{"id":"https://openalex.org/W2103149709","doi":"https://doi.org/10.1002/ijc.2910570417","title":"Successful immunotherapy of the highly metastatic murine ESb lymphoma with sensitized CD8+ T cells and IFN\u2010\u03b1/\u03b2","display_name":"Successful immunotherapy of the highly metastatic murine ESb lymphoma with sensitized CD8+ T cells and IFN\u2010\u03b1/\u03b2","publication_year":1994,"publication_date":"1994-05-15","ids":{"openalex":"https://openalex.org/W2103149709","doi":"https://doi.org/10.1002/ijc.2910570417","mag":"2103149709","pmid":"https://pubmed.ncbi.nlm.nih.gov/8181857"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.2910570417","doi":"https://doi.org/10.1002/ijc.2910570417","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910570417","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112290838","display_name":"Thomas J. Kaido","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas Kaido","raw_affiliation_strings":["Laboratory of Viral Oncology, Groupe de Laboratoires de l'Institut de Recherches Scientifiques sur le Cancer, Villejuif, France","Laboratory of Viral Oncology, Groupe de Laboratories de l'Institut de Recherches Scientifiques sur le Cancer, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Oncology, Groupe de Laboratoires de l'Institut de Recherches Scientifiques sur le Cancer, Villejuif, France","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Viral Oncology, Groupe de Laboratories de l'Institut de Recherches Scientifiques sur le Cancer, Villejuif, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046988460","display_name":"Chantal Maury","orcid":"https://orcid.org/0000-0003-3733-594X","observed_orcids":["https://orcid.org/0000-0003-3733-594X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chantal Maury","raw_affiliation_strings":["Laboratory of Viral Oncology, Groupe de Laboratories de l'Institut de Recherches Scientifiques sur le Cancer, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Oncology, Groupe de Laboratories de l'Institut de Recherches Scientifiques sur le Cancer, Villejuif, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022678830","display_name":"Volker Schirrmacher","orcid":"https://orcid.org/0000-0003-1253-9145","observed_orcids":["https://orcid.org/0000-0003-1253-9145"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Volker Schirrmacher","raw_affiliation_strings":["Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017775489","display_name":"Ion Gresser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ion Gresser","raw_affiliation_strings":["Laboratory of Viral Oncology, Groupe de Laboratories de l'Institut de Recherches Scientifiques sur le Cancer, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Oncology, Groupe de Laboratories de l'Institut de Recherches Scientifiques sur le Cancer, Villejuif, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112290838"],"corresponding_institution_ids":[],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.3067,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.81610096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"57","issue":"4","first_page":"538","last_page":"543"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.04170000180602074,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6919999718666077},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.6949999928474426},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6549999713897705},{"id":"https://openalex.org/keywords/visceral-metastasis","display_name":"visceral metastases","score":0.7160000205039978},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.6470000147819519},{"id":"https://openalex.org/keywords/tumor-specific-immunity","display_name":"tumor-specific immunity","score":0.546999990940094},{"id":"https://openalex.org/keywords/dba-2-mice","display_name":"DBA/2 mice","score":0.7950000166893005},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.7346558570861816},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7320979237556458},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6590194702148438},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.6177986264228821},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.583540141582489},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5477891564369202},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5366370677947998},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5346872806549072},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5046454668045044},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.4746575653553009},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3750070333480835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37280911207199097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3543318212032318},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2919904589653015},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016827","descriptor_name":"CD8 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.2910570417","doi":"https://doi.org/10.1002/ijc.2910570417","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910570417","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:8181857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8181857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320314924","display_name":"Philippe Foundation","ror":"https://ror.org/038drb871"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W364229405","https://openalex.org/W958123690","https://openalex.org/W1490918588","https://openalex.org/W1604374121","https://openalex.org/W1677393577","https://openalex.org/W1964288721","https://openalex.org/W1965012967","https://openalex.org/W1993559909","https://openalex.org/W1994933522","https://openalex.org/W1995631681","https://openalex.org/W2009132260","https://openalex.org/W2011544817","https://openalex.org/W2045051161","https://openalex.org/W2047403232","https://openalex.org/W2047511510","https://openalex.org/W2053492773","https://openalex.org/W2078106035","https://openalex.org/W2105998729","https://openalex.org/W2140431211","https://openalex.org/W2159801728","https://openalex.org/W2196099160","https://openalex.org/W2471721375"],"related_works":["https://openalex.org/W1601835583","https://openalex.org/W2078106035","https://openalex.org/W2022118169","https://openalex.org/W1964288721","https://openalex.org/W2322134597","https://openalex.org/W2077135455","https://openalex.org/W2029860680","https://openalex.org/W2171765809","https://openalex.org/W2086504551","https://openalex.org/W2140431211"],"abstract_inverted_index":{"Daily":[0],"IFN-alpha/beta":[1,33,54,69,104,177],"therapy":[2,34,171],"was":[3,55,85,90],"totally":[4],"ineffective":[5],"in":[6,13,78,113,143,179],"inhibiting":[7],"the":[8,19,24,36,50,73,93,109,137,161],"development":[9,74,110],"of":[10,23,26,39,59,75,111,121,140,164,172],"visceral":[11],"metastases":[12,77,112],"DBA/2":[14,80,167],"mice":[15,41,101,114],"injected":[16],"i.v.":[17],"with":[18,43,68,103,116],"ESb":[20,44,76,94],"lymphoma":[21,95],"regardless":[22],"number":[25],"tumor":[27],"cells":[28,45,62,98,124,129,154,159,175],"injected.":[29],"The":[30,87,169],"finding":[31],"that":[32,47],"increased":[35,160],"survival":[37,162],"time":[38,163],"ESb-immunized":[40,100],"rechallenged":[42],"suggested":[46],"cooperation":[48],"between":[49],"immune":[51,174],"system":[52],"and":[53,176],"important.":[56],"Adoptive":[57],"transfer":[58,135],"Esb-immune":[60],"spleen":[61,97,153],"(but":[63,125],"not":[64,107,126],"normal":[65],"cells)":[66],"together":[67,102],"treatment":[70,83,105],"did":[71,106],"inhibit":[72,108],"immunocompetent":[79],"mice.":[81,145,168],"Either":[82],"alone":[84],"ineffective.":[86],"anti-metastatic":[88],"effect":[89,139],"specific":[91],"for":[92,157],"as":[96,148],"from":[99],"challenged":[115],"IFN-alpha/beta-resistant":[117],"3C18":[118],"FLC.":[119],"Depletion":[120],"CD8+":[122,158],"T":[123,128],"CD4+":[127],"or":[130],"B":[131],"lymphocytes)":[132],"prior":[133],"to":[134,182],"eliminated":[136],"protective":[138],"ESb-immune":[141,152],"splenocytes":[142],"IFN-alpha/beta-treated":[144,165],"As":[146],"few":[147],"1":[149],"x":[150],"10(6)":[151],"highly":[155],"enriched":[156],"ESb-challenged":[166],"combined":[170],"ESb-specific":[173],"resulted":[178],"long-term":[180],"immunity":[181],"this":[183],"tumor.":[184]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}