{"id":"https://openalex.org/W2103227986","doi":"https://doi.org/10.1093/cercor/bhr360","title":"Multimodal MRI Analysis of the Corpus Callosum Reveals White Matter Differences in Presymptomatic and Early Huntington's Disease","display_name":"Multimodal MRI Analysis of the Corpus Callosum Reveals White Matter Differences in Presymptomatic and Early Huntington's Disease","publication_year":2012,"publication_date":"2012-01-05","ids":{"openalex":"https://openalex.org/W2103227986","doi":"https://doi.org/10.1093/cercor/bhr360","mag":"2103227986","pmid":"https://pubmed.ncbi.nlm.nih.gov/22223853"},"language":"en","primary_location":{"id":"doi:10.1093/cercor/bhr360","doi":"https://doi.org/10.1093/cercor/bhr360","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cercor/bhr360","pdf_url":null,"source":{"id":"https://openalex.org/S117898428","display_name":"Cerebral Cortex","issn_l":"1047-3211","issn":["1047-3211","1460-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral Cortex","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111787064","display_name":"Margherita Di Paola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26415053","display_name":"University of L'Aquila","ror":"https://ror.org/01j9p1r26","country_code":"IT","type":"education","lineage":["https://openalex.org/I26415053"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Di Paola","raw_affiliation_strings":["Laboratory of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy. m.dipaola@hsantalucia.it","Department of Internal Medicine and Public Health, University of L'Aquila, 67010 L'Aquila\u2014Coppito, Italy","Laboratory of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy. m.dipaola@hsantalucia.it","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Department of Internal Medicine and Public Health, University of L'Aquila, 67010 L'Aquila\u2014Coppito, Italy","institution_ids":["https://openalex.org/I26415053"]},{"raw_affiliation_string":"Laboratory of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109287808","display_name":"Eileen Luders A","orcid":"https://orcid.org/0000-0001-5659-992X","observed_orcids":["https://orcid.org/0000-0001-5659-992X","https://orcid.org/0000-0001-8273-7177"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Luders","raw_affiliation_strings":["Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029998334","display_name":"Andrea Cherubini","orcid":"https://orcid.org/0000-0002-5946-4390","observed_orcids":["https://orcid.org/0000-0002-5946-4390"]},"institutions":[{"id":"https://openalex.org/I4210120704","display_name":"Institute of Neurological Sciences","ror":"https://ror.org/01yg57d71","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210120704","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Cherubini","raw_affiliation_strings":["Neuroimaging Research Unit, Institute of Neurological Sciences, National Research Council, 88100 Catanzaro, Italy","Radiology Department, IRCCS Santa Lucia Foundation, 00179 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimaging Research Unit, Institute of Neurological Sciences, National Research Council, 88100 Catanzaro, Italy","institution_ids":["https://openalex.org/I4210120704","https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Radiology Department, IRCCS Santa Lucia Foundation, 00179 Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041613727","display_name":"Cristina S\u00e1nchez\u2010Casta\u00f1eda","orcid":"https://orcid.org/0000-0002-6827-9146","observed_orcids":["https://orcid.org/0000-0002-6827-9146"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES","IT"],"is_corresponding":false,"raw_author_name":"C. Sanchez-Castaneda","raw_affiliation_strings":["Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, 08036 Barcelona, Spain","Radiology Department, IRCCS Santa Lucia Foundation, 00179 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, 08036 Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Radiology Department, IRCCS Santa Lucia Foundation, 00179 Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867","observed_orcids":["https://orcid.org/0000-0002-4720-8867","https://orcid.org/0000-0003-2476-2803","https://orcid.org/0000-0002-2305-8438"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. M. Thompson","raw_affiliation_strings":["Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014949118","display_name":"Arthur W. Toga","orcid":"https://orcid.org/0000-0001-7902-3755","observed_orcids":["https://orcid.org/0000-0001-7902-3755","https://orcid.org/0000-0003-1454-8643"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. W. Toga","raw_affiliation_strings":["Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021425942","display_name":"Carlo Caltagirone","orcid":"https://orcid.org/0000-0002-0189-4515","observed_orcids":["https://orcid.org/0000-0002-0189-4515"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Caltagirone","raw_affiliation_strings":["Laboratory of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy","Neuroscience Department, University of Rome \u201cTor Vergata,\u201d 00133 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Neuroscience Department, University of Rome \u201cTor Vergata,\u201d 00133 Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075133114","display_name":"Sara Orobello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Orobello","raw_affiliation_strings":["Centre for Neurogenetics and Rare Diseases, IRCCS Neuromed, 86077 Pozzilli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurogenetics and Rare Diseases, IRCCS Neuromed, 86077 Pozzilli, Italy","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085222436","display_name":"Francesca Elifani","orcid":"https://orcid.org/0000-0002-0824-9543","observed_orcids":["https://orcid.org/0000-0002-0824-9543"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Elifani","raw_affiliation_strings":["Centre for Neurogenetics and Rare Diseases, IRCCS Neuromed, 86077 Pozzilli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurogenetics and Rare Diseases, IRCCS Neuromed, 86077 Pozzilli, Italy","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013512498","display_name":"Ferdinando Squitieri","orcid":"https://orcid.org/0000-0002-7397-1727","observed_orcids":["https://orcid.org/0000-0002-7397-1727"]},"institutions":[{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Squitieri","raw_affiliation_strings":["Centre for Neurogenetics and Rare Diseases, IRCCS Neuromed, 86077 Pozzilli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurogenetics and Rare Diseases, IRCCS Neuromed, 86077 Pozzilli, Italy","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048788146","display_name":"Umberto Sabatini","orcid":"https://orcid.org/0000-0001-5321-8626","observed_orcids":["https://orcid.org/0000-0001-5321-8626"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"U. Sabatini","raw_affiliation_strings":["Radiology Department, IRCCS Santa Lucia Foundation, 00179 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology Department, IRCCS Santa Lucia Foundation, 00179 Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5038,"currency":"USD","value_usd":5038},"apc_paid":null,"fwci":2.8997,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.91190377,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"22","issue":"12","first_page":"2858","last_page":"2866"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.10450000315904617,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/presymptomatic-huntington-s-disease","display_name":"presymptomatic Huntington's disease","score":0.9520000219345093},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.9980000257492065},{"id":"https://openalex.org/keywords/white-matter-injury","display_name":"white matter injury","score":0.7369999885559082},{"id":"https://openalex.org/keywords/myelin-damage","display_name":"myelin damage","score":0.8560000061988831},{"id":"https://openalex.org/keywords/axonal-injury","display_name":"axonal injury","score":0.9919999837875366},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.9710000157356262},{"id":"https://openalex.org/keywords/radial-diffusivity","display_name":"radial diffusivity","score":0.718999981880188},{"id":"https://openalex.org/keywords/axial-diffusivity","display_name":"axial diffusivity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/disease-burden","display_name":"disease burden","score":0.6079999804496765},{"id":"https://openalex.org/keywords/disease-progression-prediction","display_name":"disease progression prediction","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C2778183499","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Corpus callosum","level":2,"score":0.9152395129203796},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.7921390533447266},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.665815532207489},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.6450343132019043},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.6112890243530273},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5844953656196594},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.45084550976753235},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4494296908378601},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.44737374782562256},{"id":"https://openalex.org/C2776643646","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Splenium","level":4,"score":0.4275636076927185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3971022367477417},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3855639696121216},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.36141979694366455},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3299015164375305},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32259976863861084},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1889442801475525},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.16810369491577148}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003337","descriptor_name":"Corpus Callosum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009413","descriptor_name":"Nerve Fibers, Myelinated","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013382","descriptor_name":"Subtraction Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/cercor/bhr360","doi":"https://doi.org/10.1093/cercor/bhr360","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cercor/bhr360","pdf_url":null,"source":{"id":"https://openalex.org/S117898428","display_name":"Cerebral Cortex","issn_l":"1047-3211","issn":["1047-3211","1460-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral Cortex","raw_type":"journal-article"},{"id":"pmid:22223853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22223853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral cortex (New York, N.Y. : 1991)","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/77900","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/77900","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1508328883","https://openalex.org/W1557312783","https://openalex.org/W1577528636","https://openalex.org/W1579152971","https://openalex.org/W1905429970","https://openalex.org/W1964565539","https://openalex.org/W1983355263","https://openalex.org/W1986646115","https://openalex.org/W1994972002","https://openalex.org/W1995119071","https://openalex.org/W1996458768","https://openalex.org/W1997473970","https://openalex.org/W1998316883","https://openalex.org/W2006952111","https://openalex.org/W2008737807","https://openalex.org/W2019446498","https://openalex.org/W2026801435","https://openalex.org/W2027677864","https://openalex.org/W2028362961","https://openalex.org/W2047152236","https://openalex.org/W2050633133","https://openalex.org/W2050740922","https://openalex.org/W2050785417","https://openalex.org/W2050873013","https://openalex.org/W2050927523","https://openalex.org/W2058173557","https://openalex.org/W2063001897","https://openalex.org/W2078320135","https://openalex.org/W2084817972","https://openalex.org/W2084907056","https://openalex.org/W2092416075","https://openalex.org/W2092423057","https://openalex.org/W2099222162","https://openalex.org/W2101354696","https://openalex.org/W2111423651","https://openalex.org/W2118421222","https://openalex.org/W2118752846","https://openalex.org/W2119848633","https://openalex.org/W2121642311","https://openalex.org/W2124660038","https://openalex.org/W2125720885","https://openalex.org/W2131426455","https://openalex.org/W2133243301","https://openalex.org/W2136468386","https://openalex.org/W2136847718","https://openalex.org/W2138790588","https://openalex.org/W2146469513","https://openalex.org/W2150667092","https://openalex.org/W2150921243","https://openalex.org/W2154680505","https://openalex.org/W2156366271","https://openalex.org/W2157848968","https://openalex.org/W2158335018","https://openalex.org/W2160215963","https://openalex.org/W2160437678","https://openalex.org/W2161130199","https://openalex.org/W2163671213","https://openalex.org/W2169735361","https://openalex.org/W2606710341","https://openalex.org/W4206144694","https://openalex.org/W4249405972"],"related_works":["https://openalex.org/W7100428618","https://openalex.org/W2004460775","https://openalex.org/W2113441901","https://openalex.org/W2594626711","https://openalex.org/W2166533041","https://openalex.org/W2006952111","https://openalex.org/W2028362961","https://openalex.org/W4241207632","https://openalex.org/W2076044875","https://openalex.org/W2003719759"],"abstract_inverted_index":{"Recent":[0],"magnetic":[1],"resonance":[2],"imaging":[3],"(MRI)":[4],"studies":[5],"suggest":[6],"that":[7,160],"abnormalities":[8],"in":[9,19,24,136,164,186,198],"Huntington's":[10],"disease":[11,146],"(HD)":[12],"extend":[13],"to":[14,104,123,174,184],"white":[15],"matter":[16],"(WM)":[17],"tracts":[18],"early":[20],"HD":[21,39,44,111,129],"and":[22,49,57,75,87,89,117,150],"even":[23],"presymptomatic":[25],"stages.":[26],"Thus,":[27],"changes":[28,182],"of":[29,38,61,99,115],"the":[30,62,100,124,141,165,176,191],"corpus":[31],"callosum":[32],"(CC)":[33],"may":[34],"reflect":[35],"various":[36],"aspects":[37],"pathogenesis.":[40],"We":[41],"recruited":[42],"17":[43,46],"patients,":[45],"pre-HD":[47,95,109],"subjects,":[48,110],"34":[50],"healthy":[51],"age-matched":[52],"controls.":[53],"Three-dimensional":[54],"anatomical":[55],"MRI":[56],"diffusion":[58],"tensor":[59],"images":[60],"brain":[63],"were":[64],"acquired":[65],"on":[66],"a":[67,187],"3T":[68],"scanner.":[69],"Combining":[70],"region-of-interest":[71],"analyses,":[72],"voxel-based":[73],"morphometry,":[74],"tract-based":[76],"spatial":[77],"statistics,":[78],"we":[79],"investigated":[80],"callosal":[81,134,181],"thickness,":[82],"WM":[83,161],"density,":[84],"fractional":[85],"anisotropy,":[86],"radial":[88],"axial":[90],"diffusivities.":[91],"Compared":[92,107,126],"with":[93,108,119,127],"controls,":[94,128],"subjects":[96],"showed":[97,113],"reductions":[98,114],"isthmus,":[101],"likely":[102],"due":[103],"myelin":[105,149],"damage.":[106],"patients":[112,130],"isthmus":[116,166],"body,":[118],"axonal":[120,151],"damage":[121,152],"confined":[122],"body.":[125],"had":[131],"significantly":[132],"decreased":[133],"measures":[135],"extended":[137],"regions":[138],"across":[139],"almost":[140],"entire":[142],"CC.":[143],"At":[144],"this":[145,194],"stage,":[147],"both":[148],"are":[153],"detectable.":[154],"Supplementary":[155],"multiple":[156],"regression":[157],"analyses":[158],"revealed":[159],"reduction":[162],"density":[163],"as":[167,169,190],"well":[168],"Disease":[170],"Burden":[171],"scores":[172],"allowed":[173],"predict":[175],"\"HD":[177],"development\"":[178],"index.":[179],"While":[180],"seem":[183],"proceed":[185],"posterior-to-anterior":[188],"direction":[189],"diseases":[192],"progresses,":[193],"observation":[195],"requires":[196],"validation":[197],"future":[199],"longitudinal":[200],"investigations.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
