{"id":"https://openalex.org/W2102988971","doi":"https://doi.org/10.1099/vir.0.008839-0","title":"Proof of concept for the reduction of classical swine fever infection in pigs by a novel viral polymerase inhibitor","display_name":"Proof of concept for the reduction of classical swine fever infection in pigs by a novel viral polymerase inhibitor","publication_year":2009,"publication_date":"2009-05-18","ids":{"openalex":"https://openalex.org/W2102988971","doi":"https://doi.org/10.1099/vir.0.008839-0","mag":"2102988971","pmid":"https://pubmed.ncbi.nlm.nih.gov/19264669"},"language":"en","primary_location":{"id":"doi:10.1099/vir.0.008839-0","doi":"https://doi.org/10.1099/vir.0.008839-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/vir.0.008839-0","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061675407","display_name":"Robert Vrancken","orcid":"https://orcid.org/0000-0001-9364-7492","observed_orcids":["https://orcid.org/0000-0001-9364-7492"]},"institutions":[{"id":"https://openalex.org/I4210108698","display_name":"Veterinary and Agrochemical Research Centre","ror":"https://ror.org/0153sam53","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210108698"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Robert Vrancken","raw_affiliation_strings":["Veterinary and Agrochemical Research Centre, Groeselenberg 99, B-1180 Ukkel, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary and Agrochemical Research Centre, Groeselenberg 99, B-1180 Ukkel, Belgium","institution_ids":["https://openalex.org/I4210108698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005651283","display_name":"Andy Haegeman","orcid":"https://orcid.org/0000-0003-4056-214X","observed_orcids":["https://orcid.org/0000-0003-4056-214X"]},"institutions":[{"id":"https://openalex.org/I4210108698","display_name":"Veterinary and Agrochemical Research Centre","ror":"https://ror.org/0153sam53","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210108698"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Andy Haegeman","raw_affiliation_strings":["Veterinary and Agrochemical Research Centre, Groeselenberg 99, B-1180 Ukkel, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary and Agrochemical Research Centre, Groeselenberg 99, B-1180 Ukkel, Belgium","institution_ids":["https://openalex.org/I4210108698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056476810","display_name":"Jan Paeshuyse","orcid":"https://orcid.org/0000-0003-2396-354X","observed_orcids":["https://orcid.org/0000-0003-2396-354X"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Paeshuyse","raw_affiliation_strings":["Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroederstraat 10, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroederstraat 10, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028477277","display_name":"Gerhard Puerstinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gerhard Puerstinger","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056154663","display_name":"Jef Rozenski","orcid":"https://orcid.org/0000-0001-9624-5536","observed_orcids":["https://orcid.org/0000-0001-9624-5536"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jef Rozenski","raw_affiliation_strings":["Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroederstraat 10, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroederstraat 10, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055584694","display_name":"Matthew R. Wright","orcid":"https://orcid.org/0000-0002-6787-8104","observed_orcids":["https://orcid.org/0000-0002-6787-8104"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Wright","raw_affiliation_strings":["Gilead Sciences, Drug Metabolism and Pharmacokinetics, 333 Lakeside Drive, Foster City, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences, Drug Metabolism and Pharmacokinetics, 333 Lakeside Drive, Foster City, CA, USA","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012274154","display_name":"Maryl\u00e8ne Tignon","orcid":"https://orcid.org/0000-0001-9781-5289","observed_orcids":["https://orcid.org/0000-0001-9781-5289"]},"institutions":[{"id":"https://openalex.org/I4210108698","display_name":"Veterinary and Agrochemical Research Centre","ror":"https://ror.org/0153sam53","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210108698"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maryl\u00e8ne Tignon","raw_affiliation_strings":["Veterinary and Agrochemical Research Centre, Groeselenberg 99, B-1180 Ukkel, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary and Agrochemical Research Centre, Groeselenberg 99, B-1180 Ukkel, Belgium","institution_ids":["https://openalex.org/I4210108698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057464112","display_name":"Marie\u2010Fr\u00e9d\u00e9rique Le Potier","orcid":"https://orcid.org/0000-0003-3929-9129","observed_orcids":["https://orcid.org/0000-0003-3929-9129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie-Fr\u00e9d\u00e9rique Le Potier","raw_affiliation_strings":["Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments, Unit\u00e9 de Virologie Immunologie Porcines, BP53, F-22440 Ploufragan, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agence Fran\u00e7aise de S\u00e9curit\u00e9 Sanitaire des Aliments, Unit\u00e9 de Virologie Immunologie Porcines, BP53, F-22440 Ploufragan, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Johan Neyts","raw_affiliation_strings":["Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroederstraat 10, B-3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroederstraat 10, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064867306","display_name":"Frank Koenen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108698","display_name":"Veterinary and Agrochemical Research Centre","ror":"https://ror.org/0153sam53","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210108698"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Frank Koenen","raw_affiliation_strings":["Veterinary and Agrochemical Research Centre, Groeselenberg 99, B-1180 Ukkel, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterinary and Agrochemical Research Centre, Groeselenberg 99, B-1180 Ukkel, Belgium","institution_ids":["https://openalex.org/I4210108698"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5232,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.91159789,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"90","issue":"6","first_page":"1335","last_page":"1342"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/classical-swine-fever-virus","display_name":"classical swine fever virus","score":0.9850000143051147},{"id":"https://openalex.org/keywords/imidazopyridines","display_name":"imidazopyridines","score":0.9139999747276306},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.6790000200271606},{"id":"https://openalex.org/keywords/viral-polymerase-inhibitors","display_name":"viral polymerase inhibitors","score":0.7839999794960022},{"id":"https://openalex.org/keywords/feed-administration","display_name":"feed administration","score":0.5220000147819519},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/viremia","display_name":"viremia","score":0.7739999890327454},{"id":"https://openalex.org/keywords/persistent-infection","display_name":"persistent infection","score":0.7080000042915344},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.5299999713897705},{"id":"https://openalex.org/keywords/pestivirus","display_name":"pestivirus","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7882012128829956},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.7468657493591309},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7439820766448975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7263423800468445},{"id":"https://openalex.org/C2778400998","wikidata":"https://www.wikidata.org/wiki/Q1816292","display_name":"Pestivirus","level":5,"score":0.6694013476371765},{"id":"https://openalex.org/C2779005923","wikidata":"https://www.wikidata.org/wiki/Q683770","display_name":"Classical swine fever","level":3,"score":0.6393121480941772},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.49770763516426086},{"id":"https://openalex.org/C134040284","wikidata":"https://www.wikidata.org/wiki/Q1431049","display_name":"Infectious dose","level":3,"score":0.4627876579761505},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.43861401081085205},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.41770726442337036},{"id":"https://openalex.org/C2777510210","wikidata":"https://www.wikidata.org/wiki/Q1331256","display_name":"Flaviviridae","level":4,"score":0.3465244770050049},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.2593912184238434},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006691","descriptor_name":"Classical Swine Fever","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006692","descriptor_name":"Classical Swine Fever Virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014066","descriptor_name":"Palatine Tonsil","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1099/vir.0.008839-0","doi":"https://doi.org/10.1099/vir.0.008839-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/vir.0.008839-0","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},{"id":"pmid:19264669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19264669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general virology","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/221153","doi":null,"is_oa":false,"landing_page_url":"https://lirias.kuleuven.be/bitstream/123456789/221153/3/5018.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of General Virology, vol. 90 (6), (1335-1342)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W11567750","https://openalex.org/W1499500424","https://openalex.org/W1563780305","https://openalex.org/W1965506032","https://openalex.org/W1978996530","https://openalex.org/W1992631461","https://openalex.org/W2004986896","https://openalex.org/W2008405988","https://openalex.org/W2023982220","https://openalex.org/W2030368438","https://openalex.org/W2031938856","https://openalex.org/W2037306956","https://openalex.org/W2042261556","https://openalex.org/W2046238616","https://openalex.org/W2047544453","https://openalex.org/W2065250560","https://openalex.org/W2067939631","https://openalex.org/W2071186316","https://openalex.org/W2075545802","https://openalex.org/W2077767048","https://openalex.org/W2082176485","https://openalex.org/W2087861183","https://openalex.org/W2106090606","https://openalex.org/W2113066706","https://openalex.org/W2126349813","https://openalex.org/W2127136000","https://openalex.org/W2168014214","https://openalex.org/W2206636254","https://openalex.org/W2411812799","https://openalex.org/W2470804941","https://openalex.org/W2949122924","https://openalex.org/W4247646605","https://openalex.org/W6629874611"],"related_works":["https://openalex.org/W2078659296","https://openalex.org/W2030368438","https://openalex.org/W7025305846","https://openalex.org/W2765216217","https://openalex.org/W4200593707","https://openalex.org/W3097064618","https://openalex.org/W4379377180","https://openalex.org/W3159077538","https://openalex.org/W2032295666","https://openalex.org/W4210742614"],"abstract_inverted_index":{"5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine":[0],"(BPIP)":[1],"is":[2,190],"a":[3,6,57,68,88,186,220],"representative":[4],"of":[5,8,60,70,148,161,167,185,194,200,229,243,248],"class":[7],"imidazopyridines":[9],"with":[10,79],"potent":[11,213],"in":[12,38,44,65,118,127,134,138,158,206,227,232,251],"vitro":[13],"antiviral":[14,196,214],"activity":[15],"against":[16,224],"pestiviruses":[17],"including":[18],"classical":[19],"swine":[20],"fever":[21],"virus":[22,36,155,177,210,225],"(CSFV).":[23],"This":[24,237],"study":[25,238],"analysed":[26],"whether":[27],"the":[28,80,123,142,146,149,159,179,183,195,240,246],"lead":[29,202],"compound,":[30,42],"BPIP,":[31],"was":[32,46,50,129,156],"able":[33],"to":[34,174,234],"reduce":[35],"replication":[37],"infected":[39],"piglets.":[40],"The":[41,172],"administered":[43],"feed,":[45],"readily":[47],"bioavailable":[48],"and":[49,96,122,198],"well":[51],"tolerated.":[52],"Eight":[53],"specific-pathogen-free":[54],"pigs":[55,86],"received":[56],"daily":[58],"dose":[59],"75":[61],"mg":[62],"kg(-1)":[63],"(mixed":[64],"feed)":[66],"for":[67,245],"period":[69],"15":[71],"consecutive":[72],"days,":[73],"starting":[74],"1":[75],"day":[76],"before":[77],"infection":[78,189,250],"CSFV":[81,188,249],"field":[82],"isolate":[83,175],"Wingene.":[84],"BPIP-treated":[85,162],"developed":[87],"short,":[89],"transient":[90],"viraemia":[91,108],"(one":[92],"animal":[93],"remained":[94],"negative)":[95],"leukopenia":[97],"(three":[98],"animals":[99,120,136,140],"did":[100],"not":[101],"develop":[102],"leukopenia).":[103],"Virus":[104],"titres":[105],"at":[106],"peak":[107],"(7":[109],"days":[110],"post-infection)":[111],"were":[112,170],"markedly":[113],"lower":[114,132],"(approximately":[115],"1000-fold)":[116],"than":[117,137],"untreated":[119,139],"(P=0.00005)":[121],"viral":[124,168],"genome":[125],"load":[126],"blood":[128],"also":[130],"significantly":[131],"(P<or=0.001)":[133],"drug-treated":[135],"over":[141],"entire":[143],"experiment.":[144],"At":[145],"end":[147],"experiment":[150],"(day":[151],"33),":[152],"no":[153],"infectious":[154,176],"detectable":[157],"tonsils":[160,180],"animals,":[163],"although":[164],"low":[165],"levels":[166],"RNA":[169],"detected.":[171],"inability":[173],"from":[178],"indicates":[181],"that":[182],"risk":[184],"persistent":[187],"negligible.":[191],"Further":[192],"optimization":[193],"potency":[197],"bioavailability":[199],"this":[201],"compound":[203],"may":[204],"result":[205],"molecules":[207],"completely":[208],"suppressing":[209],"replication.":[211],"A":[212],"could":[215],"potentially":[216],"be":[217],"used":[218],"as":[219],"primary":[221],"control":[222],"measure":[223],"spread":[226],"case":[228],"an":[230],"outbreak,":[231],"addition":[233],"present":[235],"countermeasures.":[236],"provides":[239],"first":[241],"proof":[242],"concept":[244],"prophylaxis/treatment":[247],"pigs.":[252]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
