{"id":"https://openalex.org/W2103197676","doi":"https://doi.org/10.1111/j.1365-2133.2007.08096.x","title":"Skin wound healing in the SKH-1 female mouse following inducible nitric oxide synthase inhibition","display_name":"Skin wound healing in the SKH-1 female mouse following inducible nitric oxide synthase inhibition","publication_year":2007,"publication_date":"2007-08-02","ids":{"openalex":"https://openalex.org/W2103197676","doi":"https://doi.org/10.1111/j.1365-2133.2007.08096.x","mag":"2103197676","pmid":"https://pubmed.ncbi.nlm.nih.gov/17672879"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2133.2007.08096.x","doi":"https://doi.org/10.1111/j.1365-2133.2007.08096.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.2007.08096.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111855330","display_name":"Rosonald R. Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R.R. Bell","raw_affiliation_strings":["Drug Safety Research & Development, Pfizer Global Research & Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, U.S.A. rosonald.r.bell@pfizer.com","Drug Safety Research & Development, Pfizer Global Research & Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Research & Development, Pfizer Global Research & Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, U.S.A. rosonald.r.bell@pfizer.com","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Drug Safety Research & Development, Pfizer Global Research & Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, U.S.A","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003162707","display_name":"Robert W. Dunstan","orcid":"https://orcid.org/0000-0002-4652-434X","observed_orcids":["https://orcid.org/0000-0002-4652-434X"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.W. Dunstan","raw_affiliation_strings":["Pfizer Global Research & Development, Drug Safety Research & Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research & Development, Drug Safety Research & Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, U.S.A","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038417285","display_name":"Niamat Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N.K. Khan","raw_affiliation_strings":["Pfizer Global Research & Development, Drug Safety Research & Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Global Research & Development, Drug Safety Research & Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, U.S.A","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111855330"],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":1.7505,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.84707132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"157","issue":"4","first_page":"656","last_page":"661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-wound-healing","display_name":"skin wound healing","score":0.8659999966621399},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/inos-inhibition","display_name":"iNOS inhibition","score":0.9570000171661377},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8169999718666077},{"id":"https://openalex.org/keywords/incisional-wounds","display_name":"incisional wounds","score":0.7609999775886536},{"id":"https://openalex.org/keywords/wound-tensile-strength","display_name":"wound tensile strength","score":0.859000027179718},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.8386107087135315},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.8260884284973145},{"id":"https://openalex.org/C2779156968","wikidata":"https://www.wikidata.org/wiki/Q17141495","display_name":"Hairless","level":2,"score":0.6794310808181763},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.6208122372627258},{"id":"https://openalex.org/C2779698670","wikidata":"https://www.wikidata.org/wiki/Q408853","display_name":"Endothelial NOS","level":5,"score":0.5020067691802979},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4949480891227722},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4929039478302002},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4893743395805359},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4893049895763397},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.4516649544239044},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31606900691986084},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2756420373916626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26039132475852966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18038016557693481},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14972954988479614},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012879","descriptor_name":"Skin Physiological Phenomena","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013718","descriptor_name":"Tensile Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2133.2007.08096.x","doi":"https://doi.org/10.1111/j.1365-2133.2007.08096.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.2007.08096.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:17672879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17672879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1481630279","https://openalex.org/W1608840527","https://openalex.org/W1965434649","https://openalex.org/W1999511683","https://openalex.org/W2008422812","https://openalex.org/W2015776844","https://openalex.org/W2020309862","https://openalex.org/W2039267949","https://openalex.org/W2064178969","https://openalex.org/W2077446787","https://openalex.org/W2078198107","https://openalex.org/W2088330312","https://openalex.org/W2098543768","https://openalex.org/W2100324524","https://openalex.org/W2102685210","https://openalex.org/W2104391287","https://openalex.org/W2105916525","https://openalex.org/W2113127336","https://openalex.org/W2410915277"],"related_works":["https://openalex.org/W1554751488","https://openalex.org/W2076175450","https://openalex.org/W2607263951","https://openalex.org/W24727850","https://openalex.org/W2025112159","https://openalex.org/W2035804500","https://openalex.org/W3033652148","https://openalex.org/W2062093468","https://openalex.org/W2020693567","https://openalex.org/W2015776844"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"inducible":[2],"isoform":[3],"of":[4,26,38,65,69,74,84,105,118,140,154,167,184,272],"the":[5,36,66,72,82,102,138,143,155,234,270],"nitric":[6],"oxide":[7],"(NO)":[8],"synthase":[9],"(NOS)":[10],"enzyme":[11],"(iNOS)":[12],"is":[13,44],"upregulated":[14],"by":[15,52,149,177,210,283],"inflammatory":[16],"mediators":[17],"and/or":[18,186],"other":[19],"pathological":[20],"stresses,":[21],"generating":[22],"high,":[23],"sustained":[24],"levels":[25],"NO.":[27],"Cumulative":[28],"data":[29,87,261],"suggest":[30],"a":[31,127,193],"role":[32,104,139],"for":[33,89],"NO":[34,50],"in":[35,76,95,107,134,142,151,164,182,201,222,231,275],"regulation":[37],"skin":[39,122],"wound":[40,77,85,110,123,132,144,202,284],"healing,":[41,78],"although":[42],"it":[43],"not":[45,251,267],"clear":[46],"to":[47,60,100],"what":[48],"extent":[49],"generated":[51],"iNOS,":[53],"and":[54,213,217,236,249,287],"possibly":[55],"endothelial":[56],"NOS":[57,173],"(eNOS),":[58],"contribute":[59],"that":[61,162,263],"healing":[62,86,145,203,271],"process.":[63],"Because":[64],"current":[67],"lack":[68,83],"understanding":[70],"regarding":[71],"contribution":[73],"iNOS":[75,92,119,141,156,168,264],"as":[79,81,169,171,192,208,239,278],"well":[80,170],"available":[88],"SC-842,":[90,158],"an":[91],"inhibitor,":[93,157],"this":[94,245],"vivo":[96,152],"study":[97,114],"was":[98,147,190,225,247,250],"conducted":[99],"investigate":[101],"possible":[103],"SC-842":[106],"interfering":[108],"with":[109,241,253],"healing.":[111,124],"OBJECTIVES:":[112],"This":[113],"evaluated":[115,148,209],"whether":[116],"inhibition":[117,166,174,183,265],"affects":[120],"incisional":[121,131,273],"METHODS:":[125],"Using":[126],"cutaneous":[128],"full-thickness,":[129],"sutured,":[130],"model":[133],"hairless":[135],"SKH-1":[136,276],"mice,":[137],"process":[146],"comparing":[150],"effects":[153],"at":[159,204,227],"various":[160],"doses":[161],"result":[163],"selective":[165],"nonselective":[172],"(as":[175],"evidenced":[176],"elevated":[178],"blood":[179],"pressure":[180],"resulting":[181],"eNOS":[185],"neuronal":[187],"NOS).":[188],"Dexamethasone":[189],"used":[191],"positive":[194],"control.":[195],"RESULTS:":[196],"There":[197],"were":[198],"no":[199],"differences":[200,255],"day":[205,228],"28":[206,281],"postwounding,":[207],"tensile":[211,223,285],"strength":[212,224,286],"histology,":[214],"between":[215],"SC-842-":[216],"vehicle-treated":[218,242,257],"animals.":[219],"A":[220],"decrease":[221],"noted":[226],"14":[229],"postwounding":[230],"wounds":[232,274],"from":[233,256],"mid-":[235],"high-dose-treated":[237],"animals":[238],"compared":[240],"animals,":[243],"but":[244],"difference":[246],"slight":[248],"associated":[252],"histological":[254],"controls.":[258],"CONCLUSIONS:":[259],"These":[260],"indicate":[262],"does":[266],"adversely":[268],"affect":[269],"mice":[277],"assessed":[279],"over":[280],"days":[282],"histology.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}