-finger":[20],"proteins.":[21],"is":[23,208,283],"expressed":[24,92,209,243],"in":[25,41,77,94,135,211,228,245,261,275],"genital":[27,96,136],"ridge":[28,97,137],"adult":[30,249,263],"testis":[31],"likely":[33],"encodes":[34],"a":[35,122],"transcription":[36],"activator.":[37],"Although":[38],"potential":[39],"roles":[40],"sex":[42],"determination":[43],"spermatogenesis":[45],"have":[46],"been":[47,156],"hotly":[48],"debated,":[49],"biological":[51],"functions":[52],"of":[53,66,73,84,98,168,183,222,237,248,279],"remain":[55],"unknown.":[56],"To":[57],"study":[58],"gene's":[60],"regulation,":[61],"transgenes":[62],"with":[63,233],"21-28":[64],"kb":[65,236],"5'":[68,239],"flanking":[69,240],"DNA":[70,86,241],"placed":[71],"upstream":[72],"lacZ":[74,133],"were":[75],"constructed":[76],"plasmids":[78],"or":[79],"created":[80],"homologous":[82],"recombination":[83],"coinjected":[85],"molecules.":[87],"resulting":[89],"transgenic":[90],"mice":[91],"beta-galactosidase":[93],"both":[99],"males":[100],"females":[102],"starting":[103],"between":[104],"embryonic":[105,166,281],"day":[106],"10":[107],"11":[109],"(E10-E11),":[110],"peaking":[111],"at":[112],"E12-E13":[113],"then":[115],"declining":[116],"low":[118],"levels":[119],"E15,":[121],"pattern":[123],"that":[124,159,194,254,270],"matches":[125],"mRNA":[127,161],"as":[128,143],"detected":[129],"RT-PCR.":[131],"This":[132],"expression":[134,182,221,260,274],"was":[138,162,225,242],"confined":[139],"somatic":[141,277],"cells":[142,196,247,278],"demonstrated":[144],"its":[146],"absence":[147],"from":[148,164],"alkaline":[150],"phosphatase-positive":[151],"germ":[152,175,195,213,246,258],"cells.":[153,176,214],"It":[154],"had":[155],"reported":[157],"previously":[158],"absent":[163],"gonad":[167,282],"homozygous":[169],"W(e)":[170,191],"embryos,":[171],"virtually":[173],"lack":[174],"By":[177],"contrast,":[178],"we":[179],"observed":[180,227],"normal":[181],"Zfy-1/lacZ":[185,206],"transgene":[186,207,224,232],"when":[187],"introduced":[188],"into":[189],"background,":[192],"suggesting":[193],"are":[197],"not":[198],"necessary":[199],"for":[200,257,273],"expression.":[201],"In":[202],"adult,":[204],"abundantly":[210],"developing":[212],"Extragonadal":[215],"(kidney,":[216],"meninges,":[217],"arteries,":[218],"choroid":[219],"plexus)":[220],"also":[226],"embryos.":[229],"A":[230],"smaller":[231],"only":[234,244],"4.3":[235],"mice.":[250],"These":[251],"results":[252],"suggest":[253],"an":[255,271],"enhancer":[256,272],"cell":[259],"lies":[264],"near":[265],"promoter":[268],"located":[284],"further":[285],"5'.":[286]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}