{"id":"https://openalex.org/W2103166338","doi":"https://doi.org/10.1212/01.wnl.0000325637.38931.27","title":"Dopamine and epilepsy","display_name":"Dopamine and epilepsy","publication_year":2008,"publication_date":"2008-09-08","ids":{"openalex":"https://openalex.org/W2103166338","doi":"https://doi.org/10.1212/01.wnl.0000325637.38931.27","mag":"2103166338","pmid":"https://pubmed.ncbi.nlm.nih.gov/18779507"},"language":"en","primary_location":{"id":"doi:10.1212/01.wnl.0000325637.38931.27","doi":"https://doi.org/10.1212/01.wnl.0000325637.38931.27","is_oa":false,"landing_page_url":"https://doi.org/10.1212/01.wnl.0000325637.38931.27","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104086378","display_name":"Sheryl R. Haut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheryl R. Haut","raw_affiliation_strings":["From the Comprehensive Epilepsy Management Center and Department of Neurology (S.R.H.), Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY; and Movement Disorders Clinic and Department of Neurology (R.L.A.), University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Comprehensive Epilepsy Management Center and Department of Neurology (S.R.H.), Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY; and Movement Disorders Clinic and Department of Neurology (R.L.A.), University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002817065","display_name":"Roger L. Albin","orcid":"https://orcid.org/0000-0002-0629-608X","observed_orcids":["https://orcid.org/0000-0002-0629-608X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger L. Albin","raw_affiliation_strings":["From the Comprehensive Epilepsy Management Center and Department of Neurology (S.R.H.), Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY; and Movement Disorders Clinic and Department of Neurology (R.L.A.), University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Comprehensive Epilepsy Management Center and Department of Neurology (S.R.H.), Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY; and Movement Disorders Clinic and Department of Neurology (R.L.A.), University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525","https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"11","first_page":"784","last_page":"785"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13966","display_name":"Neurological and metabolic disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":1.0},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dopamine-agonists","display_name":"dopamine agonists","score":0.8009999990463257},{"id":"https://openalex.org/keywords/dopamine-receptor-antagonists","display_name":"dopamine antagonists","score":0.8970000147819519},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.8809999823570251},{"id":"https://openalex.org/keywords/nigrostriatal-pathway","display_name":"nigrostriatal pathway","score":0.8980000019073486},{"id":"https://openalex.org/keywords/thalamocortical-projections","display_name":"thalamocortical connections","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mesocorticolimbic-pathway","display_name":"mesocorticolimbic pathway","score":0.9509999752044678},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.9549999833106995},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.8100000023841858},{"id":"https://openalex.org/keywords/autosomal-dominant-nocturnal-frontal-lobe-epilepsy","display_name":"autosomal dominant nocturnal frontal lobe epilepsy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/juvenile-myoclonic-epilepsy","display_name":"juvenile myoclonic epilepsy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/genetic-epilepsy-syndromes","display_name":"genetic epilepsy syndromes","score":0.8479999899864197},{"id":"https://openalex.org/keywords/seizure-pathophysiology","display_name":"seizure pathophysiology","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8127537965774536},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7116521000862122},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.702817976474762},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6940528154373169},{"id":"https://openalex.org/C2779814861","wikidata":"https://www.wikidata.org/wiki/Q543517","display_name":"Juvenile myoclonic epilepsy","level":3,"score":0.5424935817718506},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5201259255409241},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.5166082978248596},{"id":"https://openalex.org/C2780948874","wikidata":"https://www.wikidata.org/wiki/Q640562","display_name":"Ventral tegmental area","level":4,"score":0.5116487145423889},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3208267390727997},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15301743149757385}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1212/01.wnl.0000325637.38931.27","doi":"https://doi.org/10.1212/01.wnl.0000325637.38931.27","is_oa":false,"landing_page_url":"https://doi.org/10.1212/01.wnl.0000325637.38931.27","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:18779507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18779507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1965008785","https://openalex.org/W1995492219","https://openalex.org/W2036052128","https://openalex.org/W2052869591","https://openalex.org/W2056177447","https://openalex.org/W2057198064","https://openalex.org/W2082281443","https://openalex.org/W2104863543","https://openalex.org/W2125559277","https://openalex.org/W2126488639","https://openalex.org/W2129442763","https://openalex.org/W2185218987"],"related_works":["https://openalex.org/W7096726629","https://openalex.org/W1989527631","https://openalex.org/W2155416349","https://openalex.org/W2056177447","https://openalex.org/W3031871821","https://openalex.org/W1822120225","https://openalex.org/W2059251768","https://openalex.org/W2547497694","https://openalex.org/W2051703153","https://openalex.org/W2048782739"],"abstract_inverted_index":{"The":[0,86],"role":[1],"of":[2,21,28,43,111,123,128,137,141,162,167,176],"dopamine":[3,124],"in":[4,46,54,83,159],"epilepsy":[5,84,179,186],"is":[6,24],"intriguing,":[7],"complex,":[8],"and":[9,57,106,144,188],"unresolved.":[10],"While":[11],"no":[12],"dopaminergic":[13,44,174],"agonists":[14],"or":[15,38,49],"antagonists":[16],"are":[17],"used":[18,150],"for":[19],"treatment":[20],"seizures,":[22,113],"there":[23],"evidence":[25],"that":[26,34,76],"many":[27,112],"these":[29],"agents":[30],"modulate":[31,77],"cerebral":[32],"networks":[33],"exert":[35],"either":[36],"anticonvulsant":[37],"proconvulsant":[39],"effects.1":[40],"Potential":[41],"roles":[42],"pathways":[45],"seizure":[47],"expression":[48],"control":[50],"have":[51],"been":[52,170],"reported":[53,158],"both":[55],"generalized":[56],"focal":[58],"epileptic":[59,129],"disorders.2\u20135":[60],"Reverberant":[61],"circuits":[62],"within":[63],"the":[64,68,91,96,107,121,126,135,139],"basal":[65,73],"ganglia,":[66],"including":[67],"dopamine-rich":[69],"nigrostriatal":[70],"projection,":[71],"affect":[72],"ganglia":[74],"outputs":[75],"thalamocortical":[78],"projections":[79],"to":[80,95,116,125,151,172],"regions":[81],"involved":[82],"syndromes.6":[85],"parallel":[87],"mesocorticolimbic":[88],"projection":[89],"from":[90],"ventral":[92],"tegmental":[93],"area":[94],"frontal":[97,101,184],"cortex":[98],"directly":[99],"regulates":[100],"cortical":[102],"function.":[103,156],"These":[104,146],"facts,":[105],"pronounced":[108],"motor":[109],"manifestations":[110],"leads":[114],"naturally":[115],"a":[117],"closer":[118],"look":[119],"at":[120],"relationship":[122],"pathophysiology":[127],"syndromes.\n\nMolecular":[130],"imaging":[131],"with":[132],"PET":[133,168],"offers":[134],"advantage":[136],"examining":[138],"distribution":[140],"neurotransmitter":[142,155],"receptors":[143],"transporters.":[145],"data":[147],"may":[148],"be":[149],"explore":[152,173],"hypotheses":[153],"about":[154],"As":[157],"this":[160,165],"issue":[161],"Neurology":[163],"\u00ae,":[164],"attribute":[166],"has":[169],"utilized":[171],"aspects":[175],"two":[177],"genetic":[178],"syndromes,":[180],"autosomal":[181],"dominant":[182],"nocturnal":[183],"lobe":[185],"(ADNFLE)":[187],"juvenile":[189],"myoclonic":[190],"\u2026":[191]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}