{"id":"https://openalex.org/W2103206008","doi":"https://doi.org/10.1111/j.1399-5618.2006.00370.x","title":"Bipolar disorder and comorbid alcoholism: prevalence rate and treatment considerations","display_name":"Bipolar disorder and comorbid alcoholism: prevalence rate and treatment considerations","publication_year":2006,"publication_date":"2006-11-27","ids":{"openalex":"https://openalex.org/W2103206008","doi":"https://doi.org/10.1111/j.1399-5618.2006.00370.x","mag":"2103206008","pmid":"https://pubmed.ncbi.nlm.nih.gov/17156154"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-5618.2006.00370.x","doi":"https://doi.org/10.1111/j.1399-5618.2006.00370.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-5618.2006.00370.x","pdf_url":null,"source":{"id":"https://openalex.org/S58085280","display_name":"Bipolar Disorders","issn_l":"1398-5647","issn":["1398-5647","1399-5618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bipolar Disorders","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029433360","display_name":"Mark A. Frye","orcid":"https://orcid.org/0000-0001-6997-4215","observed_orcids":["https://orcid.org/0000-0001-6997-4215"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark A Frye","raw_affiliation_strings":["Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA, USA. mfrye@mayo.edu","Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA, USA. mfrye@mayo.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057756765","display_name":"Ihsan M. Salloum","orcid":"https://orcid.org/0000-0001-7318-9316","observed_orcids":["https://orcid.org/0000-0001-7318-9316"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ihsan M Salloum","raw_affiliation_strings":["Department of Psychiatry, Western Psychiatric Institute and Clinic of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA","University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Western Psychiatric Institute and Clinic of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029433360"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":1.1623,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.73708381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"8","issue":"6","first_page":"677","last_page":"685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":1.0},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.8130000233650208},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.9190000295639038},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.7080000042915344},{"id":"https://openalex.org/keywords/alcohol-withdrawal-syndrome","display_name":"alcohol withdrawal","score":0.6589999794960022},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mood-stabilizers","display_name":"mood stabilizers","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":0.9449999928474426},{"id":"https://openalex.org/keywords/carbamazepine","display_name":"carbamazepine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.7770000100135803},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.9959999918937683},{"id":"https://openalex.org/keywords/quetiapine","display_name":"quetiapine","score":0.8939999938011169},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":1.0},{"id":"https://openalex.org/keywords/naltrexone","display_name":"naltrexone","score":0.9850000143051147},{"id":"https://openalex.org/keywords/acamprosate","display_name":"acamprosate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/topiramate","display_name":"topiramate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mixed-mania","display_name":"mixed mania","score":0.6470000147819519},{"id":"https://openalex.org/keywords/rapid-cycling","display_name":"rapid cycling","score":0.8320000171661377},{"id":"https://openalex.org/keywords/impulsivity","display_name":"impulsivity","score":0.6790000200271606},{"id":"https://openalex.org/keywords/suicidality","display_name":"suicidality","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.778228223323822},{"id":"https://openalex.org/C2780634440","wikidata":"https://www.wikidata.org/wiki/Q408535","display_name":"Quetiapine","level":3,"score":0.7306694984436035},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.6756017804145813},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.6544544696807861},{"id":"https://openalex.org/C2908949014","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Divalproex","level":5,"score":0.5901897549629211},{"id":"https://openalex.org/C2777683783","wikidata":"https://www.wikidata.org/wiki/Q221174","display_name":"Topiramate","level":3,"score":0.5222992897033691},{"id":"https://openalex.org/C2779992327","wikidata":"https://www.wikidata.org/wiki/Q337668","display_name":"Acamprosate","level":5,"score":0.512535810470581},{"id":"https://openalex.org/C2778609679","wikidata":"https://www.wikidata.org/wiki/Q4915474","display_name":"Bipolar I disorder","level":5,"score":0.46270421147346497},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45906001329421997},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.45399507880210876},{"id":"https://openalex.org/C2780319597","wikidata":"https://www.wikidata.org/wiki/Q1549918","display_name":"Impulsivity","level":2,"score":0.4501098692417145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4421994090080261},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4344242811203003},{"id":"https://openalex.org/C2779253243","wikidata":"https://www.wikidata.org/wiki/Q410412","display_name":"Carbamazepine","level":3,"score":0.415728360414505},{"id":"https://openalex.org/C2777972943","wikidata":"https://www.wikidata.org/wiki/Q409587","display_name":"Naltrexone","level":4,"score":0.3865908980369568},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.3066280484199524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18931257724761963},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.1100018322467804},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.07292050123214722},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1399-5618.2006.00370.x","doi":"https://doi.org/10.1111/j.1399-5618.2006.00370.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-5618.2006.00370.x","pdf_url":null,"source":{"id":"https://openalex.org/S58085280","display_name":"Bipolar Disorders","issn_l":"1398-5647","issn":["1398-5647","1399-5618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bipolar Disorders","raw_type":"journal-article"},{"id":"pmid:17156154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17156154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bipolar disorders","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3382674914","display_name":"1H-MR Spectroscopy of Bipolar Depression Before and After Lamotrigine Treatment","funder_award_id":"R01MH079261","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W118396326","https://openalex.org/W161993100","https://openalex.org/W1498271275","https://openalex.org/W1611330866","https://openalex.org/W1778494765","https://openalex.org/W1800019117","https://openalex.org/W1813498625","https://openalex.org/W1973887879","https://openalex.org/W1978713867","https://openalex.org/W1987593051","https://openalex.org/W1992454844","https://openalex.org/W1994486610","https://openalex.org/W1995357866","https://openalex.org/W2003739359","https://openalex.org/W2004244289","https://openalex.org/W2007121124","https://openalex.org/W2009143521","https://openalex.org/W2013335154","https://openalex.org/W2021716111","https://openalex.org/W2021874402","https://openalex.org/W2022936071","https://openalex.org/W2024833487","https://openalex.org/W2027560794","https://openalex.org/W2027656344","https://openalex.org/W2027778520","https://openalex.org/W2030331842","https://openalex.org/W2031460352","https://openalex.org/W2037292769","https://openalex.org/W2037894465","https://openalex.org/W2043630462","https://openalex.org/W2045210422","https://openalex.org/W2047442007","https://openalex.org/W2054484585","https://openalex.org/W2056500109","https://openalex.org/W2058392863","https://openalex.org/W2063269981","https://openalex.org/W2064119051","https://openalex.org/W2077989117","https://openalex.org/W2080271674","https://openalex.org/W2082653020","https://openalex.org/W2084835300","https://openalex.org/W2095103357","https://openalex.org/W2100872959","https://openalex.org/W2102658965","https://openalex.org/W2108740579","https://openalex.org/W2122519801","https://openalex.org/W2124457843","https://openalex.org/W2124876944","https://openalex.org/W2130261986","https://openalex.org/W2136720775","https://openalex.org/W2147343760","https://openalex.org/W2158666090","https://openalex.org/W2159488624","https://openalex.org/W2159950826","https://openalex.org/W2161282771","https://openalex.org/W2164643854","https://openalex.org/W2169269570","https://openalex.org/W2335144364","https://openalex.org/W3026523878","https://openalex.org/W4247496126","https://openalex.org/W4253565967","https://openalex.org/W4301692554"],"related_works":["https://openalex.org/W2139031901","https://openalex.org/W2072826584","https://openalex.org/W2064499594","https://openalex.org/W1575793215","https://openalex.org/W3138600251","https://openalex.org/W5236900","https://openalex.org/W2943121075","https://openalex.org/W2507707333","https://openalex.org/W3028650400","https://openalex.org/W2169156141"],"abstract_inverted_index":{"Classic":[0],"Kraepelian":[1],"observations":[2],"and":[3,16,84,92,100,138,147,154,175,180],"contemporary":[4],"epidemiological":[5],"studies":[6,125],"have":[7,127],"noted":[8],"a":[9],"high":[10],"prevalence":[11],"rate":[12],"between":[13],"bipolar":[14,46,64,159],"disorder":[15,65,160],"alcoholism.":[17,163],"The":[18],"extent":[19],"to":[20,50],"which":[21],"these":[22],"two":[23,28],"illnesses":[24],"are":[25],"comorbid":[26,162],"(i.e.,":[27],"distinct":[29],"disease":[30],"processes":[31],"each":[32],"with":[33,71,152,161],"an":[34],"independent":[35],"course":[36],"of":[37,45,74,87,131,144,158,166],"illness),":[38],"genetically":[39],"linked,":[40],"or":[41,61,76],"different":[42],"phenotypic":[43],"expressions":[44],"illness":[47,69],"itself":[48],"continues":[49],"be":[51,183],"investigated.":[52],"It":[53,94],"is":[54,95],"increasingly":[55],"clear":[56],"that":[57,98,126],"co-occurring":[58],"alcohol":[59,145],"abuse":[60],"dependence":[62],"in":[63,114,141,150,155],"phenomenologically":[66],"changes":[67],"the":[68,110,123,129,142,156,176],"presentation":[70],"higher":[72,85],"rates":[73],"mixed":[75],"dysphoric":[77],"mania,":[78],"rapid":[79],"cycling,":[80],"increased":[81,108],"symptom":[82],"severity,":[83],"levels":[86],"novelty":[88],"seeking,":[89],"suicidality,":[90],"aggressivity,":[91],"impulsivity.":[93],"very":[96],"encouraging":[97],"interest":[99],"efforts":[101],"at":[102],"evaluating":[103],"pharmacotherapeutic":[104],"compounds":[105],"has":[106],"substantially":[107],"over":[109],"past":[111],"few":[112],"years":[113],"this":[115],"difficult-to-treat":[116],"patient":[117],"population.":[118],"This":[119],"article":[120],"will":[121],"review":[122],"clinical":[124],"evaluated":[128],"effectiveness":[130],"conventional":[132],"mood":[133],"stabilizers":[134],"(lithium,":[135],"carbamazepine,":[136],"divalproex,":[137],"atypical":[139,177],"antipsychotics)":[140],"treatment":[143,157],"withdrawal":[146],"relapse":[148],"prevention":[149],"patients":[151],"alcoholism":[153],"A":[164],"number":[165],"add-on,":[167],"adjunctive":[168],"medications,":[169],"such":[170],"as":[171],"naltrexone,":[172],"acamprosate,":[173],"topiramate,":[174],"antipsychotics":[178],"quetiapine":[179],"clozapine,":[181],"may":[182],"candidates":[184],"for":[185],"further":[186],"testing.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
