{"id":"https://openalex.org/W2103371093","doi":"https://doi.org/10.1517/14656566.6.2.233","title":"Drug interactions in the management of HIV infection","display_name":"Drug interactions in the management of HIV infection","publication_year":2005,"publication_date":"2005-02-01","ids":{"openalex":"https://openalex.org/W2103371093","doi":"https://doi.org/10.1517/14656566.6.2.233","mag":"2103371093","pmid":"https://pubmed.ncbi.nlm.nih.gov/15757420"},"language":"en","primary_location":{"id":"doi:10.1517/14656566.6.2.233","doi":"https://doi.org/10.1517/14656566.6.2.233","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.6.2.233","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042918803","display_name":"Sarah M. C. Robertson","orcid":"https://orcid.org/0000-0002-8449-6482","observed_orcids":["https://orcid.org/0000-0002-8449-6482"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah M Robertson","raw_affiliation_strings":["National Institutes of Health, Clinical Pharmacokinetics Research Laboratory, Clinical Center Pharmacy Department, Bethesda, Maryland 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Clinical Pharmacokinetics Research Laboratory, Clinical Center Pharmacy Department, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019363661","display_name":"Scott R Penzak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott R Penzak","raw_affiliation_strings":["National Institutes of Health, Clinical Pharmacokinetics Research Laboratory, Clinical Center Pharmacy Department, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Clinical Pharmacokinetics Research Laboratory, Clinical Center Pharmacy Department, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064526337","display_name":"Alice K. Pau","orcid":"https://orcid.org/0000-0002-0153-0236","observed_orcids":["https://orcid.org/0000-0002-0153-0236"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice K Pau","raw_affiliation_strings":["National Institutes of Health, Office of Clinical Research, National Institute of Allergy and Infectious Diseases, Bldg 10, Room 11C103, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Office of Clinical Research, National Institute of Allergy and Infectious Diseases, Bldg 10, Room 11C103, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4951,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.4557596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"2","first_page":"233","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.996999979019165},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.9459999799728394},{"id":"https://openalex.org/keywords/macrolide-antibiotics","display_name":"macrolide antibiotics","score":0.8700000047683716},{"id":"https://openalex.org/keywords/azole-antifungals","display_name":"azole antifungals","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cholesterol-lowering-drugs","display_name":"cholesterol-lowering drugs","score":0.8799999952316284},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.9789999723434448},{"id":"https://openalex.org/keywords/drug-transport","display_name":"drug transport","score":0.9539999961853027},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9003850221633911},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7402442097663879},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6576919555664062},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6435511112213135},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.559832751750946},{"id":"https://openalex.org/C97320921","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug interaction","level":3,"score":0.442073792219162},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25007712841033936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1985936462879181},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.13298028707504272}],"mesh":[{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/14656566.6.2.233","doi":"https://doi.org/10.1517/14656566.6.2.233","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.6.2.233","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:15757420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15757420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on pharmacotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":135,"referenced_works":["https://openalex.org/W39200817","https://openalex.org/W1501551071","https://openalex.org/W1510126686","https://openalex.org/W1561327252","https://openalex.org/W1566726772","https://openalex.org/W1583934929","https://openalex.org/W1605481054","https://openalex.org/W1805485198","https://openalex.org/W1871950822","https://openalex.org/W1898849923","https://openalex.org/W1943653788","https://openalex.org/W1965233650","https://openalex.org/W1967002017","https://openalex.org/W1970111420","https://openalex.org/W1971920484","https://openalex.org/W1972286377","https://openalex.org/W1974527856","https://openalex.org/W1975720684","https://openalex.org/W1975721296","https://openalex.org/W1978372501","https://openalex.org/W1978559947","https://openalex.org/W1981172861","https://openalex.org/W1981320276","https://openalex.org/W1984270093","https://openalex.org/W1984802375","https://openalex.org/W1985059525","https://openalex.org/W1992094709","https://openalex.org/W1997056223","https://openalex.org/W1998765853","https://openalex.org/W2001607160","https://openalex.org/W2008263033","https://openalex.org/W2009340266","https://openalex.org/W2010199010","https://openalex.org/W2011428797","https://openalex.org/W2012344385","https://openalex.org/W2012487371","https://openalex.org/W2013015131","https://openalex.org/W2013641871","https://openalex.org/W2013703413","https://openalex.org/W2015616182","https://openalex.org/W2016484787","https://openalex.org/W2018464571","https://openalex.org/W2020104576","https://openalex.org/W2020276386","https://openalex.org/W2021805364","https://openalex.org/W2022671360","https://openalex.org/W2023049972","https://openalex.org/W2024189301","https://openalex.org/W2025497136","https://openalex.org/W2025649131","https://openalex.org/W2025663121","https://openalex.org/W2026219081","https://openalex.org/W2027549508","https://openalex.org/W2030127456","https://openalex.org/W2033278606","https://openalex.org/W2034727191","https://openalex.org/W2034903871","https://openalex.org/W2035409813","https://openalex.org/W2036597966","https://openalex.org/W2042467292","https://openalex.org/W2043386100","https://openalex.org/W2043935817","https://openalex.org/W2046161651","https://openalex.org/W2047006594","https://openalex.org/W2050395450","https://openalex.org/W2051194122","https://openalex.org/W2052694988","https://openalex.org/W2053450751","https://openalex.org/W2059124286","https://openalex.org/W2061088592","https://openalex.org/W2063889976","https://openalex.org/W2064961024","https://openalex.org/W2069854160","https://openalex.org/W2070677270","https://openalex.org/W2071086973","https://openalex.org/W2076382418","https://openalex.org/W2079194463","https://openalex.org/W2081298828","https://openalex.org/W2088787526","https://openalex.org/W2090632754","https://openalex.org/W2097101998","https://openalex.org/W2097269715","https://openalex.org/W2099445570","https://openalex.org/W2101089712","https://openalex.org/W2104093795","https://openalex.org/W2105540175","https://openalex.org/W2108035743","https://openalex.org/W2108524243","https://openalex.org/W2110715383","https://openalex.org/W2110885232","https://openalex.org/W2112710992","https://openalex.org/W2113515726","https://openalex.org/W2115665560","https://openalex.org/W2117640369","https://openalex.org/W2121936217","https://openalex.org/W2122169854","https://openalex.org/W2123002505","https://openalex.org/W2124669347","https://openalex.org/W2128166980","https://openalex.org/W2129496382","https://openalex.org/W2131773432","https://openalex.org/W2132346139","https://openalex.org/W2132806259","https://openalex.org/W2138266957","https://openalex.org/W2140648515","https://openalex.org/W2140880940","https://openalex.org/W2141190015","https://openalex.org/W2141505400","https://openalex.org/W2142879112","https://openalex.org/W2144190487","https://openalex.org/W2145930518","https://openalex.org/W2146240795","https://openalex.org/W2154513334","https://openalex.org/W2162997734","https://openalex.org/W2163553586","https://openalex.org/W2164261722","https://openalex.org/W2167401706","https://openalex.org/W2168463237","https://openalex.org/W2312722622","https://openalex.org/W2313704661","https://openalex.org/W2314852508","https://openalex.org/W2317687186","https://openalex.org/W2318022415","https://openalex.org/W2324725162","https://openalex.org/W2329313939","https://openalex.org/W2333057995","https://openalex.org/W2347062401","https://openalex.org/W2512454832","https://openalex.org/W2770494859","https://openalex.org/W3027692331","https://openalex.org/W3028382724","https://openalex.org/W3191746761","https://openalex.org/W4251307042","https://openalex.org/W4285719527","https://openalex.org/W4318598667"],"related_works":["https://openalex.org/W1979125889","https://openalex.org/W4211257386","https://openalex.org/W2318022415","https://openalex.org/W2438160450","https://openalex.org/W2914124626","https://openalex.org/W2092560735","https://openalex.org/W197036761","https://openalex.org/W7139128883","https://openalex.org/W2045779390","https://openalex.org/W2268671466"],"abstract_inverted_index":{"The":[0,94,137],"availability":[1],"of":[2,12,19,34,40,51,68,75,96,118,141],"antiretroviral":[3],"therapy":[4],"has":[5,42],"significantly":[6],"reduced":[7],"the":[8,32,38,49,69,73,103],"morbidity":[9],"and":[10,22,78,112,130,134,139,150],"mortality":[11],"HIV":[13,28,41,122,156],"infection.":[14],"In":[15],"addition,":[16],"improved":[17],"treatment":[18,39],"opportunistic":[20,76,148],"infections":[21,77],"comorbidities":[23],"common":[24],"to":[25,44,57,59,91],"patients":[26,157],"with":[27],"is":[29,100,114,123],"further":[30,124],"prolonging":[31],"lives":[33],"patients.":[35],"Improvement":[36],"in":[37,48,72,121,155],"led":[43],"a":[45],"significant":[46,98],"increase":[47],"number":[50],"medications":[52,152],"which":[53,106],"caregivers":[54],"are":[55,88],"able":[56],"utilise":[58],"manage":[60],"HIV/AIDS.":[61],"Antiretroviral":[62],"medications,":[63],"as":[64,66],"well":[65],"many":[67],"drugs":[70,145],"used":[71,146,154],"management":[74],"primary":[79],"care":[80],"(e.g.,":[81],"macrolide":[82],"antibiotics,":[83],"azole":[84],"antifungals,":[85],"cholesterol-lowering":[86],"medications),":[87],"particularly":[89],"prone":[90],"drug":[92,110,119],"interactions.":[93],"interpretation":[95],"clinically":[97],"interactions":[99,120,142],"complicated":[101],"by":[102,126],"rate":[104],"at":[105],"new":[107],"information":[108],"on":[109],"metabolism":[111],"transport":[113],"becoming":[115],"available.":[116],"Management":[117],"confounded":[125],"conflicting":[127],"study":[128],"results":[129],"differences":[131],"between":[132],"documented":[133],"theoretical":[135],"inter-actions.":[136],"mechanisms":[138],"significance":[140],"involving":[143],"antiretrovirals,":[144],"for":[147],"infections,":[149],"other":[151],"commonly":[153],"will":[158],"be":[159],"reviewed.":[160]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}