{"id":"https://openalex.org/W2103564124","doi":null,"title":"Central serotonin and dopamine transporters in overeating, obesity and insulin resistance","display_name":"Central serotonin and dopamine transporters in overeating, obesity and insulin resistance","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2103564124","mag":"2103564124"},"language":"en","primary_location":{"id":"pmh:oai:dare.uva.nl:openaire/a28b319d-834b-463a-95ac-1ed311f3d6b4","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/central-serotonin-and-dopamine-transporters-in-overeating-obesity-and-insulin-resistance(a28b319d-834b-463a-95ac-1ed311f3d6b4).html","pdf_url":"https://pure.uva.nl/ws/files/2188295/152309_Thesis_complete_1_.pdf","source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Koopman, K E M 2014, 'Central serotonin and dopamine transporters in overeating, obesity and insulin resistance', Doctor of Philosophy, Universiteit van Amsterdam.","raw_type":"info:eu-repo/semantics/other"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.uva.nl/ws/files/2188295/152309_Thesis_complete_1_.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061560220","display_name":"Karin E. Koopman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karin E. Koopman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061560220"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.984000027179718},{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.9990000128746033},{"id":"https://openalex.org/keywords/overeating","display_name":"overeating","score":0.9070000052452087},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":1.0},{"id":"https://openalex.org/keywords/feeding-behavior","display_name":"feeding behavior","score":0.8270000219345093},{"id":"https://openalex.org/keywords/high-calorie-diet","display_name":"hypercaloric diet","score":0.8519999980926514},{"id":"https://openalex.org/keywords/meal-patterns","display_name":"meal patterns","score":0.6019999980926514},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.8629999756813049},{"id":"https://openalex.org/keywords/diencephalon","display_name":"diencephalon","score":0.8230000138282776},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8999999761581421},{"id":"https://openalex.org/keywords/hepatic-insulin-sensitivity","display_name":"hepatic insulin sensitivity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/abdominal-fat-accumulation","display_name":"abdominal fat accumulation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/autonomic-nervous-system","display_name":"autonomic nervous system","score":0.9409999847412109},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8441156148910522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7928485870361328},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6296247243881226},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5556617379188538},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5457096695899963},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.5378533601760864},{"id":"https://openalex.org/C2778792376","wikidata":"https://www.wikidata.org/wiki/Q331632","display_name":"Overeating","level":3,"score":0.4939423203468323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4536258280277252},{"id":"https://openalex.org/C2781258526","wikidata":"https://www.wikidata.org/wiki/Q105923599","display_name":"Snacking","level":3,"score":0.4181009531021118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3203510046005249},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3198699355125427},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:dare.uva.nl:openaire/a28b319d-834b-463a-95ac-1ed311f3d6b4","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/central-serotonin-and-dopamine-transporters-in-overeating-obesity-and-insulin-resistance(a28b319d-834b-463a-95ac-1ed311f3d6b4).html","pdf_url":"https://pure.uva.nl/ws/files/2188295/152309_Thesis_complete_1_.pdf","source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Koopman, K E M 2014, 'Central serotonin and dopamine transporters in overeating, obesity and insulin resistance', Doctor of Philosophy, Universiteit van Amsterdam.","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/e3e36064-824c-4934-8c4e-ebdffd70882e","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/central-serotonin-and-dopamine-transporters-in-overeating-obesity-and-insulin-resistance(e3e36064-824c-4934-8c4e-ebdffd70882e).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/f0336a1a-1137-425f-887a-ae8bac50b3cf","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/f0336a1a-1137-425f-887a-ae8bac50b3cf","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Koopman, K E M 2014, 'Central serotonin and dopamine transporters in overeating, obesity and insulin resistance', University of Amsterdam, Amsterdam.","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/a28b319d-834b-463a-95ac-1ed311f3d6b4","doi":null,"is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/central-serotonin-and-dopamine-transporters-in-overeating-obesity-and-insulin-resistance(a28b319d-834b-463a-95ac-1ed311f3d6b4).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2103564124","doi":null,"is_oa":false,"landing_page_url":"https://pure.uva.nl/ws/files/2188295/152309_Thesis_complete_1_.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dare.uva.nl:openaire/a28b319d-834b-463a-95ac-1ed311f3d6b4","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/central-serotonin-and-dopamine-transporters-in-overeating-obesity-and-insulin-resistance(a28b319d-834b-463a-95ac-1ed311f3d6b4).html","pdf_url":"https://pure.uva.nl/ws/files/2188295/152309_Thesis_complete_1_.pdf","source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Koopman, K E M 2014, 'Central serotonin and dopamine transporters in overeating, obesity and insulin resistance', Doctor of Philosophy, Universiteit van Amsterdam.","raw_type":"info:eu-repo/semantics/other"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103564124.pdf","grobid_xml":"https://content.openalex.org/works/W2103564124.grobid-xml"},"referenced_works_count":108,"referenced_works":["https://openalex.org/W1484306029","https://openalex.org/W1512522692","https://openalex.org/W1515329225","https://openalex.org/W1549657738","https://openalex.org/W1709672860","https://openalex.org/W1776600295","https://openalex.org/W1849760882","https://openalex.org/W1864797938","https://openalex.org/W1967881863","https://openalex.org/W1968545401","https://openalex.org/W1970993456","https://openalex.org/W1972151139","https://openalex.org/W1972520687","https://openalex.org/W1975846239","https://openalex.org/W1979565994","https://openalex.org/W1980557031","https://openalex.org/W1983467559","https://openalex.org/W1985592156","https://openalex.org/W1988028110","https://openalex.org/W1989802774","https://openalex.org/W1991893150","https://openalex.org/W1993642953","https://openalex.org/W1998028256","https://openalex.org/W1999351864","https://openalex.org/W2000232109","https://openalex.org/W2001510740","https://openalex.org/W2001562531","https://openalex.org/W2002532911","https://openalex.org/W2003413351","https://openalex.org/W2009278051","https://openalex.org/W2016476659","https://openalex.org/W2020047056","https://openalex.org/W2020980272","https://openalex.org/W2025128166","https://openalex.org/W2031153362","https://openalex.org/W2035001090","https://openalex.org/W2036956142","https://openalex.org/W2038783185","https://openalex.org/W2039849925","https://openalex.org/W2045084840","https://openalex.org/W2045278261","https://openalex.org/W2046045427","https://openalex.org/W2051448042","https://openalex.org/W2056843772","https://openalex.org/W2057683939","https://openalex.org/W2059325999","https://openalex.org/W2059366384","https://openalex.org/W2059726811","https://openalex.org/W2060392637","https://openalex.org/W2063450581","https://openalex.org/W2064329557","https://openalex.org/W2064936475","https://openalex.org/W2067859532","https://openalex.org/W2068515505","https://openalex.org/W2069600955","https://openalex.org/W2069762648","https://openalex.org/W2074370892","https://openalex.org/W2074989227","https://openalex.org/W2079395662","https://openalex.org/W2081104414","https://openalex.org/W2081478664","https://openalex.org/W2089253166","https://openalex.org/W2092703117","https://openalex.org/W2093085769","https://openalex.org/W2099421491","https://openalex.org/W2102312935","https://openalex.org/W2103135709","https://openalex.org/W2107721366","https://openalex.org/W2109386189","https://openalex.org/W2111248735","https://openalex.org/W2111951188","https://openalex.org/W2117340355","https://openalex.org/W2122063356","https://openalex.org/W2123468633","https://openalex.org/W2124232607","https://openalex.org/W2128280806","https://openalex.org/W2130087327","https://openalex.org/W2130172549","https://openalex.org/W2130189158","https://openalex.org/W2131501155","https://openalex.org/W2132279532","https://openalex.org/W2133589238","https://openalex.org/W2137890984","https://openalex.org/W2142658017","https://openalex.org/W2144459143","https://openalex.org/W2145894102","https://openalex.org/W2146966453","https://openalex.org/W2148402277","https://openalex.org/W2151211427","https://openalex.org/W2151736176","https://openalex.org/W2156339883","https://openalex.org/W2158287537","https://openalex.org/W2160283765","https://openalex.org/W2163805252","https://openalex.org/W2164125772","https://openalex.org/W2165734788","https://openalex.org/W2167262287","https://openalex.org/W2167702009","https://openalex.org/W2168398505","https://openalex.org/W2171799186","https://openalex.org/W2237737651","https://openalex.org/W2281640328","https://openalex.org/W2315088926","https://openalex.org/W2318280180","https://openalex.org/W2345903479","https://openalex.org/W2401206973","https://openalex.org/W2431171340","https://openalex.org/W2470480565"],"related_works":["https://openalex.org/W2520858573","https://openalex.org/W2020047056","https://openalex.org/W2133605866","https://openalex.org/W2314634289","https://openalex.org/W3188052095","https://openalex.org/W2009278051","https://openalex.org/W2807408662","https://openalex.org/W1524717705","https://openalex.org/W2121889285","https://openalex.org/W7160826908"],"abstract_inverted_index":{"The":[0],"objectives":[1],"of":[2,44,55,165,187,206,228,247],"this":[3,139],"thesis":[4,140],"were":[5],"to":[6,35,39,202,224],"study":[7,81],"cerebral":[8],"serotonin":[9,98],"transporters":[10,18,101],"(SERT)":[11],"in":[12,20,22,33,70,105,126,147,153,162,171,185,192,200,241],"the":[13,41,66,106,148,163,193,203],"diencephalon":[14,194],"and":[15,29,38,49,61,64,90,99,103,110,121,124,134,145,157,169,195,210,236,244],"striatal":[16,50],"dopamine":[17,100],"(DAT)":[19],"humans":[21,128],"different":[23,87],"metabolic":[24,56,96,119],"conditions":[25],"(i.e.":[26],"lean,":[27],"obese":[28,127,167,172],"insulin":[30,62,132,175,198],"resistant":[31],"state)":[32],"relation":[34],"feeding":[36,242],"behavior":[37,156,231,243],"investigate":[40],"early":[42],"consequences":[43],"overeating":[45],"on":[46,52,65,208,232,237],"diencephalic":[47],"SERT":[48,123,144,159,191],"DAT,":[51],"a":[53,78],"number":[54],"parameters":[57],"including":[58],"fat":[59,212],"accumulation":[60],"sensitivity,":[63],"autonomic":[67],"nervous":[68,112],"system":[69,113],"lean":[71,136],"humans.":[72],"To":[73],"do":[74],"this,":[75],"we":[76,117,141,178],"performed":[77],"hypercaloric":[79,84,229],"diet":[80,91],"with":[82,86,129,174],"4":[83],"diets":[85],"meal":[88,215],"pattern":[89],"composition.":[92],"We":[93],"measured":[94,118],"several":[95],"parameters,":[97],"(SERT":[102],"DAT)":[104],"brain,":[107],"behavioral":[108],"outcomes":[109,120],"central":[111,245],"activity.":[114],"In":[115,138],"addition,":[116],"brain":[122,150,238],"DAT":[125,146],"or":[130],"without":[131],"resistance":[133],"matched":[135],"controls.":[137],"show":[142,220],"that":[143,158,181],"human":[149],"are":[151],"involved":[152,240],"food":[154],"motivated":[155],"is":[160],"reduced":[161],"hypothalamus":[164],"overweight/":[166],"subjects":[168],"particularly":[170],"women":[173],"resistance.":[176],"Moreover":[177],"provide":[179],"evidence":[180],"consuming":[182],"high-fat-high-sugar":[183],"snacks":[184],"excess":[186],"caloric":[188],"need":[189],"reduces":[190,196],"hepatic":[197],"sensitivity":[199],"addition":[201],"negative":[204],"effects":[205,222],"snacking":[207,230],"liver":[209],"abdominal":[211],"accumulation.":[213],"Increasing":[214],"size":[216],"only":[217],"did":[218],"not":[219],"these":[221],"pointing":[223],"an":[225],"independent":[226],"effect":[227],"peripheral":[233],"glucose":[234,248],"metabolism":[235],"circuitries":[239],"control":[246],"metabolism.":[249]},"counts_by_year":[],"updated_date":"2026-09-12T09:15:50.089291","created_date":"2016-06-24T00:00:00"}
