{"id":"https://openalex.org/W2103243265","doi":"https://doi.org/10.1101/sqb.2002.67.285","title":"Targeted Delivery of Mutant Raf Kinase to Neovessels Causes Tumor Regression","display_name":"Targeted Delivery of Mutant Raf Kinase to Neovessels Causes Tumor Regression","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2103243265","doi":"https://doi.org/10.1101/sqb.2002.67.285","mag":"2103243265","pmid":"https://pubmed.ncbi.nlm.nih.gov/12858551"},"language":"en","primary_location":{"id":"doi:10.1101/sqb.2002.67.285","doi":"https://doi.org/10.1101/sqb.2002.67.285","is_oa":false,"landing_page_url":"https://doi.org/10.1101/sqb.2002.67.285","pdf_url":null,"source":{"id":"https://openalex.org/S78756772","display_name":"Cold Spring Harbor Symposia on Quantitative Biology","issn_l":"0091-7451","issn":["0091-7451","1943-4456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Symposia on Quantitative Biology","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109426437","display_name":"John D. Hood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.D. HOOD","raw_affiliation_strings":["Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089796560","display_name":"David A. Cheresh","orcid":"https://orcid.org/0000-0002-7193-8595","observed_orcids":["https://orcid.org/0000-0002-7193-8595"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.A. CHERESH","raw_affiliation_strings":["The Scripps Research Institute, Departments of Immunology, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, Departments of Immunology, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":"0","first_page":"285","last_page":"292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/raf-kinase","display_name":"Raf kinase","score":0.7950000166893005},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.6389999985694885},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.9610000252723694},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.9539999961853027},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.8399999737739563},{"id":"https://openalex.org/keywords/vegf-signaling","display_name":"VEGF signaling","score":0.7129999995231628},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7654332518577576},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5770347714424133},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5617644786834717},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.506841242313385},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4858793616294861},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4649556577205658},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.45012688636779785},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44780150055885315},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3911758363246918},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3669027090072632},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31352996826171875},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.24791043996810913},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11717593669891357},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10923466086387634}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019908","descriptor_name":"Proto-Oncogene Proteins c-raf","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019908","descriptor_name":"Proto-Oncogene Proteins c-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1101/sqb.2002.67.285","doi":"https://doi.org/10.1101/sqb.2002.67.285","is_oa":false,"landing_page_url":"https://doi.org/10.1101/sqb.2002.67.285","pdf_url":null,"source":{"id":"https://openalex.org/S78756772","display_name":"Cold Spring Harbor Symposia on Quantitative Biology","issn_l":"0091-7451","issn":["0091-7451","1943-4456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor Symposia on Quantitative Biology","raw_type":"journal-article"},{"id":"pmid:12858551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12858551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cold Spring Harbor symposia on quantitative biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1570734769","https://openalex.org/W1610515357","https://openalex.org/W1666849257","https://openalex.org/W1740440689","https://openalex.org/W1969762227","https://openalex.org/W1980855212","https://openalex.org/W1985737377","https://openalex.org/W1989979780","https://openalex.org/W1990036692","https://openalex.org/W1994014733","https://openalex.org/W1995819749","https://openalex.org/W1996537616","https://openalex.org/W1997656209","https://openalex.org/W1998777645","https://openalex.org/W2001753204","https://openalex.org/W2003470252","https://openalex.org/W2004891705","https://openalex.org/W2018206586","https://openalex.org/W2030413647","https://openalex.org/W2037758170","https://openalex.org/W2039317622","https://openalex.org/W2041687747","https://openalex.org/W2043852940","https://openalex.org/W2050085273","https://openalex.org/W2063145905","https://openalex.org/W2064644581","https://openalex.org/W2068365812","https://openalex.org/W2073308580","https://openalex.org/W2074830112","https://openalex.org/W2077090481","https://openalex.org/W2093410560","https://openalex.org/W2103963843","https://openalex.org/W2109069224","https://openalex.org/W2114902150","https://openalex.org/W2116071714","https://openalex.org/W2123759534","https://openalex.org/W2130561652","https://openalex.org/W2131798870","https://openalex.org/W2133527571","https://openalex.org/W2143678301","https://openalex.org/W2149064406","https://openalex.org/W2171596565","https://openalex.org/W4213141530","https://openalex.org/W4249688612"],"related_works":["https://openalex.org/W1514050185","https://openalex.org/W4763225","https://openalex.org/W2152525228","https://openalex.org/W2151450478","https://openalex.org/W2090763994","https://openalex.org/W2157663078","https://openalex.org/W2050085273","https://openalex.org/W2516580226","https://openalex.org/W2919916331","https://openalex.org/W1992215422"],"abstract_inverted_index":{"Endothelial":[0],"cells":[1,64,102],"are":[2],"the":[3,50,55,58,81,95,98,141],"key":[4],"regulators":[5],"of":[6,17,21,33,57,75,83,100,143,165],"vasculartone,":[7],"permeability,":[8],"and":[9,42,46,79,149,156,162],"neovascular":[10],"growth.":[11],"Because":[12],"ofthe":[13],"enormous":[14],"biological":[15],"impact":[16],"these":[18,166],"processes,":[19],"theregulation":[20],"endothelial":[22,63,76,101],"cell":[23,77],"function":[24],"represents":[25],"a":[26,30,111,152],"keytherapeutic":[27],"target":[28],"in":[29,107,159],"wide":[31],"array":[32],"diseases":[34],"ranging":[35],"fromovert":[36],"vascular":[37,133],"diseases,":[38],"such":[39,122],"as":[40,123],"hypertension":[41],"stroke,to":[43],"tumor":[44],"growth":[45,157],"metastases.":[47],"As":[48],"such,":[49],"focus":[51],"ofmany":[52],"laboratories":[53],"is":[54],"elucidation":[56],"signal":[59],"transduction":[60],"pathways":[61],"within":[62],"which":[65],"regulatetheir":[66],"behavior.":[67],"This":[68],"has":[69,91,115],"contributed":[70],"to":[71,80,94,109,117],"an":[72],"enhanced":[73],"understanding":[74],"biology":[78],"discovery":[82],"novel":[84],"therapeutics":[85],"for":[86,154],"diseases.":[87],"Recently,":[88],"particular":[89],"attention":[90],"been":[92],"paid":[93],"processes":[96],"regulatingangiogenesis,":[97],"sprouting":[99],"from":[103,146],"apreexisting":[104],"blood":[105],"vessel":[106],"order":[108],"form":[110],"new":[112],"vessel.This":[113],"strategy":[114],"led":[116],"recent":[118,144],"clinical":[119],"successes":[120],"withcompounds":[121],"Avastin":[124],"(Langmuir":[125],"et":[126],"al.":[127],"2002),":[128],"amonoclonal":[129],"antibody":[130],"that":[131],"blocks":[132],"endothelialgrowth":[134],"factor":[135],"(VEGF)":[136],"signaling.":[137],"Here":[138],"we":[139],"examine":[140],"results":[142],"studies":[145],"our":[147],"laboratory":[148],"others":[150],"revealing":[151],"role":[153],"integrins":[155],"factors":[158],"regulating":[160],"angiogenesis":[161],"how":[163],"modulation":[164],"moleculesand":[167],"their":[168],"downstream":[169],"signaling":[170],"might":[171],"be":[172],"used":[173],"therapeutically...":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}