{"id":"https://openalex.org/W2103224809","doi":"https://doi.org/10.1177/0192623308322016","title":"Ultrasensitive Cross-species Measurement of Cardiac Troponin-I Using the Erenna Immunoassay System","display_name":"Ultrasensitive Cross-species Measurement of Cardiac Troponin-I Using the Erenna Immunoassay System","publication_year":2008,"publication_date":"2008-07-22","ids":{"openalex":"https://openalex.org/W2103224809","doi":"https://doi.org/10.1177/0192623308322016","mag":"2103224809","pmid":"https://pubmed.ncbi.nlm.nih.gov/18648092"},"language":"en","primary_location":{"id":"doi:10.1177/0192623308322016","doi":"https://doi.org/10.1177/0192623308322016","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0192623308322016","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0192623308322016","source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/0192623308322016","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026842829","display_name":"Albert Eric Schultze","orcid":"https://orcid.org/0000-0001-6437-9396","observed_orcids":["https://orcid.org/0000-0001-6437-9396","https://orcid.org/0000-0002-6731-7876"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Eric Schultze","raw_affiliation_strings":["Department of Pathology, Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, Indiana, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051170290","display_name":"Robert J. Konrad","orcid":"https://orcid.org/0000-0003-0923-0542","observed_orcids":["https://orcid.org/0000-0003-0923-0542"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Konrad","raw_affiliation_strings":["Laboratory for Experimental Medicine, Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Experimental Medicine, Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, Indiana, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022932721","display_name":"Kelly M. Credille","orcid":"https://orcid.org/0000-0003-0809-7989","observed_orcids":["https://orcid.org/0000-0003-0809-7989"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly M. Credille","raw_affiliation_strings":["Department of Pathology, Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, Indiana, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110337048","display_name":"Quynh Anh Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270101","display_name":"Singulex (United States)","ror":"https://ror.org/002s06m97","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quynh Anh Lu","raw_affiliation_strings":["Singulex, Inc., Alameda, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singulex, Inc., Alameda, California, USA","institution_ids":["https://openalex.org/I4405270101"]}]},{"author_position":"last","author":{"id":null,"display_name":"John Todd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270101","display_name":"Singulex (United States)","ror":"https://ror.org/002s06m97","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Todd","raw_affiliation_strings":["Singulex, Inc., Alameda, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singulex, Inc., Alameda, California, USA","institution_ids":["https://openalex.org/I4405270101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":7.2068,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.97168535,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"36","issue":"6","first_page":"777","last_page":"782"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.33230000734329224,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.33230000734329224,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.2125999927520752,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-troponin-i","display_name":"cardiac troponin I","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cardiotoxicity-biomarkers","display_name":"cardiotoxicity biomarkers","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cross-species-comparison","display_name":"cross-species comparison","score":0.7310000061988831},{"id":"https://openalex.org/keywords/isoproterenol-induced-cardiotoxicity","display_name":"isoproterenol-induced cardiotoxicity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/assay-sensitivity","display_name":"assay sensitivity","score":0.5799999833106995},{"id":"https://openalex.org/keywords/serum-troponin-i","display_name":"serum troponin I","score":0.5040000081062317},{"id":"https://openalex.org/keywords/immunoassay-validation","display_name":"immunoassay validation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.41200000047683716},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":1.0},{"id":"https://openalex.org/keywords/monkeys","display_name":"monkeys","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C115725540","wikidata":"https://www.wikidata.org/wiki/Q7846263","display_name":"Troponin I","level":3,"score":0.9361451864242554},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.6561295390129089},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.4999732971191406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46326449513435364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4409767687320709},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4341960549354553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41891419887542725},{"id":"https://openalex.org/C2989041947","wikidata":"https://www.wikidata.org/wiki/Q186290","display_name":"Linear correlation","level":2,"score":0.41543048620224},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3537992238998413},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1763480305671692},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1697756052017212},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15355923771858215},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14541837573051453},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019210","descriptor_name":"Troponin I","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1177/0192623308322016","doi":"https://doi.org/10.1177/0192623308322016","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0192623308322016","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0192623308322016","source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmid:18648092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18648092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic pathology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.828.3491","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.828.3491","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://tpx.sagepub.com/content/early/2008/07/22/0192623308322016.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.856.1745","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.856.1745","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://tpx.sagepub.com/content/36/6/777.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1177/0192623308322016","doi":"https://doi.org/10.1177/0192623308322016","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0192623308322016","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0192623308322016","source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103224809.pdf","grobid_xml":"https://content.openalex.org/works/W2103224809.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1615285779","https://openalex.org/W1964347215","https://openalex.org/W1991461818","https://openalex.org/W1998216060","https://openalex.org/W2001108250","https://openalex.org/W2042497751","https://openalex.org/W2048104098","https://openalex.org/W2071147750","https://openalex.org/W2080729736","https://openalex.org/W2093229841","https://openalex.org/W2100471492","https://openalex.org/W2104392185","https://openalex.org/W2104820453","https://openalex.org/W2129775201","https://openalex.org/W2133869777","https://openalex.org/W2139148683","https://openalex.org/W2141820471","https://openalex.org/W2414031596","https://openalex.org/W4236630084"],"related_works":["https://openalex.org/W2104392185","https://openalex.org/W3176932536","https://openalex.org/W2119117262","https://openalex.org/W2093229841","https://openalex.org/W1981824653","https://openalex.org/W1976538135","https://openalex.org/W1989571419","https://openalex.org/W2100605261","https://openalex.org/W4384662850","https://openalex.org/W2061755605"],"abstract_inverted_index":{"Serum":[0,35],"cardiac":[1],"troponin-I":[2],"(cTnI)":[3],"has":[4],"been":[5,33],"validated":[6],"as":[7],"a":[8],"biomarker":[9],"for":[10,74,142,153],"cardiotoxicity":[11],"in":[12,23,28,115,134,172,186],"numerous":[13],"animal":[14],"models;":[15],"however,":[16],"owing":[17],"to":[18,88,121,194],"sensitivity":[19,57],"issues":[20],"cTnI":[21,54,114,133,164,185,203],"concentrations":[22,131],"healthy,":[24],"resting":[25],"animals":[26,117,174],"used":[27],"toxicology":[29],"studies":[30,78,126],"have":[31],"not":[32],"established.":[34],"from":[36,86,119,198,205],"healthy":[37,116],"and":[38,44,65,92,95,108,147,189,201],"isoproterenol":[39],"hydrochloride":[40],"(iso)-treated":[41],"rats,":[42,187],"dogs,":[43,188],"monkeys":[45],"were":[46,72,139],"assayed":[47],"using":[48],"the":[49,130,135,160],"Erenna":[50,53,107,161,179],"system.":[51],"The":[52,178],"assay":[55,162],"provided":[56],"<":[58],"1":[59,120],"ng/L":[60,141,152],"across":[61],"human,":[62],"rat,":[63],"dog,":[64],"monkey":[66],"cTnI.":[67,111],"Linear":[68],"responses":[69],"(R(2)=":[70,102],"0.99)":[71,103],"observed":[73],"all":[75,168,173],"species.":[76],"Precision":[77],"yielded":[79],"interassay":[80],"CVs":[81],"of":[82,113,127,132,150,184,208],"curve":[83],"fit":[84],"quantification":[85],"2%":[87],"4%":[89],"between":[90,106],"1.6":[91],"5000":[93],"ng/L,":[94],"23%":[96],"at":[97,167],"0.78":[98],"ng/L.":[99,123],"Strong":[100],"correlation":[101],"was":[104,165],"obtained":[105],"Beckman":[109],"Access":[110],"Concentrations":[112],"ranged":[118],"9":[122],"In":[124],"longitudinal":[125],"iso-treated":[128],"animals,":[129],"control":[136],"vehicle-treated":[137],"groups":[138],"10-20":[140],"rats":[143],"(N":[144,155],"=":[145,156],"10)":[146],"predose":[148],"values":[149,204],"2-3":[151],"dogs":[154],"3).":[157],"Measured":[158],"with":[159,176],"system,":[163],"quantifiable":[166],"time":[169],"intervals":[170],"tested":[171],"treated":[175],"iso.":[177],"system":[180],"provides":[181,202],"sensitive":[182],"measurement":[183],"monkeys,":[190],"makes":[191],"it":[192],"possible":[193],"determine":[195],"small":[196,206],"changes":[197],"normal":[199],"concentrations,":[200],"volumes":[207],"serum.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
