{"id":"https://openalex.org/W2103383860","doi":"https://doi.org/10.1113/expphysiol.2006.036004","title":"Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms?","display_name":"Glucose sensing by hypothalamic neurones and pancreatic islet cells: AMPle evidence for common mechanisms?","publication_year":2006,"publication_date":"2006-12-08","ids":{"openalex":"https://openalex.org/W2103383860","doi":"https://doi.org/10.1113/expphysiol.2006.036004","mag":"2103383860","pmid":"https://pubmed.ncbi.nlm.nih.gov/17158178"},"language":"en","primary_location":{"id":"doi:10.1113/expphysiol.2006.036004","doi":"https://doi.org/10.1113/expphysiol.2006.036004","is_oa":true,"landing_page_url":"https://doi.org/10.1113/expphysiol.2006.036004","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/expphysiol.2006.036004","source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/expphysiol.2006.036004","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070761057","display_name":"Philip D. Mountjoy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip D. Mountjoy","raw_affiliation_strings":["Department of Cell Biology, Division of Medicine, Faculty of Medicine, Sir Alexander Fleming Building, Exhibition Road, Imperial College London, London SW7 2AZ, UK","Department of Cell Biology, Division of Medicine, Faculty of Medicine, Sir Alexander Fleming Building, Exhibition Road, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Division of Medicine, Faculty of Medicine, Sir Alexander Fleming Building, Exhibition Road, Imperial College London, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Cell Biology, Division of Medicine, Faculty of Medicine, Sir Alexander Fleming Building, Exhibition Road, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015737554","display_name":"Guy A. Rutter","orcid":"https://orcid.org/0000-0001-6360-0343","observed_orcids":["https://orcid.org/0000-0001-6360-0343"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Guy A. Rutter","raw_affiliation_strings":["Department of Cell Biology, Division of Medicine, Faculty of Medicine, Sir Alexander Fleming Building, Exhibition Road, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Division of Medicine, Faculty of Medicine, Sir Alexander Fleming Building, Exhibition Road, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":2940,"currency":"USD","value_usd":2940},"apc_paid":null,"fwci":0.315,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.25099602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"92","issue":"2","first_page":"311","last_page":"319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-detection","display_name":"glucose detection","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pancreatic-islet-cells","display_name":"pancreatic islet cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.8759999871253967},{"id":"https://openalex.org/keywords/nutrient-sensing","display_name":"nutrient sensing","score":0.8790000081062317},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/blood-glucose-regulation","display_name":"blood glucose regulation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/appetite-hormones","display_name":"appetite-regulating hormones","score":0.8339999914169312},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.492000013589859},{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5798316597938538},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.5524361729621887},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5472280383110046},{"id":"https://openalex.org/C2776030549","wikidata":"https://www.wikidata.org/wiki/Q7829395","display_name":"Nutrient sensing","level":3,"score":0.5396080613136292},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5328365564346313},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4939180016517639},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4912838339805603},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.48994630575180054},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.48867467045783997},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4364681839942932},{"id":"https://openalex.org/C76923068","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Blood sugar regulation","level":3,"score":0.4260774254798889},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.421310693025589},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.413073867559433},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3671051859855652},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.35650748014450073},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3057616949081421},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16532158851623535}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001069","descriptor_name":"Appetite Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1113/expphysiol.2006.036004","doi":"https://doi.org/10.1113/expphysiol.2006.036004","is_oa":true,"landing_page_url":"https://doi.org/10.1113/expphysiol.2006.036004","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/expphysiol.2006.036004","source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},{"id":"pmid:17158178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17158178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1113/expphysiol.2006.036004","doi":"https://doi.org/10.1113/expphysiol.2006.036004","is_oa":true,"landing_page_url":"https://doi.org/10.1113/expphysiol.2006.036004","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/expphysiol.2006.036004","source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103383860.pdf","grobid_xml":"https://content.openalex.org/works/W2103383860.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1487837909","https://openalex.org/W1506453366","https://openalex.org/W1623365227","https://openalex.org/W1757645550","https://openalex.org/W1866620858","https://openalex.org/W1913661755","https://openalex.org/W1963957834","https://openalex.org/W1968973186","https://openalex.org/W1970643756","https://openalex.org/W1973990447","https://openalex.org/W1975983146","https://openalex.org/W1977259783","https://openalex.org/W1990095603","https://openalex.org/W1993068187","https://openalex.org/W1994554353","https://openalex.org/W1994924615","https://openalex.org/W1999565511","https://openalex.org/W2002073684","https://openalex.org/W2010464096","https://openalex.org/W2012241091","https://openalex.org/W2012496594","https://openalex.org/W2015023608","https://openalex.org/W2017709986","https://openalex.org/W2022975427","https://openalex.org/W2027740042","https://openalex.org/W2029371986","https://openalex.org/W2031384783","https://openalex.org/W2039598915","https://openalex.org/W2044431563","https://openalex.org/W2047140715","https://openalex.org/W2047790518","https://openalex.org/W2050051162","https://openalex.org/W2050636523","https://openalex.org/W2053718873","https://openalex.org/W2056503433","https://openalex.org/W2057328350","https://openalex.org/W2068063361","https://openalex.org/W2068524200","https://openalex.org/W2069734729","https://openalex.org/W2074303577","https://openalex.org/W2077425635","https://openalex.org/W2080766203","https://openalex.org/W2097378006","https://openalex.org/W2099781923","https://openalex.org/W2100335412","https://openalex.org/W2102220170","https://openalex.org/W2105623584","https://openalex.org/W2106478990","https://openalex.org/W2111056062","https://openalex.org/W2111349683","https://openalex.org/W2113392334","https://openalex.org/W2116623091","https://openalex.org/W2118167994","https://openalex.org/W2120228339","https://openalex.org/W2127575529","https://openalex.org/W2132377842","https://openalex.org/W2140192657","https://openalex.org/W2140671916","https://openalex.org/W2143609607","https://openalex.org/W2143915327","https://openalex.org/W2147594695","https://openalex.org/W2156587759","https://openalex.org/W2160905895","https://openalex.org/W2164357952","https://openalex.org/W2166243077","https://openalex.org/W2178963972","https://openalex.org/W2187433450","https://openalex.org/W2198516513"],"related_works":["https://openalex.org/W1964913810","https://openalex.org/W2152303978","https://openalex.org/W2031384783","https://openalex.org/W2171223091","https://openalex.org/W2312838247","https://openalex.org/W1988576793","https://openalex.org/W2105623584","https://openalex.org/W4395451638","https://openalex.org/W1991031250","https://openalex.org/W2054519510"],"abstract_inverted_index":{"A":[0],"fuller":[1],"understanding":[2],"of":[3,27,53,84,92,110,155],"the":[4,24,33,51,81,90,97,108,111,124,152],"central":[5,82],"mechanisms":[6,100],"involved":[7],"in":[8,29,67,80,89,107,147],"controlling":[9],"food":[10,85],"intake":[11,86],"and":[12,42,56,87,150,159],"metabolism":[13],"is":[14,59],"likely":[15],"to":[16,22,38,45],"be":[17],"crucial":[18],"for":[19],"developing":[20],"treatments":[21],"combat":[23],"growing":[25],"problem":[26],"obesity":[28],"Westernised":[30],"societies.":[31],"Within":[32],"hypothalamus,":[34],"specialized":[35],"neurones":[36,58,73,104],"respond":[37],"both":[39],"appetite-regulating":[40],"hormones":[41],"circulating":[43],"metabolites":[44],"regulate":[46],"feeding":[47],"behaviour":[48],"accordingly.":[49],"Thus,":[50],"activity":[52],"hypothalamic":[54],"glucose-excited":[55],"glucose-inhibited":[57],"increased":[60],"or":[61,126],"decreased,":[62],"respectively,":[63],"by":[64],"an":[65],"increase":[66],"local":[68],"glucose":[69,94],"concentration.":[70],"These":[71],"'glucose-sensing'":[72],"may":[74],"therefore":[75],"play":[76],"a":[77],"key":[78],"role":[79],"regulation":[83,91],"potentially":[88],"blood":[93],"concentrations.":[95],"Whilst":[96],"intracellular":[98],"signalling":[99],"through":[101],"which":[102],"glucose-sensing":[103],"detect":[105],"changes":[106],"concentration":[109],"sugar":[112],"have":[113],"been":[114],"investigated":[115],"quite":[116],"extensively,":[117],"many":[118],"elements":[119],"remain":[120],"poorly":[121],"understood.":[122],"Furthermore,":[123],"similarities,":[125],"otherwise,":[127],"with":[128],"other":[129,160],"nutrient-sensing":[130],"cells,":[131,135],"including":[132],"pancreatic":[133],"islet":[134],"are":[136],"not":[137],"completely":[138],"resolved.":[139],"In":[140],"this":[141,148],"review,":[142],"we":[143],"discuss":[144],"recent":[145],"advances":[146],"field":[149],"explore":[151],"potential":[153],"involvement":[154],"AMP-activated":[156],"protein":[157,162],"kinase":[158],"nutrient-regulated":[161],"kinases.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
