{"id":"https://openalex.org/W2103098366","doi":"https://doi.org/10.1128/jvi.74.16.7694-7697.2000","title":"Characterization of a Novel Respiratory Syncytial Virus-Specific Human Cytotoxic T-Lymphocyte Epitope","display_name":"Characterization of a Novel Respiratory Syncytial Virus-Specific Human Cytotoxic T-Lymphocyte Epitope","publication_year":2000,"publication_date":"2000-08-15","ids":{"openalex":"https://openalex.org/W2103098366","doi":"https://doi.org/10.1128/jvi.74.16.7694-7697.2000","mag":"2103098366","pmid":"https://pubmed.ncbi.nlm.nih.gov/10906229","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/112296"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.74.16.7694-7697.2000","doi":"https://doi.org/10.1128/jvi.74.16.7694-7697.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.74.16.7694-7697.2000","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/112296","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043346206","display_name":"Philip Goulder","orcid":"https://orcid.org/0000-0002-9842-4674","observed_orcids":["https://orcid.org/0000-0002-9842-4674"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip J. R. Goulder","raw_affiliation_strings":["<!--label omitted: 1-->Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 021291;","<!--label omitted: 2-->Division of Infectious Diseases, The Children's Hospital, Boston, Massachusetts 021152; and","Division of Infectious Diseases, The Children's Hospital, Boston, Massachusetts 021152; and","Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 021291;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 021291;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"<!--label omitted: 2-->Division of Infectious Diseases, The Children's Hospital, Boston, Massachusetts 021152; and","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Division of Infectious Diseases, The Children's Hospital, Boston, Massachusetts 021152; and","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 021291;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056958609","display_name":"Franziska Lechner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Franziska Lechner","raw_affiliation_strings":["<!--label omitted: 3-->Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom3","Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom3","institution_ids":["https://openalex.org/I2802742124"]},{"raw_affiliation_string":"Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom3","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029546143","display_name":"Paul Klenerman","orcid":"https://orcid.org/0000-0003-4307-9161","observed_orcids":["https://orcid.org/0000-0003-4307-9161"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Klenerman","raw_affiliation_strings":["<!--label omitted: 3-->Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom3","Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 3-->Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom3","institution_ids":["https://openalex.org/I2802742124"]},{"raw_affiliation_string":"Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom3","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018848119","display_name":"Kenneth McIntosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth McIntosh","raw_affiliation_strings":["<!--label omitted: 2-->Division of Infectious Diseases, The Children's Hospital, Boston, Massachusetts 021152; and","Division of Infectious Diseases, The Children's Hospital, Boston, Massachusetts 021152; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Division of Infectious Diseases, The Children's Hospital, Boston, Massachusetts 021152; and","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Division of Infectious Diseases, The Children's Hospital, Boston, Massachusetts 021152; and","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016518899","display_name":"Bruce D. Walker","orcid":"https://orcid.org/0000-0001-6122-9245","observed_orcids":["https://orcid.org/0000-0001-6122-9245","https://orcid.org/0000-0002-8506-6740"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce D. Walker","raw_affiliation_strings":["<!--label omitted: 1-->Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 021291;","Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 021291;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 021291;","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 021291;","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3214,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.9168475,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"74","issue":"16","first_page":"7694","last_page":"7697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.1468999981880188,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-syncytial-virus","display_name":"respiratory syncytial virus","score":1.0},{"id":"https://openalex.org/keywords/ctl-epitopes","display_name":"CTL epitopes","score":0.8600000143051147},{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hla-b7","display_name":"HLA-B7","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/tetrameric-complex","display_name":"tetrameric complex","score":0.6759999990463257},{"id":"https://openalex.org/keywords/viral-immunology","display_name":"viral immunology","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.8885936737060547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8483458161354065},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7966729402542114},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7714687585830688},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6115924119949341},{"id":"https://openalex.org/C60325843","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Nucleoprotein","level":3,"score":0.6017784476280212},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.482810378074646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4601815938949585},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.4149717688560486},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3406899571418762},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.284641832113266},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06581956148147583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012136","descriptor_name":"Respiratory Syncytial Viruses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015793","descriptor_name":"HLA-B7 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018357","descriptor_name":"Respiratory Syncytial Virus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018357","descriptor_name":"Respiratory Syncytial Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.74.16.7694-7697.2000","doi":"https://doi.org/10.1128/jvi.74.16.7694-7697.2000","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.74.16.7694-7697.2000","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:112296","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/112296","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:10906229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10906229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.929.9639","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.929.9639","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Franziska_Regenass-Lechner/publication/12413672_Characterization_of_a_novel_respiratory_syncytial_virus-specific_human_cytotoxic_T-lymphocyte_epitope/links/00b4952944db92c5ef000000.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:112296","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/112296","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4894865959","display_name":"HIV 1 SPECIFIC T CELL CLONES","funder_award_id":"R37AI028568","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G577280801","display_name":"Inhibition of HIV 1 Replication by Cytotoxic Lymphocytes","funder_award_id":"R01AI030914","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G806344930","display_name":null,"funder_award_id":"AI 30914","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8352642115","display_name":"HIV 1 specific T cell clones","funder_award_id":"R01AI028568","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G908117665","display_name":null,"funder_award_id":"AI 28568","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1551043459","https://openalex.org/W1559182187","https://openalex.org/W1736303493","https://openalex.org/W1905162186","https://openalex.org/W1966145377","https://openalex.org/W1967852878","https://openalex.org/W1974643822","https://openalex.org/W1982281170","https://openalex.org/W1985366380","https://openalex.org/W2057761745","https://openalex.org/W2067069532","https://openalex.org/W2069340283","https://openalex.org/W2093218866","https://openalex.org/W2111404022","https://openalex.org/W2117003890","https://openalex.org/W2135121171","https://openalex.org/W2138773604","https://openalex.org/W2141782947","https://openalex.org/W2145928191","https://openalex.org/W2171293480","https://openalex.org/W2318325499","https://openalex.org/W2318832328","https://openalex.org/W4408879132"],"related_works":["https://openalex.org/W7101205678","https://openalex.org/W2133336662","https://openalex.org/W2123834730","https://openalex.org/W2015029787","https://openalex.org/W2004970207","https://openalex.org/W1973285403","https://openalex.org/W2168421996","https://openalex.org/W2992770241","https://openalex.org/W7096204151","https://openalex.org/W2122954689"],"abstract_inverted_index":{"Respiratory":[0],"syncytial":[1],"virus":[2],"(RSV)":[3],"infection":[4],"is":[5,24],"a":[6],"major":[7],"cause":[8],"of":[9],"morbidity":[10],"in":[11,30,35],"childhood":[12],"worldwide.":[13],"The":[14],"first":[15],"human":[16],"RSV-specific":[17],"cytotoxic":[18],"T-lymphocyte":[19],"epitope":[20,29],"to":[21,45],"be":[22],"defined":[23],"described.":[25],"This":[26],"HLA":[27],"B7-restricted":[28],"nucleoprotein":[31],"(NP)":[32],"was":[33],"detectable":[34],"four":[36],"healthy,":[37],"B7-positive":[38],"adult":[39],"subjects":[40],"using":[41],"B7-RSV-NP":[42],"tetrameric":[43],"complexes":[44],"stain":[46],"CD8(+)":[47],"T":[48],"cells.":[49]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}