{"id":"https://openalex.org/W2103476015","doi":"https://doi.org/10.1152/jappl.1999.87.3.1213","title":"Activation of the insular cortex is affected by the intensity of exercise","display_name":"Activation of the insular cortex is affected by the intensity of exercise","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W2103476015","doi":"https://doi.org/10.1152/jappl.1999.87.3.1213","mag":"2103476015","pmid":"https://pubmed.ncbi.nlm.nih.gov/10484598"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1999.87.3.1213","doi":"https://doi.org/10.1152/jappl.1999.87.3.1213","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1999.87.3.1213","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080082300","display_name":"JON W. WILLIAMSON","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. W. Williamson","raw_affiliation_strings":["Departments of Physical Therapy and","Office of the Dean - Southwestern School of Health Professions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physical Therapy and","institution_ids":[]},{"raw_affiliation_string":"Office of the Dean - Southwestern School of Health Professions","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083610730","display_name":"Roderick W. McColl","orcid":"https://orcid.org/0000-0001-7022-100X","observed_orcids":["https://orcid.org/0000-0001-7022-100X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. McColl","raw_affiliation_strings":["Radiology, and the","Radiology - Physics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, and the","institution_ids":[]},{"raw_affiliation_string":"Radiology - Physics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111569178","display_name":"Dana Mathews","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Mathews","raw_affiliation_strings":["Radiology, and the","Nuclear Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, and the","institution_ids":[]},{"raw_affiliation_string":"Nuclear Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Ginsburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Ginsburg","raw_affiliation_strings":["Radiology, and the","University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, and the","institution_ids":[]},{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108588780","display_name":"J. H. Mitchell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. H. Mitchell","raw_affiliation_strings":["Moss Heart Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235-8876","Physiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moss Heart Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235-8876","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Physiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2348,"has_fulltext":false,"cited_by_count":196,"citation_normalized_percentile":{"value":0.77073261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"87","issue":"3","first_page":"1213","last_page":"1219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insular-cortex","display_name":"insula","score":0.972000002861023},{"id":"https://openalex.org/keywords/exercise-intensity","display_name":"exercise intensity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/regional-cerebral-blood-flow","display_name":"regional cerebral blood flow","score":0.921999990940094},{"id":"https://openalex.org/keywords/static-handgrip-exercise","display_name":"static handgrip exercise","score":0.8640000224113464},{"id":"https://openalex.org/keywords/leg-cycling","display_name":"leg cycling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8730000257492065},{"id":"https://openalex.org/keywords/perceived-exertion","display_name":"perceived exertion","score":0.8180000185966492},{"id":"https://openalex.org/keywords/central-command","display_name":"central command","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C2780539906","wikidata":"https://www.wikidata.org/wiki/Q1422654","display_name":"Insular cortex","level":2,"score":0.7136633396148682},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.52961266040802},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.519531786441803},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5055060386657715},{"id":"https://openalex.org/C2776811442","wikidata":"https://www.wikidata.org/wiki/Q5420058","display_name":"Exercise intensity","level":4,"score":0.4950491487979889},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.46201884746551514},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4615466892719269},{"id":"https://openalex.org/C541528975","wikidata":"https://www.wikidata.org/wiki/Q53121","display_name":"Cycling","level":2,"score":0.46086061000823975},{"id":"https://openalex.org/C104996578","wikidata":"https://www.wikidata.org/wiki/Q827617","display_name":"Insula","level":2,"score":0.4308277368545532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4273565709590912},{"id":"https://openalex.org/C2780017030","wikidata":"https://www.wikidata.org/wiki/Q368366","display_name":"Cuff","level":2,"score":0.41636112332344055},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4131758511066437},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.40364009141921997},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.31588494777679443},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.16567650437355042},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.08084031939506531},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001642","descriptor_name":"Bicycling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018737","descriptor_name":"Hand Strength","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/jappl.1999.87.3.1213","doi":"https://doi.org/10.1152/jappl.1999.87.3.1213","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1999.87.3.1213","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:10484598","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10484598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.492.2730","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.492.2730","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.somasimple.com/pdf_files/activation_insular.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W120288851","https://openalex.org/W572107340","https://openalex.org/W639282551","https://openalex.org/W1566623382","https://openalex.org/W1938313559","https://openalex.org/W1965468082","https://openalex.org/W1967418759","https://openalex.org/W1990005524","https://openalex.org/W1999722313","https://openalex.org/W2040090425","https://openalex.org/W2042618263","https://openalex.org/W2046959522","https://openalex.org/W2065915881","https://openalex.org/W2078754525","https://openalex.org/W2079512683","https://openalex.org/W2080293194","https://openalex.org/W2082094268","https://openalex.org/W2082929721","https://openalex.org/W2083302038","https://openalex.org/W2094542138","https://openalex.org/W2114857415","https://openalex.org/W2122740073","https://openalex.org/W2132826918","https://openalex.org/W2135104622","https://openalex.org/W2161562068","https://openalex.org/W2169985903","https://openalex.org/W2216582527","https://openalex.org/W2275096253","https://openalex.org/W2279579198","https://openalex.org/W2283251116","https://openalex.org/W2395915594","https://openalex.org/W2409815028","https://openalex.org/W2411974024","https://openalex.org/W4232143967"],"related_works":["https://openalex.org/W2122740073","https://openalex.org/W1978762317","https://openalex.org/W2144348148","https://openalex.org/W1985929502","https://openalex.org/W1838223761","https://openalex.org/W2042404292","https://openalex.org/W2050828193","https://openalex.org/W2023158833","https://openalex.org/W7017684211","https://openalex.org/W2161613021"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,15,22,36,175,192,199,209],"this":[3],"investigation":[4],"was":[5,134],"to":[6,206],"determine":[7],"whether":[8],"there":[9],"were":[10,30,73,76,159],"differences":[11],"in":[12,80],"the":[13,190,197,207],"magnitude":[14,191],"insular":[16,81,153,193],"cortex":[17],"activation":[18,194],"across":[19,102],"varying":[20],"intensities":[21,35],"static":[23,47,105],"and":[24,39,65,91,101,122,172],"dynamic":[25],"exercise.":[26,185],"Eighteen":[27],"healthy":[28],"volunteers":[29],"studied:":[31],"eight":[32],"during":[33,45,83,104,136,184],"two":[34],"leg":[37],"cycling":[38,100],"ten":[40],"at":[41,49,113,123,149],"different":[42],"time":[43,103],"periods":[44],"sustained":[46,148],"handgrip":[48,106],"25%":[50],"maximal":[51],"voluntary":[52],"contraction":[53],"or":[54,212],"postexercise":[55,137],"cuff":[56,138],"occlusion.":[57],"Heart":[58],"rate,":[59],"blood":[60,68],"pressure":[61],"(BP),":[62],"perceived":[63,176,210],"exertion,":[64],"regional":[66],"cerebral":[67],"flow":[69],"(rCBF)":[70],"distribution":[71],"data":[72],"collected.":[74],"There":[75],"significantly":[77,160],"greater":[78],"increases":[79],"rCBF":[82,133,154],"lower":[84],"(6.3":[85],"+/-":[86,94,117,127,141],"1.7%;":[87],"P":[88,96,119,129,143,169,181],"<":[89,97,120,130,144,170,182],"0.05)":[90,98,145],"higher":[92],"(13.3":[93],"3.8%;":[95],"intensity":[99,198],"(change":[107],"from":[108],"rest":[109],"for":[110],"right":[111],"insula":[112],"2-3":[114],"min,":[115,125],"3.8":[116],"1.1%,":[118],"0.05;":[121],"4-5":[124],"8.6":[126],"2.8%,":[128],"0.05).":[131],"Insular":[132],"decreased":[135],"occlusion":[139],"(-5.5":[140],"1.2%;":[142],"with":[146,162,173,196],"BP":[147,164],"exercise":[150],"levels.":[151],"Right":[152],"data,":[155],"but":[156],"not":[157],"left,":[158],"related,":[161],"individual":[163],"changes":[165],"(r(2)":[166,178],"=":[167,179],"0.80;":[168],"0.001)":[171],"ratings":[174],"exertion":[177],"0.79;":[180],"0.01)":[183],"These":[186],"results":[187],"suggest":[188],"that":[189],"varies":[195],"exercise,":[200],"which":[201],"may":[202],"be":[203],"further":[204],"related":[205],"level":[208],"effort":[211],"central":[213],"command.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}