{"id":"https://openalex.org/W2103122372","doi":"https://doi.org/10.1016/j.mad.2011.12.002","title":"Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice","display_name":"Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice","publication_year":2011,"publication_date":"2011-12-31","ids":{"openalex":"https://openalex.org/W2103122372","doi":"https://doi.org/10.1016/j.mad.2011.12.002","mag":"2103122372","pmid":"https://pubmed.ncbi.nlm.nih.gov/22212415"},"language":"en","primary_location":{"id":"doi:10.1016/j.mad.2011.12.002","doi":"https://doi.org/10.1016/j.mad.2011.12.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mad.2011.12.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S004763741100193X/pdf","source":{"id":"https://openalex.org/S6761461","display_name":"Mechanisms of Ageing and Development","issn_l":"0047-6374","issn":["0047-6374","1872-6216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of Ageing and Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S004763741100193X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021083473","display_name":"Sarah Hempenstall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah Hempenstall","raw_affiliation_strings":["Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK","Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen,, AB24 2TZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK","institution_ids":["https://openalex.org/I195460627"]},{"raw_affiliation_string":"Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen,, AB24 2TZ, UK","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072680197","display_name":"Melissa M. Page","orcid":"https://orcid.org/0000-0001-5750-8962","observed_orcids":["https://orcid.org/0000-0001-5750-8962"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Melissa M. Page","raw_affiliation_strings":["Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069598772","display_name":"Katrina R. Wallen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katrina R. Wallen","raw_affiliation_strings":["Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021208221","display_name":"Colin Selman","orcid":"https://orcid.org/0000-0002-8727-0593","observed_orcids":["https://orcid.org/0000-0002-8727-0593"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Colin Selman","raw_affiliation_strings":["Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative and Environmental Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK","institution_ids":["https://openalex.org/I195460627"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021208221"],"corresponding_institution_ids":["https://openalex.org/I195460627"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":{"value":4780,"currency":"USD","value_usd":4780},"fwci":1.9457,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.86087606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"133","issue":"1","first_page":"37","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.25200000405311584,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.08399999886751175,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-restriction","display_name":"dietary restriction","score":1.0},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/citrate-synthase","display_name":"citrate synthase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mitochondrial-content","display_name":"mitochondrial content","score":0.5339999794960022},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.718999981880188},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6389999985694885},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.8222901821136475},{"id":"https://openalex.org/C111133373","wikidata":"https://www.wikidata.org/wiki/Q21132608","display_name":"Citrate synthase","level":3,"score":0.8156163096427917},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7680282592773438},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7109094262123108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6784717440605164},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.6183902621269226},{"id":"https://openalex.org/C123249941","wikidata":"https://www.wikidata.org/wiki/Q306116","display_name":"Cytochrome c oxidase","level":3,"score":0.5879313349723816},{"id":"https://openalex.org/C169415338","wikidata":"https://www.wikidata.org/wiki/Q18031951","display_name":"TFAM","level":4,"score":0.44663047790527344},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.42636218667030334},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4260948896408081},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42043739557266235},{"id":"https://openalex.org/C74438686","wikidata":"https://www.wikidata.org/wiki/Q18030218","display_name":"NRF1","level":4,"score":0.4100847542285919},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37134408950805664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3444828689098358},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16501584649085999},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10996079444885254},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06953519582748413}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004579","descriptor_name":"Electron Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008931","descriptor_name":"Mitochondria, Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.mad.2011.12.002","doi":"https://doi.org/10.1016/j.mad.2011.12.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mad.2011.12.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S004763741100193X/pdf","source":{"id":"https://openalex.org/S6761461","display_name":"Mechanisms of Ageing and Development","issn_l":"0047-6374","issn":["0047-6374","1872-6216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of Ageing and Development","raw_type":"journal-article"},{"id":"pmid:22212415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22212415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of ageing and development","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:402205","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/id/eprint/402205/2/22212415","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:193004","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078/193004","pdf_url":null,"source":{"id":"https://openalex.org/S4306400166","display_name":"Digital Access to Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800384882","host_organization_name":"Harris County Public Library","host_organization_lineage":["https://openalex.org/I2800384882"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mechanisms of Ageing and Development, Vol. 133 , p. 37-45","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.gla.ac.uk:77227","doi":null,"is_oa":false,"landing_page_url":"https://eprints.gla.ac.uk/77227/","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"}],"best_oa_location":{"id":"doi:10.1016/j.mad.2011.12.002","doi":"https://doi.org/10.1016/j.mad.2011.12.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mad.2011.12.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S004763741100193X/pdf","source":{"id":"https://openalex.org/S6761461","display_name":"Mechanisms of Ageing and Development","issn_l":"0047-6374","issn":["0047-6374","1872-6216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of Ageing and Development","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2286060576","display_name":null,"funder_award_id":"BB/H012850/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6789754052","display_name":"Dissecting the mechanisms underlying lifespan extension in insulin signalling mutant mice","funder_award_id":"BB/H012850/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320359","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103122372.pdf","grobid_xml":"https://content.openalex.org/works/W2103122372.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W954944586","https://openalex.org/W1521853181","https://openalex.org/W1600619258","https://openalex.org/W1936102533","https://openalex.org/W1960692735","https://openalex.org/W1964569690","https://openalex.org/W1966132436","https://openalex.org/W1968162183","https://openalex.org/W1971082641","https://openalex.org/W1974188155","https://openalex.org/W1975439264","https://openalex.org/W1979496891","https://openalex.org/W1986042961","https://openalex.org/W1988744799","https://openalex.org/W1989038174","https://openalex.org/W1999106865","https://openalex.org/W2000301075","https://openalex.org/W2000482070","https://openalex.org/W2001569637","https://openalex.org/W2006083028","https://openalex.org/W2007256995","https://openalex.org/W2011553299","https://openalex.org/W2015859860","https://openalex.org/W2021952329","https://openalex.org/W2027395393","https://openalex.org/W2028298077","https://openalex.org/W2035597104","https://openalex.org/W2049547722","https://openalex.org/W2055729903","https://openalex.org/W2058512647","https://openalex.org/W2061895068","https://openalex.org/W2064230441","https://openalex.org/W2066317254","https://openalex.org/W2066668773","https://openalex.org/W2078394646","https://openalex.org/W2078717687","https://openalex.org/W2087393295","https://openalex.org/W2099547258","https://openalex.org/W2103416697","https://openalex.org/W2105230781","https://openalex.org/W2114331328","https://openalex.org/W2118094282","https://openalex.org/W2119679507","https://openalex.org/W2121881475","https://openalex.org/W2121945497","https://openalex.org/W2122806349","https://openalex.org/W2123250404","https://openalex.org/W2124724687","https://openalex.org/W2125221913","https://openalex.org/W2128635872","https://openalex.org/W2128975731","https://openalex.org/W2131538332","https://openalex.org/W2134775482","https://openalex.org/W2143996615","https://openalex.org/W2151136828","https://openalex.org/W2151435349","https://openalex.org/W2151845379","https://openalex.org/W2155508482","https://openalex.org/W2160909177","https://openalex.org/W2161549180","https://openalex.org/W2161680769","https://openalex.org/W2162306102","https://openalex.org/W2163049508","https://openalex.org/W2165340797","https://openalex.org/W2166798057","https://openalex.org/W2168729166","https://openalex.org/W2170729914","https://openalex.org/W2202461136"],"related_works":["https://openalex.org/W7161557957","https://openalex.org/W2511506932","https://openalex.org/W2000482070","https://openalex.org/W4390638239","https://openalex.org/W2067453920","https://openalex.org/W1981999383","https://openalex.org/W2058512647","https://openalex.org/W2030199991","https://openalex.org/W3026256969","https://openalex.org/W2705129"],"abstract_inverted_index":{"Dietary":[0],"restriction":[1],"(DR)":[2],"is":[3],"suggested":[4],"to":[5,45],"induce":[6,163],"mitochondrial":[7,35,39,58,62,96,123,149,170,179,196],"biogenesis,":[8],"although":[9],"recently":[10],"this":[11],"has":[12],"been":[13],"challenged.":[14],"Here":[15],"we":[16,173],"determined":[17,152],"the":[18,135],"impact":[19],"of":[20,26,74,90,94,116,122],"1,":[21,102],"9":[22],"and":[23,37,54,60,86,106,168],"18":[24],"months":[25],"30%":[27,71],"DR":[28,117,132,145],"in":[29,41,64,113,138,141,156,195],"male":[30],"C57BL/6":[31],"mice":[32],"on":[33,38,79],"key":[34],"factors":[36],"function":[40],"skeletal":[42,114,158],"muscle,":[43],"relative":[44],"age-matched":[46],"ad":[47],"libitum":[48],"(AL)":[49],"controls.":[50,143],"We":[51],"examined":[52],"proteins":[53,98],"mRNAs":[55],"associated":[56,97],"with":[57,131],"biogenesis":[59],"measured":[61],"respiration":[63,124,139],"permeabilised":[65],"myofibres":[66],"using":[67],"high":[68],"resolution":[69],"respirometry.":[70],"DR,":[72,130,189],"irrespective":[73],"duration,":[75],"had":[76],"no":[77],"effect":[78],"citrate":[80,154],"synthase":[81],"activity.":[82],"In":[83],"contrast,":[84],"total":[85],"nuclear":[87],"protein":[88],"levels":[89,93],"PGC-1\u03b1,":[91],"mRNA":[92],"several":[95],"(Pgc-1\u03b1,":[99],"Nrf1,":[100],"Core":[101],"Cox":[103],"IV,":[104],"Atps)":[105],"cytochrome":[107],"c":[108],"oxidase":[109],"content":[110,197],"were":[111,126],"increased":[112,127,169],"muscle":[115],"mice.":[118],"Furthermore,":[119],"a":[120,164,176,185],"range":[121],"rates":[125],"significantly":[128],"by":[129,153],"partially":[133],"attenuating":[134],"age-related":[136],"decline":[137],"observed":[140],"AL":[142],"Therefore,":[144],"did":[146,162],"not":[147],"increase":[148,194],"content,":[150],"as":[151],"synthase,":[155],"mouse":[157],"muscle.":[159],"However,":[160],"it":[161],"PGC-1\u03b1":[165],"adaptive":[166],"response":[167],"respiration.":[171],"Thus,":[172],"suggest":[174],"that":[175],"functionally":[177],"'efficient'":[178],"electron":[180],"transport":[181],"chain":[182],"may":[183],"be":[184],"critical":[186],"mechanism":[187],"underlying":[188],"rather":[190],"than":[191],"any":[192],"net":[193],"per":[198],"se.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}