{"id":"https://openalex.org/W2103288295","doi":"https://doi.org/10.1128/jvi.77.13.7492-7501.2003","title":"Comprehensive Screening Reveals Strong and Broadly Directed Human Immunodeficiency Virus Type 1-Specific CD8 Responses in Perinatally Infected Children","display_name":"Comprehensive Screening Reveals Strong and Broadly Directed Human Immunodeficiency Virus Type 1-Specific CD8 Responses in Perinatally Infected Children","publication_year":2003,"publication_date":"2003-06-13","ids":{"openalex":"https://openalex.org/W2103288295","doi":"https://doi.org/10.1128/jvi.77.13.7492-7501.2003","mag":"2103288295","pmid":"https://pubmed.ncbi.nlm.nih.gov/12805449","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/164781"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.77.13.7492-7501.2003","doi":"https://doi.org/10.1128/jvi.77.13.7492-7501.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.77.13.7492-7501.2003","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/164781","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064818425","display_name":"Margaret E. Feeney","orcid":"https://orcid.org/0000-0002-2515-2989","observed_orcids":["https://orcid.org/0000-0002-2515-2989"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. E. Feeney","raw_affiliation_strings":["Children's Hospital, Boston, Massachusetts","Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073442241","display_name":"Kathleen A. Roosevelt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. A. Roosevelt","raw_affiliation_strings":["Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103005254","display_name":"Yanhua Tang","orcid":"https://orcid.org/0000-0001-6567-2455","observed_orcids":["https://orcid.org/0000-0001-6567-2455"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Tang","raw_affiliation_strings":["Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065065049","display_name":"Katja J. Pfafferott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. J. Pfafferott","raw_affiliation_strings":["Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018848119","display_name":"Kenneth McIntosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. McIntosh","raw_affiliation_strings":["Children's Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035191354","display_name":"Sandra K. Burchett","orcid":"https://orcid.org/0000-0002-7106-9262","observed_orcids":["https://orcid.org/0000-0002-7106-9262"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. K. Burchett","raw_affiliation_strings":["Children's Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018725181","display_name":"Charlotte Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Mao","raw_affiliation_strings":["Children's Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016518899","display_name":"Bruce D. Walker","orcid":"https://orcid.org/0000-0001-6122-9245","observed_orcids":["https://orcid.org/0000-0001-6122-9245","https://orcid.org/0000-0002-8506-6740"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. D. Walker","raw_affiliation_strings":["Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043346206","display_name":"Philip Goulder","orcid":"https://orcid.org/0000-0002-9842-4674","observed_orcids":["https://orcid.org/0000-0002-9842-4674"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"P. J. R. Goulder","raw_affiliation_strings":["Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom","Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2802742124","https://openalex.org/I40120149"]},{"raw_affiliation_string":"Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5043346206"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2802742124","https://openalex.org/I40120149","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":1.5831,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.80854389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"77","issue":"13","first_page":"7492","last_page":"7501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.8899999856948853},{"id":"https://openalex.org/keywords/perinatal-hiv-infection","display_name":"perinatal HIV infection","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cd8-t-cell-responses","display_name":"CD8+ T cell responses","score":0.777999997138977},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.6669999957084656},{"id":"https://openalex.org/keywords/epitope-breadth","display_name":"epitope breadth","score":0.7990000247955322},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.871999979019165},{"id":"https://openalex.org/keywords/viremia-suppression","display_name":"viremia suppression","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hla-class-i-restriction","display_name":"HLA class I restriction","score":0.7179999947547913},{"id":"https://openalex.org/keywords/gag","display_name":"Gag","score":0.6510000228881836},{"id":"https://openalex.org/keywords/pediatric-hiv","display_name":"pediatric HIV","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.796872615814209},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7761033773422241},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.7748146057128906},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6282771229743958},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6007763147354126},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5802236199378967},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5215620398521423},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.47555631399154663},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2556883692741394}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018445","descriptor_name":"Infectious Disease Transmission, Vertical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.77.13.7492-7501.2003","doi":"https://doi.org/10.1128/jvi.77.13.7492-7501.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.77.13.7492-7501.2003","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:164781","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/164781","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:12805449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12805449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:164781","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/164781","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2446437262","display_name":null,"funder_award_id":"K30-HL004095","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3028157465","display_name":null,"funder_award_id":"K30HL04095","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3307332419","display_name":"Immune Control of HIV in Children","funder_award_id":"K23AI052078","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4244284161","display_name":"SCHOLARS IN CLINICAL SCIENCE PROGRAM","funder_award_id":"5k30hl004095-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4894865959","display_name":"HIV 1 SPECIFIC T CELL CLONES","funder_award_id":"R37AI028568","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7990289701","display_name":"Optimizing CD8+ T-cell responses against C clade HIV infection in subSaharan Afri","funder_award_id":"R01AI046995","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8352642115","display_name":"HIV 1 specific T cell clones","funder_award_id":"R01AI028568","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000053683","display_name":null,"funder_award_id":"AI28568","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G908117665","display_name":null,"funder_award_id":"AI 28568","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320307584","display_name":"Elizabeth Glaser Pediatric AIDS Foundation","ror":"https://ror.org/00vzqmg54"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1580217007","https://openalex.org/W1606271020","https://openalex.org/W1612382123","https://openalex.org/W1655510925","https://openalex.org/W1789164989","https://openalex.org/W1815763197","https://openalex.org/W1971771720","https://openalex.org/W2001573744","https://openalex.org/W2003437497","https://openalex.org/W2006420804","https://openalex.org/W2006430661","https://openalex.org/W2011646391","https://openalex.org/W2012139740","https://openalex.org/W2027729283","https://openalex.org/W2039293710","https://openalex.org/W2039751597","https://openalex.org/W2049552324","https://openalex.org/W2053719303","https://openalex.org/W2057175548","https://openalex.org/W2064502505","https://openalex.org/W2067560365","https://openalex.org/W2081825634","https://openalex.org/W2085919513","https://openalex.org/W2086104438","https://openalex.org/W2103182811","https://openalex.org/W2108381430","https://openalex.org/W2112601022","https://openalex.org/W2113983720","https://openalex.org/W2118971416","https://openalex.org/W2124969212","https://openalex.org/W2126156212","https://openalex.org/W2127300645","https://openalex.org/W2127344222","https://openalex.org/W2129114331","https://openalex.org/W2129257965","https://openalex.org/W2141782947","https://openalex.org/W2144040832","https://openalex.org/W2144882745","https://openalex.org/W2151651155","https://openalex.org/W2158715415","https://openalex.org/W2160538807","https://openalex.org/W2161134901","https://openalex.org/W2161207924","https://openalex.org/W2161542073","https://openalex.org/W2338548517","https://openalex.org/W4245198128"],"related_works":["https://openalex.org/W2035259223","https://openalex.org/W2052593262","https://openalex.org/W1527202588","https://openalex.org/W2306000142","https://openalex.org/W1838993423","https://openalex.org/W2142124450","https://openalex.org/W2127344222","https://openalex.org/W2112475246","https://openalex.org/W2295452886","https://openalex.org/W2176256376"],"abstract_inverted_index":{"Advances":[0],"in":[1,18,52,63,69,80,115,140,169,176,202,253],"antiviral":[2,96],"therapy":[3],"have":[4,65],"dramatically":[5],"shifted":[6],"the":[7,19,55,137,166,188,194,213,265],"demographics":[8],"of":[9,26,39,60,76,92,123,127,151,212,259],"pediatric":[10],"human":[11],"immunodeficiency":[12],"virus":[13],"type":[14],"1":[15],"(HIV-1)":[16],"infection":[17],"developed":[20],"world,":[21],"and":[22,58,104,118,159,193,250,255],"a":[23,73,121,209,238],"growing":[24],"proportion":[25,168],"perinatally":[27,82,231],"HIV-1-infected":[28],"children":[29,84,178,233,276],"are":[30,47],"now":[31],"entering":[32],"their":[33],"second":[34],"or":[35,220],"even":[36,175],"third":[37],"decade":[38],"life.":[40],"Although":[41],"cellular":[42],"immune":[43],"responses":[44,61,79,112,144],"to":[45,49,88,125,136,156,257,267,270],"HIV":[46],"known":[48],"be":[50,268],"weak":[51],"early":[53],"infancy,":[54],"magnitude,":[56],"breadth,":[57],"specificity":[59],"later":[62],"childhood":[64],"not":[66],"been":[67],"characterized":[68],"detail.":[70],"We":[71],"performed":[72],"comprehensive":[74],"characterization":[75],"HIV-1-specific":[77,240],"CD8":[78,143,241],"18":[81],"infected":[83,232],"(age":[85],"range,":[86],"6":[87],"17":[89],"years),":[90],"most":[91],"whom":[93],"were":[94,113,145,172,199],"on":[95,182],"therapy,":[97,186],"using":[98],"both":[99],"previously":[100,248],"defined":[101,217],"HIV-1":[102,109,163,214],"epitopes":[103,153,216],"overlapping":[105],"peptides":[106],"spanning":[107],"all":[108,116,128,162],"proteins.":[110],"Multispecific":[111],"detected":[114,174],"subjects":[117],"accounted":[119],"for":[120,218,279],"median":[122],"0.25":[124],"0.3%":[126],"peripheral":[129],"blood":[130],"mononuclear":[131],"cells":[132],"that":[133,230,243,258],"was":[134],"similar":[135],"magnitude":[138,195,254],"seen":[139],"HIV-infected":[141],"adults.":[142,260],"broadly":[146],"directed":[147],"at":[148],"an":[149],"average":[150],"11":[152],"(range,":[154],"2":[155],"27":[157],"epitopes)":[158],"targeted":[160],"nearly":[161],"proteins,":[164],"with":[165,179],"highest":[167],"Gag.":[170],"Responses":[171],"readily":[173],"those":[177],"suppressed":[180],"viremia":[181],"highly":[183],"active":[184],"antiretroviral":[185],"although":[187],"breadth":[189,256],"(P":[190,196],"=":[191,197],"0.037)":[192],"0.021)":[198],"significantly":[200],"lower":[201],"these":[203,227,275],"subjects.":[204],"Each":[205],"child":[206],"recognized":[207],"only":[208],"small":[210],"minority":[211],"optimal":[215],"his":[219],"her":[221],"class":[222],"I":[223],"HLA":[224],"alleles.":[225],"Together,":[226],"data":[228],"indicate":[229],"who":[234],"survive":[235],"infancy":[236],"mount":[237],"robust":[239],"response":[242,263],"is":[244,251],"much":[245],"stronger":[246],"than":[247],"thought":[249],"comparable":[252],"Moreover,":[261],"this":[262],"has":[264],"potential":[266],"broadened":[269],"target":[271],"more":[272],"epitopes,":[273],"making":[274],"attractive":[277],"candidates":[278],"immunotherapeutic":[280],"interventions.":[281]},"counts_by_year":[{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
