{"id":"https://openalex.org/W2103076481","doi":"https://doi.org/10.1186/1753-2000-3-39","title":"Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder?","display_name":"Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder?","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2103076481","doi":"https://doi.org/10.1186/1753-2000-3-39","mag":"2103076481","pmid":"https://pubmed.ncbi.nlm.nih.gov/20003260","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2796990"},"language":"en","primary_location":{"id":"doi:10.1186/1753-2000-3-39","doi":"https://doi.org/10.1186/1753-2000-3-39","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1753-2000-3-39","pdf_url":"https://capmh.biomedcentral.com/track/pdf/10.1186/1753-2000-3-39","source":{"id":"https://openalex.org/S133884896","display_name":"Child and Adolescent Psychiatry and Mental Health","issn_l":"1753-2000","issn":["1753-2000"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Child and Adolescent Psychiatry and Mental Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://capmh.biomedcentral.com/track/pdf/10.1186/1753-2000-3-39","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032518803","display_name":"Oscar Gary Bukstein","orcid":"https://orcid.org/0000-0002-6324-1392","observed_orcids":["https://orcid.org/0000-0002-6324-1392"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Oscar G Bukstein","raw_affiliation_strings":["Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. buksteinog@upmc.edu","Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. buksteinog@upmc.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069598980","display_name":"Lawrence Eugene Arnold","orcid":"https://orcid.org/0000-0002-0886-0692","observed_orcids":["https://orcid.org/0000-0002-0886-0692"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Eugene Arnold","raw_affiliation_strings":["The Ohio State University, Columbus, Ohio, USA","The Ohio State University Columbus, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, Ohio, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"The Ohio State University Columbus, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110415925","display_name":"Jeanne M. Landgraf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeanne M Landgraf","raw_affiliation_strings":["HealthActCHQ Inc, Cambridge, Massachusetts, USA","HealthActCHQ Inc, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HealthActCHQ Inc, Cambridge, Massachusetts, USA","institution_ids":[]},{"raw_affiliation_string":"HealthActCHQ Inc, Cambridge, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113890775","display_name":"Paul Hodgkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Hodgkins","raw_affiliation_strings":["Shire Development, Inc, Wayne, Pennsylvania, USA","Shire Development Inc, Wayne, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shire Development, Inc, Wayne, Pennsylvania, USA","institution_ids":[]},{"raw_affiliation_string":"Shire Development Inc, Wayne, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032518803"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":1.7717,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.84073701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"3","issue":"1","first_page":"39","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extended-release-methylphenidate","display_name":"extended-release methylphenidate","score":0.9779999852180481},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.9570000171661377},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.8949999809265137},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.9470000267028809},{"id":"https://openalex.org/keywords/medication-satisfaction","display_name":"medication satisfaction","score":0.953000009059906},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.5730000138282776},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8429999947547913},{"id":"https://openalex.org/keywords/application-site-reactions","display_name":"application site reactions","score":0.5820000171661377},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.7080000042915344},{"id":"https://openalex.org/keywords/caregiver-reported-outcomes","display_name":"caregiver-reported outcomes","score":0.5730000138282776},{"id":"https://openalex.org/keywords/missed-doses","display_name":"missed doses","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2777112843","wikidata":"https://www.wikidata.org/wiki/Q422112","display_name":"Methylphenidate","level":3,"score":0.9057642221450806},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7231283187866211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6423100233078003},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.6261402368545532},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5708580017089844},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4922458231449127},{"id":"https://openalex.org/C2779978724","wikidata":"https://www.wikidata.org/wiki/Q1436482","display_name":"Worry","level":3,"score":0.49145758152008057},{"id":"https://openalex.org/C557119937","wikidata":"https://www.wikidata.org/wiki/Q1741745","display_name":"Child and adolescent psychiatry","level":2,"score":0.46448904275894165},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.4605596959590912},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.4604765474796295},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.44122669100761414},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.41603022813796997},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3865569829940796},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.28747880458831787},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.23488053679466248},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15407657623291016},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1186/1753-2000-3-39","doi":"https://doi.org/10.1186/1753-2000-3-39","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1753-2000-3-39","pdf_url":"https://capmh.biomedcentral.com/track/pdf/10.1186/1753-2000-3-39","source":{"id":"https://openalex.org/S133884896","display_name":"Child and Adolescent Psychiatry and Mental Health","issn_l":"1753-2000","issn":["1753-2000"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Child and Adolescent Psychiatry and Mental Health","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2796990","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2796990","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Child Adolesc Psychiatry Ment Health","raw_type":"Text"},{"id":"pmid:20003260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20003260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Child and adolescent psychiatry and mental health","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.357.800","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.357.800","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e8/71/Child_Adolesc_Psychiatry_Ment_Health_2009_Dec_10_3_39.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:4a0dd1959def46eb867fb68d154258d9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4a0dd1959def46eb867fb68d154258d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Child and Adolescent Psychiatry and Mental Health, Vol 3, Iss 1, p 39 (2009)","raw_type":"article"},{"id":"pmh:oai:kb.osu.edu:1811/47387","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1811/47387","pdf_url":null,"source":{"id":"https://openalex.org/S4306402304","display_name":"The Knowledge Bank (The Ohio State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52357470","host_organization_name":"The Ohio State University","host_organization_lineage":["https://openalex.org/I52357470"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/1753-2000-3-39","doi":"https://doi.org/10.1186/1753-2000-3-39","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1753-2000-3-39","pdf_url":"https://capmh.biomedcentral.com/track/pdf/10.1186/1753-2000-3-39","source":{"id":"https://openalex.org/S133884896","display_name":"Child and Adolescent Psychiatry and Mental Health","issn_l":"1753-2000","issn":["1753-2000"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Child and Adolescent Psychiatry and Mental Health","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103076481.pdf","grobid_xml":"https://content.openalex.org/works/W2103076481.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W51362970","https://openalex.org/W74971179","https://openalex.org/W93667707","https://openalex.org/W1232286304","https://openalex.org/W1503239454","https://openalex.org/W1965229373","https://openalex.org/W1965518468","https://openalex.org/W1967288147","https://openalex.org/W1969894491","https://openalex.org/W1976641170","https://openalex.org/W1985232953","https://openalex.org/W1998857835","https://openalex.org/W2005094901","https://openalex.org/W2008455052","https://openalex.org/W2008934160","https://openalex.org/W2011056969","https://openalex.org/W2012409506","https://openalex.org/W2029293970","https://openalex.org/W2029736471","https://openalex.org/W2034939353","https://openalex.org/W2054548254","https://openalex.org/W2056123413","https://openalex.org/W2056663519","https://openalex.org/W2060133519","https://openalex.org/W2064340252","https://openalex.org/W2066789625","https://openalex.org/W2077805314","https://openalex.org/W2094244099","https://openalex.org/W2108483316","https://openalex.org/W2113651750","https://openalex.org/W2114290463","https://openalex.org/W2126551185","https://openalex.org/W2148818658","https://openalex.org/W2156101594","https://openalex.org/W2157816718","https://openalex.org/W2161354465","https://openalex.org/W2166577179","https://openalex.org/W2167367466","https://openalex.org/W2601578636","https://openalex.org/W4238882874","https://openalex.org/W4250858368","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7096172744","https://openalex.org/W2021208922","https://openalex.org/W2110308126","https://openalex.org/W2020528188","https://openalex.org/W2069755605","https://openalex.org/W2047200439","https://openalex.org/W1966702474","https://openalex.org/W2319355391","https://openalex.org/W1965229373","https://openalex.org/W2023120865"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"evaluate":[2],"health-related":[3],"quality":[4],"of":[5,17,64,71,126,132,222,228,234,240,328,350],"life":[6],"(HRQL)":[7],"and":[8,75,117,134,139,160,182,195,214,251,262,277,300,309],"medication":[9,307],"satisfaction":[10,229],"after":[11,93,333],"switching":[12,321],"from":[13,60,324,343],"a":[14,28,39,61,79,109,149,165,225,325,334,359],"stable":[15,62,326],"dose":[16,63,88,96,327],"oral":[18,65,331,344],"extended-release":[19],"methylphenidate":[20,23],"(ER-MPH)":[21],"to":[22,67,100,122,247,271,293,322,346],"transdermal":[24],"system":[25],"(MTS)":[26],"via":[27,148],"dose-transition":[29,81],"schedule":[30],"in":[31,47,249,319],"children":[32,45,133,364],"with":[33,56,143,230,356,365],"attention-deficit/hyperactivity":[34],"disorder":[35],"(ADHD).":[36],"METHODS:":[37],"In":[38],"4-week,":[40],"multisite,":[41],"open-label":[42],"study,":[43],"171":[44],"(164":[46],"the":[48,86,90,95,124,130,158,189,235,252,268,317,340,348],"intent-to-treat":[49],"[ITT]":[50],"population)":[51],"aged":[52],"6-12":[53],"years":[54],"diagnosed":[55],"ADHD":[57,105,127],"abruptly":[58],"switched":[59],"ER-MPH":[66,332,345],"MTS":[68,144,203,323,357],"nominal":[69],"dosages":[70],"10,":[72],"15,":[73],"20,":[74],"30":[76],"mg":[77],"using":[78],"predefined":[80],"schedule.":[82],"Subjects":[83],"remained":[84],"on":[85,129],"scheduled":[87],"for":[89,209,362],"first":[91],"week,":[92],"which":[94],"was":[97,120,146,171],"then":[98],"titrated":[99,292],"an":[101],"optimal":[102,294],"effect.":[103],"The":[104,238],"Impact":[106],"Module-Children":[107],"(AIM-C),":[108],"disease-specific":[110],"validated":[111],"HRQL":[112,184],"survey":[113],"instrument":[114],"measuring":[115],"child":[116,181,299],"family":[118,183,301],"impact,":[119],"used":[121],"assess":[123],"impact":[125,216,311],"symptoms":[128],"lives":[131],"their":[135,231,363],"families":[136],"at":[137,154,193,199],"baseline":[138,194],"study":[140,155,236,269,286],"endpoint.":[141,156],"Satisfaction":[142,151],"use":[145,233],"assessed":[147],"Medication":[150],"Survey":[152],"(MSS)":[153],"Both":[157],"AIM-C":[159,180,217,318],"MSS":[161],"were":[162,187,196,207,245],"completed":[163],"by":[164,173,316],"caregiver":[166],"(parent/legally":[167],"authorized":[168],"representative).":[169],"Tolerability":[170],"monitored":[172],"spontaneous":[174],"adverse":[175],"event":[176],"(AE)":[177],"reporting.":[178],"RESULTS:":[179],"mean":[185],"scores":[186],"above":[188],"median":[190],"possible":[191],"score":[192],"further":[197,297],"improved":[198],"endpoint":[200],"across":[201],"all":[202],"doses.":[204],"Similar":[205],"improvements":[206],"noted":[208],"behavior,":[210],"missed":[211],"doses,":[212],"worry,":[213,308],"economic":[215,310],"item":[218,312],"scores.":[219],"Overall,":[220],"93.8%":[221],"caregivers":[223,351],"indicated":[224],"high":[226],"level":[227],"child's":[232],"medication.":[237],"majority":[239,349],"treatment-emergent":[241],"AEs":[242,256,273],"(>":[243],"98%)":[244],"mild":[246],"moderate":[248],"intensity,":[250],"most":[253],"commonly":[254],"reported":[255,352],"included":[257],"headache,":[258],"decreased":[259],"appetite,":[260],"insomnia,":[261],"abdominal":[263],"pain.":[264],"Seven":[265],"subjects":[266,320],"discontinued":[267],"due":[270],"intolerable":[272],"(n":[274,281],"=":[275,282],"3)":[276],"application":[278],"site":[279],"reactions":[280],"4).":[283],"CONCLUSION:":[284],"This":[285],"demonstrates":[287],"that":[288],"MTS,":[289,347],"when":[290],"carefully":[291],"dose,":[295],"may":[296],"improve":[298],"HRQL,":[302],"as":[303,305,314,358],"well":[304],"behavioral,":[306],"scores,":[313],"measured":[315],"routinely":[329],"prescribed":[330],"short":[335],"treatment":[336,360],"period.":[337],"Furthermore,":[338],"following":[339],"abrupt":[341],"conversion":[342],"being":[353],"highly":[354],"satisfied":[355],"option":[361],"ADHD.":[366],"TRIAL":[367],"REGISTRATION:":[368],"NCT00151983.":[369]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}