{"id":"https://openalex.org/W2103146352","doi":"https://doi.org/10.1038/nrc2870","title":"Envisioning the future of early anticancer drug development","display_name":"Envisioning the future of early anticancer drug development","publication_year":2010,"publication_date":"2010-06-10","ids":{"openalex":"https://openalex.org/W2103146352","doi":"https://doi.org/10.1038/nrc2870","mag":"2103146352","pmid":"https://pubmed.ncbi.nlm.nih.gov/20535131"},"language":"en","primary_location":{"id":"doi:10.1038/nrc2870","doi":"https://doi.org/10.1038/nrc2870","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrc2870","pdf_url":null,"source":{"id":"https://openalex.org/S160464432","display_name":"Nature reviews. Cancer","issn_l":"1474-175X","issn":["1474-175X","1474-1768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068368047","display_name":"Timothy Anthony Yap","orcid":"https://orcid.org/0000-0002-2154-3309","observed_orcids":["https://orcid.org/0000-0002-2154-3309"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timothy A. Yap","raw_affiliation_strings":["Drug Development Unit, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, United Kingdom","Timothy A. Yap, Shahneen K. Sandhu and Johann S. de Bono are at the Drug Development Unit, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, United Kingdom.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Development Unit, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, United Kingdom","institution_ids":["https://openalex.org/I1325846038"]},{"raw_affiliation_string":"Timothy A. Yap, Shahneen K. Sandhu and Johann S. de Bono are at the Drug Development Unit, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, United Kingdom.,","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064026461","display_name":"Shahneen Kaur Sandhu","orcid":"https://orcid.org/0000-0002-8660-4475","observed_orcids":["https://orcid.org/0000-0002-8660-4475"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shahneen K. Sandhu","raw_affiliation_strings":["Timothy A. Yap, Shahneen K. Sandhu and Johann S. de Bono are at the Drug Development Unit, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, United Kingdom.,","Timothy A. Yap, Shahneen K. Sandhu, Paul Workman and Johann S. de Bono are at the Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Timothy A. Yap, Shahneen K. Sandhu and Johann S. de Bono are at the Drug Development Unit, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, United Kingdom.,","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]},{"raw_affiliation_string":"Timothy A. Yap, Shahneen K. Sandhu, Paul Workman and Johann S. de Bono are at the Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.,","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003965204","display_name":"Paul Workman","orcid":"https://orcid.org/0000-0003-1659-3034","observed_orcids":["https://orcid.org/0000-0003-1659-3034"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Workman","raw_affiliation_strings":["Timothy A. Yap, Shahneen K. Sandhu, Paul Workman and Johann S. de Bono are at the Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Timothy A. Yap, Shahneen K. Sandhu, Paul Workman and Johann S. de Bono are at the Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.,","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072378199","display_name":"Johann Sebastian De Bono","orcid":"https://orcid.org/0000-0002-2034-595X","observed_orcids":["https://orcid.org/0000-0002-2034-595X"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Johann S. de Bono","raw_affiliation_strings":["Timothy A. Yap, Shahneen K. Sandhu and Johann S. de Bono are at the Drug Development Unit, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, United Kingdom.,","Timothy A. Yap, Shahneen K. Sandhu, Paul Workman and Johann S. de Bono are at the Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Timothy A. Yap, Shahneen K. Sandhu and Johann S. de Bono are at the Drug Development Unit, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, United Kingdom.,","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]},{"raw_affiliation_string":"Timothy A. Yap, Shahneen K. Sandhu, Paul Workman and Johann S. de Bono are at the Section of Medicine and Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom.,","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I2801316944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5072378199"],"corresponding_institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I142947616","https://openalex.org/I2801316944","https://openalex.org/I4210121186"],"apc_list":null,"apc_paid":null,"fwci":5.3525,"has_fulltext":false,"cited_by_count":282,"citation_normalized_percentile":{"value":0.97777778,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"10","issue":"7","first_page":"514","last_page":"523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.9480000138282776},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9340000152587891},{"id":"https://openalex.org/keywords/pharmacodynamic-markers","display_name":"pharmacodynamic biomarkers","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.8859999775886536},{"id":"https://openalex.org/keywords/regulatory-approval","display_name":"regulatory approval","score":0.7210000157356262},{"id":"https://openalex.org/keywords/drug-development-acceleration","display_name":"drug development acceleration","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.6783779263496399},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.6651221513748169},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5597281455993652},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5218378901481628},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5118686556816101},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.48177358508110046},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.4058341085910797},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3938892185688019},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34476351737976074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10346534848213196}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrc2870","doi":"https://doi.org/10.1038/nrc2870","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrc2870","pdf_url":null,"source":{"id":"https://openalex.org/S160464432","display_name":"Nature reviews. Cancer","issn_l":"1474-175X","issn":["1474-175X","1474-1768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cancer","raw_type":"journal-article"},{"id":"pmid:20535131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20535131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Cancer","raw_type":"Research Support, Non-U.S. Gov't"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W108519829","https://openalex.org/W1545086492","https://openalex.org/W1549144603","https://openalex.org/W1906314377","https://openalex.org/W1970263201","https://openalex.org/W1970392870","https://openalex.org/W1973268287","https://openalex.org/W1984160965","https://openalex.org/W1988036808","https://openalex.org/W1988219667","https://openalex.org/W1989847233","https://openalex.org/W1995236496","https://openalex.org/W1997533142","https://openalex.org/W1998836974","https://openalex.org/W1999659306","https://openalex.org/W1999868376","https://openalex.org/W2002821487","https://openalex.org/W2002962154","https://openalex.org/W2007882332","https://openalex.org/W2008145170","https://openalex.org/W2011912935","https://openalex.org/W2012047645","https://openalex.org/W2017627279","https://openalex.org/W2018723375","https://openalex.org/W2021135937","https://openalex.org/W2028395388","https://openalex.org/W2037356096","https://openalex.org/W2039849856","https://openalex.org/W2040104879","https://openalex.org/W2043297836","https://openalex.org/W2043911652","https://openalex.org/W2050574264","https://openalex.org/W2053277232","https://openalex.org/W2054022422","https://openalex.org/W2054857153","https://openalex.org/W2058763863","https://openalex.org/W2059300459","https://openalex.org/W2063370132","https://openalex.org/W2065812641","https://openalex.org/W2074839878","https://openalex.org/W2076108528","https://openalex.org/W2079671118","https://openalex.org/W2082504433","https://openalex.org/W2084654820","https://openalex.org/W2087012714","https://openalex.org/W2088561077","https://openalex.org/W2095201384","https://openalex.org/W2096899475","https://openalex.org/W2098549354","https://openalex.org/W2100240421","https://openalex.org/W2104505549","https://openalex.org/W2105540740","https://openalex.org/W2106723663","https://openalex.org/W2106789440","https://openalex.org/W2107343029","https://openalex.org/W2108710215","https://openalex.org/W2109076938","https://openalex.org/W2109785424","https://openalex.org/W2111976640","https://openalex.org/W2112417555","https://openalex.org/W2114095518","https://openalex.org/W2114282952","https://openalex.org/W2115499099","https://openalex.org/W2118342205","https://openalex.org/W2119597015","https://openalex.org/W2124301570","https://openalex.org/W2125440931","https://openalex.org/W2126236874","https://openalex.org/W2126503665","https://openalex.org/W2126575569","https://openalex.org/W2128373232","https://openalex.org/W2128923437","https://openalex.org/W2131456094","https://openalex.org/W2132628497","https://openalex.org/W2132630169","https://openalex.org/W2133999831","https://openalex.org/W2137935883","https://openalex.org/W2138896702","https://openalex.org/W2139799027","https://openalex.org/W2140693313","https://openalex.org/W2140765540","https://openalex.org/W2141393790","https://openalex.org/W2148885898","https://openalex.org/W2148998801","https://openalex.org/W2149875674","https://openalex.org/W2153477391","https://openalex.org/W2153557899","https://openalex.org/W2161531371","https://openalex.org/W2162300921","https://openalex.org/W2164738374","https://openalex.org/W2168264491","https://openalex.org/W2169644362","https://openalex.org/W2170544517","https://openalex.org/W2171722798","https://openalex.org/W2171972386","https://openalex.org/W2187761249","https://openalex.org/W2205149318","https://openalex.org/W2220670435","https://openalex.org/W2224373765","https://openalex.org/W2227477053","https://openalex.org/W2241837682","https://openalex.org/W2318605753","https://openalex.org/W2324278934","https://openalex.org/W2467250903","https://openalex.org/W2523320031","https://openalex.org/W2571325080","https://openalex.org/W4242011915"],"related_works":["https://openalex.org/W2537913141","https://openalex.org/W2161588876","https://openalex.org/W2064170540","https://openalex.org/W2054625537","https://openalex.org/W2126428160","https://openalex.org/W646834581","https://openalex.org/W2091596615","https://openalex.org/W3036959286","https://openalex.org/W2166499722","https://openalex.org/W10691706"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":33},{"year":2012,"cited_by_count":41}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}