{"id":"https://openalex.org/W2103430146","doi":"https://doi.org/10.1074/jbc.m109317200","title":"Hyperoxia-induced Apoptosis Does Not Require Mitochondrial Reactive Oxygen Species and Is Regulated by Bcl-2 Proteins","display_name":"Hyperoxia-induced Apoptosis Does Not Require Mitochondrial Reactive Oxygen Species and Is Regulated by Bcl-2 Proteins","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2103430146","doi":"https://doi.org/10.1074/jbc.m109317200","mag":"2103430146","pmid":"https://pubmed.ncbi.nlm.nih.gov/11877388"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109317200","doi":"https://doi.org/10.1074/jbc.m109317200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109317200","pdf_url":"http://www.jbc.org/article/S0021925819357114/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819357114/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020820588","display_name":"G. R. Scott Budinger","orcid":"https://orcid.org/0000-0002-3114-5208","observed_orcids":["https://orcid.org/0000-0002-3114-5208"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G. R. Scott Budinger","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611, USA. s-buding@northwestern.edu","From the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611, USA. s-buding@northwestern.edu","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"From the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611,","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083446295","display_name":"May Tso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"May Tso","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611","From the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"From the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611,","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020068097","display_name":"David S. McClintock","orcid":"https://orcid.org/0000-0003-4297-4367","observed_orcids":["https://orcid.org/0000-0003-4297-4367"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. McClintock","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611","From the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"From the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611,","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017939101","display_name":"David A. Dean","orcid":"https://orcid.org/0000-0001-7748-8073","observed_orcids":["https://orcid.org/0000-0001-7748-8073"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Dean","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611","From the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"From the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611,","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084997419","display_name":"Jacob Iasha Sznajder","orcid":"https://orcid.org/0000-0002-2089-4764","observed_orcids":["https://orcid.org/0000-0002-2089-4764"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob I. Sznajder","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611","From the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"From the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611,","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046518034","display_name":"Navdeep S. Chandel","orcid":"https://orcid.org/0000-0001-7208-3886","observed_orcids":["https://orcid.org/0000-0001-7208-3886"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navdeep S. Chandel","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611","From the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"From the Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois 60611,","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020820588"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.773,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.91328742,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"277","issue":"18","first_page":"15654","last_page":"15660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.8629999756813049},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.9350000023841858},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bak","display_name":"Bak","score":1.0},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.8820000290870667},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mitochondrial-electron-transport-chain","display_name":"mitochondrial electron transport chain","score":0.6800000071525574},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5109999775886536},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.6439999938011169},{"id":"https://openalex.org/keywords/mitochondrial-dna-deletions","display_name":"mitochondrial DNA deletions","score":0.5799999833106995},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.6850000023841858},{"id":"https://openalex.org/keywords/alveolar-epithelium","display_name":"alveolar epithelium","score":0.7860000133514404},{"id":"https://openalex.org/keywords/endothelium","display_name":"endothelium","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.9778056144714355},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.703681468963623},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6714886426925659},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6202256679534912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4916394352912903},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4787523150444031},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.44416117668151855},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.327308714389801},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31791388988494873},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15842097997665405},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.14260625839233398},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000968","descriptor_name":"Antimycin A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005354","descriptor_name":"Fibrosarcoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018496","descriptor_name":"Hyperoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m109317200","doi":"https://doi.org/10.1074/jbc.m109317200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109317200","pdf_url":"http://www.jbc.org/article/S0021925819357114/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11877388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11877388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109317200","doi":"https://doi.org/10.1074/jbc.m109317200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109317200","pdf_url":"http://www.jbc.org/article/S0021925819357114/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1276823796","display_name":null,"funder_award_id":"HL67835-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1717661384","display_name":"Mitochondrial Regulation of Hyperoxic Cell Death","funder_award_id":"K08HL067835","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7683894326","display_name":"Mechanisms of HIF activation in pulmonary vasculature.","funder_award_id":"R01GM060472","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103430146.pdf","grobid_xml":"https://content.openalex.org/works/W2103430146.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W9096134","https://openalex.org/W91740401","https://openalex.org/W1532194993","https://openalex.org/W1550247880","https://openalex.org/W1550989404","https://openalex.org/W1559531158","https://openalex.org/W1564202134","https://openalex.org/W1813230101","https://openalex.org/W1858666486","https://openalex.org/W1970345057","https://openalex.org/W1976226379","https://openalex.org/W1984547206","https://openalex.org/W1994885986","https://openalex.org/W2021994448","https://openalex.org/W2026873116","https://openalex.org/W2030573603","https://openalex.org/W2031578545","https://openalex.org/W2032361307","https://openalex.org/W2041909933","https://openalex.org/W2050550285","https://openalex.org/W2056134483","https://openalex.org/W2057380297","https://openalex.org/W2065197965","https://openalex.org/W2070920469","https://openalex.org/W2083545792","https://openalex.org/W2099379562","https://openalex.org/W2104986494","https://openalex.org/W2113999599","https://openalex.org/W2127179996","https://openalex.org/W2132625535","https://openalex.org/W2145287139","https://openalex.org/W2149229440","https://openalex.org/W2152247516","https://openalex.org/W2161877652","https://openalex.org/W2168330194","https://openalex.org/W2169260922","https://openalex.org/W2170418712","https://openalex.org/W2171285875","https://openalex.org/W2318252390","https://openalex.org/W4254119740"],"related_works":["https://openalex.org/W2056318894","https://openalex.org/W2907441616","https://openalex.org/W1979399988","https://openalex.org/W2030325789","https://openalex.org/W1981122354","https://openalex.org/W2079510855","https://openalex.org/W2145588122","https://openalex.org/W2041909933","https://openalex.org/W2021994448","https://openalex.org/W2063057532"],"abstract_inverted_index":{"Exposure":[0],"of":[1,16,51,70,74,85,102,174,179],"animals":[2],"to":[3,36,42,62,96,115,121,134,141,151,157,191],"hyperoxia":[4,26,43,63,142,158],"results":[5,27,159],"in":[6,28,160],"lung":[7],"injury":[8],"that":[9,40,47,79,132,155,162],"is":[10,183],"characterized":[11,66],"by":[12,24,67,82,171],"apoptosis":[13,46,65,161],"and":[14,20,76,112,167],"necrosis":[15],"the":[17,38,49,68,83,103,172],"alveolar":[18],"epithelium":[19],"endothelium.":[21],"The":[22,100,176],"mechanism":[23],"which":[25],"cell":[29,98,117,147,187],"death,":[30],"however,":[31],"remains":[32],"unclear.":[33],"We":[34,153],"sought":[35],"test":[37],"hypothesis":[39],"exposure":[41,120,140,150,156,190],"causes":[44],"mitochondria-dependent":[45],"requires":[48,163],"generation":[50,178],"reactive":[52,136,180],"oxygen":[53,137,181],"species":[54,138,182],"from":[55,90],"mitochondrial":[56,128,177],"electron":[57],"transport.":[58],"Rat1a":[59],"cells":[60,125],"exposed":[61],"underwent":[64],"release":[69],"cytochrome":[71],"c,":[72],"activation":[73],"caspase-9,":[75],"nuclear":[77],"fragmentation":[78],"was":[80],"prevented":[81,170],"overexpression":[84,173],"Bcl-X(L.)":[86],"Murine":[87],"embryonic":[88],"fibroblasts":[89],"bax(-/-)":[91],"bak(-/-)":[92],"mice":[93],"were":[94,143],"resistant":[95],"hyperoxia-induced":[97],"death.":[99],"administration":[101],"antioxidants":[104],"manganese":[105],"(III)":[106],"tetrakis":[107],"(4-benzoic":[108],"acid)":[109],"porphyrin,":[110],"ebselen,":[111],"N-acetylcysteine":[113],"failed":[114,133],"prevent":[116],"death":[118,148,188],"following":[119,149,189],"hyperoxia.":[122,152,192],"Human":[123],"fibrosarcoma":[124],"(HT1080)":[126],"lacking":[127],"DNA":[129],"(rho(0)":[130],"cells)":[131],"generate":[135],"during":[139],"not":[144,184],"protected":[145],"against":[146],"conclude":[154],"Bax":[164],"or":[165],"Bak":[166],"can":[168],"be":[169],"Bcl-X(L).":[175],"required":[185],"for":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
