{"id":"https://openalex.org/W2103464580","doi":"https://doi.org/10.1161/01.res.0000090994.15442.42","title":"Endothelin B Receptor Deficiency Predisposes to Pulmonary Edema Formation via Increased Lung Vascular Endothelial Cell Growth Factor Expression","display_name":"Endothelin B Receptor Deficiency Predisposes to Pulmonary Edema Formation via Increased Lung Vascular Endothelial Cell Growth Factor Expression","publication_year":2003,"publication_date":"2003-08-19","ids":{"openalex":"https://openalex.org/W2103464580","doi":"https://doi.org/10.1161/01.res.0000090994.15442.42","mag":"2103464580","pmid":"https://pubmed.ncbi.nlm.nih.gov/12919946"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.0000090994.15442.42","doi":"https://doi.org/10.1161/01.res.0000090994.15442.42","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.0000090994.15442.42","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.0000090994.15442.42","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.0000090994.15442.42","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089926752","display_name":"Todd C. Carpenter","orcid":"https://orcid.org/0000-0002-9855-0021","observed_orcids":["https://orcid.org/0000-0002-9855-0021"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Carpenter","raw_affiliation_strings":["From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059766451","display_name":"Stacey Schomberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey Schomberg","raw_affiliation_strings":["From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111699738","display_name":"Wolfgang Steudel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolfgang Steudel","raw_affiliation_strings":["From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Ozimek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Ozimek","raw_affiliation_strings":["From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006435516","display_name":"Kelley L. Colvin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelley Colvin","raw_affiliation_strings":["From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014076592","display_name":"Kurt R. Stenmark","orcid":"https://orcid.org/0000-0001-6918-6411","observed_orcids":["https://orcid.org/0000-0001-6918-6411"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kurt Stenmark","raw_affiliation_strings":["From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023923057","display_name":"D. Dunbar Ivy","orcid":"https://orcid.org/0000-0003-2541-3402","observed_orcids":["https://orcid.org/0000-0003-2541-3402"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Dunbar Ivy","raw_affiliation_strings":["From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pediatrics (T.C., S.S., K.C., K.S., D.D.I.) and Anesthesiology (W.S., J.O.), University of Colorado Health Sciences Center, Denver, Colo","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I921990950"],"apc_list":null,"apc_paid":null,"fwci":2.0876,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.85472267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"93","issue":"5","first_page":"456","last_page":"463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.3122999966144562,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.07980000227689743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-b-receptor","display_name":"endothelin B receptor","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pulmonary-edema","display_name":"pulmonary edema","score":0.8550000190734863},{"id":"https://openalex.org/keywords/endothelin","display_name":"endothelin","score":0.5699999928474426},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.921999990940094},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/endothelin-a-receptor-antagonism","display_name":"endothelin-A receptor antagonism","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6678406596183777},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6485378742218018},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6483176350593567},{"id":"https://openalex.org/C2776468924","wikidata":"https://www.wikidata.org/wiki/Q857667","display_name":"Pulmonary edema","level":3,"score":0.6478341221809387},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5808141827583313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.55448979139328},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.49889445304870605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48398375511169434},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.48263034224510193},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4762156903743744},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.443676233291626},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.43130791187286377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31237947940826416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21584168076515198},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0628330409526825},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011922","descriptor_name":"Rats, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017466","descriptor_name":"Receptors, Endothelin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D017466","descriptor_name":"Receptors, Endothelin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044022","descriptor_name":"Receptor, Endothelin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044023","descriptor_name":"Receptor, Endothelin B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065128","descriptor_name":"Endothelin Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.res.0000090994.15442.42","doi":"https://doi.org/10.1161/01.res.0000090994.15442.42","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.0000090994.15442.42","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.0000090994.15442.42","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:12919946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12919946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/01.res.0000090994.15442.42","doi":"https://doi.org/10.1161/01.res.0000090994.15442.42","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.0000090994.15442.42","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.0000090994.15442.42","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1129487112","display_name":"ROLE OF ENDOTHELIN IN PERINATAL PULMONARY VASOREGULATION","funder_award_id":"K08HL003823","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1624647856","display_name":"VEIN GRAFT PRESERVATION: THROMBOSIS &NEOINTIMAL DISEASE","funder_award_id":"K08HL004484","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103464580.pdf","grobid_xml":"https://content.openalex.org/works/W2103464580.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1535466351","https://openalex.org/W1967594200","https://openalex.org/W1979046531","https://openalex.org/W1982654862","https://openalex.org/W1988050363","https://openalex.org/W1999841046","https://openalex.org/W2002842362","https://openalex.org/W2003055862","https://openalex.org/W2003857273","https://openalex.org/W2011351479","https://openalex.org/W2022779833","https://openalex.org/W2026429147","https://openalex.org/W2029327309","https://openalex.org/W2050508409","https://openalex.org/W2056299580","https://openalex.org/W2061988336","https://openalex.org/W2066199622","https://openalex.org/W2069653003","https://openalex.org/W2086261176","https://openalex.org/W2107340529","https://openalex.org/W2119615201","https://openalex.org/W2119725736","https://openalex.org/W2122600153","https://openalex.org/W2125297546","https://openalex.org/W2127770653","https://openalex.org/W2131233762","https://openalex.org/W2132363122","https://openalex.org/W2142130443","https://openalex.org/W2146966841","https://openalex.org/W2188647398","https://openalex.org/W2293444504","https://openalex.org/W2296585221","https://openalex.org/W2299845288","https://openalex.org/W2403888093","https://openalex.org/W2408939907","https://openalex.org/W2414047451","https://openalex.org/W2418887980"],"related_works":["https://openalex.org/W1977525068","https://openalex.org/W7096142031","https://openalex.org/W1992155974","https://openalex.org/W2122600153","https://openalex.org/W2112585717","https://openalex.org/W2246965587","https://openalex.org/W2036100871","https://openalex.org/W2411779599","https://openalex.org/W2410295702","https://openalex.org/W2418817078"],"abstract_inverted_index":{"Endothelin":[0],"(ET)":[1],"may":[2],"contribute":[3],"to":[4,20,55,199],"pulmonary":[5,42,49,67],"edema":[6,43,68],"formation,":[7,69],"particularly":[8],"under":[9],"hypoxic":[10,108,114,168],"conditions,":[11],"and":[12,35,70,107,127,131,143,145,148,161,191],"decreases":[13],"in":[14,33,38,44,80,124,136,140,167,184,196,203],"ET-B":[15,51,81,174],"receptor":[16,52,155,159],"expression":[17],"can":[18],"lead":[19],"reduced":[21,152,164],"ET":[22,24,61,122],"clearance.":[23],"increases":[25,62],"vascular":[26,50,93,102,165,181],"endothelial":[27],"cell":[28],"growth":[29],"factor":[30],"(VEGF)":[31],"production":[32],"vitro,":[34],"VEGF":[36,64,132,149,162,205],"overexpression":[37],"the":[39,137],"lung":[40,57,63,92,121,180,204],"causes":[41],"vivo.":[45],"We":[46,76,171],"hypothesized":[47],"that":[48,59,71,173,186,189,192],"deficiency":[53],"leads":[54],"increased":[56,101],"ET,":[58],"excess":[60],"levels,":[65],"promoting":[66],"hypoxia":[72,187],"exaggerates":[73],"these":[74,78],"effects.":[75],"studied":[77],"hypotheses":[79],"receptor-deficient":[82,175],"rats.":[83],"In":[84],"normoxia,":[85,185],"homozygous":[86],"ET-B-deficient":[87,109,117,138,169],"animals":[88,110,118,139,176],"had":[89,119],"significantly":[90],"more":[91,112],"leak":[94,103,166,183],"than":[95,113],"heterozygous":[96],"or":[97],"control":[98,115],"animals.":[99,116,170],"Hypoxia":[100],"regardless":[104],"of":[105],"genotype,":[106],"leaked":[111],"higher":[120],"levels":[123,150],"both":[125,141,146],"normoxia":[126,142],"hypoxia.":[128],"Lung":[129],"HIF-1alpha":[130,147],"content":[133],"was":[134],"greater":[135],"hypoxia,":[144],"were":[151],"by":[153],"ET-A":[154,158],"antagonism.":[156],"Both":[157],"blockade":[160],"antagonism":[163],"conclude":[172],"display":[177],"an":[178,200],"exaggerated":[179],"protein":[182],"exacerbates":[188],"leak,":[190],"this":[193],"effect":[194],"is":[195],"part":[197],"attributable":[198],"ET-mediated":[201],"increase":[202],"content.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}