{"id":"https://openalex.org/W2103043503","doi":"https://doi.org/10.1002/14651858.cd009744.pub2","title":"Niacin for primary and secondary prevention of cardiovascular events","display_name":"Niacin for primary and secondary prevention of cardiovascular events","publication_year":2017,"publication_date":"2017-06-14","ids":{"openalex":"https://openalex.org/W2103043503","doi":"https://doi.org/10.1002/14651858.cd009744.pub2","mag":"2103043503","pmid":"https://pubmed.ncbi.nlm.nih.gov/28616955","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6481694"},"language":"en","primary_location":{"id":"doi:10.1002/14651858.cd009744.pub2","doi":"https://doi.org/10.1002/14651858.cd009744.pub2","is_oa":true,"landing_page_url":"https://doi.org/10.1002/14651858.cd009744.pub2","pdf_url":"https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009744.pub2/pdf/full","source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009744.pub2/pdf/full","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075098080","display_name":"Stefan Schandelmaier","orcid":"https://orcid.org/0000-0002-8429-0337","observed_orcids":["https://orcid.org/0000-0002-8429-0337"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Stefan Schandelmaier","raw_affiliation_strings":["McMaster University; Department of Health Research Methods, Evidence, and Impact; 1280 Main Street West Hamilton ON Canada L8S4L8"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McMaster University; Department of Health Research Methods, Evidence, and Impact; 1280 Main Street West Hamilton ON Canada L8S4L8","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019888759","display_name":"Matthias Briel","orcid":"https://orcid.org/0000-0002-2070-5230","observed_orcids":["https://orcid.org/0000-0002-2070-5230"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthias Briel","raw_affiliation_strings":["University of Basel; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research; Basel Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Basel; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research; Basel Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041641205","display_name":"Ramon T. Saccilotto","orcid":"https://orcid.org/0000-0002-3362-4851","observed_orcids":["https://orcid.org/0000-0002-3362-4851"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ramon Saccilotto","raw_affiliation_strings":["University of Basel; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research; Basel Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Basel; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research; Basel Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110478392","display_name":"Kelechi Kalu Olu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Kelechi K Olu","raw_affiliation_strings":["University of Basel; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research; Basel Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Basel; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research; Basel Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066810053","display_name":"Armon Arpagaus","orcid":"https://orcid.org/0009-0007-2065-6698","observed_orcids":["https://orcid.org/0009-0007-2065-6698"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Armon Arpagaus","raw_affiliation_strings":["University of Basel; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research; Basel Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Basel; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research; Basel Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074510368","display_name":"Lars G. Hemkens","orcid":"https://orcid.org/0000-0002-3444-1432","observed_orcids":["https://orcid.org/0000-0002-3444-1432"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lars G Hemkens","raw_affiliation_strings":["University of Basel; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research; Basel Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Basel; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research; Basel Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108658898","display_name":"Alain J. Nordmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alain J Nordmann","raw_affiliation_strings":["University of Basel; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research; Basel Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Basel; Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research; Basel Switzerland","institution_ids":["https://openalex.org/I1850255"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5100,"currency":"USD","value_usd":5100},"apc_paid":null,"fwci":2.4133,"has_fulltext":true,"cited_by_count":119,"citation_normalized_percentile":{"value":0.91485969,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"2017","issue":"6","first_page":"CD009744","last_page":"CD009744"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niacin","display_name":"nicotinic acid","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.906000018119812},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.847000002861023},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9430000185966492},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9940000176429749},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9020000100135803},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.9409999847412109},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6349999904632568},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2780092750","wikidata":"https://www.wikidata.org/wiki/Q134658","display_name":"Niacin","level":2,"score":0.961927592754364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8303568959236145},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.679071843624115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6154038906097412},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5837445259094238},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.5779585838317871},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5284333825111389},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5138090252876282},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4975567162036896},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3592100441455841},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.1699029803276062},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009525","descriptor_name":"Niacin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009525","descriptor_name":"Niacin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011322","descriptor_name":"Primary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/14651858.cd009744.pub2","doi":"https://doi.org/10.1002/14651858.cd009744.pub2","is_oa":true,"landing_page_url":"https://doi.org/10.1002/14651858.cd009744.pub2","pdf_url":"https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009744.pub2/pdf/full","source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6481694","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6481694","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database Syst Rev","raw_type":"Text"},{"id":"pmid:28616955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28616955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cochrane database of systematic reviews","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/14651858.cd009744.pub2","doi":"https://doi.org/10.1002/14651858.cd009744.pub2","is_oa":true,"landing_page_url":"https://doi.org/10.1002/14651858.cd009744.pub2","pdf_url":"https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009744.pub2/pdf/full","source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103043503.pdf","grobid_xml":"https://content.openalex.org/works/W2103043503.grobid-xml"},"referenced_works_count":176,"referenced_works":["https://openalex.org/W68098806","https://openalex.org/W125680830","https://openalex.org/W145425403","https://openalex.org/W150670263","https://openalex.org/W424467158","https://openalex.org/W1486824465","https://openalex.org/W1504402037","https://openalex.org/W1554040650","https://openalex.org/W1566044237","https://openalex.org/W1596902544","https://openalex.org/W1856460279","https://openalex.org/W1859162852","https://openalex.org/W1959291640","https://openalex.org/W1965908094","https://openalex.org/W1965952643","https://openalex.org/W1966431818","https://openalex.org/W1968660758","https://openalex.org/W1970516435","https://openalex.org/W1972846585","https://openalex.org/W1975931406","https://openalex.org/W1977787417","https://openalex.org/W1980243442","https://openalex.org/W1980454378","https://openalex.org/W1982224576","https://openalex.org/W1982351423","https://openalex.org/W1982384451","https://openalex.org/W1983999556","https://openalex.org/W1986304796","https://openalex.org/W1991065972","https://openalex.org/W1992330736","https://openalex.org/W1994954183","https://openalex.org/W1996447072","https://openalex.org/W1996592745","https://openalex.org/W1997299383","https://openalex.org/W1999405539","https://openalex.org/W1999603233","https://openalex.org/W2003847068","https://openalex.org/W2007239019","https://openalex.org/W2007862652","https://openalex.org/W2009580736","https://openalex.org/W2010173489","https://openalex.org/W2011382665","https://openalex.org/W2012074634","https://openalex.org/W2014083842","https://openalex.org/W2014894063","https://openalex.org/W2015708524","https://openalex.org/W2019071303","https://openalex.org/W2023813030","https://openalex.org/W2025468498","https://openalex.org/W2026737636","https://openalex.org/W2027750202","https://openalex.org/W2028308533","https://openalex.org/W2028737910","https://openalex.org/W2029465901","https://openalex.org/W2029833995","https://openalex.org/W2035333536","https://openalex.org/W2039172250","https://openalex.org/W2039302239","https://openalex.org/W2039517796","https://openalex.org/W2042154620","https://openalex.org/W2042650201","https://openalex.org/W2044465607","https://openalex.org/W2044507358","https://openalex.org/W2045452486","https://openalex.org/W2046991199","https://openalex.org/W2047693255","https://openalex.org/W2048070048","https://openalex.org/W2048766067","https://openalex.org/W2050906039","https://openalex.org/W2051556928","https://openalex.org/W2052188710","https://openalex.org/W2052568385","https://openalex.org/W2053599662","https://openalex.org/W2055318521","https://openalex.org/W2055790796","https://openalex.org/W2058867908","https://openalex.org/W2059934146","https://openalex.org/W2061161053","https://openalex.org/W2063149202","https://openalex.org/W2063728789","https://openalex.org/W2063921997","https://openalex.org/W2064968463","https://openalex.org/W2068944125","https://openalex.org/W2070345301","https://openalex.org/W2070855777","https://openalex.org/W2072161879","https://openalex.org/W2073638666","https://openalex.org/W2074571762","https://openalex.org/W2075496970","https://openalex.org/W2077421021","https://openalex.org/W2077771812","https://openalex.org/W2078489774","https://openalex.org/W2079408175","https://openalex.org/W2080243329","https://openalex.org/W2082031296","https://openalex.org/W2084571470","https://openalex.org/W2084675507","https://openalex.org/W2085062503","https://openalex.org/W2085713634","https://openalex.org/W2090992457","https://openalex.org/W2093355041","https://openalex.org/W2097744101","https://openalex.org/W2098566970","https://openalex.org/W2099238521","https://openalex.org/W2100039126","https://openalex.org/W2101969945","https://openalex.org/W2102979586","https://openalex.org/W2103767333","https://openalex.org/W2104463342","https://openalex.org/W2106400815","https://openalex.org/W2106975075","https://openalex.org/W2108475045","https://openalex.org/W2108640626","https://openalex.org/W2110533098","https://openalex.org/W2112213729","https://openalex.org/W2115251078","https://openalex.org/W2115572248","https://openalex.org/W2118472708","https://openalex.org/W2119005141","https://openalex.org/W2119065130","https://openalex.org/W2120986848","https://openalex.org/W2125435699","https://openalex.org/W2126930838","https://openalex.org/W2130771193","https://openalex.org/W2133655864","https://openalex.org/W2141935250","https://openalex.org/W2145034104","https://openalex.org/W2145117630","https://openalex.org/W2145799136","https://openalex.org/W2147188435","https://openalex.org/W2150799450","https://openalex.org/W2152789823","https://openalex.org/W2155499238","https://openalex.org/W2157327355","https://openalex.org/W2157417277","https://openalex.org/W2157823046","https://openalex.org/W2158221233","https://openalex.org/W2160420401","https://openalex.org/W2160689800","https://openalex.org/W2163014518","https://openalex.org/W2165332933","https://openalex.org/W2165605025","https://openalex.org/W2165767690","https://openalex.org/W2168085417","https://openalex.org/W2169033201","https://openalex.org/W2170521505","https://openalex.org/W2176487045","https://openalex.org/W2181795284","https://openalex.org/W2187593761","https://openalex.org/W2189339462","https://openalex.org/W2247997571","https://openalex.org/W2305718992","https://openalex.org/W2324454784","https://openalex.org/W2324712847","https://openalex.org/W2327580402","https://openalex.org/W2331694204","https://openalex.org/W2334940140","https://openalex.org/W2410405995","https://openalex.org/W2413331280","https://openalex.org/W2414040621","https://openalex.org/W2473662207","https://openalex.org/W2491061016","https://openalex.org/W2556689280","https://openalex.org/W2587412035","https://openalex.org/W2612273282","https://openalex.org/W2725187802","https://openalex.org/W2748276396","https://openalex.org/W4232354154","https://openalex.org/W4243528279","https://openalex.org/W4246764494","https://openalex.org/W4285719527","https://openalex.org/W4293084779","https://openalex.org/W4299412107","https://openalex.org/W6661071086","https://openalex.org/W6676550427","https://openalex.org/W6721097544"],"related_works":["https://openalex.org/W2535265582","https://openalex.org/W2986510868","https://openalex.org/W2939435551","https://openalex.org/W2015708524","https://openalex.org/W2748135137","https://openalex.org/W2737186820","https://openalex.org/W2082031296","https://openalex.org/W2519892274","https://openalex.org/W1612233377","https://openalex.org/W2123068849"],"abstract_inverted_index":{"BACKGROUND:":[0],"Nicotinic":[1],"acid":[2],"(niacin)":[3],"is":[4,27,300],"known":[5],"to":[6,24,44,120,166,211,241,257,269],"decrease":[7],"LDL-cholesterol,":[8],"and":[9,11,63,71,76,95,149,168,178,201,207,218,230],"triglycerides,":[10],"increase":[12],"HDL-cholesterol":[13],"levels.":[14],"The":[15,253],"evidence":[16,271],"of":[17,34,53,59,85,90,98,175,199,220,223,232,245,285,294,312],"benefits":[18],"with":[19,49,127,152,225,302],"niacin":[20,35,118,124,139,274,307],"monotherapy":[21,41,119],"or":[22,42,50,123,153,186,287,296],"add-on":[23,43],"statin-based":[25,45],"therapy":[26,36,46,308],"controversial.":[28],"OBJECTIVES:":[29],"To":[30],"assess":[31,242],"the":[32,243,283,292,310],"effectiveness":[33],"versus":[37,130],"placebo,":[38],"administered":[39,138],"as":[40],"in":[47,57,72,103,125,169,309],"people":[48],"at":[51,141],"risk":[52,174,198],"cardiovascular":[54,279,313],"disease":[55,229,314],"(CVD)":[56],"terms":[58],"mortality,":[60,278,280,282],"CVD":[61],"events,":[62],"side":[64,303],"effects.":[65,304],"SEARCH":[66],"METHODS:":[67],"Two":[68,161],"reviewers":[69,162],"independently":[70,167],"duplicate":[73,170],"screened":[74],"records":[75],"potentially":[77],"eligible":[78],"full":[79],"texts":[80],"identified":[81],"through":[82],"electronic":[83],"searches":[84],"CENTRAL,":[86],"MEDLINE,":[87],"Embase,":[88],"Web":[89],"Science,":[91],"two":[92],"trial":[93],"registries,":[94],"reference":[96],"lists":[97],"relevant":[99],"articles":[100],"(latest":[101],"search":[102],"August":[104],"2016).":[105],"SELECTION":[106],"CRITERIA:":[107],"We":[108,134,190,238],"included":[109,150],"all":[110],"randomised":[111],"controlled":[112],"trials":[113,172],"(RCTs)":[114],"that":[115,137,273],"either":[116],"compared":[117],"placebo/usual":[121],"care":[122],"combination":[126],"other":[128,131],"component":[129,132],"alone.":[133],"considered":[135],"RCTs":[136],"for":[140,204,263],"least":[142],"six":[143],"months,":[144],"reported":[145],"a":[146],"clinical":[147],"outcome,":[148],"adults":[151],"without":[154],"established":[155,226],"CVD.":[156],"DATA":[157],"COLLECTION":[158],"AND":[159],"ANALYSIS:":[160],"used":[163,208,239],"pre-piloted":[164],"forms":[165],"extract":[171],"characteristics,":[173],"bias":[176,200],"items,":[177],"outcomes":[179],"data.":[180,265],"Disagreements":[181],"were":[182,255],"resolved":[183],"by":[184],"consensus":[185],"third":[187],"party":[188],"arbitration.":[189],"conducted":[191],"random-effects":[192],"meta-analyses,":[193],"sensitivity":[194,258],"analyses":[195,210,259],"based":[196],"on":[197],"different":[202,261],"assumptions":[203,262],"missing":[205,264],"data,":[206],"meta-regression":[209],"investigate":[212],"potential":[213],"relationships":[214],"between":[215],"treatment":[216],"effects":[217],"duration":[219],"treatment,":[221],"proportion":[222,231],"participants":[224,233],"coronary":[227],"heart":[228],"receiving":[234],"background":[235],"statin":[236],"therapy.":[237],"GRADE":[240],"quality":[244],"evidence.":[246],"MAIN":[247],"RESULTS:":[248],"=":[249],"77%;":[250],"moderate-quality":[251],"evidence).":[252],"results":[254],"robust":[256],"using":[260],"AUTHORS'":[266],"CONCLUSIONS:":[267],"Moderate-":[268],"high-quality":[270],"suggests":[272],"does":[275],"not":[276],"reduce":[277],"non-cardiovascular":[281],"number":[284,293],"fatal":[286,295],"non-fatal":[288,297],"myocardial":[289],"infarctions,":[290],"nor":[291],"strokes":[298],"but":[299],"associated":[301],"Benefits":[305],"from":[306],"prevention":[311],"events":[315],"are":[316],"unlikely.":[317]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
