{"id":"https://openalex.org/W2103531362","doi":null,"title":"Nuclear c-Abl is a COOH-terminal repeated domain (CTD)-tyrosine (CTD)-tyrosine kinase-specific for the mammalian RNA polymerase II: possible role in transcription elongation.","display_name":"Nuclear c-Abl is a COOH-terminal repeated domain (CTD)-tyrosine (CTD)-tyrosine kinase-specific for the mammalian RNA polymerase II: possible role in transcription elongation.","publication_year":1999,"publication_date":"1999-06-01","ids":{"openalex":"https://openalex.org/W2103531362","mag":"2103531362","pmid":"https://pubmed.ncbi.nlm.nih.gov/10392900"},"language":"en","primary_location":{"id":"pmid:10392900","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10392900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"R Baskaran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Baskaran","raw_affiliation_strings":["Department of Biology, Center for Molecular Genetics, University of California, San Diego, La Jolla 92093-0322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Center for Molecular Genetics, University of California, San Diego, La Jolla 92093-0322, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078526251","display_name":"S R Escobar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S R Escobar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081169331","display_name":"Jean Y. J. Wang","orcid":"https://orcid.org/0000-0002-8217-0868","observed_orcids":["https://orcid.org/0000-0002-8217-0868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Y Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0534,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.73949474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"6","first_page":"387","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-abl-kinase","display_name":"c-Abl kinase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.9089999794960022},{"id":"https://openalex.org/keywords/transcription-elongation","display_name":"transcription elongation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/species-specificity","display_name":"species specificity","score":0.6079999804496765},{"id":"https://openalex.org/keywords/hiv-1-promoter","display_name":"HIV-1 promoter","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tat-protein","display_name":"Tat protein","score":0.796999990940094},{"id":"https://openalex.org/keywords/serine-threonine-phosphorylation","display_name":"serine/threonine phosphorylation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C125533998","wikidata":"https://www.wikidata.org/wiki/Q1024499","display_name":"CTD","level":2,"score":0.8485690951347351},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.8209601640701294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7634400129318237},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.654039204120636},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6119272112846375},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5592164397239685},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4418776333332062},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4343090057373047},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.43369054794311523},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.42952823638916016},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.42829716205596924},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3120192289352417},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.21190011501312256},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.133976012468338},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1124245822429657},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07920709252357483},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012319","descriptor_name":"RNA Polymerase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016315","descriptor_name":"Proto-Oncogene Proteins c-abl","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016315","descriptor_name":"Proto-Oncogene Proteins c-abl","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020079","descriptor_name":"Terminal Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10392900","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10392900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.484.7763","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.484.7763","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cgd.aacrjournals.org/cgi/reprint/10/6/387.pdf","raw_type":"text"},{"id":"mag:2103531362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10392900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7276880513","display_name":"Nuclear Function of the c-Abl Protooncoprotien","funder_award_id":"R37CA043054","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8912220342","display_name":"Nuclear Function of Abl in DNA Damage Response","funder_award_id":"R01CA043054","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W267927007","https://openalex.org/W1448454920","https://openalex.org/W1590827448","https://openalex.org/W1606267994","https://openalex.org/W1965376325","https://openalex.org/W1973085375","https://openalex.org/W1976220823","https://openalex.org/W1985214340","https://openalex.org/W1986427733","https://openalex.org/W1999401115","https://openalex.org/W1999450178","https://openalex.org/W2000507674","https://openalex.org/W2006467763","https://openalex.org/W2012116939","https://openalex.org/W2030180039","https://openalex.org/W2038182463","https://openalex.org/W2045766250","https://openalex.org/W2058860422","https://openalex.org/W2060527795","https://openalex.org/W2062195188","https://openalex.org/W2064510642","https://openalex.org/W2066534222","https://openalex.org/W2070758793","https://openalex.org/W2072836045","https://openalex.org/W2074395777","https://openalex.org/W2076100163","https://openalex.org/W2078036317","https://openalex.org/W2084957288","https://openalex.org/W2091250415","https://openalex.org/W2092824623","https://openalex.org/W2101865104","https://openalex.org/W2108422586","https://openalex.org/W2109384031","https://openalex.org/W2122411833","https://openalex.org/W2144206181","https://openalex.org/W2145218041","https://openalex.org/W2148330261","https://openalex.org/W2152927202","https://openalex.org/W2162245996","https://openalex.org/W2179112409","https://openalex.org/W2294290446"],"related_works":["https://openalex.org/W7099329075","https://openalex.org/W2064510642","https://openalex.org/W2101865104","https://openalex.org/W1965376325","https://openalex.org/W2146986827","https://openalex.org/W2041888986","https://openalex.org/W2093633115","https://openalex.org/W2101296785","https://openalex.org/W2081494228","https://openalex.org/W2066534222"],"abstract_inverted_index":{"The":[0,170],"c-Abl":[1,85,156,181],"tyrosine":[2,24,89,188,198],"kinase":[3,157],"has":[4,114],"been":[5,115],"shown":[6],"to":[7,48,117,160,207],"interact":[8],"with":[9,103,186],"the":[10,23,27,30,33,41,52,88,104,112,118,125,139,144,155,162,166,173,177,201],"COOH-terminal":[11,54],"repeated":[12],"domain":[13],"(CTD)":[14],"of":[15,79,91,106,111,120,146,168,172,180,190,200],"mammalian":[16,42],"RNA":[17,93,191],"polymerase":[18,94,192],"II":[19],"and":[20,96,182],"can":[21],"phosphorylate":[22],"residues":[25],"in":[26,165,211],"CTD.":[28,108],"Interestingly,":[29],"Drosophila":[31],"or":[32],"yeast":[34],"CTD":[35,55,66,83,113,149,202],"were":[36],"not":[37,59,101],"efficiently":[38],"phosphorylated":[39,73],"by":[40,51,138],"c-Abl.":[43,75],"This":[44],"species-specificity":[45],"was":[46,100,158],"found":[47,159],"be":[49,72,184,204],"determined":[50],"extreme":[53],"sequences":[56],"that":[57,197],"are":[58],"conserved":[60],"through":[61,143],"evolution.":[62],"In":[63,76,151],"vitro,":[64],"COOH-terminal-truncated":[65,107],"could":[67,183],"neither":[68],"bind":[69],"to,":[70],"nor":[71],"by,":[74],"vivo,":[77],"coexpression":[78,105],"a":[80],"full":[81],"length":[82],"prevents":[84],"from":[86,124],"inducing":[87],"phosphorylation":[90,110,189,199,210],"endogenous":[92],"II,":[95],"such":[97],"inhibitory":[98],"effect":[99],"observed":[102],"Serine/threonine":[109],"linked":[116],"regulation":[119],"transcription":[121,213],"elongation.":[122,214],"Transcription":[123],"human":[126],"immunodeficiency":[127],"virus":[128],"type":[129],"1":[130],"(HIV-1)":[131],"promoter":[132,164,175],"requires":[133],"CTD-phosphorylation,":[134],"which":[135],"is":[136],"stimulated":[137],"viral":[140],"Tat":[141],"protein":[142],"recruitment":[145],"cellular":[147],"Ser/Thr":[148],"kinases.":[150],"transient":[152],"cotransfection":[153],"experiments,":[154],"activate":[161],"HIV":[163,174],"absence":[167],"Tat.":[169],"activation":[171],"required":[176],"nuclear":[178],"localization":[179],"correlated":[185],"increased":[187],"II.":[193],"These":[194],"observations":[195],"suggest":[196],"may":[203],"functionally":[205],"equivalent":[206],"its":[208],"serine/threonine":[209],"stimulating":[212]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}