{"id":"https://openalex.org/W2103149659","doi":"https://doi.org/10.1080/08916930601061603","title":"Tolerizing DNA vaccines for autoimmune arthritis","display_name":"Tolerizing DNA vaccines for autoimmune arthritis","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2103149659","doi":"https://doi.org/10.1080/08916930601061603","mag":"2103149659","pmid":"https://pubmed.ncbi.nlm.nih.gov/17178564"},"language":"fi","primary_location":{"id":"doi:10.1080/08916930601061603","doi":"https://doi.org/10.1080/08916930601061603","is_oa":false,"landing_page_url":"https://doi.org/10.1080/08916930601061603","pdf_url":null,"source":{"id":"https://openalex.org/S41163404","display_name":"Autoimmunity","issn_l":"0891-6934","issn":["0891-6934","1026-7859","1607-842X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autoimmunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110181145","display_name":"Peggy Pui-Kay Ho","orcid":"https://orcid.org/0000-0002-6848-318X","observed_orcids":["https://orcid.org/0000-0002-6848-318X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peggy P. Ho","raw_affiliation_strings":["Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081820203","display_name":"John Higgins","orcid":"https://orcid.org/0000-0003-4405-2614","observed_orcids":["https://orcid.org/0000-0003-4405-2614"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Higgins","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Stanford, CA94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Stanford, CA94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053941259","display_name":"Brian\u00a0A. Kidd","orcid":"https://orcid.org/0000-0003-2110-1145","observed_orcids":["https://orcid.org/0000-0003-2110-1145"]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian A. Kidd","raw_affiliation_strings":["Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA; GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA","Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA","GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA; GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA","institution_ids":["https://openalex.org/I204866599","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA","institution_ids":["https://openalex.org/I204866599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079558126","display_name":"Beren H. Tomooka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beren Tomooka","raw_affiliation_strings":["Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA; GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA","Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA","GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA; GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA","institution_ids":["https://openalex.org/I204866599","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA","institution_ids":["https://openalex.org/I204866599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033985822","display_name":"Carla DiGennaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla DiGennaro","raw_affiliation_strings":["Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036723888","display_name":"Lowen Y. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lowen Y. Lee","raw_affiliation_strings":["Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064243460","display_name":"Henry E. Neuman de Vegvar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry E. Neuman de Vegvar","raw_affiliation_strings":["Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA; GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA","Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA","GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA; GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA","institution_ids":["https://openalex.org/I204866599","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA","institution_ids":["https://openalex.org/I204866599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066671501","display_name":"Lawrence Steinman","orcid":"https://orcid.org/0000-0002-2437-2250","observed_orcids":["https://orcid.org/0000-0002-2437-2250"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence Steinman","raw_affiliation_strings":["Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014721829","display_name":"William H. Robinson","orcid":"https://orcid.org/0000-0003-4385-704X","observed_orcids":["https://orcid.org/0000-0003-4385-704X","https://orcid.org/0000-0002-0841-7148"]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William H. Robinson","raw_affiliation_strings":["Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA; GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA","Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA","GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA; GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA","institution_ids":["https://openalex.org/I204866599","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"GRECC, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA94304, USA","institution_ids":["https://openalex.org/I204866599"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3129,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.81033231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"39","issue":"8","first_page":"675","last_page":"682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.05169999971985817,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.9919999837875366},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.527999997138977},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/protein-microarrays","display_name":"protein microarrays","score":0.7459999918937683},{"id":"https://openalex.org/keywords/antibody-profiling","display_name":"antibody profiling","score":0.8140000104904175},{"id":"https://openalex.org/keywords/autoimmune-disease-treatment","display_name":"autoimmune disease therapy","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7139019966125488},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6215709447860718},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.5976973176002502},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.5680704712867737},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.4955374002456665},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.4745098948478699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47311708331108093},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4720873534679413},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4488704800605774},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4343096911907196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3269122242927551},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.30665701627731323},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.2534659802913666}],"mesh":[{"descriptor_ui":"D000069059","descriptor_name":"Atorvastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007596","descriptor_name":"Joints","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007596","descriptor_name":"Joints","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/08916930601061603","doi":"https://doi.org/10.1080/08916930601061603","is_oa":false,"landing_page_url":"https://doi.org/10.1080/08916930601061603","pdf_url":null,"source":{"id":"https://openalex.org/S41163404","display_name":"Autoimmunity","issn_l":"0891-6934","issn":["0891-6934","1026-7859","1607-842X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autoimmunity","raw_type":"journal-article"},{"id":"pmid:17178564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17178564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autoimmunity","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.418.3460","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.418.3460","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://robinsonlab.stanford.edu/publications/ho_autoimmunity_06.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1347710858","display_name":null,"funder_award_id":"K08 AR02133","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G465681081","display_name":null,"funder_award_id":"N01-HV-28 183","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6497951441","display_name":"DNA VACCINE MEDIATED IMMUNOTHERAPY OF RHEUMATIC DISEASE","funder_award_id":"K08AR002133","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G7217982950","display_name":"NHLBI PROTEOMICS INITIATIVE","funder_award_id":"n01hv28183-13-0-0","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320306237","display_name":"Arthritis Foundation","ror":"https://ror.org/04zk9fe75"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1536516084","https://openalex.org/W1754391675","https://openalex.org/W1964653776","https://openalex.org/W1980787877","https://openalex.org/W1980857453","https://openalex.org/W1980990177","https://openalex.org/W1992498864","https://openalex.org/W2007954685","https://openalex.org/W2014081699","https://openalex.org/W2017885661","https://openalex.org/W2025939140","https://openalex.org/W2031138302","https://openalex.org/W2032247503","https://openalex.org/W2040937120","https://openalex.org/W2049476767","https://openalex.org/W2056877436","https://openalex.org/W2079448776","https://openalex.org/W2099014795","https://openalex.org/W2116887543","https://openalex.org/W2122176733","https://openalex.org/W2131139785","https://openalex.org/W2133888839","https://openalex.org/W2136266810","https://openalex.org/W2142232563","https://openalex.org/W2147292685","https://openalex.org/W2150926065","https://openalex.org/W2155178236","https://openalex.org/W2155440953","https://openalex.org/W2160243675","https://openalex.org/W2160887077","https://openalex.org/W2319316833","https://openalex.org/W2326606386","https://openalex.org/W4233988008","https://openalex.org/W4249838284"],"related_works":["https://openalex.org/W1554044775","https://openalex.org/W2808196245","https://openalex.org/W1530294263","https://openalex.org/W2206646568","https://openalex.org/W3207021350","https://openalex.org/W4412785359","https://openalex.org/W4380354445","https://openalex.org/W2156130318","https://openalex.org/W2016387081","https://openalex.org/W6384627"],"abstract_inverted_index":{"Current":[0],"therapies":[1],"for":[2,19,62,178],"rheumatoid":[3],"arthritis":[4,41],"(RA)":[5],"and":[6,14,45,55,80,132,156,166,183],"other":[7,184],"autoimmune":[8,60,185],"diseases":[9],"non-specifically":[10],"suppress":[11],"immune":[12],"function,":[13],"there":[15],"is":[16],"great":[17],"need":[18],"fundamental":[20],"approaches":[21],"such":[22,172],"as":[23,119],"antigen-specific":[24,34],"tolerizing":[25,35,69,115,153],"therapy.":[26],"In":[27],"this":[28],"paper":[29],"we":[30],"describe":[31],"development":[32,151],"of":[33,47,82,93,98,104,127,140,152,159,165,181],"DNA":[36,70,99,116,147,154],"vaccines":[37,71,100],"to":[38,50,53,56,89,121,162,167,171],"treat":[39],"collagen-induced":[40],"(CIA)":[42],"in":[43,143],"mice,":[44],"use":[46,158],"protein":[48],"microarrays":[49],"monitor":[51,168],"response":[52],"therapy":[54],"identify":[57],"potential":[58],"additional":[59],"targets":[61],"next":[63],"generation":[64],"vaccines.":[65],"We":[66],"demonstrate":[67],"that":[68],"encoding":[72,101,117,148],"type":[73],"II":[74],"collagen":[75],"(CII)":[76],"reduced":[77,125,138],"the":[78,91,96,128,157,179],"incidence":[79],"severity":[81,92],"CIA.":[83],"Atorvastatin,":[84],"a":[85,175],"statin":[86],"drug":[87],"found":[88],"reduce":[90],"autoimmunity,":[94],"potentiated":[95],"effect":[97],"CII.":[102,149],"Analysis":[103],"cytokines":[105,130],"produced":[106],"by":[107],"collagen-reactive":[108],"T":[109],"cells":[110],"derived":[111],"from":[112],"mice":[113,144],"receiving":[114],"CII,":[118],"compared":[120],"control":[122],"vaccines,":[123,155,173],"revealed":[124],"production":[126],"pro-inflammatory":[129],"IFN-gamma":[131],"TNF-alpha.":[133],"Arthritis":[134],"microarray":[135],"analysis":[136],"demonstrated":[137],"spreading":[139],"autoantibody":[141],"responses":[142,170],"treated":[145],"with":[146],"The":[150],"antibody":[160],"profiling":[161],"guide":[163],"design":[164],"therapeutic":[169],"represents":[174],"promising":[176],"approach":[177],"treatment":[180],"RA":[182],"diseases.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}