{"id":"https://openalex.org/W2103401545","doi":"https://doi.org/10.1093/protein/gzg113","title":"Similarity between the C-terminal domain of the prion protein and chimpanzee cytomegalovirus glycoprotein UL9","display_name":"Similarity between the C-terminal domain of the prion protein and chimpanzee cytomegalovirus glycoprotein UL9","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W2103401545","doi":"https://doi.org/10.1093/protein/gzg113","mag":"2103401545","pmid":"https://pubmed.ncbi.nlm.nih.gov/14983063"},"language":"en","primary_location":{"id":"doi:10.1093/protein/gzg113","doi":"https://doi.org/10.1093/protein/gzg113","is_oa":false,"landing_page_url":"https://doi.org/10.1093/protein/gzg113","pdf_url":null,"source":{"id":"https://openalex.org/S44492648","display_name":"Protein Engineering Design and Selection","issn_l":"0269-2139","issn":["0269-2139","1460-213X","1741-0126","1741-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Engineering Design and Selection","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031363135","display_name":"Igor B. Kuznetsov","orcid":"https://orcid.org/0000-0003-3741-8964","observed_orcids":["https://orcid.org/0000-0003-3741-8964"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"I. B. Kuznetsov","raw_affiliation_strings":["Department of Biomathematical Sciences, Mount Sinai School of Medicine, Box 1023, One Gustave L. Levy Place, New York, NY 10029, USA. igor@ku.edu","Department of Biomathematical Sciences, Mount Sinai School of Medicine, Box 1023, One Gustave L. Levy Place, New York, NY 10029, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomathematical Sciences, Mount Sinai School of Medicine, Box 1023, One Gustave L. Levy Place, New York, NY 10029, USA. igor@ku.edu","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Biomathematical Sciences, Mount Sinai School of Medicine, Box 1023, One Gustave L. Levy Place, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016932360","display_name":"Shalom R. Rackovsky","orcid":"https://orcid.org/0000-0002-6186-7893","observed_orcids":["https://orcid.org/0000-0002-6186-7893"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Rackovsky","raw_affiliation_strings":["Department of Biomathematical Sciences, Mount Sinai School of Medicine, Box 1023, One Gustave L. Levy Place, New York, NY 10029, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomathematical Sciences, Mount Sinai School of Medicine, Box 1023, One Gustave L. Levy Place, New York, NY 10029, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031363135"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":4656,"currency":"USD","value_usd":4656},"apc_paid":null,"fwci":0.2299,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.51198801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"12","first_page":"861","last_page":"863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prion-protein","display_name":"prion protein","score":0.953000009059906},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.7590000033378601},{"id":"https://openalex.org/keywords/prpsc","display_name":"PrPSc","score":0.6589999794960022},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.6309999823570251},{"id":"https://openalex.org/keywords/chimpanzees","display_name":"chimpanzees","score":0.6620000004768372},{"id":"https://openalex.org/keywords/sequence-similarity","display_name":"sequence similarity","score":0.699999988079071},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"protein structure prediction","score":0.5170000195503235},{"id":"https://openalex.org/keywords/structural-templates","display_name":"structural templates","score":0.6150000095367432},{"id":"https://openalex.org/keywords/beta-sheet-conformation","display_name":"\u03b2-sheet conformation","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C139489369","wikidata":"https://www.wikidata.org/wiki/Q770846","display_name":"Structural similarity","level":2,"score":0.6179243326187134},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5949990153312683},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5286185145378113},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.49568402767181396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4782796800136566},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4615279734134674},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.4297299087047577},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3788207769393921},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35033345222473145},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/protein/gzg113","doi":"https://doi.org/10.1093/protein/gzg113","is_oa":false,"landing_page_url":"https://doi.org/10.1093/protein/gzg113","pdf_url":null,"source":{"id":"https://openalex.org/S44492648","display_name":"Protein Engineering Design and Selection","issn_l":"0269-2139","issn":["0269-2139","1460-213X","1741-0126","1741-0134"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Engineering Design and Selection","raw_type":"journal-article"},{"id":"pmid:14983063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14983063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1339559462","display_name":"Optimized Protein Informatics","funder_award_id":"R01LM006789","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320338283","display_name":"Office of Experimental Program to Stimulate Competitive Research","ror":"https://ror.org/04k9mqs78"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092955929","https://openalex.org/W2023834863","https://openalex.org/W3200437637","https://openalex.org/W2038000294","https://openalex.org/W2790111956","https://openalex.org/W3170652052","https://openalex.org/W7132928519","https://openalex.org/W2059899689","https://openalex.org/W2107929274","https://openalex.org/W7217752808"],"abstract_inverted_index":{"Prion":[0],"diseases":[1],"are":[2,61],"a":[3,14,23,68,72,81,103,126,149,163,172,182],"group":[4],"of":[5,13,30,38,43,99,111],"fatal":[6],"neurodegenerative":[7],"disorders":[8],"associated":[9],"with":[10,56,87,160],"structural":[11,69,183],"conversion":[12],"normal,":[15],"mostly":[16],"alpha-helical":[17],"cellular":[18],"prion":[19],"protein,":[20],"PrP(C),":[21],"into":[22,71,96],"pathogenic":[24],"beta-sheet-rich":[25,73],"conformation,":[26],"PrP(Sc).":[27,100],"The":[28],"structure":[29,45,177],"PrP(C)":[31],"is":[32],"well":[33],"studied,":[34],"whereas":[35],"the":[36,41,57,97,108,119,156,167],"insolubility":[37],"PrP(Sc)":[39,186],"makes":[40],"characterization":[42],"its":[44,54],"problematic.":[46],"No":[47],"proteins":[48,78],"similar":[49],"to":[50,92,107,117,152,155],"PrP,":[51],"except":[52],"for":[53,175,185],"paralog":[55],"same":[58],"fold,":[59,166],"PrP-Doppel,":[60],"known.":[62],"However,":[63],"PrP-Doppel":[64,143],"does":[65],"not":[66],"undergo":[67],"transition":[70],"conformation.":[74],"Structural":[75],"information":[76],"from":[77],"that":[79],"share":[80],"weak":[82],"but":[83],"significant":[84,127],"sequence":[85,104,128,158],"similarity":[86,129,159],"PrP":[88,112,131,161],"may":[89,170],"be":[90],"used":[91],"gain":[93],"additional":[94],"insights":[95],"conformation":[98],"We":[101,124],"construct":[102],"profile":[105,116],"corresponding":[106],"structured":[109],"domain":[110],"and":[113,121,132,162],"use":[114],"this":[115],"search":[118],"SWISS-PROT":[120],"TrEMBL":[122],"databases.":[123],"identify":[125],"between":[130],"chimpanzee":[133],"cytomegalovirus":[134],"glycoprotein":[135,138,169],"UL9.":[136,153],"This":[137],"scores":[139],"higher":[140],"than":[141],"all":[142],"sequences.":[144],"Fold":[145],"recognition":[146],"methods":[147],"assign":[148],"mainly-beta":[150,165],"fold":[151],"Owing":[154],"observed":[157],"putative":[164],"UL9":[168],"represent":[171],"potential":[173],"target":[174],"experimental":[176],"determination":[178],"aimed":[179],"at":[180],"obtaining":[181],"template":[184],"modeling.":[187]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}