{"id":"https://openalex.org/W2102952080","doi":"https://doi.org/10.1039/b705800d","title":"Probing key coordination interactions: configurationally restricted metal activated CXCR4 antagonists","display_name":"Probing key coordination interactions: configurationally restricted metal activated CXCR4 antagonists","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2102952080","doi":"https://doi.org/10.1039/b705800d","mag":"2102952080","pmid":"https://pubmed.ncbi.nlm.nih.gov/17992286"},"language":"en","primary_location":{"id":"doi:10.1039/b705800d","doi":"https://doi.org/10.1039/b705800d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b705800d","pdf_url":null,"source":{"id":"https://openalex.org/S166159787","display_name":"Dalton Transactions","issn_l":"1477-9226","issn":["1477-9226","1477-9234"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dalton Transactions","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073431430","display_name":"Graeme McRobbie","orcid":"https://orcid.org/0000-0002-6725-7754","observed_orcids":["https://orcid.org/0000-0002-6725-7754"]},"institutions":[{"id":"https://openalex.org/I191240316","display_name":"University of Hull","ror":"https://ror.org/04nkhwh30","country_code":"GB","type":"education","lineage":["https://openalex.org/I191240316"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graeme McRobbie","raw_affiliation_strings":["Department of Chemistry, The University of Hull, Cottingham Road, Hull, UK HU6 7RX","Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Hull, Cottingham Road, Hull, UK HU6 7RX","institution_ids":["https://openalex.org/I191240316"]},{"raw_affiliation_string":"Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK","institution_ids":["https://openalex.org/I191240316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034998449","display_name":"Gina C. Valks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191240316","display_name":"University of Hull","ror":"https://ror.org/04nkhwh30","country_code":"GB","type":"education","lineage":["https://openalex.org/I191240316"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gina C. Valks","raw_affiliation_strings":["Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK","institution_ids":["https://openalex.org/I191240316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024868945","display_name":"Christopher J. Empson","orcid":"https://orcid.org/0000-0002-4808-8561","observed_orcids":["https://orcid.org/0000-0002-4808-8561"]},"institutions":[{"id":"https://openalex.org/I191240316","display_name":"University of Hull","ror":"https://ror.org/04nkhwh30","country_code":"GB","type":"education","lineage":["https://openalex.org/I191240316"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher J. Empson","raw_affiliation_strings":["Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK","institution_ids":["https://openalex.org/I191240316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050741985","display_name":"Abid Ali Khan","orcid":"https://orcid.org/0000-0003-0968-8705","observed_orcids":["https://orcid.org/0000-0003-0968-8705"]},"institutions":[{"id":"https://openalex.org/I191240316","display_name":"University of Hull","ror":"https://ror.org/04nkhwh30","country_code":"GB","type":"education","lineage":["https://openalex.org/I191240316"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Abid Khan","raw_affiliation_strings":["Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK","institution_ids":["https://openalex.org/I191240316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007726703","display_name":"J.D. Silversides","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191240316","display_name":"University of Hull","ror":"https://ror.org/04nkhwh30","country_code":"GB","type":"education","lineage":["https://openalex.org/I191240316"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jon D. Silversides","raw_affiliation_strings":["Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK","institution_ids":["https://openalex.org/I191240316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016741562","display_name":"Christophe C. Pannecouque","orcid":"https://orcid.org/0000-0002-1254-4473","observed_orcids":["https://orcid.org/0000-0002-1254-4473"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Christophe Pannecouque","raw_affiliation_strings":["Rega Institute for Medical Research, Katholieke Universiteit, Leuven, B-3000, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Katholieke Universiteit, Leuven, B-3000, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040662398","display_name":"Erik De Clercq","orcid":"https://orcid.org/0000-0002-2985-8890","observed_orcids":["https://orcid.org/0000-0002-2985-8890"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Erik De Clercq","raw_affiliation_strings":["Rega Institute for Medical Research, Katholieke Universiteit, Leuven, B-3000, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Katholieke Universiteit, Leuven, B-3000, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080353199","display_name":"Steven G. Fiddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802015276","display_name":"Daresbury Laboratory","ror":"https://ror.org/0089bg420","country_code":"GB","type":"facility","lineage":["https://openalex.org/I162524378","https://openalex.org/I2802015276","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven G. Fiddy","raw_affiliation_strings":["CCLRC Daresbury Laboratory, Warrington, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CCLRC Daresbury Laboratory, Warrington, UK","institution_ids":["https://openalex.org/I2802015276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027699970","display_name":"Adam J. Bridgeman","orcid":"https://orcid.org/0000-0003-2007-1650","observed_orcids":["https://orcid.org/0000-0003-2007-1650"]},"institutions":[{"id":"https://openalex.org/I191240316","display_name":"University of Hull","ror":"https://ror.org/04nkhwh30","country_code":"GB","type":"education","lineage":["https://openalex.org/I191240316"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adam J. Bridgeman","raw_affiliation_strings":["Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK","institution_ids":["https://openalex.org/I191240316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075191912","display_name":"Nigel A. Young","orcid":"https://orcid.org/0000-0003-4620-5119","observed_orcids":["https://orcid.org/0000-0003-4620-5119"]},"institutions":[{"id":"https://openalex.org/I191240316","display_name":"University of Hull","ror":"https://ror.org/04nkhwh30","country_code":"GB","type":"education","lineage":["https://openalex.org/I191240316"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nigel A. Young","raw_affiliation_strings":["Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK","institution_ids":["https://openalex.org/I191240316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001893764","display_name":"Stephen J. Archibald","orcid":"https://orcid.org/0000-0001-7581-8817","observed_orcids":["https://orcid.org/0000-0001-7581-8817"]},"institutions":[{"id":"https://openalex.org/I191240316","display_name":"University of Hull","ror":"https://ror.org/04nkhwh30","country_code":"GB","type":"education","lineage":["https://openalex.org/I191240316"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Stephen J. Archibald","raw_affiliation_strings":["Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK","institution_ids":["https://openalex.org/I191240316"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001893764"],"corresponding_institution_ids":["https://openalex.org/I191240316"],"apc_list":null,"apc_paid":null,"fwci":2.3237,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.88568437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":null,"issue":"43","first_page":"5008","last_page":"5008"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10464","display_name":"Crystal structures of chemical compounds","score":0.058400001376867294,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.047200001776218414,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cxcr4-antagonist","display_name":"CXCR4 antagonist","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cu-ii-complexes","display_name":"copper(II) complexes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hiv-1-inhibition","display_name":"HIV-1 inhibition","score":0.5339999794960022},{"id":"https://openalex.org/keywords/aspartate-binding","display_name":"aspartate binding","score":0.5260000228881836},{"id":"https://openalex.org/keywords/coordination-geometry","display_name":"coordination geometry","score":0.5260000228881836},{"id":"https://openalex.org/keywords/exafs","display_name":"EXAFS","score":0.6899999976158142},{"id":"https://openalex.org/keywords/x-ray-crystal-structure","display_name":"X-ray crystal structure","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8656948208808899},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.6342307329177856},{"id":"https://openalex.org/C178516000","wikidata":"https://www.wikidata.org/wiki/Q3023362","display_name":"Denticity","level":3,"score":0.5874159932136536},{"id":"https://openalex.org/C2780709120","wikidata":"https://www.wikidata.org/wiki/Q407189","display_name":"Perchlorate","level":3,"score":0.525770902633667},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5232102870941162},{"id":"https://openalex.org/C2777454769","wikidata":"https://www.wikidata.org/wiki/Q11172462","display_name":"Methylene","level":2,"score":0.512211263179779},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.5028428435325623},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.46947988867759705},{"id":"https://openalex.org/C68913812","wikidata":"https://www.wikidata.org/wiki/Q238156","display_name":"Coordination complex","level":3,"score":0.45334410667419434},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3811100125312805},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.24788588285446167},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1545824110507965},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.14488020539283752}],"mesh":[{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015498","descriptor_name":"HIV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1039/b705800d","doi":"https://doi.org/10.1039/b705800d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b705800d","pdf_url":null,"source":{"id":"https://openalex.org/S166159787","display_name":"Dalton Transactions","issn_l":"1477-9226","issn":["1477-9226","1477-9234"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dalton Transactions","raw_type":"journal-article"},{"id":"pmid:17992286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17992286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dalton transactions (Cambridge, England : 2003)","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/0215cbab-6f5c-4c2f-84a5-c18902ec8790","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/0215cbab-6f5c-4c2f-84a5-c18902ec8790","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"McRobbie, G, Valks, G C, Empson, C J, Khan, A, Silversides, J D, Pannecouque, C, De Clercq, E, Fiddy, S G, Bridgeman, A J, Young, N A & Archibald, S J 2007, 'Probing key coordination interactions: Configurationally restricted metal activated CXCR4 antagonists', Dalton Transactions, no. 43, pp. 5008-5018. https://doi.org/10.1039/b705800d","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:epubs.cclrc.ac.uk:work/57560","doi":null,"is_oa":false,"landing_page_url":"http://purl.org/net/epubs/work/57560","pdf_url":null,"source":{"id":"https://openalex.org/S4306400334","display_name":"Science and Technology Facilities Council","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I162524378","host_organization_name":"Science and Technology Facilities Council","host_organization_lineage":["https://openalex.org/I162524378"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8120881469","display_name":"High stability copper complex bioconjugates for position emission tomography imaging applications.","funder_award_id":"069719/Z/02/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1503380073","https://openalex.org/W1602000691","https://openalex.org/W1927934418","https://openalex.org/W1966095382","https://openalex.org/W1971193160","https://openalex.org/W1975944525","https://openalex.org/W1984898528","https://openalex.org/W1985510414","https://openalex.org/W1985544263","https://openalex.org/W1986055046","https://openalex.org/W1988712134","https://openalex.org/W1994415948","https://openalex.org/W1994857035","https://openalex.org/W1996196555","https://openalex.org/W2001207474","https://openalex.org/W2013732865","https://openalex.org/W2014692878","https://openalex.org/W2015326137","https://openalex.org/W2016940199","https://openalex.org/W2019879894","https://openalex.org/W2025925440","https://openalex.org/W2031221162","https://openalex.org/W2031322186","https://openalex.org/W2041314324","https://openalex.org/W2051600817","https://openalex.org/W2051801254","https://openalex.org/W2056404820","https://openalex.org/W2059020082","https://openalex.org/W2059900269","https://openalex.org/W2061190622","https://openalex.org/W2061876104","https://openalex.org/W2063334178","https://openalex.org/W2063825413","https://openalex.org/W2066018873","https://openalex.org/W2067024003","https://openalex.org/W2068892353","https://openalex.org/W2069462588","https://openalex.org/W2070580261","https://openalex.org/W2076019709","https://openalex.org/W2076519573","https://openalex.org/W2078386562","https://openalex.org/W2079658152","https://openalex.org/W2080792219","https://openalex.org/W2080919811","https://openalex.org/W2094115571","https://openalex.org/W2094191513","https://openalex.org/W2094988151","https://openalex.org/W2095353999","https://openalex.org/W2097842164","https://openalex.org/W2098274164","https://openalex.org/W2119423984","https://openalex.org/W2131112498","https://openalex.org/W2147381557","https://openalex.org/W2150345533","https://openalex.org/W2151324716","https://openalex.org/W2152022589","https://openalex.org/W2157638951","https://openalex.org/W2167109242","https://openalex.org/W2167792482","https://openalex.org/W2168909190","https://openalex.org/W3136451142","https://openalex.org/W4255220892"],"related_works":["https://openalex.org/W7018061098","https://openalex.org/W2167109242","https://openalex.org/W2487458527","https://openalex.org/W7073901205","https://openalex.org/W2153134667","https://openalex.org/W2085886339","https://openalex.org/W2945975362","https://openalex.org/W1966095382","https://openalex.org/W2123477510","https://openalex.org/W4401088004"],"abstract_inverted_index":{"The":[0,90],"syntheses":[1],"of":[2,22,60,63,82,172],"configurationally":[3,141,178],"restricted":[4,142,179],"mono-":[5],"and":[6,13,18,53,116],"bis-macrocyclic":[7,34],"copper(II)":[8,24],"perchlorate":[9],"complexes":[10],"(copper(II)":[11],"5-benzyl-1,5,8,12-tetraazabicyclo[10.2.2]hexadecane":[12],"dicopper(II)":[14,143,158],"5,5'-[1,4-phenylenebis(methylene)]-bis(1,5,8,12-tetraazabicyclo[10.2.2]hexadecane))":[15],"are":[16,45],"reported":[17],"the":[19,23,33,41,49,58,75,80,103,108,113,117,130,140,156,177],"X-ray":[20],"structure":[21],"mono-macrocyclic":[25],"complex":[26,144],"has":[27,112],"been":[28],"determined.":[29],"EXAFS":[30],"studies":[31],"on":[32],"species":[35],"in":[36,57],"aqueous":[37],"solution":[38],"show":[39,138],"that":[40,107,139],"copper":[42,131],"coordination":[43],"spheres":[44],"essentially":[46],"identical":[47],"to":[48,78,101],"solid":[50],"state":[51],"structure,":[52],"do":[54],"not":[55],"vary":[56],"presence":[59],"20":[61],"equivalents":[62],"sodium":[64],"acetate":[65,99,118],"per":[66],"metal":[67],"centre.":[68,132],"DFT":[69],"calculations":[70],"were":[71],"carried":[72],"out":[73],"at":[74,129],"BP86/TZP":[76],"level":[77],"determine":[79],"nature":[81],"potential":[83],"binding":[84],"interactions":[85],"with":[86,97],"CXCR4":[87],"aspartate":[88,104],"residues.":[89],"alkylated":[91],"single":[92],"macrocyclic":[93],"compound":[94],"was":[95],"modelled":[96],"an":[98,170],"included":[100],"represent":[102],"residue,":[105],"demonstrating":[106],"predicted":[109],"macrocycle":[110],"configuration":[111],"lowest":[114],"energy":[115],"interaction":[119],"is":[120,145,169],"effectively":[121],"monodentate":[122],"giving":[123],"a":[124],"distorted":[125],"trigonal":[126],"bipyramidal":[127],"geometry":[128],"In":[133],"vitro":[134],"anti-HIV":[135],"infection":[136],"assays":[137],"more":[146],"active":[147,175],"(average":[148,160],"EC(50)":[149,161],"=":[150,162],"0.026":[151],"microM":[152,164],"against":[153,165],"HIV-1)":[154,166],"than":[155,176],"non-constrained":[157],"1,1'-[1,4-phenylenebis(methylene)]-bis(1,4,8,11-tetraazacyclotetradecane)":[159],"0.047":[163],"although":[167],"it":[168],"order":[171],"magnitude":[173],"less":[174],"dizinc(II)":[180],"complex.":[181]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}