{"id":"https://openalex.org/W2102959619","doi":"https://doi.org/10.1152/ajprenal.00034.2013","title":"Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice","display_name":"Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice","publication_year":2013,"publication_date":"2013-10-23","ids":{"openalex":"https://openalex.org/W2102959619","doi":"https://doi.org/10.1152/ajprenal.00034.2013","mag":"2102959619","pmid":"https://pubmed.ncbi.nlm.nih.gov/24154695"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.00034.2013","doi":"https://doi.org/10.1152/ajprenal.00034.2013","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00034.2013","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110040812","display_name":"Hiromi Tachibana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Tachibana","raw_affiliation_strings":["Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103268123","display_name":"Daisuke Ogawa","orcid":"https://orcid.org/0000-0001-5500-7996","observed_orcids":["https://orcid.org/0000-0001-5500-7996"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Daisuke Ogawa","raw_affiliation_strings":["Department of Diabetic Nephropathy, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetic Nephropathy, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046637631","display_name":"Norio Sogawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Sogawa","raw_affiliation_strings":["Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026597336","display_name":"Masato Asanuma","orcid":"https://orcid.org/0000-0002-2904-7836","observed_orcids":["https://orcid.org/0000-0002-2904-7836"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Asanuma","raw_affiliation_strings":["Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan; and","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050295898","display_name":"Ikuko Miyazaki","orcid":"https://orcid.org/0000-0002-2732-094X","observed_orcids":["https://orcid.org/0000-0002-2732-094X"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikuko Miyazaki","raw_affiliation_strings":["Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan; and","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000894769","display_name":"Naoto Terami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoto Terami","raw_affiliation_strings":["Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109869489","display_name":"Takashi Hatanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Hatanaka","raw_affiliation_strings":["Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071064609","display_name":"Chikage Sato Horiguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikage Sato Horiguchi","raw_affiliation_strings":["Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061756485","display_name":"Atsuko Nakatsuka","orcid":"https://orcid.org/0000-0002-3154-4073","observed_orcids":["https://orcid.org/0000-0002-3154-4073"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuko Nakatsuka","raw_affiliation_strings":["Department of Diabetic Nephropathy, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetic Nephropathy, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060034527","display_name":"Jun Eguchi","orcid":"https://orcid.org/0000-0003-2215-7343","observed_orcids":["https://orcid.org/0000-0003-2215-7343"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Eguchi","raw_affiliation_strings":["Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007276836","display_name":"Jun Wada","orcid":"https://orcid.org/0000-0003-1468-5170","observed_orcids":["https://orcid.org/0000-0003-1468-5170"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Wada","raw_affiliation_strings":["Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091097806","display_name":"Hiroshi Yamada","orcid":"https://orcid.org/0000-0002-9328-3446","observed_orcids":["https://orcid.org/0000-0002-9328-3446"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Yamada","raw_affiliation_strings":["Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049447022","display_name":"Kohji Takei","orcid":"https://orcid.org/0000-0002-6555-9425","observed_orcids":["https://orcid.org/0000-0002-6555-9425"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohji Takei","raw_affiliation_strings":["Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101668258","display_name":"Hirofumi Makino","orcid":"https://orcid.org/0000-0002-1559-3799","observed_orcids":["https://orcid.org/0000-0002-1559-3799"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Makino","raw_affiliation_strings":["Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103268123"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":null,"apc_paid":null,"fwci":1.6419,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.83809955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"306","issue":"1","first_page":"F105","last_page":"F115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8119999766349792},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.7940000295639038},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/proximal-tubular-epithelial-cells","display_name":"proximal tubular epithelial cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.9419999718666077},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9240000247955322},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.8557583093643188},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7582296133041382},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.7172732353210449},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6884598135948181},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.669799268245697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6519147157669067},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6213511228561401},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5947684645652771},{"id":"https://openalex.org/C20719415","wikidata":"https://www.wikidata.org/wiki/Q416896","display_name":"Metallothionein","level":3,"score":0.5451000928878784},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.5325462222099304},{"id":"https://openalex.org/C2776553924","wikidata":"https://www.wikidata.org/wiki/Q5270132","display_name":"Diabetic cardiomyopathy","level":4,"score":0.4909510910511017},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4369913339614868},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4010363817214966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29859280586242676},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.0763024389743805},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.05618754029273987},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajprenal.00034.2013","doi":"https://doi.org/10.1152/ajprenal.00034.2013","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00034.2013","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmid:24154695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24154695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Renal physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G119112833","display_name":"Development of neuroprotective therapy for amyotrophic lateral sclerosis using serotonergic reagent","funder_award_id":"24659431","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6196327922","display_name":"The beneficial role of vaspin in metabolic syndrome by amelioration of ER stress","funder_award_id":"24790926","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G624738200","display_name":"The significance of vaspin in metabolic syndrome and drug discovery","funder_award_id":"23390241","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7791077649","display_name":"Studies on mechanism of rotenone-induced neurodegeneration in central and peripheral nervous systems and involvement of neuron-astrocyte interaction.","funder_award_id":"25461279","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1563264493","https://openalex.org/W1993360039","https://openalex.org/W1996854381","https://openalex.org/W1997664579","https://openalex.org/W2004351069","https://openalex.org/W2007506049","https://openalex.org/W2008255759","https://openalex.org/W2010216461","https://openalex.org/W2017501501","https://openalex.org/W2020871623","https://openalex.org/W2025223586","https://openalex.org/W2028473141","https://openalex.org/W2031540197","https://openalex.org/W2034001221","https://openalex.org/W2034900642","https://openalex.org/W2051266289","https://openalex.org/W2054393454","https://openalex.org/W2068362864","https://openalex.org/W2078450519","https://openalex.org/W2087622819","https://openalex.org/W2088664861","https://openalex.org/W2090360729","https://openalex.org/W2095891929","https://openalex.org/W2105662115","https://openalex.org/W2105731956","https://openalex.org/W2106133771","https://openalex.org/W2120309176","https://openalex.org/W2124502714","https://openalex.org/W2129742896","https://openalex.org/W2136487005","https://openalex.org/W2142693924","https://openalex.org/W2144664904","https://openalex.org/W2417746959"],"related_works":["https://openalex.org/W2051266289","https://openalex.org/W2379115333","https://openalex.org/W7098943790","https://openalex.org/W2382058954","https://openalex.org/W4385641582","https://openalex.org/W1997480450","https://openalex.org/W2012022623","https://openalex.org/W2957504916","https://openalex.org/W2997062414","https://openalex.org/W2137348715"],"abstract_inverted_index":{"Oxidative":[0],"stress":[1,50],"and":[2,51,62,76,103,107,130,171,203],"inflammation":[3,78,108,205],"play":[4,191],"important":[5],"roles":[6],"in":[7,17,25,34,59,111,136,146,151,175,195,206],"diabetic":[8,11,27,46,101,112,117,138,152,207],"complications,":[9],"including":[10],"nephropathy.":[12,208],"Metallothionein":[13],"(MT)":[14],"is":[15],"induced":[16,55],"proximal":[18,82,147],"tubular":[19,83,148],"epithelial":[20,84,149],"cells":[21,86,150,177],"as":[22],"an":[23],"antioxidant":[24],"the":[26,30,92,134,137,197],"kidney;":[28],"however,":[29],"role":[31,93,194],"of":[32,94,100,105,123,161,184],"MT":[33,43,95,125,162,189],"renal":[35],"function":[36],"remains":[37],"unclear.":[38],"We":[39],"therefore":[40],"investigated":[41],"whether":[42],"deficiency":[44,126],"accelerates":[45],"nephropathy":[47,102],"through":[48],"oxidative":[49],"inflammation.":[52],"Diabetes":[53],"was":[54],"by":[56,163],"streptozotocin":[57],"injection":[58],"MT-deficient":[60],"(MT(-/-))":[61],"MT(+/+)":[63,118],"mice.":[64,154],"Urinary":[65],"albumin":[66],"excretion,":[67],"histological":[68],"changes,":[69],"markers":[70,104],"for":[71],"reactive":[72],"oxygen":[73],"species":[74],"(ROS),":[75],"kidney":[77,198],"were":[79,87,109],"measured.":[80],"Murine":[81],"(mProx24)":[85],"used":[88],"to":[89],"further":[90],"elucidate":[91],"under":[96,179],"high-glucose":[97,180],"conditions.":[98,181],"Parameters":[99],"ROS":[106,169,202],"accelerated":[110,127],"MT(-/-)":[113,153],"mice":[114],"compared":[115],"with":[116],"mice,":[119],"despite":[120],"equivalent":[121],"levels":[122],"hyperglycemia.":[124],"interstitial":[128],"fibrosis":[129],"macrophage":[131],"infiltration":[132],"into":[133],"interstitium":[135],"kidney.":[139],"Electron":[140],"microscopy":[141],"revealed":[142],"abnormal":[143],"mitochondrial":[144,168],"morphology":[145],"In":[155],"vitro":[156],"studies":[157],"demonstrated":[158],"that":[159,188],"knockdown":[160],"small":[164],"interfering":[165],"RNA":[166],"enhanced":[167],"generation":[170],"inflammation-related":[172],"gene":[173],"expression":[174],"mProx24":[176],"cultured":[178],"The":[182],"results":[183],"this":[185],"study":[186],"suggest":[187],"may":[190],"a":[192],"key":[193],"protecting":[196],"against":[199],"high":[200],"glucose-induced":[201],"subsequent":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
