{"id":"https://openalex.org/W2103475485","doi":null,"title":"Contribution of Nitric Oxide in Doxorubicin-Related Cytotoxicity in Murine Tumour Model","display_name":"Contribution of Nitric Oxide in Doxorubicin-Related Cytotoxicity in Murine Tumour Model","publication_year":2014,"publication_date":"2014-08-27","ids":{"openalex":"https://openalex.org/W2103475485","mag":"2103475485"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.424.3048","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.424.3048","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.nci.edu.eg/Journal/June 2002 3.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085935137","display_name":"Mohamad M Sayed-Ahmad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamad M. Sayed-ahmad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ph. D. Samia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ph. D. Samia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A. Shouman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Shouman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ph. D","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ph. D","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Laila A. Ramadan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laila A. Ramadan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Ph. D","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ph. D","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1637,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52384011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.365200012922287,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.365200012922287,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.26809999346733093,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.08079999685287476,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9900000095367432},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7760000228881836},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ehrlich-ascites-carcinoma","display_name":"Ehrlich ascites carcinoma","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ehrlich-ascites-tumor-cells","display_name":"Ehrlich ascites tumor cells","score":0.6639999747276306},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5680000185966492},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.8188290596008301},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7472144365310669},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6788930892944336},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6732426285743713},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6280891299247742},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5493434071540833},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5420111417770386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5417665839195251},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.45413336157798767},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3824416399002075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3017868995666504},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2776089310646057},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2561342120170593},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21817752718925476},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16816598176956177},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15566101670265198},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.424.3048","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.424.3048","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.nci.edu.eg/Journal/June 2002 3.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1559331259","https://openalex.org/W1565731923","https://openalex.org/W1764308599","https://openalex.org/W1853125923","https://openalex.org/W1964285713","https://openalex.org/W1971199376","https://openalex.org/W1973535328","https://openalex.org/W1982021457","https://openalex.org/W1984646045","https://openalex.org/W1989090217","https://openalex.org/W1991633818","https://openalex.org/W1994303699","https://openalex.org/W2009098269","https://openalex.org/W2015295078","https://openalex.org/W2017844141","https://openalex.org/W2018230268","https://openalex.org/W2025334605","https://openalex.org/W2028458233","https://openalex.org/W2029587579","https://openalex.org/W2030657262","https://openalex.org/W2041973544","https://openalex.org/W2068463090","https://openalex.org/W2091653450","https://openalex.org/W2092145002","https://openalex.org/W2107132176","https://openalex.org/W2110361956","https://openalex.org/W2118234018","https://openalex.org/W2131138310","https://openalex.org/W2163982650","https://openalex.org/W2169623299","https://openalex.org/W2419620437"],"related_works":["https://openalex.org/W3088937305","https://openalex.org/W1677499164","https://openalex.org/W2051977433","https://openalex.org/W2095586932","https://openalex.org/W2734869579","https://openalex.org/W2149558643","https://openalex.org/W2037258107","https://openalex.org/W2601961649","https://openalex.org/W2053626884","https://openalex.org/W1931050730"],"abstract_inverted_index":{"Background:":[0],"Doxorubicin":[1],"(DOX)":[2],"is":[3],"an":[4],"anthracycline":[5],"antibiotic":[6],"with":[7,90],"broad":[8],"spectrum":[9],"antineoplastic":[10],"activity":[11],"against":[12,107],"different":[13],"types":[14],"of":[15,24,36,66],"experimental":[16],"and":[17,47,84,94],"human":[18],"tumours.":[19],"However,":[20],"the":[21,34],"optimal":[22],"usefulness":[23],"this":[25],"important":[26],"anticancer":[27,42],"drug":[28,39],"has":[29,59,72],"been":[30,50,60,73],"limited":[31],"due":[32],"to":[33,52,62,75,95,102],"development":[35],"tumour":[37,67],"cell":[38],"resistance.":[40],"Several":[41],"drugs":[43],"including":[44],"cisplatin,":[45],"hydroxyurea":[46],"DOX":[48,78],"have":[49],"shown":[51],"stimulate":[53],"nitric":[54],"oxide":[55],"(NO)":[56],"production,":[57],"which":[58],"demonstrated":[61],"affect":[63],"several":[64],"aspects":[65],"biology.":[68],"Purpose:":[69],"This":[70],"study":[71],"initiated":[74],"determine":[76,96],"if":[77,85,97],"stimulates":[79],"NO":[80,88,99],"production":[81,100],"in":[82,105],"EAC-cells":[83],"so,":[86],"whether":[87],"interferes":[89],"p-glycoprotein":[91],"(p-gp)":[92],"function":[93],"DOX-stimulated":[98],"contributes":[101],"DOX's":[103],"cytotoxicity":[104],"vivo":[106],"solid":[108],"Ehrlich":[109]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-27T00:00:00"}
