{"id":"https://openalex.org/W2103297906","doi":"https://doi.org/10.1038/sj.bjp.0705607","title":"Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors","display_name":"Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2103297906","doi":"https://doi.org/10.1038/sj.bjp.0705607","mag":"2103297906","pmid":"https://pubmed.ncbi.nlm.nih.gov/14707029","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1574194"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjp.0705607","doi":"https://doi.org/10.1038/sj.bjp.0705607","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0705607","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0705607","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0705607","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050433553","display_name":"James D. Leggett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210137227","display_name":"Queen's Medical Centre","ror":"https://ror.org/03ap6wx93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210137227"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"James D Leggett","raw_affiliation_strings":["School of Biomedical Sciences, University of Nottingham Medical School, Queens Medical Centre, Nottingham, UK. mbxjdl@nottingham.ac.uk","School of Biomedical Sciences, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences, University of Nottingham Medical School, Queens Medical Centre, Nottingham, UK. mbxjdl@nottingham.ac.uk","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210137227"]},{"raw_affiliation_string":"School of Biomedical Sciences, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210137227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073049066","display_name":"Sue Aspley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Aspley","raw_affiliation_strings":["Current address: Pharmaceutical Profiles Ltd, Nottingham NG11 6JS, U.K","Knoll Ltd, Pennyfoot St, Nottingham NG1 1GF"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Pharmaceutical Profiles Ltd, Nottingham NG11 6JS, U.K","institution_ids":[]},{"raw_affiliation_string":"Knoll Ltd, Pennyfoot St, Nottingham NG1 1GF","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050639889","display_name":"Simon R. G. Beckett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210137227","display_name":"Queen's Medical Centre","ror":"https://ror.org/03ap6wx93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210137227"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S R G Beckett","raw_affiliation_strings":["School of Biomedical Sciences, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Sciences, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210137227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080308855","display_name":"Aaron M. D\u2019Antona","orcid":"https://orcid.org/0000-0003-0063-5594","observed_orcids":["https://orcid.org/0000-0003-0063-5594"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A M D'Antona","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269-3044, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269-3044, U.S.A","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030447237","display_name":"Debra A. Kendall","orcid":"https://orcid.org/0000-0002-4991-9953","observed_orcids":["https://orcid.org/0000-0002-4991-9953"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210137227","display_name":"Queen's Medical Centre","ror":"https://ror.org/03ap6wx93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210137227"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"D A Kendall","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269-3044, U.S.A","School of Biomedical Sciences, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269-3044, U.S.A","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"School of Biomedical Sciences, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210137227"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030447237","display_name":"Debra A. Kendall","orcid":"https://orcid.org/0000-0002-4991-9953","observed_orcids":["https://orcid.org/0000-0002-4991-9953"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]},{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210137227","display_name":"Queen's Medical Centre","ror":"https://ror.org/03ap6wx93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468","https://openalex.org/I4210137227"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"D A Kendall","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269-3044, U.S.A","School of Biomedical Sciences, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269-3044, U.S.A","institution_ids":["https://openalex.org/I140172145"]},{"raw_affiliation_string":"School of Biomedical Sciences, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210137227"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050433553"],"corresponding_institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210137227"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":8.4743,"has_fulltext":true,"cited_by_count":177,"citation_normalized_percentile":{"value":0.98206426,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"141","issue":"2","first_page":"253","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oleamide","display_name":"oleamide","score":0.871999979019165},{"id":"https://openalex.org/keywords/endocannabinoids","display_name":"endocannabinoids","score":0.7039999961853027},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cb2-receptor","display_name":"CB2 receptor","score":1.0},{"id":"https://openalex.org/keywords/arachidonoyl-ethanolamide","display_name":"arachidonoyl ethanolamide","score":0.7770000100135803},{"id":"https://openalex.org/keywords/fatty-acid-amides","display_name":"fatty acid amides","score":0.8450000286102295},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.5899999737739563},{"id":"https://openalex.org/keywords/gtpgammas-binding","display_name":"GTPgammaS binding","score":0.6539999842643738},{"id":"https://openalex.org/keywords/cp-55-940","display_name":"CP55,940","score":0.7710000276565552},{"id":"https://openalex.org/keywords/sr141716a","display_name":"SR141716A","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C2778684643","wikidata":"https://www.wikidata.org/wiki/Q5514740","display_name":"GTPgammaS","level":4,"score":0.9457446336746216},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.60451340675354},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.5611377954483032},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5408331751823425},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.5120535492897034},{"id":"https://openalex.org/C2780433416","wikidata":"https://www.wikidata.org/wiki/Q5032579","display_name":"Cannabinoid receptor antagonist","level":5,"score":0.47642573714256287},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.46340322494506836},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46048885583877563},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33894819021224976}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009829","descriptor_name":"Oleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009829","descriptor_name":"Oleic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043884","descriptor_name":"Receptor, Cannabinoid, CB1","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063385","descriptor_name":"Cannabinoid Receptor Modulators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063385","descriptor_name":"Cannabinoid Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjp.0705607","doi":"https://doi.org/10.1038/sj.bjp.0705607","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0705607","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0705607","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1574194","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1574194","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:14707029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14707029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1038/sj.bjp.0705607","doi":"https://doi.org/10.1038/sj.bjp.0705607","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0705607","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0705607","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8267340761","display_name":"Determinants of the Cannabinoid Receptor Life Cycle","funder_award_id":"R01DA020763","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103297906.pdf","grobid_xml":"https://content.openalex.org/works/W2103297906.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W190123861","https://openalex.org/W1506258765","https://openalex.org/W1651476949","https://openalex.org/W1830687359","https://openalex.org/W1844090762","https://openalex.org/W1931308193","https://openalex.org/W1935108555","https://openalex.org/W1936589897","https://openalex.org/W1943648506","https://openalex.org/W1950723000","https://openalex.org/W1966231083","https://openalex.org/W1975161769","https://openalex.org/W1976899484","https://openalex.org/W1977107035","https://openalex.org/W1981936285","https://openalex.org/W1989073099","https://openalex.org/W1991461690","https://openalex.org/W1992388910","https://openalex.org/W1992753989","https://openalex.org/W2000082939","https://openalex.org/W2010227307","https://openalex.org/W2015614945","https://openalex.org/W2025509480","https://openalex.org/W2030623240","https://openalex.org/W2031823540","https://openalex.org/W2042544913","https://openalex.org/W2046614626","https://openalex.org/W2049770492","https://openalex.org/W2053209637","https://openalex.org/W2059784467","https://openalex.org/W2059997087","https://openalex.org/W2064685985","https://openalex.org/W2064876535","https://openalex.org/W2065793570","https://openalex.org/W2071631452","https://openalex.org/W2073999787","https://openalex.org/W2075362359","https://openalex.org/W2094600724","https://openalex.org/W2098730433","https://openalex.org/W2099292182","https://openalex.org/W2100338555","https://openalex.org/W2104449978","https://openalex.org/W2115202208","https://openalex.org/W2115754584","https://openalex.org/W2128635872","https://openalex.org/W2129714107","https://openalex.org/W2131054307","https://openalex.org/W2139261360","https://openalex.org/W2156019215","https://openalex.org/W2418870034","https://openalex.org/W2748647222"],"related_works":["https://openalex.org/W2104449978","https://openalex.org/W2062217246","https://openalex.org/W2005295755","https://openalex.org/W1604739454","https://openalex.org/W1950723000","https://openalex.org/W2071631452","https://openalex.org/W2069460649","https://openalex.org/W2807695993","https://openalex.org/W1651476949","https://openalex.org/W2057054987"],"abstract_inverted_index":{"1.":[0],"The":[1,205],"ability":[2],"of":[3,28,47,75,99,122,143,145,157,165,208,220,223,302,318],"the":[4,29,35,193,233,316,325],"endogenous":[5],"fatty":[6,311],"acid":[7,312],"amide,":[8],"cis-oleamide":[9],"(ODA),":[10],"to":[11,13,40,173,181,229,299,310],"bind":[12],"and":[14,18,34,55,237,269,305],"activate":[15],"cannabinoid":[16,31,292],"CB(1)":[17,37,91,195,293,326],"CB(2)":[19,107],"receptors":[20,304],"was":[21,190,216,260,270],"investigated.":[22],"2.":[23],"ODA":[24,84,115,126,185,240,288,319],"competitively":[25,85],"inhibited":[26,65,86,244],"binding":[27,67,88,129,153,177,189,211],"nonselective":[30],"agonist":[32],"[(3)H]CP55,940":[33,66,87,123],"selective":[36,194],"antagonist":[38,196],"[(3)H]SR141716A":[39],"rat":[41,69,213],"whole-brain":[42,70],"membranes":[43,71,94],"with":[44,72,95,140,154,275],"K(i)":[45,74,97],"values":[46],"1.14":[48],"microm":[49,57,101,114,135,159,265],"(0.52-2.53":[50],"microm,":[51,59,103,161],"Hill":[52,60,80],"slope=0.80,":[53],"n=6)":[54],"2.63":[56],"(0.62-11.20":[58],"slope=0.92,":[61],"n=4),":[62],"respectively.":[63],"AEA":[64,150],"in":[68,89,130,212,232,250,297],"a":[73,96,118,131,290],"428":[76],"nm":[77,199],"(346-510":[78],"nm,":[79],"slope=-1.33,":[81],"n=3).":[82],"3.":[83],"human":[90,106],"(hCB(1))":[92],"cell":[93,111],"value":[98],"8.13":[100],"(4.97-13.32":[102],"n=2).":[104],"In":[105],"transfected":[108],"(hCB(2))":[109],"HEK-293T":[110],"membranes,":[112],"100":[113,148,182],"produced":[116],"only":[117],"partial":[119],"(42.5+/-7%)":[120],"inhibition":[121,259],"binding.":[124],"4.":[125],"stimulated":[127,151],"[(35)S]GTPgammaS":[128,152,176,188,210],"concentration-dependent":[132],"manner":[133],"(EC(50)=1.64":[134],"(0.29-9.32":[136],"microm),":[137],"R(2)=0.99,":[138],"n=4-9),":[139],"maximal":[141],"stimulation":[142],"188+/-9%":[144],"basal":[146,166],"at":[147,167,178],"microm.":[149,183],"an":[155],"EC(50)":[156],"10.43":[158],"(4.45-24.42":[160],"R(2)=1.00,":[162,202],"n=3,":[163],"195+/-4%":[164],"300":[168,276],"microm).":[169],"Trans-oleamide":[170],"(trans-ODA)":[171],"failed":[172],"significantly":[174,243],"stimulate":[175],"concentrations":[179],"up":[180],"5.":[184],"(10":[186,241],"microm)-stimulated":[187],"reversed":[191,262,272],"by":[192,263,273],"SR141716A":[197,266],"(IC(50)=2.11":[198],"(0.32-13.77":[200],"nm),":[201],"n=6).":[203,282],"6.":[204],"anatomical":[206],"distribution":[207],"ODA-stimulated":[209],"brain":[214],"sections":[215],"indistinguishable":[217],"from":[218],"that":[219,287],"HU210.":[221],"Increases":[222],"similar":[224],"magnitude":[225],"were":[226],"observed":[227],"due":[228,309],"both":[230],"agonists":[231],"striatum,":[234],"cortex,":[235],"hippocampus":[236],"cerebellum.":[238],"7.":[239],"microm)":[242],"forskolin-stimulated":[245],"cyclic":[246],"AMP":[247],"(cAMP)":[248],"accumulation":[249],"mouse":[251],"neuroblastoma":[252],"N1E":[253],"115":[254],"cells":[255],"(P=0.02,":[256],"n=11).":[257],"ODA-mediated":[258],"completely":[261],"1":[264],"(P<0.001,":[267,281],"n=11)":[268],"also":[271],"pretreatment":[274],"ng":[277],"ml(-1)":[278],"pertussis":[279],"toxin":[280],"8.":[283],"These":[284],"data":[285],"demonstrate":[286],"is":[289],"full":[291],"receptor":[294],"agonist.":[295],"Therefore,":[296],"addition":[298],"allosteric":[300],"modulation":[301],"other":[303],"possible":[306],"entourage":[307],"effects":[308,317],"amide":[313],"hydrolase":[314],"inhibition,":[315],"may":[320],"be":[321],"mediated":[322],"directly":[323],"via":[324],"receptor.":[327]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
