{"id":"https://openalex.org/W2103126286","doi":"https://doi.org/10.4097/kjae.2009.57.6.693","title":"The effects of lidocaine and fentanyl on airway irritability during inhalation induction with desflurane","display_name":"The effects of lidocaine and fentanyl on airway irritability during inhalation induction with desflurane","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2103126286","doi":"https://doi.org/10.4097/kjae.2009.57.6.693","mag":"2103126286","pmid":"https://pubmed.ncbi.nlm.nih.gov/30625950"},"language":"en","primary_location":{"id":"doi:10.4097/kjae.2009.57.6.693","doi":"https://doi.org/10.4097/kjae.2009.57.6.693","is_oa":true,"landing_page_url":"https://doi.org/10.4097/kjae.2009.57.6.693","pdf_url":"https://ekja.org/upload/pdf/kjae-57-693.pdf","source":{"id":"https://openalex.org/S4210221379","display_name":"Korean Journal of Anesthesiology","issn_l":"0302-5780","issn":["0302-5780","2005-6419","2005-7563"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","jufo-1","kci-registered","medline","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319500","host_organization_name":"Korean Society of Anesthesiologists","host_organization_lineage":["https://openalex.org/P4310319500"],"host_organization_lineage_names":["Korean Society of Anesthesiologists"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ekja.org/upload/pdf/kjae-57-693.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100924579","display_name":"In Gyu Choi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"In Gyu Choi","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101561355","display_name":"Young Soon Choi","orcid":"https://orcid.org/0000-0002-3819-0271","observed_orcids":["https://orcid.org/0000-0002-3819-0271"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young Soon Choi","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109996187","display_name":"Jin-Hye Min","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin-Hye Min","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100760941","display_name":"Yong Ho Kim","orcid":"https://orcid.org/0000-0001-7527-0134","observed_orcids":["https://orcid.org/0000-0001-7527-0134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-Ho Kim","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011955332","display_name":"Young Keun Chae","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young Keun Chae","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Woo-Kyung Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Woo-Kyung Lee","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044784817","display_name":"Yong Kyung Lee","orcid":"https://orcid.org/0000-0002-8921-8174","observed_orcids":["https://orcid.org/0000-0002-8921-8174"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Kyung Lee","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100517562","display_name":"Ae Re Na Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ae Re Na Lee","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hyong-Rae Cho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyong-Rae Cho","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Kwandong University, College of Medicine, Goyang, Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110196679","display_name":"Hong-Seok Chae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hong-Seok Chae","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Yonsei University, College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Yonsei University, College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21295844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"57","issue":"6","first_page":"693","last_page":"693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10830","display_name":"Airway Management and Intubation Techniques","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.8429999947547913},{"id":"https://openalex.org/keywords/fentanyl","display_name":"fentanyl","score":1.0},{"id":"https://openalex.org/keywords/desflurane","display_name":"desflurane","score":0.9539999961853027},{"id":"https://openalex.org/keywords/inhalational-induction","display_name":"inhalation induction","score":0.9470000267028809},{"id":"https://openalex.org/keywords/laryngospasm","display_name":"laryngospasm","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hemodynamic-response","display_name":"hemodynamic response","score":0.8579999804496765},{"id":"https://openalex.org/keywords/sympathetic-stimulation","display_name":"sympathetic stimulation","score":0.847000002861023},{"id":"https://openalex.org/keywords/midazolam-premedication","display_name":"midazolam premedication","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cough","display_name":"cough","score":0.3479999899864197},{"id":"https://openalex.org/keywords/apnea","display_name":"apnea","score":0.7049999833106995},{"id":"https://openalex.org/keywords/bispectral-index","display_name":"bispectral index","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9103221893310547},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.8808622360229492},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.8139218091964722},{"id":"https://openalex.org/C2780842079","wikidata":"https://www.wikidata.org/wiki/Q1324592","display_name":"Laryngospasm","level":3,"score":0.6601073145866394},{"id":"https://openalex.org/C2776442465","wikidata":"https://www.wikidata.org/wiki/Q419383","display_name":"Desflurane","level":3,"score":0.6592864990234375},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.6050444841384888},{"id":"https://openalex.org/C2778000748","wikidata":"https://www.wikidata.org/wiki/Q423071","display_name":"Midazolam","level":3,"score":0.5963020324707031},{"id":"https://openalex.org/C2781382112","wikidata":"https://www.wikidata.org/wiki/Q7053142","display_name":"Normocapnia","level":4,"score":0.5277534127235413},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.4713206887245178},{"id":"https://openalex.org/C2778029997","wikidata":"https://www.wikidata.org/wiki/Q750195","display_name":"Tracheal intubation","level":3,"score":0.46376797556877136},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.4482635259628296},{"id":"https://openalex.org/C2780820931","wikidata":"https://www.wikidata.org/wiki/Q29299","display_name":"Irritability","level":3,"score":0.4309956431388855},{"id":"https://openalex.org/C2778716859","wikidata":"https://www.wikidata.org/wiki/Q939018","display_name":"Intubation","level":2,"score":0.3959294855594635},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.32575803995132446},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.20052006840705872},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1220463216304779},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.07497096061706543},{"id":"https://openalex.org/C2777037550","wikidata":"https://www.wikidata.org/wiki/Q615759","display_name":"Hypercapnia","level":3,"score":0.0741952657699585},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4097/kjae.2009.57.6.693","doi":"https://doi.org/10.4097/kjae.2009.57.6.693","is_oa":true,"landing_page_url":"https://doi.org/10.4097/kjae.2009.57.6.693","pdf_url":"https://ekja.org/upload/pdf/kjae-57-693.pdf","source":{"id":"https://openalex.org/S4210221379","display_name":"Korean Journal of Anesthesiology","issn_l":"0302-5780","issn":["0302-5780","2005-6419","2005-7563"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","jufo-1","kci-registered","medline","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319500","host_organization_name":"Korean Society of Anesthesiologists","host_organization_lineage":["https://openalex.org/P4310319500"],"host_organization_lineage_names":["Korean Society of Anesthesiologists"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Anesthesiology","raw_type":"journal-article"},{"id":"pmid:30625950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30625950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean journal of anesthesiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4097/kjae.2009.57.6.693","doi":"https://doi.org/10.4097/kjae.2009.57.6.693","is_oa":true,"landing_page_url":"https://doi.org/10.4097/kjae.2009.57.6.693","pdf_url":"https://ekja.org/upload/pdf/kjae-57-693.pdf","source":{"id":"https://openalex.org/S4210221379","display_name":"Korean Journal of Anesthesiology","issn_l":"0302-5780","issn":["0302-5780","2005-6419","2005-7563"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","jufo-1","kci-registered","medline","oarl","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319500","host_organization_name":"Korean Society of Anesthesiologists","host_organization_lineage":["https://openalex.org/P4310319500"],"host_organization_lineage_names":["Korean Society of Anesthesiologists"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103126286.pdf","grobid_xml":"https://content.openalex.org/works/W2103126286.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1978357169","https://openalex.org/W1985744249","https://openalex.org/W1994289213","https://openalex.org/W2000524798","https://openalex.org/W2033687737","https://openalex.org/W2039849248","https://openalex.org/W2044827110","https://openalex.org/W2045111503","https://openalex.org/W2047223439","https://openalex.org/W2055858464","https://openalex.org/W2058197006","https://openalex.org/W2061081741","https://openalex.org/W2079687767","https://openalex.org/W2089314605","https://openalex.org/W2091212743","https://openalex.org/W2094661766","https://openalex.org/W2098984908","https://openalex.org/W2120134944","https://openalex.org/W2137471533","https://openalex.org/W2140013015","https://openalex.org/W2144991562","https://openalex.org/W2148798302","https://openalex.org/W2154225271","https://openalex.org/W2160743951","https://openalex.org/W2168202526","https://openalex.org/W2411150223"],"related_works":["https://openalex.org/W2322685569","https://openalex.org/W2039849248","https://openalex.org/W2094661766","https://openalex.org/W2380899212","https://openalex.org/W4392288196","https://openalex.org/W2315380609","https://openalex.org/W2352817847","https://openalex.org/W1994289213","https://openalex.org/W1981695019","https://openalex.org/W2349340333"],"abstract_inverted_index":{"BACKGROUND:":[0],"Inhalation":[1],"induction":[2,65,168],"with":[3,35,66,169,177],"desflurane":[4,67,170],"can":[5],"cause":[6],"airway":[7,75,156],"irritability":[8,76,90],"and":[9,22,70,82,85,107,110,118,148],"sympathetic":[10],"stimulation.":[11],"The":[12,139],"aim":[13],"of":[14,42,126,141],"this":[15],"study":[16,143],"was":[17,91],"to":[18,40,45,154],"investigate":[19],"whether":[20],"lidocaine":[21,51,149],"fentanyl":[23,56,147,160],"could":[24,161],"reduce":[25,155,163],"these":[26],"unwanted":[27],"reactions.":[28],"METHODS:":[29],"Seventy-five":[30],"patients":[31,173],"who":[32,174],"had":[33,150],"premedication":[34],"midazolam":[36],"were":[37,122,134,175],"randomly":[38],"allocated":[39],"one":[41],"three":[43],"groups":[44],"receive":[46],"intravenous":[47,146,159],"saline":[48],"(S":[49],"group),":[50,55,60],"1.5":[52],"mg/kg":[53],"(L":[54],"1":[57],"microgram/kg":[58],"(F":[59],"respectively,":[61],"before":[62,120],"tidal":[63],"volume":[64],"in":[68,171],"oxygen":[69],"nitrous":[71],"oxide.":[72],"We":[73],"recorded":[74],"such":[77],"as":[78],"cough,":[79],"apnea,":[80],"laryngospasm":[81],"excitatory":[83],"movement":[84],"hemodynamic":[86,164],"changes.":[87],"RESULTS:":[88],"Airway":[89],"not":[92,135],"significantly":[93,136,162],"different":[94],"between":[95],"the":[96,142,172],"groups.":[97],"In":[98],"F":[99],"group,":[100],"mean":[101],"blood":[102],"pressure":[103],"at":[104,113],"LOC":[105,108,114,116],"ver":[106],"BIS":[109,117],"heart":[111],"rate":[112],"ver,":[115],"just":[119],"intubation":[121],"lower":[123],"than":[124],"those":[125],"S":[127],"group":[128],"(P":[129],"<":[130],"0.05).":[131],"Other":[132],"results":[133,140],"different.":[137],"CONCLUSIONS:":[138],"showed":[144],"that":[145],"no":[151],"beneficial":[152],"effects":[153],"irritability,":[157],"but":[158],"stimulation":[165],"during":[166],"inhalation":[167],"premedicated":[176],"midazolam.":[178]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}