{"id":"https://openalex.org/W2103067948","doi":"https://doi.org/10.1111/j.1743-6109.2012.02913.x","title":"Separate or Combined Treatments with Daily Sildenafil, Molsidomine, or Muscle-Derived Stem Cells Prevent Erectile Dysfunction in a Rat Model of Cavernosal Nerve Damage","display_name":"Separate or Combined Treatments with Daily Sildenafil, Molsidomine, or Muscle-Derived Stem Cells Prevent Erectile Dysfunction in a Rat Model of Cavernosal Nerve Damage","publication_year":2012,"publication_date":"2012-09-13","ids":{"openalex":"https://openalex.org/W2103067948","doi":"https://doi.org/10.1111/j.1743-6109.2012.02913.x","mag":"2103067948","pmid":"https://pubmed.ncbi.nlm.nih.gov/22974131","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3485410"},"language":"en","primary_location":{"id":"doi:10.1111/j.1743-6109.2012.02913.x","doi":"https://doi.org/10.1111/j.1743-6109.2012.02913.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1743-6109.2012.02913.x","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3485410","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012809768","display_name":"Istvan Kovanecz","orcid":"https://orcid.org/0000-0002-3514-2338","observed_orcids":["https://orcid.org/0000-0002-3514-2338"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Istvan Kovanecz","raw_affiliation_strings":["Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA","Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]},{"raw_affiliation_string":"Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083113819","display_name":"Steve Rivera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Rivera","raw_affiliation_strings":["Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051684627","display_name":"Gaby Nolazco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]},{"id":"https://openalex.org/I52710748","display_name":"Charles R. Drew University of Medicine and Science","ror":"https://ror.org/038x2fh14","country_code":"US","type":"education","lineage":["https://openalex.org/I52710748"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaby Nolazco","raw_affiliation_strings":["Department of Internal Medicine, Charles Drew University (CDU), Los Angeles, CA, USA","Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Charles Drew University (CDU), Los Angeles, CA, USA","institution_ids":["https://openalex.org/I52710748"]},{"raw_affiliation_string":"Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042189383","display_name":"Dolores A Vernet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dolores Vernet","raw_affiliation_strings":["Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037320420","display_name":"Denesse Segura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I290598920","display_name":"California State University, Dominguez Hills","ror":"https://ror.org/04pyvbw03","country_code":"US","type":"education","lineage":["https://openalex.org/I290598920"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denesse Segura","raw_affiliation_strings":["California State University at Dominguez Hills, Carson, CA, USA","Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California State University at Dominguez Hills, Carson, CA, USA","institution_ids":["https://openalex.org/I290598920"]},{"raw_affiliation_string":"Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113659585","display_name":"Sahir Gharib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I290598920","display_name":"California State University, Dominguez Hills","ror":"https://ror.org/04pyvbw03","country_code":"US","type":"education","lineage":["https://openalex.org/I290598920"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sahir Gharib","raw_affiliation_strings":["California State University at Dominguez Hills, Carson, CA, USA","Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California State University at Dominguez Hills, Carson, CA, USA","institution_ids":["https://openalex.org/I290598920"]},{"raw_affiliation_string":"Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112129547","display_name":"Jacob Rajfer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Rajfer","raw_affiliation_strings":["Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA","Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]},{"raw_affiliation_string":"Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034784511","display_name":"N\u00e9stor F. Gonz\u00e1lez-Cadavid","orcid":"https://orcid.org/0000-0003-3181-2944","observed_orcids":["https://orcid.org/0000-0003-3181-2944"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]},{"id":"https://openalex.org/I52710748","display_name":"Charles R. Drew University of Medicine and Science","ror":"https://ror.org/038x2fh14","country_code":"US","type":"education","lineage":["https://openalex.org/I52710748"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nestor F. Gonzalez-Cadavid","raw_affiliation_strings":["Department of Internal Medicine, Charles Drew University (CDU), Los Angeles, CA, USA","Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA","Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Charles Drew University (CDU), Los Angeles, CA, USA","institution_ids":["https://openalex.org/I52710748"]},{"raw_affiliation_string":"Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute (LABioMed) at Harbor\u2010UCLA Medical Center, Torrance, CA, USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]},{"raw_affiliation_string":"Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5034784511"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I177607063","https://openalex.org/I4210165985","https://openalex.org/I52710748"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":3.8624,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.93139603,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"11","first_page":"2814","last_page":"2826"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13313","display_name":"Dupuytren's Contracture and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sildenafil","display_name":"sildenafil","score":0.5889999866485596},{"id":"https://openalex.org/keywords/molsidomine","display_name":"molsidomine","score":0.9459999799728394},{"id":"https://openalex.org/keywords/muscle-derived-stem-cells","display_name":"muscle-derived stem cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/smooth-muscle-cell-loss","display_name":"smooth muscle cell loss","score":0.7929999828338623},{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":0.7919999957084656},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7630000114440918},{"id":"https://openalex.org/keywords/neuronal-nitric-oxide-synthase","display_name":"neuronal nitric oxide synthase","score":0.8109999895095825},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/collagen-fibrosis","display_name":"collagen fibrosis","score":0.6240000128746033},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.6898757815361023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5940865278244019},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5476601719856262},{"id":"https://openalex.org/C74534348","wikidata":"https://www.wikidata.org/wiki/Q410798","display_name":"cGMP-specific phosphodiesterase type 5","level":3,"score":0.542605996131897},{"id":"https://openalex.org/C2780773033","wikidata":"https://www.wikidata.org/wiki/Q408132","display_name":"Molsidomine","level":3,"score":0.5065141916275024},{"id":"https://openalex.org/C2776768464","wikidata":"https://www.wikidata.org/wiki/Q191521","display_name":"Sildenafil","level":2,"score":0.5032500624656677},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48956379294395447},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4569855034351349},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4456324875354767},{"id":"https://openalex.org/C2780994212","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic guanosine monophosphate","level":3,"score":0.4411274790763855},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.42449867725372314},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.38238129019737244},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3622204661369324}],"mesh":[{"descriptor_ui":"D000068677","descriptor_name":"Sildenafil Citrate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008981","descriptor_name":"Molsidomine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009121","descriptor_name":"Muscle Denervation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010410","descriptor_name":"Penile Erection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010410","descriptor_name":"Penile Erection","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D018783","descriptor_name":"Impotence, Vasculogenic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018783","descriptor_name":"Impotence, Vasculogenic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1743-6109.2012.02913.x","doi":"https://doi.org/10.1111/j.1743-6109.2012.02913.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1743-6109.2012.02913.x","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"},{"id":"pmid:22974131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22974131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of sexual medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:2800524","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3485410","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3485410","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3485410","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Sex Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2800524","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3485410","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8525691426","display_name":"CELL-SELECTIVE EXPRESSION OF FIBROTIC GENE PATHWAYS","funder_award_id":"R21DK070003","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1233276","https://openalex.org/W185199015","https://openalex.org/W1488462362","https://openalex.org/W1491677997","https://openalex.org/W1605698794","https://openalex.org/W1873065862","https://openalex.org/W1965329004","https://openalex.org/W1965714321","https://openalex.org/W1969161637","https://openalex.org/W1974024889","https://openalex.org/W1979922183","https://openalex.org/W1984061147","https://openalex.org/W1990048810","https://openalex.org/W1990931626","https://openalex.org/W1991653488","https://openalex.org/W1992110330","https://openalex.org/W1997759619","https://openalex.org/W1998095820","https://openalex.org/W2000339546","https://openalex.org/W2015308966","https://openalex.org/W2016826067","https://openalex.org/W2018624715","https://openalex.org/W2031931848","https://openalex.org/W2048209468","https://openalex.org/W2050709789","https://openalex.org/W2057757944","https://openalex.org/W2058477354","https://openalex.org/W2068421751","https://openalex.org/W2072278433","https://openalex.org/W2080629446","https://openalex.org/W2090503365","https://openalex.org/W2094518579","https://openalex.org/W2096938896","https://openalex.org/W2103790034","https://openalex.org/W2114691923","https://openalex.org/W2119396409","https://openalex.org/W2123718017","https://openalex.org/W2134027554","https://openalex.org/W2135603240","https://openalex.org/W2144847368","https://openalex.org/W2145023494","https://openalex.org/W2151298198","https://openalex.org/W2158072358","https://openalex.org/W2158137364","https://openalex.org/W2158272906","https://openalex.org/W2160293700","https://openalex.org/W2162669869","https://openalex.org/W2166016524","https://openalex.org/W2402859176"],"related_works":["https://openalex.org/W1966645235","https://openalex.org/W1965714321","https://openalex.org/W2225205856","https://openalex.org/W7098387784","https://openalex.org/W2337047480","https://openalex.org/W2594621333","https://openalex.org/W2605009493","https://openalex.org/W4239479719","https://openalex.org/W2032922505","https://openalex.org/W2604767332"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Long-term":[1],"daily":[2],"administration":[3,261],"of":[4,48,77,256,266],"phosphodiesterase":[5],"type":[6],"5":[7],"(PDE5)":[8],"inhibitors":[9],"in":[10,28,71,84,108,127,156,186,217,225,268,284],"the":[11,42,72,75,89,96,128,151,211,226,254,264,269,280,285,302],"rat":[12,44,109,271,287],"prevents":[13],"or":[14,83,88,124,130,144,147,155,176,245],"reverses":[15,54],"corporal":[16,46,98,110,218],"veno-occlusive":[17],"dysfunction":[18],"(CVOD)":[19],"and":[20,26,31,59,95,105,135,140,185,195,208,214,221,233,249],"smooth":[21],"muscle":[22,173],"cell":[23,66],"(CSMC)":[24],"loss":[25],"fibrosis,":[27],"both":[29],"aging":[30,43,286],"bilateral":[32],"cavernosal":[33],"nerve":[34],"resection":[35],"(BCNR)":[36],"models":[37],"for":[38,119,171,178,192,198],"erectile":[39,204],"dysfunction.":[40],"In":[41],"model,":[45,288],"implantation":[47,149],"skeletal":[49],"muscle-derived":[50],"stem":[51,65],"cells":[52],"(MDSC)":[53],"CVOD.":[55,160],"Nitric":[56],"oxide":[57,181],"(NO)":[58],"cyclic":[60],"guanosine":[61],"monophosphate":[62],"can":[63],"modulate":[64],"lineage.":[67],"AIM:":[68],"To":[69],"investigate":[70],"BCNR":[73,116,270],"model":[74],"effects":[76],"sildenafil":[78,126,246,260,298],"at":[79,132],"lower":[80],"doses,":[81],"alone":[82],"combination":[85,238],"with":[86,295],"MDSC":[87,148,229,244,289],"NO":[90],"donor":[91],"molsidomine,":[92,146],"on":[93,164,279],"CVOD":[94,267],"underlying":[97,281],"histopathology.":[99,282],"MAIN":[100],"OUTCOMES":[101],"MEASURES:":[102],"CVOD,":[103,292],"histological,":[104],"biochemical":[106],"markers":[107,194],"tissue.":[111],"Methods.":[112],"Rats":[113],"subjected":[114],"to":[115,243],"were":[117],"maintained":[118,263],"45":[120],"days":[121],"either":[122],"untreated,":[123],"received":[125],"water":[129],"retrolingually":[131],"10,":[133],"2.5,":[134],"1.25":[136],"mg/kg/day":[137],"(medium,":[138],"low,":[139],"very":[141,296],"low":[142],"doses),":[143],"intraperitoneal":[145],"into":[150],"corpora":[152],"cavernosa":[153],"separately":[154],"combination.":[157],"Cavernosometry":[158],"evaluated":[159],"Histopathology":[161],"was":[162,240,276],"assessed":[163],"penile":[165,227],"sections":[166],"by":[167,189],"Masson":[168],"trichrome,":[169],"immunohistochemistry":[170],"\u03b1-smooth":[172],"actin":[174],"(ASMA),":[175],"immunofluorescence":[177],"neuronal":[179],"nitric":[180],"synthase":[182],"(nNOS)/neurofilament":[183],"70,":[184],"fresh":[187],"tissue":[188,219],"Western":[190],"blot":[191],"various":[193],"picrosirius":[196],"red":[197],"collagen.":[199],"RESULTS:":[200],"All":[201],"treatments":[202],"normalized":[203],"function":[205],"(drop":[206],"rate),":[207],"most":[209],"increased":[210,231],"CSMC/collagen":[212],"ratio":[213],"ASMA":[215],"expression":[216],"sections,":[220],"reduced":[222],"collagen":[223],"content":[224],"shaft.":[228],"also":[230,290],"nNOS":[232],"brain-derived":[234],"neurotrophic":[235],"factor.":[236],"The":[237],"treatment":[239],"not":[241,300],"superior":[242],"given":[247],"alone,":[248],"upregulated":[250],"PDE5.":[251],"CONCLUSIONS:":[252],"Lowering":[253],"dose":[255],"a":[257],"continuous":[258],"long-term":[259],"still":[262],"prevention":[265],"previously":[272],"observed,":[273],"but":[274,293],"it":[275],"less":[277],"effective":[278],"As":[283],"counteracted":[291],"supplementation":[294],"low-dose":[297],"did":[299],"improve":[301],"outcome.":[303]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}