{"id":"https://openalex.org/W2103201992","doi":"https://doi.org/10.1158/0008-5472.can-06-1499","title":"Activation of EDTA-Resistant Gelatinases in Malignant Human Tumors","display_name":"Activation of EDTA-Resistant Gelatinases in Malignant Human Tumors","publication_year":2006,"publication_date":"2006-10-15","ids":{"openalex":"https://openalex.org/W2103201992","doi":"https://doi.org/10.1158/0008-5472.can-06-1499","mag":"2103201992","pmid":"https://pubmed.ncbi.nlm.nih.gov/17047060","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1626657"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-06-1499","doi":"https://doi.org/10.1158/0008-5472.can-06-1499","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-1499","pdf_url":"https://cancerres.aacrjournals.org/content/canres/66/20/9977.full.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://cancerres.aacrjournals.org/content/canres/66/20/9977.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025510664","display_name":"Donghai Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donghai Chen","raw_affiliation_strings":["1Medicine and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medicine and Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065876259","display_name":"Alanna Kennedy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alanna Kennedy","raw_affiliation_strings":["1Medicine and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medicine and Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053604127","display_name":"Jaw\u2010Yuan Wang","orcid":"https://orcid.org/0000-0002-7705-2621","observed_orcids":["https://orcid.org/0000-0002-7705-2621"]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jaw-Yuan Wang","raw_affiliation_strings":["1Medicine and Departments of","3Department of Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medicine and Departments of","institution_ids":[]},{"raw_affiliation_string":"3Department of Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan;","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041785371","display_name":"Wei Zeng","orcid":"https://orcid.org/0000-0002-5613-867X","observed_orcids":["https://orcid.org/0000-0002-5613-867X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Zeng","raw_affiliation_strings":["1Medicine and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medicine and Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056742440","display_name":"Qiang Zhao","orcid":"https://orcid.org/0000-0002-6369-1393","observed_orcids":["https://orcid.org/0000-0002-6369-1393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiang Zhao","raw_affiliation_strings":["1Medicine and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medicine and Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014079598","display_name":"Michael L. Pearl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Pearl","raw_affiliation_strings":["2Obstetrics, Gynecology, and Reproductive Medicine, Stony Brook University, Stony Brook, New York;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Obstetrics, Gynecology, and Reproductive Medicine, Stony Brook University, Stony Brook, New York;","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101865213","display_name":"Mengzhen Zhang","orcid":"https://orcid.org/0000-0002-0019-7320","observed_orcids":["https://orcid.org/0000-0002-0019-7320"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN","NO"],"is_corresponding":false,"raw_author_name":"Mengzhen Zhang","raw_affiliation_strings":["4Department of Pathology, The National Hospital-The Norwegian Radium Hospital, University of Oslo, Oslo, Norway;","5Department of Gynecology and Obstetrics, Zhengzhou University, Henan, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Pathology, The National Hospital-The Norwegian Radium Hospital, University of Oslo, Oslo, Norway;","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"5Department of Gynecology and Obstetrics, Zhengzhou University, Henan, China;","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113747013","display_name":"Zhenhe Suo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Zhenhe Suo","raw_affiliation_strings":["4Department of Pathology, The National Hospital-The Norwegian Radium Hospital, University of Oslo, Oslo, Norway;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Pathology, The National Hospital-The Norwegian Radium Hospital, University of Oslo, Oslo, Norway;","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109081203","display_name":"Jahn M. Nesland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Jahn M. Nesland","raw_affiliation_strings":["4Department of Pathology, The National Hospital-The Norwegian Radium Hospital, University of Oslo, Oslo, Norway;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Pathology, The National Hospital-The Norwegian Radium Hospital, University of Oslo, Oslo, Norway;","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110516115","display_name":"Yuhuan Qiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhuan Qiao","raw_affiliation_strings":["5Department of Gynecology and Obstetrics, Zhengzhou University, Henan, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Gynecology and Obstetrics, Zhengzhou University, Henan, China;","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103411096","display_name":"Ah\u2010Kau Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73443619","display_name":"University of Southern Maine","ror":"https://ror.org/03ke6tv85","country_code":"US","type":"education","lineage":["https://openalex.org/I2802397601","https://openalex.org/I73443619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ah-Kau Ng","raw_affiliation_strings":["6Department of Applied Medical Science, University of Southern Maine, Portland, Maine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Department of Applied Medical Science, University of Southern Maine, Portland, Maine;","institution_ids":["https://openalex.org/I73443619"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Naoko Hirashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoko Hirashima","raw_affiliation_strings":["7Department of Pathology, Faculty of Medicine, Yamanashi Medical University, Shimokato Tamaho Nakakoma, Yamanashi, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Pathology, Faculty of Medicine, Yamanashi Medical University, Shimokato Tamaho Nakakoma, Yamanashi, Japan;","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111403263","display_name":"Tetsu Yamane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsu Yamane","raw_affiliation_strings":["7Department of Pathology, Faculty of Medicine, Yamanashi Medical University, Shimokato Tamaho Nakakoma, Yamanashi, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Pathology, Faculty of Medicine, Yamanashi Medical University, Shimokato Tamaho Nakakoma, Yamanashi, Japan;","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoshiyuki Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiyuki Mori","raw_affiliation_strings":["7Department of Pathology, Faculty of Medicine, Yamanashi Medical University, Shimokato Tamaho Nakakoma, Yamanashi, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Pathology, Faculty of Medicine, Yamanashi Medical University, Shimokato Tamaho Nakakoma, Yamanashi, Japan;","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057593582","display_name":"Masako Mitsumata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]},{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masako Mitsumata","raw_affiliation_strings":["7Department of Pathology, Faculty of Medicine, Yamanashi Medical University, Shimokato Tamaho Nakakoma, Yamanashi, Japan;","8Department of Pathology, School of Medicine, Nihon University, Itabashi, Tokyo, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Pathology, Faculty of Medicine, Yamanashi Medical University, Shimokato Tamaho Nakakoma, Yamanashi, Japan;","institution_ids":["https://openalex.org/I66906201"]},{"raw_affiliation_string":"8Department of Pathology, School of Medicine, Nihon University, Itabashi, Tokyo, Japan; and","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054380274","display_name":"Giulio Ghersi","orcid":"https://orcid.org/0000-0001-7250-9808","observed_orcids":["https://orcid.org/0000-0001-7250-9808"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulio Ghersi","raw_affiliation_strings":["9Dipartimento di Biologia Cellulare e dello Sviluppo, Universita\u0300 di Palermo, Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Dipartimento di Biologia Cellulare e dello Sviluppo, Universita\u0300 di Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062711026","display_name":"Wen\u2010Tien Chen","orcid":"https://orcid.org/0000-0002-7239-0939","observed_orcids":["https://orcid.org/0000-0002-7239-0939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-Tien Chen","raw_affiliation_strings":["1Medicine and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Medicine and Departments of","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2898,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.80854701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"66","issue":"20","first_page":"9977","last_page":"9985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.05939999967813492,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/seprase","display_name":"seprase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fibroblast-activation-protein","display_name":"fibroblast activation protein","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dipeptidyl-peptidase","display_name":"dipeptidyl peptidase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/proteolytic-processing","display_name":"proteolytic processing","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6909999847412109},{"id":"https://openalex.org/keywords/collagen-proteolysis","display_name":"collagen proteolysis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ovarian-carcinoma","display_name":"ovarian carcinoma","score":0.906000018119812},{"id":"https://openalex.org/keywords/colon-adenocarcinoma","display_name":"colon adenocarcinoma","score":0.8579999804496765},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/invasive-ductal-breast-carcinoma","display_name":"breast invasive ductal carcinoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.949999988079071},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C111798993","wikidata":"https://www.wikidata.org/wiki/Q21117471","display_name":"Fibroblast activation protein, alpha","level":3,"score":0.9887521266937256},{"id":"https://openalex.org/C2776232661","wikidata":"https://www.wikidata.org/wiki/Q5530373","display_name":"Gelatinase","level":3,"score":0.7605987191200256},{"id":"https://openalex.org/C2781469919","wikidata":"https://www.wikidata.org/wiki/Q5279728","display_name":"Dipeptidyl peptidase","level":3,"score":0.6162639856338501},{"id":"https://openalex.org/C2910246616","wikidata":"https://www.wikidata.org/wiki/Q5530373","display_name":"Gelatinases","level":4,"score":0.4668702781200409},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.4592682123184204},{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.4325340688228607},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4263969361782074},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.4061121642589569},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3786082863807678},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3751727044582367},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36625367403030396},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3345295786857605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2859113812446594},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.25289762020111084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23075398802757263},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19017985463142395},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15293669700622559},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11728054285049438}],"mesh":[{"descriptor_ui":"D000099167","descriptor_name":"Fibroblast Activation Protein Alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004152","descriptor_name":"Dipeptidyl-Peptidases and Tripeptidyl-Peptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004492","descriptor_name":"Edetic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D018093","descriptor_name":"Gelatinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-06-1499","doi":"https://doi.org/10.1158/0008-5472.can-06-1499","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-1499","pdf_url":"https://cancerres.aacrjournals.org/content/canres/66/20/9977.full.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:17047060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17047060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1341562","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1626657","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:iris.unipa.it:10447/15781","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10447/15781","pdf_url":"http://hdl.handle.net/10447/15781","source":{"id":"https://openalex.org/S4377196289","display_name":"IRIS UniPA (University of Palermo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I900890020","host_organization_name":"University of Palermo","host_organization_lineage":["https://openalex.org/I900890020"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-06-1499","doi":"https://doi.org/10.1158/0008-5472.can-06-1499","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-1499","pdf_url":"https://cancerres.aacrjournals.org/content/canres/66/20/9977.full.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1545681430","display_name":null,"funder_award_id":"R01CA0039077","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3626967175","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR010710","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6596252048","display_name":null,"funder_award_id":"R01CA0039077","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7491190671","display_name":"Molecular mechanism of cell invasion","funder_award_id":"R01CA039077","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8866194773","display_name":"Regulation of tissue repair","funder_award_id":"R01EB002065","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000115614","display_name":null,"funder_award_id":"MO1-RR-10710","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103201992.pdf","grobid_xml":"https://content.openalex.org/works/W2103201992.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W22020251","https://openalex.org/W91004240","https://openalex.org/W175339624","https://openalex.org/W1490344763","https://openalex.org/W1507054304","https://openalex.org/W1975016799","https://openalex.org/W1987144286","https://openalex.org/W1991669931","https://openalex.org/W1994016632","https://openalex.org/W2002145465","https://openalex.org/W2027847535","https://openalex.org/W2040888996","https://openalex.org/W2047764904","https://openalex.org/W2051536806","https://openalex.org/W2055870150","https://openalex.org/W2057043051","https://openalex.org/W2062459814","https://openalex.org/W2066357115","https://openalex.org/W2070451297","https://openalex.org/W2072061914","https://openalex.org/W2074861906","https://openalex.org/W2099992960","https://openalex.org/W2101545809","https://openalex.org/W2115294768","https://openalex.org/W2117089720","https://openalex.org/W2118872306","https://openalex.org/W2124408216","https://openalex.org/W2159929445","https://openalex.org/W3142523607","https://openalex.org/W4237195954"],"related_works":["https://openalex.org/W1977017266","https://openalex.org/W4308809","https://openalex.org/W1507054304","https://openalex.org/W175339624","https://openalex.org/W140440376","https://openalex.org/W1992592944","https://openalex.org/W2057043051","https://openalex.org/W2141766327","https://openalex.org/W2052047439","https://openalex.org/W2239714141"],"abstract_inverted_index":{"Among":[0],"the":[1,62,129,165,173],"many":[2],"proteases":[3],"associated":[4,39],"with":[5,40],"human":[6,98],"cancer,":[7],"seprase":[8,41,59,78,100,138,186],"or":[9,125],"fibroblast":[10],"activation":[11,36,139,145],"protein":[12],"alpha,":[13],"a":[14,29,50,56,82],"type":[15],"II":[16],"transmembrane":[17],"glycoprotein,":[18],"has":[19],"two":[20],"types":[21],"of":[22,37,64,77,90,131,164,172],"EDTA-resistant":[23],"protease":[24],"activities:":[25],"dipeptidyl":[26,91],"peptidase":[27,92],"and":[28,113,120,144,167,175,198],"170-kDa":[30],"gelatinase":[31,86],"activity.":[32],"To":[33],"test":[34],"if":[35],"gelatinases":[38],"could":[42],"be":[43],"involved":[44],"in":[45,85,104,110,128,140,149,156,183,195],"malignant":[46,97,121,159,176,184],"tumors,":[47,99,185],"we":[48],"used":[49],"mammalian":[51],"expression":[52,143],"system":[53],"to":[54,73,190],"generate":[55],"soluble":[57],"recombinant":[58],"(r-seprase).":[60],"In":[61,96],"presence":[63,130],"putative":[65],"EDTA-sensitive":[66],"activators,":[67],"r-seprase":[68],"was":[69],"converted":[70],"into":[71],"70-":[72],"50-kDa":[74],"shortened":[75],"forms":[76],"(s-seprase),":[79],"which":[80],"exhibited":[81],"7-fold":[83],"increase":[84],"activity,":[87],"whereas":[88],"levels":[89],"activity":[93],"remained":[94],"unchanged.":[95],"is":[101,187],"expressed":[102],"predominantly":[103],"tumor":[105,160,199],"cells":[106],"as":[107],"shown":[108],"by":[109],"situ":[111],"hybridization":[112],"immunohistochemistry.":[114],"Proteins":[115],"purified":[116],"from":[117],"experimental":[118],"xenografts":[119],"tumors":[122],"using":[123],"antibody-":[124],"lectin-affinity":[126],"columns":[127],"5":[132],"mmol/L":[133],"EDTA":[134],"were":[135,153],"assayed":[136],"for":[137],"vivo.":[141],"Seprase":[142],"occur":[146],"most":[147],"prevalently":[148],"ovarian":[150],"carcinoma":[151,171],"but":[152],"also":[154],"detected":[155],"four":[157],"other":[158],"types,":[161],"including":[162],"adenocarcinoma":[163],"colon":[166],"stomach,":[168],"invasive":[169],"ductal":[170],"breast,":[174],"melanoma.":[177],"Together,":[178],"these":[179],"data":[180],"show":[181],"that,":[182],"proteolytically":[188],"activated":[189],"confer":[191],"its":[192],"substrate":[193],"specificity":[194],"collagen":[196],"proteolysis":[197],"invasion.":[200]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
