{"id":"https://openalex.org/W2103052169","doi":"https://doi.org/10.1677/jme.0.0190241","title":"Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions","display_name":"Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W2103052169","doi":"https://doi.org/10.1677/jme.0.0190241","mag":"2103052169","pmid":"https://pubmed.ncbi.nlm.nih.gov/9460645"},"language":"en","primary_location":{"id":"doi:10.1677/jme.0.0190241","doi":"https://doi.org/10.1677/jme.0.0190241","is_oa":false,"landing_page_url":"https://doi.org/10.1677/jme.0.0190241","pdf_url":null,"source":{"id":"https://openalex.org/S15622159","display_name":"Journal of Molecular Endocrinology","issn_l":"0952-5041","issn":["0952-5041","1479-6813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008774810","display_name":"Y Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Wang","raw_affiliation_strings":["National Institute on Aging/Gerontology Research Center, Diabetes Section, Baltimore, Maryland 21224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute on Aging/Gerontology Research Center, Diabetes Section, Baltimore, Maryland 21224, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003065394","display_name":"Kole Hk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HK Kole","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068146796","display_name":"Chahrzad Montrose\u2010Rafizadeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Montrose-Rafizadeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008946836","display_name":"Riccardo Perfetti","orcid":"https://orcid.org/0000-0002-0545-8964","observed_orcids":["https://orcid.org/0000-0002-0545-8964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Perfetti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075258877","display_name":"Michel Bernier","orcid":"https://orcid.org/0000-0002-5948-368X","observed_orcids":["https://orcid.org/0000-0002-5948-368X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Bernier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110909181","display_name":"JM Egan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JM Egan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3375,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.54653431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"19","issue":"3","first_page":"241","last_page":"248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.4699999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.4699999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.2531999945640564,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.07900000363588333,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.7829999923706055},{"id":"https://openalex.org/keywords/glucose-transporters","display_name":"glucose transporters","score":0.7509999871253967},{"id":"https://openalex.org/keywords/glut1","display_name":"GLUT1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/glut4","display_name":"GLUT4","score":1.0},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.753000020980835},{"id":"https://openalex.org/keywords/3t3-l1-cells","display_name":"3T3-L1 cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.9419999718666077},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6549999713897705},{"id":"https://openalex.org/keywords/insulin-stimulated-glucose-uptake","display_name":"insulin-stimulated glucose uptake","score":0.703000009059906},{"id":"https://openalex.org/keywords/gastrointestinal-hormones","display_name":"gastrointestinal hormones","score":0.843999981880188},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.9222273826599121},{"id":"https://openalex.org/C2777952866","wikidata":"https://www.wikidata.org/wiki/Q24722601","display_name":"GLUT1","level":4,"score":0.9061540365219116},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.8412118554115295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7854204773902893},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.7750328183174133},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7571585774421692},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7532104253768921},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.5554258227348328},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5344573259353638},{"id":"https://openalex.org/C142536801","wikidata":"https://www.wikidata.org/wiki/Q4636414","display_name":"3T3-L1","level":4,"score":0.5321288108825684},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.505805253982544},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4939191937446594},{"id":"https://openalex.org/C2908666080","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose Transporter Type 1","level":5,"score":0.4735010266304016},{"id":"https://openalex.org/C2776393687","wikidata":"https://www.wikidata.org/wiki/Q339725","display_name":"Hexose","level":3,"score":0.46175456047058105},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4254530072212219},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.35723307728767395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3303258419036865},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.29562872648239136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22803258895874023},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1457112431526184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14396163821220398},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08243033289909363},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.07145872712135315}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003847","descriptor_name":"Deoxyglucose","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006601","descriptor_name":"Hexoses","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051272","descriptor_name":"Glucose Transporter Type 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051275","descriptor_name":"Glucose Transporter Type 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1677/jme.0.0190241","doi":"https://doi.org/10.1677/jme.0.0190241","is_oa":false,"landing_page_url":"https://doi.org/10.1677/jme.0.0190241","pdf_url":null,"source":{"id":"https://openalex.org/S15622159","display_name":"Journal of Molecular Endocrinology","issn_l":"0952-5041","issn":["0952-5041","1479-6813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmid:9460645","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9460645","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1237155366","https://openalex.org/W1547729980","https://openalex.org/W1569546742","https://openalex.org/W1586627930","https://openalex.org/W1909310469","https://openalex.org/W1965035890","https://openalex.org/W2000465889","https://openalex.org/W2012184766","https://openalex.org/W2017752093","https://openalex.org/W2017906253","https://openalex.org/W2020604155","https://openalex.org/W2022101780","https://openalex.org/W2025592833","https://openalex.org/W2041548056","https://openalex.org/W2043535342","https://openalex.org/W2045764192","https://openalex.org/W2060616628","https://openalex.org/W2076892293","https://openalex.org/W2082411535","https://openalex.org/W2089557095","https://openalex.org/W2091157148","https://openalex.org/W2100837269","https://openalex.org/W2136433521","https://openalex.org/W2145329719","https://openalex.org/W2156627717"],"related_works":["https://openalex.org/W198522820","https://openalex.org/W2030910550","https://openalex.org/W2041501810","https://openalex.org/W2020604155","https://openalex.org/W1556115207","https://openalex.org/W7055920659","https://openalex.org/W79090095","https://openalex.org/W2468626022","https://openalex.org/W1995630379","https://openalex.org/W1987488904"],"abstract_inverted_index":{"Glucagon-like":[0],"peptide-1":[1],"(7-36":[2],"amide)":[3],"(GLP-1)":[4],"is":[5,182],"known":[6],"to":[7,127,151,189],"increase":[8,89,100],"insulin":[9,74,128],"release":[10],"when":[11,160],"given":[12],"as":[13],"a":[14,130],"bolus":[15],"in":[16,30,59,90,101,112,133,197],"the":[17,38,47,52,113,121,134,165,170,184],"fasted":[18],"and":[19,27,45,57,76,92,103,117,139,141],"fed":[20],"state.":[21],"GLP-1":[22,41,68,85,161,181],"also":[23],"increases":[24],"glucose":[25,43,54,95,145,173,194],"uptake":[26,44,96,146,174],"lipid":[28],"synthesis":[29],"cultured":[31,198],"adipocytes.":[32,63,199],"In":[33,120,168],"this":[34],"study":[35],"we":[36],"investigated":[37],"effects":[39],"of":[40,49,51,115,123,136,144,156,192],"on":[42,46],"levels":[48,135,196],"expression":[50,114],"facilitative":[53],"transporters,":[55],"GLUT1":[56,102,116],"GLUT4,":[58],"fully":[60],"differentiated":[61],"3T3-L1":[62],"Cells":[64],"were":[65],"incubated":[66],"with":[67,71,98],"(10":[69,75],"nM)":[70,78],"or":[72],"without":[73],"100":[77],"for":[79],"24":[80],"h.":[81],"Under":[82],"these":[83],"conditions,":[84],"alone":[86],"caused":[87,129],"an":[88,99,142,148],"basal":[91],"acute":[93,149,171],"insulin-stimulated":[94,172],"along":[97],"GLUT4":[104,118,137,157],"protein":[105],"levels.":[106],"However,":[107],"there":[108],"was":[109,158,162],"no":[110],"change":[111],"mRNAs.":[119],"absence":[122],"GLP-1,":[124],"prolonged":[125],"exposure":[126,150],"marked":[131],"reduction":[132],"mRNA":[138],"protein,":[140],"inhibition":[143],"after":[147],"insulin.":[152],"This":[153],"insulin-induced":[154],"down-regulation":[155],"prevented":[159],"present":[163],"during":[164],"24-h":[166],"treatment.":[167],"contrast,":[169],"could":[175],"not":[176],"be":[177,190],"restored":[178],"by":[179],"GLP-1.":[180],"therefore":[183],"first":[185],"gut":[186],"hormone":[187],"shown":[188],"capable":[191],"modulating":[193],"transporter":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
