{"id":"https://openalex.org/W2103245014","doi":"https://doi.org/10.1080/03639040701842485","title":"Development of Nitrendipine Controlled Release Formulations Based on SLN and NLC for Topical Delivery: In Vitro and Ex Vivo Characterization","display_name":"Development of Nitrendipine Controlled Release Formulations Based on SLN and NLC for Topical Delivery: In Vitro and Ex Vivo Characterization","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2103245014","doi":"https://doi.org/10.1080/03639040701842485","mag":"2103245014","pmid":"https://pubmed.ncbi.nlm.nih.gov/18612912"},"language":"en","primary_location":{"id":"doi:10.1080/03639040701842485","doi":"https://doi.org/10.1080/03639040701842485","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03639040701842485","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103451729","display_name":"Kesavan Bhaskar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138876546","display_name":"Vels University","ror":"https://ror.org/00tscx035","country_code":"IN","type":"education","lineage":["https://openalex.org/I138876546"]},{"id":"https://openalex.org/I28210344","display_name":"Kakatiya University","ror":"https://ror.org/012zpbg81","country_code":"IN","type":"education","lineage":["https://openalex.org/I28210344"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kesavan Bhaskar","raw_affiliation_strings":["Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India. bhaskurra@yahoo.com","Department of Pharmaceutics, Vel's College of Pharmacy, Velan Nagar, Pallavaram, Chennai, Tamil Nadu, India","Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India. bhaskurra@yahoo.com","institution_ids":["https://openalex.org/I28210344"]},{"raw_affiliation_string":"Department of Pharmaceutics, Vel's College of Pharmacy, Velan Nagar, Pallavaram, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I138876546"]},{"raw_affiliation_string":"Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India","institution_ids":["https://openalex.org/I28210344"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chinnala Krishna Mohan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28210344","display_name":"Kakatiya University","ror":"https://ror.org/012zpbg81","country_code":"IN","type":"education","lineage":["https://openalex.org/I28210344"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chinnala Krishna Mohan","raw_affiliation_strings":["Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India","institution_ids":["https://openalex.org/I28210344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024038819","display_name":"Meka Lingam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28210344","display_name":"Kakatiya University","ror":"https://ror.org/012zpbg81","country_code":"IN","type":"education","lineage":["https://openalex.org/I28210344"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Meka Lingam","raw_affiliation_strings":["Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India","institution_ids":["https://openalex.org/I28210344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054283781","display_name":"Prabhakar Reddy Veerareddy","orcid":"https://orcid.org/0000-0002-8973-6692","observed_orcids":["https://orcid.org/0000-0002-8973-6692"]},"institutions":[{"id":"https://openalex.org/I28210344","display_name":"Kakatiya University","ror":"https://ror.org/012zpbg81","country_code":"IN","type":"education","lineage":["https://openalex.org/I28210344"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Veerareddy Prabhakar Reddy","raw_affiliation_strings":["Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India","institution_ids":["https://openalex.org/I28210344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017473916","display_name":"Vobalaboina Venkateswarlu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28210344","display_name":"Kakatiya University","ror":"https://ror.org/012zpbg81","country_code":"IN","type":"education","lineage":["https://openalex.org/I28210344"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vobalaboina Venkateswarlu","raw_affiliation_strings":["Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India","institution_ids":["https://openalex.org/I28210344"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100920710","display_name":"Yamsani Madhusudan Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28210344","display_name":"Kakatiya University","ror":"https://ror.org/012zpbg81","country_code":"IN","type":"education","lineage":["https://openalex.org/I28210344"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yamsani Madhusudan Rao","raw_affiliation_strings":["Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novel Drug Delivery Systems Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India","institution_ids":["https://openalex.org/I28210344"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8937,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.68220782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"34","issue":"7","first_page":"719","last_page":"725"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrendipine","display_name":"nitrendipine","score":1.0},{"id":"https://openalex.org/keywords/solid-lipid-nanoparticles","display_name":"solid lipid nanoparticles","score":0.9710000157356262},{"id":"https://openalex.org/keywords/nanostructured-lipid-carriers","display_name":"nanostructured lipid carriers","score":0.9599999785423279},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.9520000219345093},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.7860000133514404},{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/drug-release-kinetics","display_name":"drug release kinetics","score":0.6039999723434448},{"id":"https://openalex.org/keywords/higuchi-kinetics","display_name":"Higuchi model","score":0.8669999837875366},{"id":"https://openalex.org/keywords/weibull-model","display_name":"Weibull model","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipophilic-drug-delivery","display_name":"lipophilic drug delivery","score":0.6100000143051147},{"id":"https://openalex.org/keywords/rat-skin","display_name":"rat skin","score":0.44699999690055847},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.781000018119812},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.7437217235565186},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.713547945022583},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.6713720560073853},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.590168297290802},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5674392580986023},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.5648939609527588},{"id":"https://openalex.org/C2780548744","wikidata":"https://www.wikidata.org/wiki/Q416584","display_name":"Nitrendipine","level":3,"score":0.48970940709114075},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.46560364961624146},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.45627278089523315},{"id":"https://openalex.org/C104628117","wikidata":"https://www.wikidata.org/wiki/Q3964828","display_name":"Sonication","level":2,"score":0.4329732656478882},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4159308671951294},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.3970385491847992},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.33945396542549133},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26822444796562195},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.26761895418167114},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.24763476848602295},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.21802890300750732},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11227494478225708},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10366946458816528},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0816100537776947},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004356","descriptor_name":"Drug Storage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009568","descriptor_name":"Nitrendipine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009568","descriptor_name":"Nitrendipine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013010","descriptor_name":"Sonication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/03639040701842485","doi":"https://doi.org/10.1080/03639040701842485","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03639040701842485","pdf_url":null,"source":{"id":"https://openalex.org/S162444473","display_name":"Drug Development and Industrial Pharmacy","issn_l":"0363-9045","issn":["0363-9045","1520-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Development and Industrial Pharmacy","raw_type":"journal-article"},{"id":"pmid:18612912","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18612912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development and industrial pharmacy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W37840549","https://openalex.org/W116002160","https://openalex.org/W137791175","https://openalex.org/W1569663436","https://openalex.org/W1955706623","https://openalex.org/W1989492660","https://openalex.org/W2011607617","https://openalex.org/W2034579556","https://openalex.org/W2054189154","https://openalex.org/W2054297002","https://openalex.org/W2054321199","https://openalex.org/W2081699252","https://openalex.org/W2115439624","https://openalex.org/W2115547163","https://openalex.org/W2142404968","https://openalex.org/W2146408988","https://openalex.org/W2151782404","https://openalex.org/W2156878630"],"related_works":["https://openalex.org/W3025509433","https://openalex.org/W2081785971","https://openalex.org/W2358638332","https://openalex.org/W4400586841","https://openalex.org/W4384024588","https://openalex.org/W2406630098","https://openalex.org/W4389054170","https://openalex.org/W3085674930","https://openalex.org/W1980884204","https://openalex.org/W769857814"],"abstract_inverted_index":{"The":[0,77,101,163,188,217,246,261,301],"aim":[1],"of":[2,22,59,86,97,129,135,161,166,200,214,249],"the":[3,56,118,127,142,151,198,277,282,318],"investigation":[4],"is":[5,251],"to":[6,174,233,255],"develop":[7],"solid":[8],"lipid":[9,14,202],"nanoparticles":[10,203],"(SLN)":[11],"and":[12,27,38,50,64,83,93,123,149,178,185,229,243,253,258,273,311],"nano-structured":[13],"carrier":[15],"(NLC)":[16],"as":[17,204],"carriers":[18],"for":[19,42,180,208,266,285],"topical":[20],"delivery":[21],"nitrendipine":[23],"(NDP).":[24],"NDP-loaded":[25],"SLN":[26],"NLC":[28],"were":[29,40,66,88,125,231,264],"prepared":[30],"by":[31,36,106],"hot":[32],"homogenization":[33],"technique":[34],"followed":[35],"sonication,":[37],"they":[39],"characterized":[41],"particle":[43,102],"size,":[44],"zeta":[45,113],"potential,":[46],"entrapment":[47,152],"efficiency,":[48],"stability,":[49],"in":[51,68,126,192,221,241],"vitro":[52,193,222],"release":[53,168,194,206,223,247],"profiles.":[54],"Also":[55],"percutaneous":[57],"permeation":[58,81,262],"NDPSLN":[60,62,119,121,147,181,183,225,227,269,271,305],"A,":[61,120,146,182,226,270],"B,":[63,122,148,184,228,272],"NDPNLC":[65,124,230,280,312],"investigated":[67],"abdominal":[69],"rat":[70],"skin":[71],"using":[72,111],"modified":[73,205],"Franz":[74],"diffusion":[75],"cells.":[76],"steady":[78],"state":[79],"flux,":[80],"coefficient,":[82],"lag":[84],"time":[85],"NDP":[87,286],"estimated":[89],"over":[90,211,295],"24":[91,170,215],"h":[92,171],"compared":[94],"with":[95,304],"that":[96,117],"control":[98,296],"(NDP":[99],"solution).":[100],"size":[103],"was":[104,154,172,239,293],"analyzed":[105,252],"photon":[107],"correlation":[108,238],"spectroscopy":[109],"(PCS)":[110],"Malvern":[112],"sizer,":[114],"which":[115,292],"shows":[116],"range":[128],"124-300":[130],"nm":[131],"during":[132],"90":[133,159],"days":[134,160],"storage":[136],"at":[137,169],"room":[138],"temperature.":[139],"For":[140],"all":[141,267,276],"tested":[143],"formulations":[144,207],"(NDPSLN":[145],"NDPNLC),":[150],"efficiency":[153],"higher":[155],"than":[156],"75%":[157],"after":[158],"storage.":[162],"cumulative":[164],"percentage":[165],"drug":[167,210,250],"found":[173,254],"be":[175],"26.21,":[176],"30.81,":[177],"37.52":[179],"NDPNLC,":[186],"respectively.":[187],"results":[189],"obtained":[190,219,240,265,303],"from":[191,220,224],"profiles":[195,263],"also":[196],"indicated":[197],"use":[199],"these":[201],"lipophilic":[209],"a":[212],"period":[213],"h.":[216],"data":[218],"fitted":[232],"various":[234],"kinetic":[235],"models.":[236],"High":[237],"Higuchi":[242,259],"Weibull":[244,257],"model.":[245],"pattern":[248],"follow":[256],"equations.":[260],"formulations:":[268],"NDPNLC.":[274],"Of":[275],"three":[278],"formulations,":[279],"provided":[281],"greatest":[283],"enhancement":[284],"flux":[287,302,320],"(21.485":[288,313],"+/-":[289,298,308,314],"2.82":[290,315],"microg/h/cm(2)),":[291],"fourfold":[294],"(4.881":[297],"0.96":[299],"microg/h/cm(2)).":[300,322],"B":[306],"(16.983":[307],"2.91":[309],"microg/h/cm(2))":[310,316],"meets":[317],"required":[319],"(16.85":[321]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}