{"id":"https://openalex.org/W2103508740","doi":null,"title":"Interaction of CpG-oligodeoxynucleotides with Toll like receptor 9 induces apoptosis and modulates metaloproteinase-2 activity in human intestinal epithelium.","display_name":"Interaction of CpG-oligodeoxynucleotides with Toll like receptor 9 induces apoptosis and modulates metaloproteinase-2 activity in human intestinal epithelium.","publication_year":2007,"publication_date":"2007-09-01","ids":{"openalex":"https://openalex.org/W2103508740","mag":"2103508740","pmid":"https://pubmed.ncbi.nlm.nih.gov/17893430"},"language":"en","primary_location":{"id":"pmid:17893430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17893430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of allergy, asthma, and immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035986777","display_name":"Mohammad Reza Khorramizadeh","orcid":"https://orcid.org/0000-0003-2563-8468","observed_orcids":["https://orcid.org/0000-0003-2563-8468","https://orcid.org/0000-0002-3295-535X"]},"institutions":[{"id":"https://openalex.org/I23946033","display_name":"University of Tehran","ror":"https://ror.org/05vf56z40","country_code":"IR","type":"education","lineage":["https://openalex.org/I23946033"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Reza Khorramizadeh","raw_affiliation_strings":["Department of Pathobiology, School of Public Health, Medical Sciences, University of Tehran, Tehran, Iran. khoramza@sina.tums.ac.ir"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, School of Public Health, Medical Sciences, University of Tehran, Tehran, Iran. khoramza@sina.tums.ac.ir","institution_ids":["https://openalex.org/I23946033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004687402","display_name":"Shahnaz Hosseinzadeh","orcid":"https://orcid.org/0000-0002-2628-9864","observed_orcids":["https://orcid.org/0000-0002-2628-9864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shahnaz Hosseinzadeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087909050","display_name":"Farnaz Safavifar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farnaz Safavifar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065245337","display_name":"Farshid Saadat","orcid":"https://orcid.org/0000-0002-5457-4195","observed_orcids":["https://orcid.org/0000-0002-5457-4195"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farshid Saadat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058832759","display_name":"Nastaran Aalizadeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nastaran Aalizadeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014602432","display_name":"Reza Falak","orcid":"https://orcid.org/0000-0002-1842-2952","observed_orcids":["https://orcid.org/0000-0002-1842-2952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reza Falak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111887983","display_name":"Zohre Jadali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zohre Jadali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079456740","display_name":"Mohammad Zakaria Pezeshki","orcid":"https://orcid.org/0000-0003-1810-0467","observed_orcids":["https://orcid.org/0000-0003-1810-0467"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Pezeshki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1198,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.47973156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"6","issue":"3","first_page":"107","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cpg-oligodeoxynucleotides","display_name":"CpG oligodeoxynucleotides","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.9679999947547913},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9509999752044678},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9789999723434448},{"id":"https://openalex.org/keywords/endosomal-acidification","display_name":"endosomal acidification","score":0.7360000014305115},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.8809999823570251},{"id":"https://openalex.org/keywords/immunostimulatory-sequences","display_name":"immunostimulatory sequences","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C22801619","wikidata":"https://www.wikidata.org/wiki/Q477471","display_name":"CpG Oligodeoxynucleotide","level":5,"score":0.93584144115448},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.783930778503418},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6320034265518188},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5584050416946411},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5194587111473083},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.4914144277572632},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4860094487667084},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4795503318309784},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.46919912099838257},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45749741792678833},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4511201083660126},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.42764389514923096},{"id":"https://openalex.org/C2908999202","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"Toll-Like Receptor 9","level":5,"score":0.42364081740379333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3838476836681366},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.33863312005996704},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32799971103668213},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32630980014801025},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1515553593635559},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.08348330855369568},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.06198924779891968},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:17893430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17893430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of allergy, asthma, and immunology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.902.7426","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.902.7426","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.sid.ir/en/VEWSSID/J_pdf/94320070302.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:99dbc21679f0470ab23908e445b218e0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/99dbc21679f0470ab23908e445b218e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Allergy, Asthma and Immunology, Vol 6, Iss 3 (2007)","raw_type":"article"},{"id":"mag:2103508740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17893430","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W297439836","https://openalex.org/W1580727454","https://openalex.org/W1930598094","https://openalex.org/W1956007715","https://openalex.org/W1975632439","https://openalex.org/W1978148639","https://openalex.org/W2001062496","https://openalex.org/W2015645110","https://openalex.org/W2019382232","https://openalex.org/W2023564006","https://openalex.org/W2034188980","https://openalex.org/W2038173007","https://openalex.org/W2039190975","https://openalex.org/W2044423309","https://openalex.org/W2072368659","https://openalex.org/W2083036309","https://openalex.org/W2083089709","https://openalex.org/W2087264412","https://openalex.org/W2101330192","https://openalex.org/W2118011548","https://openalex.org/W2132078058","https://openalex.org/W2146278165","https://openalex.org/W2148704093","https://openalex.org/W2151777859","https://openalex.org/W2159021562","https://openalex.org/W2159763069","https://openalex.org/W2161625612","https://openalex.org/W2168522148","https://openalex.org/W2172078968","https://openalex.org/W2338130374"],"related_works":["https://openalex.org/W7097415267","https://openalex.org/W2085620170","https://openalex.org/W1980235553","https://openalex.org/W244531451","https://openalex.org/W2154536286","https://openalex.org/W2034188980","https://openalex.org/W2356873186","https://openalex.org/W2042437855","https://openalex.org/W2058547224","https://openalex.org/W2029401998"],"abstract_inverted_index":{"Recent":[0],"reports":[1],"have":[2],"indicated":[3,211],"different":[4],"effects":[5,35],"of":[6,20,36,134,143,154,193,202],"immunostimulatory":[7],"sequences":[8],"containing":[9],"CpG-Oligodeoxynucleotides":[10],"(ODN)":[11],"on":[12,38,47,117],"various":[13],"immune":[14],"cells.":[15,171],"However,":[16,172],"the":[17,23,29,141],"exact":[18],"role":[19],"CpG-ODN":[21,37,61,124,135,138,144,185,232],"in":[22,224,236,243],"human":[24],"gut":[25],"is":[26,218],"unclear.":[27],"In":[28],"present":[30],"study,":[31],"we":[32],"assessed":[33,181],"potential":[34],"non":[39],"lymphoid":[40],"cell":[41,44,55,215],"(intestinal":[42],"epithelial":[43,54,214],"line":[45,56,216],"HT-29)":[46],"a":[48,90],"dose-response":[49],"and":[50,64,74,86,99,125,169,198,226,233],"time-course":[51,87],"basis.":[52],"Intestinal":[53],"HT-29":[57,217,237],"was":[58,110,180],"treated":[59,145,168,186],"with":[60],"(CpG":[62],"2006)":[63],"lipopolysaccharide":[65],"(LPS)":[66],"at":[67,152,200],"5,":[68,76,203],"10,":[69,204],"25,":[70],"50":[71],"microg/":[72,78],"ml":[73,79],"1,":[75],"10":[77],"concentrations,":[80],"respectively.":[81,207],"Following":[82],"treatments,":[83],"dose-":[84],"response":[85],"cytotoxicity":[88],"using":[89],"colorimetric":[91],"method,":[92],"Metaloproteinase-2":[93],"(MMP-2)":[94],"activity":[95,162,179],"(using":[96,101],"gelatin":[97],"zymography)":[98],"apoptosis":[100,191],"annexin-v":[102],"flowcytometry":[103],"method)":[104],"assays":[105],"were":[106,175],"performed.":[107],"Chloroquine":[108],"treatment":[109],"also":[111],"used":[112],"for":[113],"its":[114],"inhibitory":[115],"effect":[116,223],"endosomal":[118],"acidification":[119],"process":[120],"to":[121,149,221],"verify":[122],"specific":[123],"Toll":[126],"Like":[127],"Receptor":[128],"9":[129],"(TLR9)":[130],"interactions.":[131],"Cytotoxicity":[132],"analysis":[133,163],"showed":[136,164],"that":[137,212],"increased":[139],"significantly":[140],"proliferation":[142],"cells,":[146,151],"as":[147],"compared":[148],"untreated":[150,170],"concentrations":[153,201],"10-25":[155],"microg/ml":[156],"(p":[157],"<":[158],"0.05).":[159],"Overall":[160],"MMP-2":[161,178],"significant":[165],"differences":[166],"between":[167],"minimal":[173],"changes":[174],"observed":[176],"when":[177],"per":[182],"cell.":[183],"Moreover,":[184],"cells":[187,238],"demonstrated":[188],"an":[189],"increasing":[190],"rate":[192],"0.8":[194],"%,":[195],"6.46":[196],"%":[197],"14.21%":[199],"25":[205],"microg/ml,":[206],"Collectively,":[208],"our":[209],"data":[210],"intestinal":[213],"highly":[219],"responsive":[220],"CpG":[222],"vitro":[225],"exhibits":[227],"modified":[228],"activities.":[229],"The":[230],"direct":[231],"TLR-9":[234],"interactions":[235],"could":[239],"provide":[240],"new":[241],"approaches":[242],"malignant":[244],"tumor":[245],"therapeutic":[246],"strategies.":[247]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}