{"id":"https://openalex.org/W2103098596","doi":"https://doi.org/10.1161/jaha.113.000731","title":"Glutathionylation Mediates Angiotensin II\u2013Induced eNOS Uncoupling, Amplifying NADPH Oxidase\u2010Dependent Endothelial Dysfunction","display_name":"Glutathionylation Mediates Angiotensin II\u2013Induced eNOS Uncoupling, Amplifying NADPH Oxidase\u2010Dependent Endothelial Dysfunction","publication_year":2014,"publication_date":"2014-03-24","ids":{"openalex":"https://openalex.org/W2103098596","doi":"https://doi.org/10.1161/jaha.113.000731","mag":"2103098596","pmid":"https://pubmed.ncbi.nlm.nih.gov/24755153","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4187489"},"language":"en","primary_location":{"id":"doi:10.1161/jaha.113.000731","doi":"https://doi.org/10.1161/jaha.113.000731","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.113.000731","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/JAHA.113.000731","source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/JAHA.113.000731","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058433623","display_name":"Keyvan Karimi Galougahi","orcid":"https://orcid.org/0000-0001-8352-8369","observed_orcids":["https://orcid.org/0000-0001-8352-8369"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Keyvan Karimi Galougahi","raw_affiliation_strings":["Department of Cardiology, Royal North Shore Hospital, Sydney, Australia","North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Royal North Shore Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I2800079252"]},{"raw_affiliation_string":"North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020129162","display_name":"Chia\u2010Chi Liu","orcid":"https://orcid.org/0000-0003-0801-5234","observed_orcids":["https://orcid.org/0000-0003-0801-5234","https://orcid.org/0000-0003-1662-1218"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chia\u2010Chi Liu","raw_affiliation_strings":["North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048884410","display_name":"Carmine Gentile","orcid":"https://orcid.org/0000-0002-3689-4275","observed_orcids":["https://orcid.org/0000-0002-3689-4275"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2801241159","display_name":"The Heart Research Institute","ror":"https://ror.org/046fa4y88","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801241159"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Carmine Gentile","raw_affiliation_strings":["Heart Research Institute, Sydney, Australia","Sydney Medical School, University of Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Research Institute, Sydney, Australia","institution_ids":["https://openalex.org/I2801241159"]},{"raw_affiliation_string":"Sydney Medical School, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036361675","display_name":"Cindy Kok","orcid":"https://orcid.org/0000-0003-3086-7097","observed_orcids":["https://orcid.org/0000-0003-3086-7097"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Cindy Kok","raw_affiliation_strings":["North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102887705","display_name":"Andrea C. Nunez","orcid":"https://orcid.org/0000-0002-4671-1436","observed_orcids":["https://orcid.org/0000-0002-4671-1436"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrea Nunez","raw_affiliation_strings":["North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046856456","display_name":"Alvaro Garcia","orcid":"https://orcid.org/0000-0002-1159-4567","observed_orcids":["https://orcid.org/0000-0002-1159-4567"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alvaro Garcia","raw_affiliation_strings":["North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026367098","display_name":"Natasha A. S. Fry","orcid":"https://orcid.org/0000-0001-7882-2547","observed_orcids":["https://orcid.org/0000-0001-7882-2547"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Natasha A. S. Fry","raw_affiliation_strings":["North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069317976","display_name":"Michael J. Davies","orcid":"https://orcid.org/0000-0002-5196-6919","observed_orcids":["https://orcid.org/0000-0002-5196-6919"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2801241159","display_name":"The Heart Research Institute","ror":"https://ror.org/046fa4y88","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801241159"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael J. Davies","raw_affiliation_strings":["Heart Research Institute, Sydney, Australia","Sydney Medical School, University of Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Research Institute, Sydney, Australia","institution_ids":["https://openalex.org/I2801241159"]},{"raw_affiliation_string":"Sydney Medical School, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082145076","display_name":"Clare Louise Hawkins","orcid":"https://orcid.org/0000-0003-2738-5089","observed_orcids":["https://orcid.org/0000-0003-2738-5089"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2801241159","display_name":"The Heart Research Institute","ror":"https://ror.org/046fa4y88","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801241159"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Clare L. Hawkins","raw_affiliation_strings":["Heart Research Institute, Sydney, Australia","Sydney Medical School, University of Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Research Institute, Sydney, Australia","institution_ids":["https://openalex.org/I2801241159"]},{"raw_affiliation_string":"Sydney Medical School, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027891469","display_name":"H Rasmussen","orcid":"https://orcid.org/0000-0003-2409-4083","observed_orcids":["https://orcid.org/0000-0003-2409-4083"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Helge H. Rasmussen","raw_affiliation_strings":["Department of Cardiology, Royal North Shore Hospital, Sydney, Australia","North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia","Sydney Medical School, University of Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Royal North Shore Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I2800079252"]},{"raw_affiliation_string":"North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Sydney Medical School, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010661645","display_name":"Gemma  Alexandra Figtree","orcid":"https://orcid.org/0000-0002-5080-6083","observed_orcids":["https://orcid.org/0000-0002-5080-6083"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gemma A. Figtree","raw_affiliation_strings":["Department of Cardiology, Royal North Shore Hospital, Sydney, Australia","North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia","Sydney Medical School, University of Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Royal North Shore Hospital, Sydney, Australia","institution_ids":["https://openalex.org/I2800079252"]},{"raw_affiliation_string":"North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Sydney Medical School, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":{"value":3810,"currency":"USD","value_usd":3810},"fwci":7.0582,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.97756989,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"3","issue":"2","first_page":"e000731","last_page":"e000731"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathionylation","display_name":"glutathionylation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/enos-uncoupling","display_name":"eNOS uncoupling","score":0.984000027179718},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.996999979019165},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9629999995231628},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.8640000224113464},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9179999828338623},{"id":"https://openalex.org/keywords/glutaredoxin-1","display_name":"glutaredoxin 1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme-inhibition","display_name":"angiotensin-converting enzyme inhibition","score":0.7229999899864197},{"id":"https://openalex.org/keywords/redox-modification","display_name":"redox modification","score":0.6830000281333923},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.8827000856399536},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.6650416254997253},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.6255618333816528},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5962005853652954},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5870636701583862},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5836448669433594},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5753238201141357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5563560128211975},{"id":"https://openalex.org/C2777989768","wikidata":"https://www.wikidata.org/wiki/Q28747","display_name":"Nicotinamide adenine dinucleotide phosphate","level":4,"score":0.5531904101371765},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5454448461532593},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.539043664932251},{"id":"https://openalex.org/C2908688039","wikidata":"https://www.wikidata.org/wiki/Q408853","display_name":"Nitric Oxide Synthase Type III","level":5,"score":0.5222300291061401},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.5092538595199585},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.45225974917411804},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4466908276081085},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.31798794865608215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2631790041923523},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2592355012893677},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25692522525787354},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18171244859695435},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12483358383178711}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1161/jaha.113.000731","doi":"https://doi.org/10.1161/jaha.113.000731","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.113.000731","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/JAHA.113.000731","source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3186447","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4187489","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4187489","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4187489","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Heart Assoc","raw_type":"Text"},{"id":"pmid:24755153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24755153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.782.9087","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.782.9087","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8b/c9/jah3-3-e000731.PMC4187489.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1161/jaha.113.000731","doi":"https://doi.org/10.1161/jaha.113.000731","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.113.000731","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/JAHA.113.000731","source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320442","display_name":"National Heart Foundation of Australia","ror":"https://ror.org/039d9wr27"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103098596.pdf","grobid_xml":"https://content.openalex.org/works/W2103098596.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1575122477","https://openalex.org/W1969197079","https://openalex.org/W1971202292","https://openalex.org/W1976555160","https://openalex.org/W1977848350","https://openalex.org/W1980021377","https://openalex.org/W1998113633","https://openalex.org/W2001297765","https://openalex.org/W2004819277","https://openalex.org/W2006659891","https://openalex.org/W2006668050","https://openalex.org/W2009013636","https://openalex.org/W2009304280","https://openalex.org/W2013405562","https://openalex.org/W2021650429","https://openalex.org/W2022100597","https://openalex.org/W2026685522","https://openalex.org/W2027228574","https://openalex.org/W2038965219","https://openalex.org/W2039940772","https://openalex.org/W2045290631","https://openalex.org/W2048635427","https://openalex.org/W2055870525","https://openalex.org/W2057060920","https://openalex.org/W2058412625","https://openalex.org/W2063370370","https://openalex.org/W2069725690","https://openalex.org/W2090663259","https://openalex.org/W2092078309","https://openalex.org/W2101111871","https://openalex.org/W2114547396","https://openalex.org/W2118676803","https://openalex.org/W2118711119","https://openalex.org/W2133421404","https://openalex.org/W2137926824","https://openalex.org/W2147136957","https://openalex.org/W2162007164","https://openalex.org/W2335254029"],"related_works":["https://openalex.org/W7098283619","https://openalex.org/W2027377494","https://openalex.org/W1980021377","https://openalex.org/W2886623884","https://openalex.org/W2038965219","https://openalex.org/W7054890753","https://openalex.org/W2217525440","https://openalex.org/W2013405562","https://openalex.org/W178805993","https://openalex.org/W2014589733"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glutathionylation":[1],"of":[2,91,136,147,152,163,177,185,208,216],"endothelial":[3,36,51,219,241],"nitric":[4,15],"oxide":[5,16],"synthase":[6],"(eNOS)":[7],"\"uncouples\"":[8],"the":[9,140,170],"enzyme,":[10],"switching":[11],"its":[12,222],"function":[13,92],"from":[14],"(NO)":[17],"to":[18,116],"O2(\u2022-)":[19,75,100,238],"generation.":[20,76],"We":[21,233],"examined":[22],"whether":[23],"this":[24],"reversible":[25],"redox":[26],"modification":[27],"plays":[28],"a":[29,213,225],"role":[30],"in":[31,46,59,80,99,103,107,142,154,181,240],"angiotensin":[32,187],"II":[33,42,119,179],"(Ang":[34],"II)-induced":[35],"dysfunction.":[37],"METHODS":[38],"AND":[39],"RESULTS:":[40],"Ang":[41,77,96,118,160,178,217,236],"increased":[43,74,195],"eNOS":[44,69,81,113,143,148,193,209,252],"glutathionylation":[45,144,153,211],"cultured":[47],"human":[48,57],"umbilical":[49],"vein":[50],"cells":[52],"(HUVECs),":[53],"rabbit":[54],"aorta,":[55],"and":[56,68,101,145,202,221],"arteries":[58],"vitro.":[60],"This":[61],"was":[62,83,157,167],"associated":[63],"with":[64,111,131],"decreased":[65],"NO":[66,104],"bioavailability":[67],"activity":[70,82],"as":[71,73,87],"well":[72],"II-induced":[78,97,161,218,237],"decrease":[79,102],"mediated":[84],"by":[85,89,93,159,169,183,210,230,250],"glutathionylation,":[86,194],"shown":[88],"restoration":[90],"glutaredoxin-1.":[94],"Moreover,":[95],"increase":[98,141],"were":[105,121],"abolished":[106,139,168],"HUVECs":[108],"transiently":[109],"transfected,":[110],"mutant":[112],"rendered":[114],"resistant":[115],"glutathionylation.":[117],"effects":[120],"nicotinamide":[122],"adenine":[123],"dinucleotide":[124],"phosphate":[125],"(NADPH)":[126],"oxidase":[127],"dependent":[128,244],"because":[129],"preincubation":[130],"gp":[132],"91ds-tat,":[133],"an":[134,186],"inhibitor":[135,191],"NADPH":[137,246],"oxidase,":[138,247],"loss":[146],"activity.":[149],"Functional":[150],"significance":[151],"intact":[155],"vessels":[156],"supported":[158],"impairment":[162],"endothelium-dependent":[164,200],"vasorelaxation":[165,201],"that":[166,235],"disulfide":[171],"reducing":[172],"agent,":[173],"dithiothreitol.":[174],"Furthermore,":[175],"attenuation":[176],"signaling":[180],"vivo":[182],"administration":[184],"converting":[188],"enzyme":[189],"(ACE)":[190],"reduced":[192,203],"NO,":[196],"diminished":[197],"O2(\u2022-),":[198],"improved":[199],"blood":[204],"pressure.":[205],"CONCLUSIONS:":[206],"Uncoupling":[207],"is":[212,224,248],"key":[214],"mediator":[215],"dysfunction,":[220],"reversal":[223],"mechanism":[226],"for":[227],"cardiovascular":[228],"protection":[229],"ACE":[231],"inhibition.":[232],"suggest":[234],"generation":[239],"cells,":[242],"although":[243],"on":[245],"amplified":[249],"glutathionylation-dependent":[251],"uncoupling.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
