{"id":"https://openalex.org/W2103196707","doi":"https://doi.org/10.1152/ajpheart.00393.2010","title":"Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats","display_name":"Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats","publication_year":2010,"publication_date":"2010-12-11","ids":{"openalex":"https://openalex.org/W2103196707","doi":"https://doi.org/10.1152/ajpheart.00393.2010","mag":"2103196707","pmid":"https://pubmed.ncbi.nlm.nih.gov/21148769","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3064310"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.00393.2010","doi":"https://doi.org/10.1152/ajpheart.00393.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00393.2010","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3064310","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111923198","display_name":"Kyu-Tae Kang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyu-Tae Kang","raw_affiliation_strings":["Vascular Biology Center, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Center, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia; and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049445146","display_name":"Jennifer C. Sullivan","orcid":"https://orcid.org/0000-0003-0541-0247","observed_orcids":["https://orcid.org/0000-0003-0541-0247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer C. Sullivan","raw_affiliation_strings":["Vascular Biology Center, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Center, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia; and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082451578","display_name":"Frank Travis Spradley","orcid":"https://orcid.org/0000-0003-3293-2753","observed_orcids":["https://orcid.org/0000-0003-3293-2753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank T. Spradley","raw_affiliation_strings":["Vascular Biology Center, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Center, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia; and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031586964","display_name":"Livius V. d\u2019Uscio","orcid":"https://orcid.org/0000-0001-9577-9480","observed_orcids":["https://orcid.org/0000-0001-9577-9480"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Livius V. d'Uscio","raw_affiliation_strings":["Departments of Anesthesiology and Molecular, Pharmacology, and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Molecular, Pharmacology, and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082346434","display_name":"Zvonimir S. Katu\u0161i\u0107","orcid":"https://orcid.org/0000-0001-7016-7883","observed_orcids":["https://orcid.org/0000-0001-7016-7883"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zvonimir S. Katusic","raw_affiliation_strings":["Departments of Anesthesiology and Molecular, Pharmacology, and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Molecular, Pharmacology, and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003642259","display_name":"Jennifer S. Pollock","orcid":"https://orcid.org/0000-0003-1956-0449","observed_orcids":["https://orcid.org/0000-0003-1956-0449"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer S. Pollock","raw_affiliation_strings":["Vascular Biology Center, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Center, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia; and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003642259"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1638,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.86413552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"300","issue":"3","first_page":"H718","last_page":"H724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrahydrobiopterin","display_name":"tetrahydrobiopterin","score":0.984000027179718},{"id":"https://openalex.org/keywords/no-cgmp-signaling","display_name":"NO/cGMP signaling","score":0.8610000014305115},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/angiotensin-ii-induced-hypertension","display_name":"angiotensin II-induced hypertension","score":0.8790000081062317},{"id":"https://openalex.org/keywords/small-arteries","display_name":"small arteries","score":0.7400000095367432},{"id":"https://openalex.org/keywords/mesenteric-arteries","display_name":"mesenteric arteries","score":0.8500000238418579},{"id":"https://openalex.org/keywords/gtp-cyclohydrolase-i","display_name":"GTP cyclohydrolase I","score":0.9679999947547913},{"id":"https://openalex.org/keywords/reserpine","display_name":"reserpine","score":0.6460000276565552},{"id":"https://openalex.org/keywords/hydrochlorothiazide","display_name":"hydrochlorothiazide","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hydralazine","display_name":"hydralazine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bh4-supplementation","display_name":"BH4 supplementation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2780771799","wikidata":"https://www.wikidata.org/wiki/Q109592502","display_name":"Mesenteric arteries","level":3,"score":0.8331432342529297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7742801904678345},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.769767165184021},{"id":"https://openalex.org/C2780521442","wikidata":"https://www.wikidata.org/wiki/Q419987","display_name":"Hydralazine","level":3,"score":0.684330940246582},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6688162684440613},{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.6243541240692139},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.49942827224731445},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.48113858699798584},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.4670362174510956},{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.46691229939460754},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.46583595871925354},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4195234775543213},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.28029248118400574},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.2762172818183899},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23364728689193726},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.1513124406337738},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06476941704750061}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006136","descriptor_name":"GTP Cyclohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006830","descriptor_name":"Hydralazine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006852","descriptor_name":"Hydrochlorothiazide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008638","descriptor_name":"Mesenteric Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008638","descriptor_name":"Mesenteric Arteries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012110","descriptor_name":"Reserpine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpheart.00393.2010","doi":"https://doi.org/10.1152/ajpheart.00393.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.00393.2010","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3064310","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3064310","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Heart Circ Physiol","raw_type":"Text"},{"id":"pmid:21148769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21148769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Heart and circulatory physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3064310","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3064310","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Heart Circ Physiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1886427930","display_name":null,"funder_award_id":"HL-53524","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1952327251","display_name":null,"funder_award_id":"HL-60653","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2581756160","display_name":"Tetrahydrobiopterin: regulator of endothelial function","funder_award_id":"R01HL053524","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2858015359","display_name":"Stress Related Mechanisms of Hypertension Risk","funder_award_id":"P01HL069999","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G596453221","display_name":null,"funder_award_id":"HL 69999","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6145320680","display_name":"Nitric Oxide Synthase Isoforms in the Kidney","funder_award_id":"R01HL060653","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W133994298","https://openalex.org/W200875727","https://openalex.org/W1678800844","https://openalex.org/W1965261569","https://openalex.org/W1966934777","https://openalex.org/W1982828326","https://openalex.org/W1991507615","https://openalex.org/W2002725819","https://openalex.org/W2015989606","https://openalex.org/W2018344800","https://openalex.org/W2035105779","https://openalex.org/W2042038416","https://openalex.org/W2047770461","https://openalex.org/W2050548878","https://openalex.org/W2058651919","https://openalex.org/W2059694609","https://openalex.org/W2066982827","https://openalex.org/W2074858413","https://openalex.org/W2086723085","https://openalex.org/W2092369342","https://openalex.org/W2094415007","https://openalex.org/W2094881557","https://openalex.org/W2105287497","https://openalex.org/W2106121696","https://openalex.org/W2107293885","https://openalex.org/W2114547396","https://openalex.org/W2119223703","https://openalex.org/W2127072099","https://openalex.org/W2127866291","https://openalex.org/W2132212482","https://openalex.org/W2133791947","https://openalex.org/W2134402538","https://openalex.org/W2146190354","https://openalex.org/W2147648729","https://openalex.org/W2151915722","https://openalex.org/W2152172533","https://openalex.org/W2153933777","https://openalex.org/W2160042367","https://openalex.org/W2160057247","https://openalex.org/W2165073849","https://openalex.org/W2171411731","https://openalex.org/W2184086673","https://openalex.org/W2312352352","https://openalex.org/W2318903045"],"related_works":["https://openalex.org/W2014844679","https://openalex.org/W2318984179","https://openalex.org/W3141126146","https://openalex.org/W2041994865","https://openalex.org/W2153627957","https://openalex.org/W2058651919","https://openalex.org/W2974537231","https://openalex.org/W2106932023","https://openalex.org/W1966934777","https://openalex.org/W2046605798"],"abstract_inverted_index":{"We":[0,18],"previously":[1],"reported":[2],"that":[3,20],"small":[4,41,47,98,135,149,192],"mesenteric":[5,48],"arteries":[6,49,99,136,150,193],"from":[7,50,151],"hypertensive":[8],"rats":[9,52,56,59,69,92,114],"have":[10],"increased":[11,104,127],"NOS-derived":[12],"H(2)O(2)":[13],"and":[14,34,65,79,93,108,161,167,198],"reduced":[15,147],"NO/cGMP":[16,32,95,189],"signaling.":[17],"hypothesized":[19],"antihypertensive":[21,186],"therapy":[22,62,73,78,82,102,120,177,187],"lowers":[23],"blood":[24,88],"pressure":[25,89],"through":[26,194],"a":[27,138],"tetrahydrobiopterin":[28],"(BH(4))-dependent":[29],"mechanism":[30],"restoring":[31],"signaling":[33,96,190],"endothelial":[35],"NOS":[36],"(NOS3;":[37],"eNOS)":[38],"phosphorylation":[39,143,158,170,200],"in":[40,86,90,97,134,140,148,165,181,191],"arteries.":[42],"To":[43],"test":[44],"this":[45],"hypothesis,":[46],"normotensive":[51],"(NORM),":[53],"angiotensin":[54],"II-infused":[55],"(ANG),":[57],"ANG":[58,68,91,113,152,166,182],"with":[60,70,115,154,175],"triple":[61,77,119,176],"(reserperine,":[63],"hydrochlorothiazide,":[64],"hydralazine),":[66],"or":[67,178],"oral":[71,80,123,179],"BH(4)":[72,81,106,116,124,180,196],"were":[74,163],"studied.":[75],"Both":[76],"attenuated":[83],"the":[84],"rise":[85],"systolic":[87],"restored":[94,174],"similarly.":[100],"Triple":[101],"significantly":[103,126],"vascular":[105],"levels":[107,197],"BH(4)-to-BH(2)":[109],"ratio":[110],"similar":[111,164],"to":[112],"supplementation.":[117],"Furthermore,":[118],"(but":[121],"not":[122],"therapy)":[125],"GTP":[128],"cyclohydrolase":[129],"I":[130],"(GTPCH":[131],"I)":[132],"activity":[133],"without":[137],"change":[139],"expression.":[141],"NOS3":[142,157,169,199],"at":[144,159,171,201],"Ser1177":[145,172],"was":[146,173],"compared":[153],"NORM,":[155],"while":[156],"Ser633":[160],"Thr495":[162],"NORM.":[168],"rats.":[183],"In":[184],"conclusion,":[185],"regulates":[188],"increasing":[195],"Ser1177.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
